کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6813659 | 545654 | 2016 | 38 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulators of mitochondrial complex I activity: A review of literature and evaluation in postmortem prefrontal cortex from patients with bipolar disorder
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
6-OHDAGrx2DHEAGlutaredoxin 2FMNGSHSTAT-36-HydroxydopamineDJ-1SIRTROS - ROSSCZ - SBSbipolar disorder - اختلال دو قطبیSchizophrenia - اسکیزوفرنی یا شیزوفرنیGene expression - بیان ژنdihydroxyphenylacetic acid - دی هیدروکسی فنیل اسیدهای اسیدMicroarray - ریزآرایهsignal transducer and activator of transcription 3 - مبدل سیگنال و فعال کننده رونویسی 3Mitochondrial complex I - مجتمع میتوکندری Iflavine mononucleotide - مونونوکلئوتید فلایینیNitric oxide - نیتریک اکسیدGlutathione - گلوتاتیونReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Phenomenologically, bipolar disorder (BD) is characterized by biphasic increases and decreases in energy. As this is a state-related phenomenon, identifying regulators responsible for this phasic dysregulation has the potential to uncover key elements in the pathophysiology of BD. Given the evidence suggesting mitochondrial complex I dysfunction in BD, we aimed to identify the main regulators of complex I in BD by reviewing the literature and using the published microarray data to examine their gene expression profiles. We also validated protein expression levels of the main complex I regulators by immunohistochemistry. Upon reviewing the literature, we found PARK-7, STAT-3, SIRT-3 and IMP-2 play an important role in regulating complex I activity. Published microarray studies however revealed no significant direction of regulation of STAT-3, SIRT-3, and IMP-2, but a trend towards downregulation of PARK-7 was observed in BD. Immunocontent of DJ-1 (PARK-7-encoded protein) were not elevated in post mortem prefrontal cortex from patients with BD. We also found a trend towards upregulation of DJ-1 expression with age. Our results suggest that DJ-1 is not significantly altered in BD subjects, however further studies are needed to examine DJ-1 expression levels in a cohort of older patients with BD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 236, 28 February 2016, Pages 148-157
Journal: Psychiatry Research - Volume 236, 28 February 2016, Pages 148-157
نویسندگان
Angela Duong, Yi Che, Deniz Ceylan, Arsene Pinguelo, Ana C. Andreazza, L. Trevor Young, Michael Berk,