Keywords: DNMT، DNA methyltransferase; Atrial fibrillation; Epigenetic; DNA methylation; histone modification; microRNAAF, atrial fibrillation; DNMT, DNA methyltransferase; ECM, extracellular matrix; HP1, heterochromatin protein 1; MBD, methyl-binding domain; SOD1, superoxide dismutase 1; IL-1
مقالات ISI DNMT، DNA methyltransferase (ترجمه نشده)
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Keywords: DNMT، DNA methyltransferase; CpG, cytosine–phosphate–guanine; DM, diabetes mellitus; DNA, deoxyribonucleic acid; DNMT, DNA methyltransferase; TNF-α, tumor necrosis factor-alphaProcainamide; Epigenetic mechanisms; Metformin; Diabetes mellitus
Keywords: DNMT، DNA methyltransferase; Oral cancer; DNA methylation; Histone modifications; microRNA; Biomarkers; EpidrugsHPV, Human Papilloma Virus; DNMT, DNA methyltransferase; HDAC, histone deacetylase; miRNA, microRNA; NNK, nicotine-derived nitrosamine ketone; EDNRB, endothelin receptor ty
Keywords: DNMT، DNA methyltransferase; ACL, ATP-citrate lyase; AD, Alzheimer's disease; APP, amyloid-β precursor protein; BACE, β-site APP-cleaving enzyme; C/EBP, CCAAT-enhancer binding protein; DNMT, DNA methyltransferase; Drp, dynamin-related protein; ER, endoplasmic reticulum; FH, fumarate
Keywords: DNMT، DNA methyltransferase; AVP, arginine vasopressin; BNST, bed nucleus of the stria terminalis; DNMT, DNA methyltransferase; ERα, estrogen receptor alpha; ERβ, estrogen receptor beta; GnRH, gonadotropin-releasing hormone; HDAC, histone deacetylase; HPA, hypothalamic–pituitary–adre
Keywords: DNMT، DNA methyltransferase; ABCA1, ATP binding cassette transporter A1; CAD, coronary artery disease; CREBP, cAMP (adenosine 3′5′ cyclic monophosphate) response element-binding protein; CVD, cardiovascular disease; DNMT, DNA methyltransferase; DOTIL, disruption of telomeric silencin
Keywords: DNMT، DNA methyltransferase; SZ, schizophrenia; C1, one-carbon; Hcy, homocysteine; ROS, reactive oxygen species; SAM, S-adenosylmethionine; DNMT, DNA methyltransferase; FFQ, food frequency questionnaire; 24HDR, 24-hour dietary recall; RBC, red blood cell; SD, standard deviation; WMD,
The dynamic changes of DNA methylation in primordial germ cell differentiation
Keywords: DNMT، DNA methyltransferase; DNMT, DNA methyltransferase; ESCs, embryonic stem cells; PGCs, Primordial germ cells; ICM, inner cell mass; H3K4me3, histone 3 lysine 4 trimethylation; DMRs, Differentially Methylated Regions; Gadd45a, growth arrest and DNA-damage-inducible protein 45 alp
Transcriptional activity of acetylcholinesterase gene is regulated by DNA methylation during C2C12 myogenesis
Keywords: DNMT، DNA methyltransferase; AChE, Acetylcholinesterase; 5-Aza, 5-Azacytidine; DNMT, DNA methyltransferase; SP1, Specificity protein 1; TSA, Trichostatin AAChE; DNA methylation; Epigenetics; Myogenesis; Transcription regulation
Methylation-dependent and independent regulatory regions in the Na,K-ATPase alpha4 (Atp1a4) gene may impact its testis-specific expression
Keywords: DNMT، DNA methyltransferase; bp, base pair; CGI, CpG island; CMV, human cytomegalovirus; Dnmt, DNA methyltransferase; DMEM, Dulbecco's Modified Eagle's media; DKO, double knockout; ES cell, mouse embryonic stem cell; FBS, fetal bovine serum; HB-EGF-C, C-terminal fragment of heparin-b
Human DNA methyltransferase gene-transformed yeasts display an inducible flocculation inhibited by 5-aza-2′-deoxycytidine
Keywords: DNMT، DNA methyltransferase; 5AZ, 5-aza-2′-deoxycytidine; ACT1, β-actin; CpG, cytosine–phosphate–guanine; DNMT, DNA methyltransferase; OD600, optical density at 600 nm; ORF, open reading frame; PCR, polymerase chain reaction; RT-PCR, reverse-transcription polymerase chain reactionDNA
