دانلود مقالات ISI درباره کشف مواد مخدر + ترجمه فارسی

Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes

Keywords: کشف مواد مخدر; G-quadruplex; Virtual screening; Anticancer agents; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2017 سفارش ترجمه

Exploring the potential of T7 bacteriophage protein Gp2 as a novel inhibitor of mycobacterial RNA polymerase

Keywords: کشف مواد مخدر; Mycobacterium tuberculosis; RNA polymerase; In silico analysis; T7 bacteriophage; Molecular modelling; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2017 سفارش ترجمه

Chemomechanically engineered 3D organotypic platforms of bladder cancer dormancy and reactivation

Keywords: کشف مواد مخدر; 3D Tissue models; Cancer dormancy; Reactivation; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2017 سفارش ترجمه

Therapeutic molecules for multiple human diseases identified from pigeon pea (Cajanus cajan L. Millsp.) through GC-MS and molecular docking

Keywords: کشف مواد مخدر; Breast cancer; Drug discovery; Herbal medicine; In silico; Malaria; Measles; Phyto-compounds; Rheumatoid arthritis; Sickle cell disease; Type II diabetes;

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2017 سفارش ترجمه

CRISPR system in filamentous fungi: Current achievements and future directions

Keywords: کشف مواد مخدر; CRISPR; clustered regularly interspaced short palindromic repeats; NHEJ; non-homologous end joining; HDR; high-fidelity homology-directed repair; ZFN; zinc finger nucleases; TALEN; transcription activator-like effector nucleases; tef1; translation-elongat

دانلود رایگان متن کامل مقاله ISI 59 صفحه سال انتشار : 2017 سفارش ترجمه

CRISPR/Cas9-mediated target validation of the splicing inhibitor Pladienolide B

Keywords: کشف مواد مخدر; CRIPSR/Cas9; Pladienolide B; Spliceosome; Pre-mRNA splicing; Drug target validation; Drug discovery; SSNs; Site Specific Nucleases; ZFN; Zing Finger Nucleases; TALENs; Transcription Like Effector Nucleases; CRISPR; Clustered Regulatory Interspaced Short P

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Design and synthesis of 5-cyclopropyl substituted cyclic acylguanidine compounds as BACE1 inhibitors

Keywords: کشف مواد مخدر; Alzheimer's disease; BACE1 inhibitor; β-Secretase; Drug discovery; Cyclic acylguanidine;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Molecular insights to the bioactive form of BV02, a reference inhibitor of 14-3-3σ protein–protein interactions

Keywords: کشف مواد مخدر; 14-3-3; Drug discovery; Bioactive form; NMR; Lead compound; Chemical transformation; Chemical instability

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Discovery of novel TAOK2 inhibitor scaffolds from high-throughput screening

Keywords: کشف مواد مخدر; Kinase; MAP3K; High-throughput screening; Autophagy; Drug discovery; Inhibitor

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Zika Virus Replicons for Drug Discovery

Keywords: کشف مواد مخدر; Zika; Drug discovery; Replicon; Flavivirus;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Promiscuous activity of the LXR antagonist GSK2033 in a mouse model of fatty liver disease

Keywords: کشف مواد مخدر; Nuclear receptor; LXR; Transcription; NASH; Lipogenesis; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis of novel, functionalised tricycles utilising the interrupted Pummerer reaction

Keywords: کشف مواد مخدر; Interrupted Pummerer; Cyclisation; Heterocycle; Drug discovery; Medicinal chemistry;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Direct detection of SERCA calcium transport and small-molecule inhibition in giant unilamellar vesicles

Keywords: کشف مواد مخدر; Biomimetic membrane; Calcium regulation; Drug discovery; Electrostatic fusion; Lipid reconstitution; Transport proteins;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

C-H activation reactions as useful tools for medicinal chemists

Keywords: کشف مواد مخدر; C-H activation; Heterocycles; Pharmaceuticals; Drug discovery; Medicinal chemistry;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Lead discovery for mammalian elongation of long chain fatty acids family 6 using a combination of high-throughput fluorescent-based assay and RapidFire mass spectrometry assay

Keywords: کشف مواد مخدر; Elongation of long chain fatty acids family 6 (Elovl6); High-throughput screening (HTS); RapidFire mass spectrometry (RF-MS); Drug discovery;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

The discovery and the structural basis of an imidazo[4,5-b]pyridine-based p21-activated kinase 4 inhibitor

Keywords: کشف مواد مخدر; PAK4; Inhibitor; FBDD; Cancer; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

A new application of micellar liquid chromatography in the determination of free ampicillin concentration in the drug–human serum albumin standard solution in comparison with the adsorption method

