Keywords: جذب مواد مخدر; Controlled release formulations; Colon; Colonic permeability; Drug absorption; Oral route;
مقالات ISI جذب مواد مخدر (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: جذب مواد مخدر; ASBT; apical sodium-dependent bile acid transporter; ASDs; amorphous solid dispersions; BACS; bile acid-CoA synthase; BAT; bile acid-amino acid transferase; BCS; biopharmaceutics classification system; BSH; bile salt hydrolase; C4; 7α-hydroxy-4-cholesten
Keywords: جذب مواد مخدر; Drug absorption; drug metabolism; elimination; excretion; half-life; pharmacokinetics
Keywords: جذب مواد مخدر; Drug absorption; Oral drug delivery; Gastrointestinal dynamics; Gastrointestinal hydrodynamics; Gastrointestinal motility; Absorption window; Food effect; Biorelevant dissolution testing;
Keywords: جذب مواد مخدر; Particulate matter; Skin; Barrier function; Stratum corneum; Tight junction; Drug absorption
Keywords: جذب مواد مخدر; Biopharmaceutics; Biopharmaceutical classification system; PBPK; IVIVC; Dissolution; Drug absorption;
Parameter study of shipping conditions for the ready-to-use application of a 3D human hemicornea construct in drug absorption studies
Keywords: جذب مواد مخدر; Human hemicornea construct; 3D in vitro model; Drug absorption; Epithelial barrier; Shipping parameter; Ready-to-use application;
Results of ASERTAA, a Randomized Prospective Crossover Pharmacogenetic Study of Immediate-Release Versus Extended-Release Tacrolimus in African American Kidney Transplant Recipients
Keywords: جذب مواد مخدر; Immunosuppression; tacrolimus; kidney transplantation; pharmacogenetics; tacrolimus dosing; randomized clinical trial; African American ancestry; genetic differences; CYP3A5 allele; pharmacokinetics; drug absorption; genotype;
Improved in vitro models for preclinical drug and formulation screening focusing on 2D and 3D skin and cornea constructs
Keywords: جذب مواد مخدر; In silico models; Numerical modeling; Tissue-engineered skin; Tissue-engineered cornea; Cryopreservation; Drug absorption; Wound closure of cultivated tissue; Anti-proliferation; Toxicity; DynaMiTES;
Research paperConcomitant solubility-permeability increase: Vitamin E TPGS vs. amorphous solid dispersion as oral delivery systems for etoposide
Keywords: جذب مواد مخدر; Drug absorption; Supersaturation; P-glycoprotein inhibition; Intestinal permeability; Oral drug delivery; Solubility;
Impaired oral absorption of methylphenidate after Roux-en-Y gastric bypass
Keywords: جذب مواد مخدر; ADHD; Bariatric Surgery; Drug absorption; Methylphenidate; Obesity; Oral drug administration; Roux-en-Y gastric bypass;
Osmolality of Orally Administered Solutions Influences Luminal Water Volume and Drug Absorption in Intestine
Keywords: جذب مواد مخدر; water absorption; luminal water volume; gastrointestinal fluid volume; osmolality; drug absorption; FITC-dextran; atenolol; antipyrine; intestine; rat; AQP; aquaporin; FD-4; fluorescein isothiocyanate dextran 4000; GI; gastrointestinal; ka; first-order ab
Oral biopharmaceutics tools - Time for a new initiative - An introduction to the IMI project OrBiTo
Keywords: جذب مواد مخدر; BCS; PBPK; IVIVC; Dissolution; Drug absorption; Permeability;
‘Stealth’ lipid-based formulations: Poly(ethylene glycol)-mediated digestion inhibition improves oral bioavailability of a model poorly water soluble drug
Keywords: جذب مواد مخدر; Drug absorption; Stealth; PEGylation; In vitro digestion; Lipid-based drug delivery; Pharmacokinetics
Transdermal delivery of relatively high molecular weight drugs using novel self-dissolving microneedle arrays fabricated from hyaluronic acid and their characteristics and safety after application to the skin
Keywords: جذب مواد مخدر; HA; hyaluronic acid; FD4; fluorescein isothiocyanate-labeled dextran with an average molecular weight of 4Â kDa; TEWL; transepidermal water loss; TER; transcutaneous electrical resistance; H&E; hematoxylin and eosin; P.I.I.; Primary Irritation Index; Micr
Expression analysis of MDR1, BCRP and MRP3 transporter proteins in different in vitro and ex vivo cornea models for drug absorption studies
Keywords: جذب مواد مخدر; Cornea; Drug absorption; Cell culture; In vitro model; ABC transporter;
