دانلود مقالات ISI درباره کشف مواد مخدر + ترجمه فارسی

An ELISA for the study of calcineurin-NFAT unstructured region interaction

Keywords: کشف مواد مخدر; Calcineurin-NFAT; T-cell activation; Drug discovery; ELISA; Protein-protein interactions;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2018 سفارش ترجمه

Targeting polyamine transport in Trypanosoma cruzi

Keywords: کشف مواد مخدر; Polyamine transport; Polyamine analogs; Drug discovery; Chagas disease; Trypanosoma cruzi;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2018 سفارش ترجمه

IRF4 in multiple myeloma-Biology, disease and therapeutic target

Keywords: کشف مواد مخدر; Multiple myeloma; IRF4; Transcription regulation; Treatment; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

Patient-derived xenografts: A platform for accelerating translational research in prostate cancer

Keywords: کشف مواد مخدر; Patient-derived xenograft; Prostate cancer; Cancer models; Drug discovery; Personalized medicine; Translational research;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Applications of ENCODE data to systematic analyses via data integration

Keywords: کشف مواد مخدر; ENCODE; Data integration; Transcription factors; Genomic alterations; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Myxobacterial natural products: An under-valued source of products for drug discovery for neurological disorders

Keywords: کشف مواد مخدر; Drug discovery; Neurodegenerative diseases; Natural products; Myxobacteria;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Selective, C-3 Friedel-Crafts acylation to generate functionally diverse, acetylated Imidazo[1,2-a]pyridine derivatives

Keywords: کشف مواد مخدر; Imidazo[1,2-a]pyridine; Combinatorial chemistry; Friedel-Crafts acylation; Drug discovery; Library generation;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Establishment of a novel microscale thermophoresis ligand-binding assay for characterization of SLC solute carriers using oligopeptide transporter PepT1 (SLC15 family) as a model system

Keywords: کشف مواد مخدر; Microscale thermophoresis (MST); Ligand-binding assay (LBA); Compound screening; Membrane transport; Solute carrier family SLC; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

N-Acylhydrazones as drugs

Keywords: کشف مواد مخدر; ADME; absorption, distribution, metabolism, excretion; BBNH; N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone; BISH; boronyl salicylaldehyde isonicotinoyl hydrazone; DB; drug bank; DHBNH; dihydroxy benzoyl naphthyl hydrazone; FDA; food and dru

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Overexpressing cell systems are a competitive option to primary adipocytes when predicting in vivo potency of dual GPR81/GPR109A agonists

Keywords: کشف مواد مخدر; GPR81; GPR109A; In vitro-in vivo correlation; Non-esterified fatty acids (NEFA); PKPD modeling; Nonlinear mixed effects (NLME) modeling; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Patient Derived Xenografts (PDX) for personalized treatment of pancreatic cancer: emerging allies in the war on a devastating cancer?

Keywords: کشف مواد مخدر; Pancreatic ductal adenocarcinoma; Patient Derived Xenografts; Biomarkers; Drug discovery; Personalized medicine;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Discovery of the bifunctional modulator of angiotensin II type 1 receptor (AT1R) and PPARγ derived from the AT1R antagonist, Fimasartan

Keywords: کشف مواد مخدر; Drug discovery; Dual modulator; Antihypertensives; Antidiabetics; PPARγ; Angiotensin II type 1 receptor antagonist; Fimasartan;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Macrophage CD31 Signaling in Dissecting Aortic Aneurysm

Keywords: کشف مواد مخدر; aortic dissection; CD31; drug discovery; intramural hematoma; macrophages; peptides; ADIM; acute aortic dissection and intramural hematoma; Ang II; angiotensin II; Apo E−/−; apolipoprotein E knockout; BMDM; bone marrow-derived macrophage; IL; interl

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

Zebrafish (Danio rerio): A valuable tool for predicting the metabolism of xenobiotics in humans?