Functional linc-POU3F3 is overexpressed and contributes to tumorigenesis in glioma
Keywords: DNMT، DNA methyltransferase; lncRNA, long noncoding RNA; lincRNA, long intergenic non-coding RNA; mRNA, messenger RNA; DNMT, DNA methyltransferase; MNP, multipotential neural precursor; SC, Schwann cells; ACC, adenoid cystic carcinomaGlioma; Long non-coding RNA; Linc-POU3F3
A novel method to analyze 5-hydroxymethylcytosine in CpG sequences using maintenance DNA methyltransferase, DNMT1
Keywords: DNMT، DNA methyltransferase; Dnmt, DNA methyltransferase; ES cells, embryonic stem cells; 5hmC, hydroxymethylcytosine; 5mC, methylcytosine; SAM, S-adenosyl-l-methionine; Tet, ten eleven translocation; 2i, two kinase inhibitorsHydroxymethylcytosine; Bisulfite sequencing; DNMT1
c-ETS transcription factors play an essential role in the licensing of human MCM4 origin of replication
Keywords: DNMT، DNA methyltransferase; BrdU, 5-bromo-2′-deoxy-uridine; ChiP, chromatin immunoprecipitation; DMSO, dimethylsulfoxide; DNMT, DNA methyltransferase; EMSA, electrophoretic mobility shift assay; HAT, histone acetyltransferase; HDAC, histone deacetylase; MCM4, minichromosome maintena
Compendium of aberrant DNA methylation and histone modifications in cancer
Keywords: DNMT، DNA methyltransferase; K, lysine; ac, acetylation; me1, mono-methylation; me2, di-methylation; me3, tri-methylation; DNMT, DNA methyltransferase; FDA, U.S. Food and Drug Administration; POC, proof-of-conceptCancer; Epigenetics; DNA methylation; Histone modification
Prenatal caffeine ingestion induces aberrant DNA methylation and histone acetylation of steroidogenic factor 1 and inhibits fetal adrenal steroidogenesis
Keywords: DNMT، DNA methyltransferase; 3β-HSD, 3β-hydroxysteroid dehydrogenase; IUGR, intrauterine growth restriction; StAR, steroidogenic acute regulatory protein; P450scc, cytochrome P450 cholesterol side chain cleavage; SF-1, steroidogenic factor-1; Dnmt, DNA methyltransferase; Hdac, histon
Constitutive activation of the ATM/BRCA1 pathway prevents DNA damage-induced apoptosis in 5-azacytidine-resistant cell lines
Keywords: DNMT، DNA methyltransferase; AZA, 5-azacytidine; MDS, myelodysplastic syndromes; AML, acute myeloid leukemia; azaCMP, azacytidine monophosphate; azaCTP, azacytidine triphosphate; DNMT, DNA methyltransferase; DAC, 2-desoxy-AZA; CDKN, cyclin dependent kinase inhibitor; TP53, tumor prot
Global DNA hypomethylation: A potential mechanism in King pigeon nerve tissue damage induced by avermectin
Keywords: DNMT، DNA methyltransferase; AVM, avermectin; AVMs, avermectins; DNMT, DNA methyltransferase; DNMTs, DNA methyltransferases; MBD2, methyl-CpG-binding domain protein 2; HPLC, high performance liquid chromatography; ROS, reactive oxygen species; TCS, triclosan; MCA, 3-methylcholanthren
The TWEAK-Fn14 pathway: A potent regulator of skeletal muscle biology in health and disease
Keywords: DNMT، DNA methyltransferase; ALS, autophagy-lysosomal system; α-SMA, α-smooth muscle actin; Dnmt, DNA methyltransferase; ECM, extracellular matrix; Fn14, fibroblast growth factor-inducible 14; HDAC, histone deacetylase; IBM, inclusion-body myositis; KO, knockout; PGC-1α, peroxisome p
Retinoids induce stem cell differentiation via epigenetic changes
Keywords: DNMT، DNA methyltransferase; 5mC, 5-methylcytosine; 5hmC, 5-hydroxymethylcytosine; CARM, co-activator associated arginine methyltransferase 1; DNMT, DNA methyltransferase; ES, embryonic stem; miRNA, micro RNA; MLL, mixed lineage leukemia; PRC, Polycomb group-repressive complex; RA, a
Oxidative stress causes epigenetic alteration of CDX1 expression in colorectal cancer cells