Keywords: کشف مواد مخدر; Free drug concentration; Human serum albumin; Drug–protein complex; Micellar liquid chromatography; Drug discovery

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

A novel compact mass detection platform for the open access (OA) environment in drug discovery and early development

Keywords: کشف مواد مخدر; Compact mass detector; Open-access; UPLC-MS; Process; Development; Drug discovery

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Inhibition of RORα/γ suppresses atherosclerosis via inhibition of both cholesterol absorption and inflammation

Keywords: کشف مواد مخدر; Drug discovery; Nuclear receptor; Atherosclerosis; Cholesterol; Heart disease; ROR;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Novel small molecule binders of human N-glycanase 1, a key player in the endoplasmic reticulum associated degradation pathway

Keywords: کشف مواد مخدر; NGLY1; N-glycanase; ER; endoplasmic reticulum; ERAD; endoplasmic reticulum associated degradation; SDS-PAGE; sodium dodecyl sulfate polyacrylamide gel electrophoresis; TSA; thermal shift assay; DSF; differential scanning fluorimetry; Drug discovery; N-g

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Possible mechanisms of antinociception of methanol extract of Melastoma malabathricum leaves

Keywords: کشف مواد مخدر; Melastomaceae; Herbal; Pain-killing; Natural products; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Modeling Barrier Tissues In Vitro: Methods, Achievements, and Challenges

Keywords: کشف مواد مخدر; Microfluidic technologies; Barrier tissues; In vitro modeling; Organ-on-a-chip; Drug discovery; Microphysiological systems

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Antibiotic Adjuvants: Rescuing Antibiotics from Resistance

Keywords: کشف مواد مخدر; drug combinations; inhibitor; drug discovery; antibacterial;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Investigation of utility of cerebrospinal fluid drug concentration as a surrogate for interstitial fluid concentration using microdialysis coupled with cisternal cerebrospinal fluid sampling in wild-type and Mdr1a(−/−) rats

Keywords: کشف مواد مخدر; P-glycoprotein; Central nervous system; Brain; Cerebrospinal fluid; Interstitial fluid; Microdialysis; Rats; Drug discovery; AUC; area under the plasma concentration-time curve; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; BCSFB;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Biased agonism: An emerging paradigm in GPCR drug discovery

Keywords: کشف مواد مخدر; Biased ligand; Functional selectivity; GPCR; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

Keywords: کشف مواد مخدر; Tuberculosis; Antibiotic; InhA; Bactericidal; Drug discovery; Single-cell imaging; Catalase

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of TS and AICARFTase and as potential antitumor agents

Keywords: کشف مواد مخدر; Pyrrolo[2,3-d]pyrimidines; Antiproliferation; Thymidylate biosynthesis; Purine biosynthesis; Drug discovery

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

New design of nucleotide excision repair (NER) inhibitors for combination cancer therapy

Keywords: کشف مواد مخدر; DNA repair; ERCC1; XPA; In silico modeling; Drug discovery; Cancer

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

SPME as a promising tool in translational medicine and drug discovery: From bench to bedside

Keywords: کشف مواد مخدر; Solid phase microextraction; SPME; Translational medicine; Drug discovery; Cell culturing; Animal studies; In vivo analysis; Drug; Analysis;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications

Keywords: کشف مواد مخدر; cardiac regeneration; disease modeling; drug discovery; induced pluripotent stem cells; ESC; embryonic stem cell(s); iCM; induced pluripotent stem cell-derived cardiomyocyte(s); iEC; induced pluripotent stem cell-derived endothelial cell(s); iPSC; i

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Review ArticleIBM Watson: How Cognitive Computing Can Be Applied to Big Data Challenges in Life Sciences Research

Keywords: کشف مواد مخدر; big data; cognitive computing; data science; drug discovery; genetics; personalized medicine;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Microfluidics for cell-based high throughput screening platforms—A review

Keywords: کشف مواد مخدر; High throughput screening; Cell-based microfluidics; Drug discovery

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

Pharmacogenomic study using bio- and nanobioelectrochemistry: Drug-DNA interaction

Keywords: کشف مواد مخدر; Electrochemical DNA biosensor; Pharmacogenomics; Drug-DNA interaction; Drug discovery; DNA damage; DNA hybridization;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2016 سفارش ترجمه

New agents for the treatment of drug-resistant Mycobacterium tuberculosis

Keywords: کشف مواد مخدر; Mtb; Mycobacterium tuberculosis; TB; Tuberculosis; MDR-TB; Multidrug-resistant tuberculosis; RIF; Rifampicin; INH; Isoniazid; PZA; Pyrazinamide; ETH; Ethambutol; WHO; World Health Organization; CYP; Cytochrome P450; ADME; Absorption, distribution, metabol

