Factors that influence T box riboswitch efficacy and tRNA affinity
Keywords: کشف مواد مخدر; RNA; Drug discovery; T box riboswitch; Spermidine; Molecular crowding;
مقالات ISI کشف مواد مخدر (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Structure-based virtual screening as a tool for the identification of novel inhibitors against Mycobacterium tuberculosis 3-dehydroquinate dehydratase
Keywords: کشف مواد مخدر; Tuberculosis; Drug discovery; Shikimate pathway; DHQase; Virtual screening
Structures, semisyntheses, and absolute configurations of the antiplasmodial α-substituted β-lactam monamphilectines B and C from the sponge Svenzea flava
Keywords: کشف مواد مخدر; β-Lactams; Svenzea flava; Monamphilectines; Malaria; Ugi multicomponent reaction; Drug discovery; Isocyanide;
Reprint of: Highthroughtput analysis of behavior for drug discovery
Keywords: کشف مواد مخدر; High-throughput; Behavioral screening; Drug screening; Phenotyping; Computer vision software; Machine learning algorithms; CNS diseases; Social behavior, animal models; Disease models; Preclinical research; Drug discovery; SmartCube; NeuroCube, PhenoCube;
PhenoPredict: A disease phenome-wide drug repositioning approach towards schizophrenia drug discovery
Keywords: کشف مواد مخدر; Drug repositioning; Drug discovery; Systems biology; Disease phenotype; Schizophrenia;
Evolution in medicinal chemistry of ursolic acid derivatives as anticancer agents
Keywords: کشف مواد مخدر; Natural products; Ursolic acid derivatives; Anticancer agents; Drug discovery; Chemical biologyUA, ursolic acid; NF-κB, nuclear factor-κB; STAT3, signal transducer and activator of transcription 3; TRAIL, tumor necrosis factor (TNF)-related apoptosis indu
Development of novel Asf1-H3/H4 inhibitors
Keywords: کشف مواد مخدر; VLMHBNNOEWUVNP-ZMOGYAJESA-N; PKBYULAWXQAMBX-UHFFFAOYSA-N; PVPGIWTVFMFAFF-AWQFTUOYSA-N; PKDJQOGOVQLPPG-UHFFFAOYSA-N; Asf1; Histone chaperone; Hydrazone; H3/H4; Drug discovery;
Estimation of alkane–water log P for neutral, acidic, and basic compounds using an alkylated polystyrene-divinylbenzene high-performance liquid chromatography column
Keywords: کشف مواد مخدر; Partition coefficient; HPLC; Lipophilicity; Δlog P; Drug discovery; Linear solvation energy relationship (LSER)
Targeting the IRE1α-XBP1 branch of the unfolded protein response in human diseases
Keywords: کشف مواد مخدر; ER stress; Protein folding; Drug discovery; Therapy; Compounds;
A novel 3D method of locomotor analysis in adult zebrafish: Implications for automated detection of CNS drug-evoked phenotypes
Keywords: کشف مواد مخدر; Zebrafish; High-throughput screening; Drug discovery; Video tracking; Neurophenotype;
Chemical inhibitor targeting the replication protein A–DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer
Keywords: کشف مواد مخدر; DNA repair; Cisplatin; Combination therapy; Drug discovery; Replication protein A
Introducing ferrocene into imidazo[1,2-a]pyridine by Groebke three-component-reaction for scavenging radicals and inhibiting DNA oxidation
Keywords: کشف مواد مخدر; Multicomponent reaction; Groebke 3CR; N-heterocycle; Drug discovery; AAPH; 2,2â²-azobis(2-amidinopropane hydrochloride); ABTS+·; 2,2â²-azinobis(3-ethylbenzothiazoline-6-sulfonate) cationic radical; DPPH; 2,2â²-diphenyl-1-picrylhydrazyl radical; k; rat
Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds
Keywords: کشف مواد مخدر; Prenylated chalcone; Leishmanicidal activity; Trypanocidal activity; Leishmania amazonensis; Leishmania infantum; Trypanosoma cruzi; Drug discovery;
Down syndrome and Alzheimer's disease: Common pathways, common goals
Keywords: کشف مواد مخدر; Down syndrome; Alzheimer's disease; Dementia; Animal models; Ts65Dn; Drug discovery; Neuroinflammation; Cognitive assessment; Amyloid precursor protein; Beta-amyloid; Tau; Clinical trials; Biomarkers; Trisomy 21; ADNI; DS-Connect; Neuroimaging; Workshop;
Searching for novel applications of the benzohomoadamantane scaffold in medicinal chemistry: Synthesis of novel 11β-HSD1 inhibitors
Keywords: کشف مواد مخدر; Adamantane; Cage compounds; 11β-HSD1 inhibitors; Drug discovery; Molecular dynamics;
A combinatorial biophysical approach; FTSA and SPR for identifying small molecule ligands and PAINs
Keywords: کشف مواد مخدر; FTSA; SPR; Biophysics; Drug discovery; Assay interference; Screening;
Natural Product Biosynthetic Diversity and Comparative Genomics of the Cyanobacteria
Keywords: کشف مواد مخدر; cyanobacteria; natural products; drug discovery; diversity; genomics; genome mining; evolution