Keywords: DNMT، DNA methyltransferase; CDX1, caudal type homeobox-1; ROS, reactive oxygen species; 5-Aza-dC, 5-aza-2-deoxycytidine; DNMT, DNA methyltransferase; HDAC, histone deacetylase; MS-PCR, methylation-specific-polymerase chain reactionCaudal type homeobox-1; Tumor suppressor gene; Color
Alcohol exposure during development: Impact on the epigenome
Keywords: DNMT، DNA methyltransferase; ARND, alcohol-related neurodevelopmental disorder; BAC, blood alcohol concentration; BDNF, brain-derived neurotrophic factor; CNS, central nervous system; CT, crossing threshold; DMR, differentially methylated region; DNMT, DNA methyltransferase; ET, etha
Exposure to caregiver maltreatment alters expression levels of epigenetic regulators in the medial prefrontal cortex
Keywords: DNMT، DNA methyltransferase; mPFC, medial prefrontal cortex; DNMT, DNA methyltransferase; MeCP2, Methyl-CpG Binding Protein-2; Gadd45b, Growth Arrest and DNA-Damage-Inducible beta; HAT, histone acetyltransferase; HDAC, histone deacetylase; PN, postnatal day; Bdnf, brain-derived neuro
Biology and clinical implications of CD133+ liver cancer stem cells
Keywords: DNMT، DNA methyltransferase; HCC, hepatocellular carcinoma; CSC, cancer stem cell; SP, side population; TGFβ, transforming growth factor β; DNMT, DNA methyltransferase; Line-1, long interspersed nuclear element-1; TP53INP1, tumor protein 53-inducible protein 1; HBsAg, surface antigen
Expression of WWOX and FHIT is downregulated by exposure to arsenite in human uroepithelial cells
Keywords: DNMT، DNA methyltransferase; ATR, ataxia telangiectasia and Rad3 related; WWOX, WW domain-containing oxidoreductase; FHIT, fragile histidine triad; BFD, blackfoot disease; ERK1/2, extracellular signal-regulated kinase1/2; CFSs, common fragile sites; DNMT, DNA methyltransferase; MEK,
Efficacy of decitabine-loaded nanogels in overcoming cancer drug resistance is mediated via sustained DNA methyltransferase 1 (DNMT1) depletion
Keywords: DNMT، DNA methyltransferase; APS, ammonium persulfate; DAC, 5-aza-2′deoxycytidine (decitabine); Dox, doxorubicin; DMEM, Dulbecco’s modified Eagle’s medium; DNMT, DNA methyltransferase; DPBS, Dulbecco’s phosphate-buffered saline; HVSMCs, human vascular smooth muscle cells; IC50, inhib
MicroRNA-195 and microRNA-378 mediate tumor growth suppression by epigenetical regulation in gastric cancer
Keywords: DNMT، DNA methyltransferase; DNMT, DNA methyltransferase; 5-aza-dC, 5-aza-2′-deoxycytidine; TSG, tumor suppressor gene; miRNA, microRNA; MSP, methylation specific PCR; TNM, tumor-node-metastasis; FBS, fetal bovine serum; NC, negative control; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-dip
Drugging the undruggable: Transcription therapy for cancer
Keywords: DNMT، DNA methyltransferase; AR, androgen receptor; DHFR, dihydrofolate reductase; DNMT, DNA methyltransferase; ER, estrogen receptor; HDAC, histone deacetylase; HMT, histone methyltransferase; HTS, high-throughput screening; MDR1, multidrug resistance protein 1; ODN, oligodeoxynucle
Global and gene specific DNA methylation changes during zebrafish development
Keywords: DNMT، DNA methyltransferase; CpG, Cytosine phosphate guanine; CGI, CpG island; dnmt, DNA methyltransferase; hpf, Hours post fertilization; HCP, High CpG promoter; ICP, Intermediate CpG promoter; PGCs, Primordial germ cells; gnmt, Glycine N-methyltransferase; LCP, Low CpG promoter; ra
Benzo[a]pyrene decreases global and gene specific DNA methylation during zebrafish development
Keywords: DNMT، DNA methyltransferase; BaP, benzo[a]pyrene; BPDE, anti-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; CpG, cytosine phosphate guanine; CGI, CpG island; dnmt, DNA methyltransferase; DMSO, dimethyl sulfoxide; hpf, hours post fertilization; gnmt, glycine N-methylt