Fatty acids as therapeutic auxiliaries for oral and parenteral formulations
Keywords: جذب مواد مخدر; Drug delivery; Protein binding; Endogenous drug carriers; Albumin; Drug absorption; Drug formulation; Fatty acids; Triglycerides; Lipid prodrugs; Reversible lipidization
Mucus as a barrier to lipophilic drugs
Keywords: جذب مواد مخدر; Mucin; Permeability; Drug absorption; Diffusion; Mucopenetration; Poorly soluble drug
The development and characteristics of novel microneedle arrays fabricated from hyaluronic acid, and their application in the transdermal delivery of insulin
Keywords: جذب مواد مخدر; Transdermal delivery; Insulin; Microneedle; Hyaluronic acid; Drug absorption; Peptide delivery
Developability assessment of clinical drug products with maximum absorbable doses
Keywords: جذب مواد مخدر; Developability assessment; Maximum absorbable dose; Drug absorption; Simulation; GastroPlusâ¢;
Caco-2 monolayers in experimental and theoretical predictions of drug transport
Keywords: جذب مواد مخدر; Drug transport; Drug absorption; Intestinal epithelium; Caco-2; Cell monolayer; Partition coefficient; Hydrogen bonding potential; Desolvation energy; Molecular surface area; In vitro-in vivo correlation
Novel pectin-based nanoparticles prepared from nanoemulsion templates for improving in vitro dissolution and in vivo absorption of poorly water-soluble drug
Keywords: جذب مواد مخدر; Poorly water-soluble drug; Itraconazole; Pectin; Nanoemulsion templates; Nanoparticles; Drug absorption
Prevalidation of a Human Cornea Construct as an Alternative to Animal Corneas for In Vitro Drug Absorption Studies
Keywords: جذب مواد مخدر; cornea; drug absorption; cell culture; in vitro model; serum-free cultivation; prevalidation;
Polyamidoamine dendrimers as novel potential absorption enhancers for improving the small intestinal absorption of poorly absorbable drugs in rats
Keywords: جذب مواد مخدر; Intestinal absorption; Polyamidoamine (PAMAM) dendrimer; Absorption enhancer; Drug absorption; Absorption enhancement; Intestinal toxicity
In situ artificial membrane permeation assay under hydrodynamic control: Correlation between drug in vitro permeability and fraction absorbed in humans
Keywords: جذب مواد مخدر; In situ permeation; Stirring; PAMPA; Drug absorption; Paracellular transport; Unstirred water layer
Development of a serum-free human cornea construct for in vitro drug absorption studies: The influence of varying cultivation parameters on barrier characteristics
Keywords: جذب مواد مخدر; Cornea; Drug absorption; Cell culture; In vitro model; Serum-free cultivation
Polyamidoamine Dendrimers Can Improve the Pulmonary Absorption of Insulin and Calcitonin in Rats
Keywords: جذب مواد مخدر; Dendrimer; pulmonary absorption; pulmonary drug delivery; absorption enhancer; drug absorption; bioavailability; peptide delivery; permeation enhancer; insulin; calcitonin;
Modelling the effects of microgravity on the permeability of air interface respiratory epithelial cell layers
Keywords: جذب مواد مخدر; Drug absorption; Cell culture; Microgravity simulation; 3D-clinostat; Biological effects; Permeability
Paracellular Porosity and Pore Size of the Human Intestinal Epithelium in Tissue and Cell Culture Models
Keywords: جذب مواد مخدر; paracellular permeation; drug absorption; human intestine; Cacoâ2; MDCKII; 2/4/A1; epithelial permeability;
Novel Topical Therapeutics
Keywords: جذب مواد مخدر; Topical therapy; Implantable therapeutics; Drug-eluting stent; Drug absorption; Drug-eluting polymer;
Polymeric micelles for oral drug delivery
Keywords: جذب مواد مخدر; Polymeric micelles; Oral administration; Drug solubilization; Drug absorption; Bioavailability; pH-sensitivity
Herbal interactions on absorption of drugs: Mechanisms of action and clinical risk assessment
Keywords: جذب مواد مخدر; Herb–drug interactions; Herbal medicines; Drug absorption; P-glycoprotein; Cytochrome P450; Safety; Risk assessment; Pharmacogenetics
Expert Panel report on a study of Splenda in male rats
Keywords: جذب مواد مخدر; Splenda; Sucralose; Weight gain; Body weight; Gut bacteria; Fecal microflora; P-glycoprotein (P-gp); P450 enzymes; Safety; Drug absorption