New small-molecule drug design strategies for fighting resistant influenza A
Keywords: کشف مواد مخدر; Influenza A virus; Drug discovery; Resistance; M2 ion channel; Neuraminidase
Systems pharmacology-based drug discovery for marine resources: An example using sea cucumber (Holothurians)
Keywords: کشف مواد مخدر; Natural marine resource; Drug discovery; Systems pharmacology; Sea cucumber
Targeting GLI factors to inhibit the Hedgehog pathway
Keywords: کشف مواد مخدر; Hedgehog pathway; GLI antagonists; drug discovery; cancer
Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils
Keywords: کشف مواد مخدر; α-syn; α-synuclein; PD; Parkinson's disease; Aβ; beta amyloid; LBs; Lewy bodies; LNs; Lewy neuritis; Gn; ginsenoside; GST; glutathione S-transferase; IPTG; isopropyl β-d-1-thiogalactopyranoside; DTT; dithiothreitol; SDS; sodium dodecyl sulfate; PBS; p
Two dimensional NMR spectroscopic approaches for exploring plant metabolome: A review
Keywords: کشف مواد مخدر; Nuclear magnetic resonance (NMR); Phytomedicines; Drug discovery; 2D NMR; Metabolomics; Chemometrics
Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease
Keywords: کشف مواد مخدر; Alzheimer's disease; Aβ seeding-mediated aggregation; Aβ-propagation; Amyloid protein; Drug discovery; Inhibitors;
Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidines as potential nonclassical antifolates targeting both thymidylate and purine nucleotide biosynthesis
Keywords: کشف مواد مخدر; Pyrrolo[2,3-d]pyrimidines; Antiproliferation; Thymidylate biosynthesis; Purine biosynthesis; Drug discovery
The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs
Keywords: کشف مواد مخدر; Plasmodium; Antimalarial; PfATP4; Resistance selection; Drug discovery; Cipargamin
“Domain gauges”: A reference system for multivariate profiling of brain fMRI activation patterns induced by psychoactive drugs in rats
Keywords: کشف مواد مخدر; Pharmacological MRI (phMRI); Arterial spin labeling (ASL); Drug discovery; Psychoactive drugs; Multivariate pattern analysis (MVPA); Linear discriminant analysis (LDA);
Machine learning in computational docking
Keywords: کشف مواد مخدر; Machine learning; Random forest; Support vector machine; Drug discovery; Computational docking; Scoring function; Virtual screening; Complex binding affinity; Ligands ranking accuracy; Force field interaction; Pharmacophore fingerprint
Rifampicin-resistance, rpoB polymorphism and RNA polymerase genetic engineering
Keywords: کشف مواد مخدر; Act; actinorhodin; Crs; catabolite-resistant sporulation; hVISA; heterogeneously vancomycin-intermediate in S. aureus; LB; Luria Bertani; MRSA; methicillin-resistant S. aureus; NTD; 3,3â²-neotrehalosadiamine; PDIM; phthiocerol dimycocerosate; PKS; polyke
Elucidation of the in vitro and in vivo activities of bridged 1,2,4-trioxolanes, bridged 1,2,4,5-tetraoxanes, tricyclic monoperoxides, silyl peroxides, and hydroxylamine derivatives against Schistosoma mansoni
Keywords: کشف مواد مخدر; Schistosomiasis; Schistosoma mansoni; Peroxides; In vitro; In vivo; Drug discovery;
Associate editor: B. TeicherEpigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation
Keywords: کشف مواد مخدر; Histone demethylation; DNA methylation; Inhibitor; Chemical probe; Drug discovery; LSD; lysine-specific histone demethylase; HDAC; histone deacetylase; REST; REST corepressor; DNMT; DNA methyltransferase; MAO; monoamine oxidase; AML; acute myeloid leukemi
Discovery of substituted 1,4-dihydroquinolines as novel class of ABCB1 modulators
Keywords: کشف مواد مخدر; Drug discovery; Structure-activity data; Multidrug resistance (MDR); Inhibitor; Efflux pump inhibition;
GPCR crystal structures: Medicinal chemistry in the pocket
Keywords: کشف مواد مخدر; GPCR; Medicinal chemistry; Crystal structure; Drug discovery; Receptor activation; Ligand–receptor interactions; Receptor selectivity
Epigenetic-based therapy: From single- to multi-target approaches
Keywords: کشف مواد مخدر; Epigenetics; Drug discovery; Multi epi-target approaches; Single epi-target approaches; Cancer therapy;
Characterization of kappa opioid receptor mediated, dynorphin-stimulated [35S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting
Keywords: کشف مواد مخدر; Dynorphin; Kappa opioid receptor; [35S]GTPγS binding; Mouse striatum; Selectivity; Drug discovery; KOR antagonist; CTOP; D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2; DAMGO; [D-Ala2, NMe-Phe4, Gly-ol5]-enkephalin; Dyn; dynorphin; DOR; delta opioid receptor; [