Epigenetic origins of metabolic disease: The impact of the maternal condition to the offspring epigenome and later health consequences
Keywords: DNMT، DNA methyltransferase; AMPK, AMP-activated protein kinase; C/EBPβ, CCAAT/enhancer-binding protein β; CpG islands, cytosine-guanine dinucleotides; CPT1, carnitine palmitoyltransferase 1; CRP, C reactive protein; DNMT, DNA methyltransferase; GLUT 4, glucose transporter 4; GR, glu
Manipulating the epigenome for the treatment of urological malignancies
Keywords: DNMT، DNA methyltransferase; CRPC, castration-resistant prostate cancer; DNMT, DNA methyltransferase; DNMTi, DNA methyltransferase inhibitors; HDAC, histone deacetylase; HDACi, histone deacetylation inhibitors; PSA, prostate specific antigen; RCC, renal cell carcinoma; TCC, transitio
Dysregulation of the epigenome in triple-negative breast cancers: Basal-like and claudin-low breast cancers express aberrant DNA hypermethylation
Keywords: DNMT، DNA methyltransferase; DNMT, DNA methyltransferase; EMT, epithelial-to-mesenchymal transition; ER, estrogen receptor; HER2, gene encoding the epidermal growth factor receptor 2; miR, microRNA; PR, progesterone receptor; TIC, tumor initiating cell; TMI, total methylation indexTr
Induced production of mycotoxins in an endophytic fungus from the medicinal plant Datura stramonium L.
Keywords: DNMT، DNA methyltransferase; DNMT, DNA methyltransferase; 5-AC, 5-azacytidine; SBHA, Suberoylanilide hydroxamic acidEpigenetic modifier; Endophytic fungi; Datura stramonium L.; DNA methyltransferase inhibitor; Histone deacetylase inhibitor
On the epigenetic origin of cancer stem cells
Keywords: DNMT، DNA methyltransferase; ESC, embryonic stem cell; CSC, cancer stem cell; HP1, heterochromatin protein 1; PcG, polycomb group protein; HDAC, histone deacetylase; DNMT, DNA methyltransferase; BMI-1, B cell Moloney murine leukemia virus Insertion regionCancer; Cancer stem cell; Epi
Hypomethylation mediated by decreased DNMTs involves in the activation of proto-oncogene MPL in TK6 cells treated with hydroquinone
Keywords: DNMT، DNA methyltransferase; AML, acute myelogenous leukemia; 5-AZA, 5-aza-2′-deoxycytidine; BRAF, v-raf murine sarcoma viral oncogene homolog B1; DMSO, dimethyl sulphoxide; DNMT, DNA methyltransferase; ERBB2, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblast
The differentiating and apoptotic effects of 2-aza-5′-deoxycytidine are dependent on the PU.1 expression level in PU.1-transgenic K562 cells
Keywords: DNMT، DNA methyltransferase; MDS, myelodysplastic syndrome; AML, acute myeloid leukemia; CML, chronic myeloid leukemia; MEL, murine erythroleukemia; DNMT, DNA methyltransferase; 5-azadc, 5-aza-2′-deoxycytidine; HIFBS, heat-inactivated fetal bovine serum; HBA1, hemoglobin A1; GAPDH, g
Global DNA promoter methylation in frontal cortex of alcoholics and controls
Keywords: DNMT، DNA methyltransferase; Bp, Base pair; DNA, Deoxyribonucleic acid; DNMT, DNA methyltransferase; KS, Kolmogorov-Smirnov; MeDIP, Methylated DNA immunoprecipitation; PMI, Post mortem interval; RNA, Ribonucleic acid; miRNA, Micro ribonucleic acid; SAM, S-adenosyl methionine; SNPs, S
Grape seed proanthocyanidins reactivate silenced tumor suppressor genes in human skin cancer cells by targeting epigenetic regulators
Keywords: DNMT، DNA methyltransferase; GSPs, grape seed proanthocyanidins; DNMT, DNA methyltransferase; HDAC, histone deacetylase; H3-Lys 9, lysine 9 on histone H3; PCR, polymerase chain reaction; TSA, trichostatin A; 5-aza-dc, 5-aza-2′-deoxycytidineGrape seed proanthocyanidins; DNA methylatio
Inflammation-Associated Cancer Development in Digestive Organs: Mechanisms and Roles for Genetic and Epigenetic Modulation