Characterisation of the R3/1 cell line as an alveolar epithelial cell model for drug disposition studies
Keywords: جذب مواد مخدر; Drug disposition; Alveolar epithelial cells; Tight junctions; Peptidases; Drug absorption
N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a “chemical knock-out equivalent” to assess the impact of efflux transporters on oral drug absorption in the rat
Keywords: جذب مواد مخدر; MDR1; BCRP; CP-100,356; drug absorption; bioavailability; P450; efflux; drug-drug interaction;
The direct comparison of health and ulcerated stomach tissue: A multiple probe microdialysis sampling approach
Keywords: جذب مواد مخدر; Microdialysis sampling; Gastric ulcers; In vivo sampling; Drug absorption
Ordered mesoporous silica induces pH-independent supersaturation of the basic low solubility compound itraconazole resulting in enhanced transepithelial transport
Keywords: جذب مواد مخدر; Supersaturation; Drug absorption; Ordered mesoporous silica; Itraconazole
Combined 4D‐Fingerprint and Clustering Based Membrane‐Interaction QSAR Analyses for Constructing Consensus Caco‐2 Cell Permeation Virtual Screens
Keywords: جذب مواد مخدر; Caco‐2 cell permeation; membrane; QSAR; universal 4D‐fingerprint descriptors; drug absorption; molecular similarity; cluster analysis
Enhancing intestinal drug solubilisation using lipid-based delivery systems
Keywords: جذب مواد مخدر; Drug absorption; Lipid-based delivery systems; Self-emulsifying drug delivery systems; In vitro lipolysis; Solubilisation
Effect of administration site in the gastrointestinal tract on bioavailability of poorly absorbed drugs taken after a meal
Keywords: جذب مواد مخدر; Food-drug interaction; Negative food effect; Drug absorption; Bioavailability; Site-specific drug delivery
An investigation into the influence of drug lipophilicity on the in vivo absorption profiles from subcutaneous microspheres and in situ forming depots
Keywords: جذب مواد مخدر; Microspheres; In situ forming implants; Lipophilicity; Drug absorption; In vivo; Subcutaneous
Absorption and metabolism of albendazole after intestinal ischemia/reperfusion
Keywords: جذب مواد مخدر; Ischemia–reperfusion; Intestine; Cytochrome P450; Flavin monooxygenase; Drug absorption; Albendazole
Pharmacokinetics of gefitinib in humans: The influence of gastrointestinal factors
Keywords: جذب مواد مخدر; Dissolution; Drug absorption; Gastric emptying; Gefitinib; Intestinal perfusion
Oral lipid-based formulations
Keywords: جذب مواد مخدر; Lipid-based formulations; Drug solubility; Lipid excipients; Lipid digestion; Drug absorption; Surfactant; Drug delivery
Exploration of linear modelling techniques and their combination with multivariate adaptive regression splines to predict gastro-intestinal absorption of drugs
Keywords: جذب مواد مخدر; QSAR; Drug absorption; In silico prediction; TMARS;
Absorption of poorly water soluble drugs subject to apical efflux using phospholipids as solubilizers in the Caco-2 cell model
Keywords: جذب مواد مخدر; Caco-2; Drug absorption; HIV-protease inhibitors; Efflux; Liposomes; Phospholipids; Kinetic modeling
In vivo animal models for drug delivery across the lung mucosal barrier
Keywords: جذب مواد مخدر; Systemic drug delivery; Respiratory delivery; Inhalation; Aerosol; Pharmacokinetics; Toxicity; Drug deposition; Drug absorption
Drug absorption in the elderly: Biopharmaceutical considerations for the antiepileptic drugs
Keywords: جذب مواد مخدر; Geriatric; Epilepsy; Elderly; Pharmacokinetics; Drug absorption; Gastrointestinal system
Identification of P-glycoprotein substrates using open tubular chromatography on an immobilized P-glycoprotein column: Comparison of chromatographic results with Caco-2 permeability
Keywords: جذب مواد مخدر; Online screening; Drug absorption; Affinity chromatography
A Convenient Method for Estimating the Quantity of Drug Eliminated by the Routes Other than Hepatic Metabolism and Renal Excretion and the Fraction of Drug that Reaches the “First Pass” after Oral Administration
Keywords: جذب مواد مخدر; hepatic metabolism; renal excretion; other routes of drug elimination; oral bioavailability; drug absorption; peripheral drug elimination;