μ-Opioid receptor 6-transmembrane isoform: A potential therapeutic target for new effective opioids
Keywords: کشف مواد مخدر; MOR; μ-opioid receptor; 6TM MOR; six transmembrane helices μ-opioid receptor; 7TM MOR; seven transmembrane helices μ-opioid receptor; OIH; opioid induced hyperalgesia; VGCC; voltage-gated Ca2 + channels; cAMP; cyclic adenosine monophosphate; AC; adeny
Recent progresses in the exploration of machine learning methods as in-silico ADME prediction tools
Keywords: کشف مواد مخدر; ADME; Absorption; Distribution; Metabolism; Excretion; Drug discovery; Machine learning; Molecular descriptors; QSAR;
Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR
Keywords: کشف مواد مخدر; acetyl-CoA; acetyl coenzyme A; ALARM NMR; a La assay to detect reactive molecules by nuclear magnetic resonance; Asf1; anti-silencing function 1; AZ; AstraZeneca; BME; β-mercaptoethanol; BSA; bovine serum albumin; CoA; coenzyme A; CPM; N-[4-(7-diethylami
Ligand binding studies, preliminary structure-activity relationship and detailed mechanistic characterization of 1-phenyl-6,6-dimethyl-1,3,5-triazine-2,4-diamine derivatives as inhibitors of Escherichia coli dihydrofolate reductase
Keywords: کشف مواد مخدر; Mechanistic characterization; Inhibition kinetics; Escherichia coli dihydrofolate reductase; QSAR; Drug discovery; 2,4-Diamino-1,3,5-triazine; 2,4-Diamino 1,2,4-triazine; EcDHFR; Escherichia coli dihydrofolate reductase; NADPH; nicotinamide adenine dinucl
New paradigm of an old target: An update on structural biology and current progress in drug design towards plasmepsin II
Keywords: کشف مواد مخدر; Malaria; Plasmepsin II; Aspartic protease; Peptidomimetics; Protease inhibitor; Drug discovery;
Probing the 'bipolar' nature of the carbonic anhydrase active site: Aromatic sulfonamides containing 1,3-oxazol-5-yl moiety as picomolar inhibitors of cytosolic CA I and CA II isoforms
Keywords: کشف مواد مخدر; Drug discovery; Carbonic anhydrase inhibitors; Isoform selectivity; Anti-glaucoma drugs; 1,3-oxadiazol-5-yl aromatics; Chemoselective sulfochlorination;
El caso Glivec®: primer ejemplo de debate global en torno al sistema de patentes de medicamentos
Keywords: کشف مواد مخدر; Descubrimiento de fármacos; Difusión de la innovación; Genéricos; India; Industria farmacéutica; Países del Tercer Mundo; Propiedad intelectualDeveloping countries; Diffusion of innovation; Drug discovery; Generic drugs; India; Intellectual property; Phar
Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases
Keywords: کشف مواد مخدر; Serine carboxypeptidase; Crystal structure; Heart failure; Drug discovery; Endothelin; Tetrahedral intermediate; Covalent inhibitor;
Mutant p53 reactivation by small molecules makes its way to the clinic
Keywords: کشف مواد مخدر; p53; Mutation; Cancer; Cell death; Drug discovery; Clinical trial;
Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform
Keywords: کشف مواد مخدر; TDP1; PARP; Topoisomerases; Drug discovery; Combination therapy
Discovery and the structural basis of a novel p21-activated kinase 4 inhibitor
Keywords: کشف مواد مخدر; PAK4; HTS; Protein kinase; Cancer; Drug discovery; X-ray crystallography
Fragment based discovery of arginine isosteres through REPLACE: Towards non-ATP competitive CDK inhibitors
Keywords: کشف مواد مخدر; Cyclin dependent kinase; Drug discovery; Inhibitor; Anti-tumor therapeutic; REPLACE;
Discovery of quinoline small molecules with potent dispersal activity against methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis biofilms using a scaffold hopping strategy
Keywords: کشف مواد مخدر; Drug discovery; Biofilm dispersal agent; Biofilm inhibitor; Antibacterial agent; Quinoline;
Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells
Keywords: کشف مواد مخدر; 4E-BP1; eukaryotic initiation factor 4E binding protein 1; AMPK; 5â²-AMP-activated protein kinase; APC; adenomatous polyposis coli; CK1; casein kinase 1; CM; conditioned medium; eIF4E; eukaryotic initiation factor 4E; GSK3β; glycogen synthase kinase-3β
Phytopharmacological review on flowers: Source of inspiration for drug discovery
Keywords: کشف مواد مخدر; Flowers; Plants; Pharmacology; Drug discovery
UHPLC-MS for the analytical characterization of traditional Chinese medicines
Keywords: کشف مواد مخدر; Analytical characterization; Drug discovery; Identification; Mass spectrometry (MS); Metabolite; Metabolomics; Phytochemical; Traditional Chinese medicine (TCM); UHPLC-MS; Ultra-high-performance liquid chromatography (UHPLC);