Keywords: DNMT، DNA methyltransferase; H pylori; HCV; Mutation Induction; EpigeneticsA, adenine; AID, activation-induced cytidine deaminase; C, cytosine; CDKN, cyclin-dependent kinase inhibitor; COX-2, cyclooxygenase 2; DNMT, DNA methyltransferase; DSS, dextran sulfate sodium; EZH2, enhancer o
Inhibition of angiogenesis by S-adenosylmethionine
Keywords: DNMT، DNA methyltransferase; DNMT, DNA methyltransferase; EBM-2, endothelial basal medium; ECs, endothelial cells; EGM-2, endothelial growth medium; FBS, fetal bovine serum; HDAC, histone deacetylase; HUVEC, human umbilical vein endothelial cell; MTT, (3-(4,5-dimethyl-2-thiazolyl)-2,
Homocysteine levels impact directly on epigenetic reprogramming in astrocytes
Keywords: DNMT، DNA methyltransferase; SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine; Hcys, homocysteine; DNMT, DNA methyltransferase; NMDA, N-methyl-d-aspartate; mGluR, metabotropic glutamate receptorsAstrocytes; Epigenetics; DNA methylation; Homocysteine
Molecular dynamics simulations of human DNA methyltransferase 3B with selective inhibitor nanaomycin A
Keywords: DNMT، DNA methyltransferase; DNMT, DNA methyltransferase; MD, molecular dynamics; SAM, S-adenosyl-l-methionineCancer; DNA methylation; DNMT3B; Enzyme; Epigenetics; Inhibitor
An overview of epigenetics and chemoprevention
Keywords: DNMT، DNA methyltransferase; DNMT, DNA methyltransferase; SAM, S-adenosylmethionine; HAT, histone acetylase; HDAC, histone deacetylase; MBD, methyl-CpG-binding domain; IBD, inflammatory bowel disease; SFRP, secreted frizzled-related protein; APC, adenomatous polyposis coli; ACF, aber
Locust phase polyphenism: Does epigenetic precede endocrine regulation?
Keywords: DNMT، DNA methyltransferase; Dnmt, DNA methyltransferase; JH, juvenile hormone; EST, expressed sequence tagPhenotypic plasticity; Ageing; Insect; Epigenetics; Phase polyphenism; DNA methylation
Analysis of the GAD1 promoter: Trans-acting factors and DNA methylation converge on the 5′ untranslated region
Keywords: DNMT، DNA methyltransferase; Schizophrenia; Methylation; Regulation; Histone deacetylase inhibitors; InterneuronsChIP, chromatin immuneprecipitation; DNMT, DNA methyltransferase; GABA, gamma-aminobutyric acid; GAD25, glutamate decarboxylase25-the truncated protein that arises from a
ICF Syndrome Mutations Cause a Broad Spectrum of Biochemical Defects in DNMT3B-Mediated De Novo DNA Methylation
Keywords: DNMT، DNA methyltransferase; DNMT, DNA methyltransferase; ICF, immunodeficiency, centromere instability, and facial anomalies; SAM, S-adenosyl-L-methionine; MBP, maltose-binding protein; dsDNA, double-stranded DNA; EMSA, electrophoretic mobility shift assay; EDTA, ethylenediaminetetr
An epigenetic mechanism for capecitabine resistance in mesothelioma
Keywords: DNMT، DNA methyltransferase; TS, thymidylate synthase; TP, thymidine phosphorylase; DPD, dihydropyrimidine dehydrogenase; DNMT, DNA methyltransferase; DFUR, 5′-deoxy-5-fluorouridine; ECGF-1, extracellular growth factor-1; 5-aza-CdR, 5-aza-2′-deoxycytidineThymidine phosphorylase; Cape
DNA methyltransferase 3a expression decreases during apoptosis in primary cultures of hepatocytes
Keywords: DNMT، DNA methyltransferase; 18S rRNA, 18S ribosomal RNA; Ac-DEVD-AFC, acetyl-Asp-Glu-Val-Asp-7-amino-4-trifluoromethylcoumarin; CHX, cycloheximide; DNMT, DNA methyltransferase; FasL, Fas ligand; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; LDH, lactate dehydrogenase; PBS, phosph
Improved transplantation outcome by epigenetic changes
Keywords: DNMT، DNA methyltransferase; BMT, Bone marrow transplantation; CGI, CpG island; DC, Dendritic cell; DNMT, DNA methyltransferase; GVHD, Graft-versus-host-disease; GVL, Graft-versus-leukemia effect; HDAC, Histone deacetylase; HIF, Hypoxia-inducible factor; IDO, Indoleamine 2,3-dioxygen