Keywords: کشف مواد مخدر; Zebrafish (Danio rerio); Xenobiotic metabolism; Cytochrome P450; Non-human model; Drug discovery; Toxicology;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

Fragment screening for drug leads by weak affinity chromatography (WAC-MS)

Keywords: کشف مواد مخدر; 3-ABA; 3-aminobenzamidine; 4-ABA; 4-aminobenzamidine; AmAc; ammonium acetate; APCI; atmospheric pressure chemical ionization; AQP1; human aquaporin-1; BA; benzamidine; BCA; bicinchoninic acid; CMC; critical micelle concentration; DMSO; dimethyl sulfoxide;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

Drug targets exploited in Mycobacterium tuberculosis: Pitfalls and promises on the horizon

Keywords: کشف مواد مخدر; Tuberculosis; Drug targets; Mycobacterium tuberculosis; Drug resistance; HIV-TB; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2018 سفارش ترجمه

Engineered Kidney Tubules for Modeling Patient-Specific Diseases and Drug Discovery

Keywords: کشف مواد مخدر; Tubule engineering; Human pluripotent stem cells; Polycystic kidney disease; Ureteric bud; Drug discovery; PAX2;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2018 سفارش ترجمه

Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition

Keywords: کشف مواد مخدر; FHQDWTRKEXLBKC-UHFFFAOYSA-N; SKFIVWCBYVFRGO-UHFFFAOYSA-N; RLSFJBBDDMJWQC-UHFFFAOYSA-N; BLRHMMGNCXNXJL-UHFFFAOYSA-N; JDFIJVJKRTZYCK-UHFFFAOYSA-N; UJQAQVXJQOQUEK-UHFFFAOYSA-N; CAZQKJLURLSIJF-UHFFFAOYSA-N; TUYYDUWGJUCGJQ-UHFFFAOYSA-M; BLSFHFDDRSFGHE-UHFFFAOY

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2018 سفارش ترجمه

An update on β-lactamase inhibitor discovery and development

Keywords: کشف مواد مخدر; Beta-lactamase; Inhibitor; Crystal structure; Antibiotic resistance; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2018 سفارش ترجمه

The new plant Parinari kerstingii Engl.: Toxicity studies and anti-inflammatory properties

Keywords: کشف مواد مخدر; PKWE; Parinari kerstingii Engl. water extract; PKEE; Parinari kerstingii Engl. ethanol extract; IL; interleukin; TNF; tumor necrosis factor-alpha; COX; cyclooxygenase; NF-κB; nuclear factor-kappa B; PGE2; prostaglandin E2; AST; aspartate aminotransferase

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2018 سفارش ترجمه

Identification of cysteine protease inhibitors as new drug leads against Naegleria fowleri

Keywords: کشف مواد مخدر; Naegleria fowleri; Primary amebic meningoencephalitis; cysteine protease; Inhibitors; Drug discovery; Drug leads;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2018 سفارش ترجمه

MS methods to study macromolecule-ligand interaction: Applications in drug discovery

Keywords: کشف مواد مخدر; MS; mass spectrometry; IM-MS; ion mobility mass spectrometry; HR-MS; high resolution mass spectrometry; MS/MS; tandem mass spectrometry; ESI; electrospray ionization; NSI; nanoelectrospray ionization; MALDI; matrix assisted laser desorption ionization; FT

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2018 سفارش ترجمه

Lipid bilayer position and orientation of novel carprofens, modulators of γ-secretase in Alzheimer's disease

Keywords: کشف مواد مخدر; γ-Secretase; Alzheimer's disease; Neutron diffraction; Nuclear magnetic resonance; Molecular dynamics; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2018 سفارش ترجمه

Screening of the MMV and GSK open access chemical boxes using a viability assay developed against the kinetoplastid Crithidia fasciculata

Keywords: کشف مواد مخدر; Crithidia fasciculata; Kinetoplastid; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2018 سفارش ترجمه

Arylpyrrole and fipronil analogues that inhibit the motility and/or development of Haemonchus contortus in vitro

Keywords: کشف مواد مخدر; Arylpyrrole; Fipronil; Haemonchus contortus; Anthelmintic; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2018 سفارش ترجمه

Mimicking brain tissue binding in an in vitro model of the blood-brain barrier illustrates differences between in vitro and in vivo methods for assessing the rate of brain penetration

Keywords: کشف مواد مخدر; Blood-brain barrier; Endothelial cells; Brain exposure; Drug discovery; BBB permeability; Brain tissue binding; In vitro model; In-situ brain perfusion; BBB; blood-brain barrier; bBCEC; bovine brain capillary endothelial cells; EC; endothelial cells; CNS;

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

Ligand-selective small molecule modulators of the constitutively active vGPCR US28

Keywords: کشف مواد مخدر; Drug discovery; G protein-coupled receptor; Virtual screening; Molecular modeling;

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

FilTer BaSe: A web accessible chemical database for small compound libraries

Keywords: کشف مواد مخدر; ADMET; absorption distribution metabolism excretion and toxicity; MW; molecular weight; tPSA; topological polar surface area; PAINS; pan assay interference compounds; QASR; quantitative structure-activity relationship; Compound libraries; FilTer BaSe; V

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

In silico toxicity profiling of natural product compound libraries from African flora with anti-malarial and anti-HIV properties

Keywords: کشف مواد مخدر; 2D; two dimensional; 3D; three dimensional; Afro-HIV; dataset of molecules from African flora with known activities against the human immunodeficiency virus; AfroMalariaDb; dataset of anti-malarial compounds from African flora; DMPK; drug metabolism and p

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

Promise and challenges for direct small molecule AMPK activators

Keywords: کشف مواد مخدر; AMPK; Energy metabolism; Small molecule activator; Therapeutics; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery

Keywords: کشف مواد مخدر; Neuroscience; Automation; Drug discovery; Alzheimer's Disease; Parkinson's Disease;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

Pyrazolo[1,5-a]pyrimidine TRPC6 antagonists for the treatment of gastric cancer

Keywords: کشف مواد مخدر; Nonselective cation channels; TRPC channels; Ca2+ signaling; Anticancer; Drug discovery; [Ca2+]i; Intracellular Ca2+ concentration; CCh; Carbachol; EC50; Half maximal stimulation; FMP; FLIPR membrane potential; PLC; phospholipase C; SAR; Structure-activit

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2018 سفارش ترجمه

Performance of machine learning algorithms for qualitative and quantitative prediction drug blockade of hERG1 channel

Keywords: کشف مواد مخدر; Drug-induced cardiotoxicity; Herg1 channel; Machine-learning; Gradient-boosting; Lead optimization; Drug discovery; Quantitative structure activity relationship;

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2018 سفارش ترجمه

A novel NAE/UAE dual inhibitor LP0040 blocks neddylation and ubiquitination leading to growth inhibition and apoptosis of cancer cells

Keywords: کشف مواد مخدر; NEDD8 activating enzyme; Ubiquitin activating enzyme; Dual inhibitor; Apoptosis; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2018 سفارش ترجمه

Calmodulin and IQGAP1 activation of PI3Kα and Akt in KRAS, HRAS and NRAS-driven cancers

Keywords: کشف مواد مخدر; KRAS4B; Ras isoforms; K-Ras; H-Ras; N-Ras; Plasma membrane; Calcium; Proliferation; Phosphorylated tyrosine motif; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

Elucidating structural and molecular mechanisms of β-arrestin-biased agonism at GPCRs via MS-based proteomics

Keywords: کشف مواد مخدر; 7TMR; GPCR; Arrestin; β-Arrestin; Biased agonism; Biased agonist; Mass spectrometry; Proteomics; Pharmacology; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

Methylated flavonoids as anti-seizure agents: Naringenin 4′,7-dimethyl ether attenuates epileptic seizures in zebrafish and mouse models

Keywords: کشف مواد مخدر; Epilepsy; Drug discovery; Methylated flavonoids; Naringenin; Zebrafish; Mouse; AED; anti-epileptogenic drug; ASD; anti-seizure drug; cLogP; calculated LogP; dpf; days post-fertilization; DMSO; dimethyl sulfoxide; GABA; γ-aminobutyric acid; IL-1β; interl

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

Structural basis for potent inhibition of d-amino acid oxidase by thiophene carboxylic acids

Keywords: کشف مواد مخدر; Flavoenzyme; Schizophrenia; Drug discovery; X-ray crystallography; Molecular dynamics; DAO/DAAO; d-amino acid oxidase; D-Ser; d-serine; SAR; Structure-activity relationship; MD; molecular dynamics; H-bond; hydrogen bond; DOPA; dihydroxyphenylalanine; CPC;

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2018 سفارش ترجمه

Identification of potential inhibitors of sortase A: Binding studies, in-silico docking and protein-protein interaction studies of sortase A from Enterococcus faecalis

Keywords: کشف مواد مخدر; In-silico modelling; Potential EfSrtA inhibitors; Drug discovery; Protein-protein interaction;

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2018 سفارش ترجمه

Identification of chalcone-based antileishmanial agents targeting trypanothione reductase

Keywords: کشف مواد مخدر; Chalcone; Drug discovery; Leishmaniasis; Natural products; Neglected tropical disease; Trypanothione reductase;

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2018 سفارش ترجمه

AGC kinases, mechanisms of regulation ‎and innovative drug development

Keywords: کشف مواد مخدر; AGC kinase; group of kinases related to PKA PKG and PKC; PKA; protein kinase A; PKC; protein kinase C; PKG; protein kinase G; PRK; protein kinase C related kinase (also termed PKN protein kinase N); PDK1; 3-phosphoinositide-dependent protein kinase 1; PKB

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2018 سفارش ترجمه

Identification of a pyrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening

Keywords: کشف مواد مخدر; Drug discovery; Toll-like receptors; TLR2; Virtual screening; Competitive antagonist;

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2018 سفارش ترجمه

Dengue virus NS2 and NS4: Minor proteins, mammoth roles

Keywords: کشف مواد مخدر; Dengue virus; Non-structural proteins; Direct-acting antivirals; Drug discovery; Therapeutic targets; Small NS proteins;

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2018 سفارش ترجمه

GPCRs: Emerging anti-cancer drug targets

Keywords: کشف مواد مخدر; GPCR; Signalling; Cancer; Drug targets; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 51 صفحه سال انتشار : 2018 سفارش ترجمه

Hybrid MS/NMR methods on the prioritization of natural products: Applications in drug discovery

Keywords: کشف مواد مخدر; Dereplication; Hyphenated techniques; Drug discovery; Natural products; MS; NMR;

دانلود رایگان متن کامل مقاله ISI 51 صفحه سال انتشار : 2018 سفارش ترجمه

Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors

Keywords: کشف مواد مخدر; Hybrid drugs; AChE inhibitor; BuChE inhibitor; Alzheimer's disease; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 52 صفحه سال انتشار : 2018 سفارش ترجمه

Critical differences in drug metabolic properties of human hepatic cellular models, including primary human hepatocytes, stem cell derived hepatocytes, and hepatoma cell lines

Keywords: کشف مواد مخدر; ACN; acetonitrile; BCA; bicinchoninic acid; DMSO; dimethyl sulfoxide; ESI; electrospray ionization; HPLC; high pressure liquid chromatography; iPSC; induced pluripotent stem cell; LDA; low density array; MS; mass spectrometry; P450; cytochrome P450; PCA;

دانلود رایگان متن کامل مقاله ISI 52 صفحه سال انتشار : 2018 سفارش ترجمه

Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor

Keywords: کشف مواد مخدر; ACh; acetylcholine; mAChR; muscarinic acetylcholine receptor; GPCR; G protein-coupled receptor; AD; Alzheimer's disease; PAM; positive allosteric modulator; NAM; negative allosteric modulator; TM; transmembrane domain; ECL; extracellular loop; CHO; Chin

دانلود رایگان متن کامل مقاله ISI 54 صفحه سال انتشار : 2018 سفارش ترجمه

Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition

Keywords: کشف مواد مخدر; Idebenone (PubChem CID: 3686); acarbose (PubChem CID: 41774); BI78D3 (PubChem CID: 2747117); candesartan cilexetil (PubChem CID: 2540); PQ401 (PubChem CID: 9549305); Src I1 (PubChem CID: 1474853); 17a-Hydroxyprogesterone (PubChem CID: 6238); FPA 124 (PubC

دانلود رایگان متن کامل مقاله ISI 54 صفحه سال انتشار : 2018 سفارش ترجمه

Receptor binding kinetics equations: Derivation using the Laplace transform method

Keywords: کشف مواد مخدر; Methods; Receptor binding kinetics; Receptor theory; Data analysis; Ligand binding; Drug discovery; Drug kinetics; Residence time;

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2018 سفارش ترجمه