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2016 سفارش ترجمه

Pharmacophore-based screening targeted at upregulated FN1, MMP-9, APP reveals therapeutic compounds for nasopharyngeal carcinoma

Keywords: کشف مواد مخدر; Nasopharyngeal carcinoma; Bioinformatics; Drug discovery; Virtual screening; Pharmacophore; Docking;

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2016 سفارش ترجمه

Modulation of DNA damage response and induction of apoptosis mediates synergism between doxorubicin and a new imidazopyridine derivative in breast and lung cancer cells

Keywords: کشف مواد مخدر; DNA damage response; Drug discovery; Doxorubicin; p21; Cyclin-dependent kinase (CDK); Apoptosis;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2016 سفارش ترجمه

Three stories on Eph kinase inhibitors: From in silico discovery to in vivo validation

Keywords: کشف مواد مخدر; Drug discovery; EphB4; In silico; Kinase; Potency; Selectivity;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2016 سفارش ترجمه

High throughput physiological screening of iPSC-derived cardiomyocytes for drug development

Keywords: کشف مواد مخدر; Drug discovery; High content screening; Cardiomyocyte; Heart; Physiology; Automated microscopy; Particle image velocimetry;

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2016 سفارش ترجمه

RF-amide neuropeptides and their receptors in Mammals: Pharmacological properties, drug development and main physiological functions

Keywords: کشف مواد مخدر; RF-amide neuropeptides; RF-amide receptors; Feeding; Reproduction; Pain; Drug discovery; AHA; anterior hypothalamic area; Amd; amygdala; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AP; area postrema; ARC; arcuate nucleus; AVPV; anterovent

دانلود رایگان متن کامل مقاله ISI 134 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis of hexahydropyrrolo[2,1-a]isoquinoline compound libraries through a Pictet-Spengler cyclization/metal-catalyzed cross coupling/amidation sequence

Keywords: کشف مواد مخدر; Drug discovery; Molecular libraries; Heterocycles; Pictet-Spengler; Molecular diversity;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Novel 11β-HSD1 inhibitors: C-1 versus C-2 substitution and effect of the introduction of an oxygen atom in the adamantane scaffold

Keywords: کشف مواد مخدر; Adamantane; 11β-HSD1 inhibitors; Drug discovery; Molecular modeling;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Development of a rapid, reliable and quantitative method - “SPOTi” for testing antifungal efficacy

Keywords: کشف مواد مخدر; SPOTi; Antifungals; Dermatophytes; Screening; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

In vivo occupancy of the 5-HT1A receptor by a novel pan 5-HT1(A/B/D) receptor antagonist, GSK588045, using positron emission tomography

Keywords: کشف مواد مخدر; Antidepressive agents; Anti-anxiety agents; Drug discovery; 5-HT1 receptors; Positron emission tomography;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

A selective small molecule NOP (ORL-1 receptor) partial agonist for the treatment of anxiety

Keywords: کشف مواد مخدر; Nociceptin; NOP receptor; Orphanin FQ; Opioid receptor-like receptor-1; Drug discovery

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold

Keywords: کشف مواد مخدر; Alzheimer’s disease; Drug discovery; BACE1; Indanone; AChE

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

In vitro screening of 1-aryl-6-hydroxy-1,2,3,4-tetrahydroisoquinolines: Structure related activity against pathogenic bacteria

Keywords: کشف مواد مخدر; Antibiotics; Drug discovery; Antibacterial agents; Tetrahydroisoquinolines; Cytotoxicity

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery of deoxyvasicinone derivatives as inhibitors of NEDD8-activating enzyme

Keywords: کشف مواد مخدر; Drug discovery; Ubiquitin-like; NEDD8; Deoxyvasicinone; Pharmacophore

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Cyclopentitol as a scaffold for a natural product-like compound library for drug discovery

Keywords: کشف مواد مخدر; Cyclopentitols; Focused library; Natural product-like compounds; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M1 agonists

Keywords: کشف مواد مخدر; KOQVBYSCBCRVQJ-SVUXJTORSA-N; GPCR; G protein-coupled receptors; CHO; Chinese hamster ovary; GTPγ35S; [35S]-guanosine-5′-O-(3-thio)triphosphate; BOC; butoxycarbony; EC50; half maximal effective concentration of drug; pKa; log of acid dissociation consta

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Factors that influence T box riboswitch efficacy and tRNA affinity

Keywords: کشف مواد مخدر; RNA; Drug discovery; T box riboswitch; Spermidine; Molecular crowding;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه