کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8414152 | 1545344 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transdermal delivery of relatively high molecular weight drugs using novel self-dissolving microneedle arrays fabricated from hyaluronic acid and their characteristics and safety after application to the skin
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کلمات کلیدی
MicroneedleTEWLFD4Barrier disruptionH&E - H & ETransepidermal water loss - از دست دادن آب دریچهHyaluronic acid - اسید هیالورونیکAbsorption enhancement - افزایش جذبTransdermal drug delivery - تحویل داروی ترانزیستورTransdermal absorption - جذب ترشحیDrug absorption - جذب مواد مخدرTER - داشتنPrimary Irritation Index - شاخص تحریک اولیهTranscutaneous Electrical Resistance - مقاومت الکتریکی بر روی پوستHematoxylin and Eosin - هماتوکسیلین و ائوزین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
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چکیده انگلیسی
The purpose of this study was to develop novel dissolving microneedle arrays fabricated from hyaluronic acid (HA) as a material and to improve the transdermal permeability of relatively high molecular weight drugs. In this study, fluorescein isothiocyanate-labeled dextran with an average molecular weight of 4Â kDa (FD4) was used as a model drug with a relatively high molecular weight. The microneedle arrays significantly increased transepidermal water loss (TEWL) and reduced transcutaneous electrical resistance (TER), indicating that they could puncture the skin and create drug permeation pathways successfully. Both TEWL and TER almost recovered to baseline levels in the microneedle array group, and relatively small pathways created by the microneedles rapidly recovered as compared with those created by a tape stripping treatment. These findings confirmed that the microneedle arrays were quite safe. Furthermore, we found that the transdermal permeability of FD4 using the microneedle arrays was much higher than that of the FD4 solution. Furthermore, we found that the microneedle arrays were much more effective for increasing the amount of FD4 accumulated in the skin.These findings indicated that using novel microneedle arrays fabricated from HA is a very useful and effective strategy to improve the transdermal delivery of drugs, especially relatively high molecular weight drugs without seriously damaging the skin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 86, Issue 2, February 2014, Pages 267-276
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 86, Issue 2, February 2014, Pages 267-276
نویسندگان
Shu Liu, Mei-na Jin, Ying-shu Quan, Fumio Kamiyama, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto,