دانلود مقالات ISI درباره کشف مواد مخدر + ترجمه فارسی

Aminoacyl-tRNA synthetases: Structure, function, and drug discovery

Keywords: کشف مواد مخدر; Aminoacyl-tRNA synthetase; Rossmann fold; Motif; Inhibitor; Protein synthesis; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2018 سفارش ترجمه

Natural product-derived compounds in HIV suppression, remission, and eradication strategies

Keywords: کشف مواد مخدر; HIV; Latency; Reservoirs; Shock-and-kill; Block-and-lock; Drug discovery; Natural product-derived compounds;

دانلود رایگان متن کامل مقاله ISI 57 صفحه سال انتشار : 2018 سفارش ترجمه

Experimental and Clinical Strategies for Treating Spinocerebellar Ataxia Type 3

Keywords: کشف مواد مخدر; atx-3,; ataxin-3; BDNF,; brain-derived neurotrophic factor; C. elegans,; Caenorhabditis elegans; CBP,; cAMP response element-binding protein CREB-binding protein; CHIP,; C-terminal Hsp70-interacting protein; CK2,; casein kinase 2; DRPLA,; dentatorubral-pa

دانلود رایگان متن کامل مقاله ISI 60 صفحه سال انتشار : 2018 سفارش ترجمه

Kinetic operational models of agonism for G-protein-coupled receptors

Keywords: کشف مواد مخدر; Drug discovery; Drug kinetics; Ligand binding; Receptor binding; Kinetics; Receptor theory;

دانلود رایگان متن کامل مقاله ISI 161 صفحه سال انتشار : 2018 سفارش ترجمه

Anti-tuberculosis lupane-type isoprenoids from Syzygium guineense Wild DC. (Myrtaceae) stem bark

Keywords: کشف مواد مخدر; 3-β-Hydroxylupane; Tuberculosis; Drug discovery; Ethno-medicine;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis, in vitro and in vivo giardicidal activity of nitrothiazole-NSAID chimeras displaying broad antiprotozoal spectrum

Keywords: کشف مواد مخدر; Antiparasitic; Nitazoxanide; Drug discovery; In vivo; Giardia;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and evaluation of 5-(1H-indol-3-yl)-N-aryl-1,3,4-oxadiazol-2-amines as Bcl-2 inhibitory anticancer agents

Keywords: کشف مواد مخدر; Anti-apoptotic Bcl-2; Indoles; Oxadiazoles; Anticancer; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

A High-Content Screening Technology for Quantitatively Studying Podocyte Dynamics

Keywords: کشف مواد مخدر; High-Content Screening; Image Analysis; Podocyte; Drug Discovery;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

GZ-793A inhibits the neurochemical effects of methamphetamine via a selective interaction with the vesicular monoamine transporter-2

Keywords: کشف مواد مخدر; Methamphetamine; Vesicular monoamine transporter; Dopamine; Lobeline; Lobelane; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Species specificity profiling of rat and human organic cation/carnitine transporter Slc22a5/SLC22A5 (Octn2/OCTN2)

Keywords: کشف مواد مخدر; OCTN2; l-carnitine; 3-(2,2,2-Trimethylhydrazinium)propionate; Characterization; Drug discovery; Toxicity; Transporter;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Genome analysis of Chlamydia trachomatis for functional characterization of hypothetical proteins to discover novel drug targets

Keywords: کشف مواد مخدر; Hypothetical proteins; Virulence factors; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2

Keywords: کشف مواد مخدر; Drug discovery; Structural biology; Allosteric; Inhibitor; Phosphatase; SHP2;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Design and synthesis of bicyclic acetals as Beta Secretase (BACE1) inhibitors

Keywords: کشف مواد مخدر; Peptidomimetics; Amino acids; Enzyme inhibition; Alzheimer's disease; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Escape from adamantane: Scaffold optimization of novel P2X7 antagonists featuring complex polycycles

Keywords: کشف مواد مخدر; Adamantane; Drug discovery; Homology models; P2X7 antagonists; Scaffold replacement; SRTPJHDMWSZRKW-JSYDPECLSA-N; KQPWSKBFHUATDV-LZEHCIAKSA-N; JXPMRNDEYMUUAN-CXKWTYGFSA-N; NTECRYDXIDEWOW-CXKWTYGFSA-N;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

A new target for Parkinson's disease: Small molecule SERCA activator CDN1163 ameliorates dyskinesia in 6-OHDA-lesioned rats

Keywords: کشف مواد مخدر; Parkinson's disease; ER stress; Endoplasmic reticulum; Drug discovery; Small molecules; Medicinal chemistry;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Lead discovery and chemical biology approaches targeting the ubiquitin proteasome system

Keywords: کشف مواد مخدر; Proteasome; Protein degradation; Molecular glue; Drug discovery; High-throughput; Ubiquitin;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleSRI36160 is a specific inhibitor of Wnt/β-catenin signaling in human pancreatic and colorectal cancer cells

Keywords: کشف مواد مخدر; Wnt signaling; Benzimidazole; Niclosamide; Targeted therapy; Drug discovery; APC; adenomatous polyposis coli; CIC; cancer initiating cell; Fzd; frizzled; LRP6; low-density lipoprotein receptor-related protein-6; PDAC; pancreatic ductal adenocarcinoma; PI;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Novel Zebrafish EAE model: A quick in vivo screen for multiple sclerosis

Keywords: کشف مواد مخدر; Zebrafish; Experimental autoimmune encephalomyelitis (EAE); Multiple Sclerosis (MS); Myelin oligodendrocyte glycoprotein (MOG); Fingolimod (Gilenya); Drug Discovery;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Medicinal plants and traditional treatment practices used in the management of HIV/AIDS clients in Mpigi District, Uganda

Keywords: کشف مواد مخدر; Drug discovery; Traditional treatments; Ethnobotany; Ethnomedicine;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Molecular docking, discovery, synthesis, and pharmacological properties of new 6-substituted-2-(3-phenoxyphenyl)-4-phenyl quinoline derivatives; an approach to developing potent DNA gyrase inhibitors/antibacterial agents

Keywords: کشف مواد مخدر; Phenoxyphenyl quinolines; Antibacterial; DNA gyrase A; Molecular docking; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Evolutionary conservation of influenza A PB2 sequences reveals potential target sites for small molecule inhibitors

Keywords: کشف مواد مخدر; PB2; polymerase basic protein 2; PB1; polymerase basic protein 1; PA; polymerase acidic; PAINS; pan assay interference compounds; NCI; National Cancer Institute; NCBI; National Centre for Biotechnology Information; NP; nucleoprotein; mGTP; methylguanosine

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Selective inhibition of BET proteins reduces pancreatic damage and systemic inflammation in bile acid- and fatty acid ethyl ester- but not caerulein-induced acute pancreatitis

Keywords: کشف مواد مخدر; Acute pancreatitis; Epigenetics; BET inhibition; Drug discovery; AP; acute pancreatitis; AUC; area under the curve; BET proteins; bromodomain and extra-terminal proteins; CCL2; chemokine (C-C motif) ligand 2; CER-AP; caerulein-induced AP; Cmax; peak serum

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Drug discovery targeting heme-based sensors and their coupled activities

Keywords: کشف مواد مخدر; Drug discovery; Heme-based sensor; Nucleotide cyclase; Phosphodiesterase; Histidine protein kinase; Nuclear receptor;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Lipopolysaccharide biogenesis and transport at the outer membrane of Gram-negative bacteria

Keywords: کشف مواد مخدر; Outer membrane biogenesis; Lipopolysaccharide transport; ABC transporter; Sensing LPS defects; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Antiviral activity of a synthesized shikonin ester against influenza A (H1N1) virus and insights into its mechanism

Keywords: کشف مواد مخدر; CC50; half-maximal cytotoxic concentration; CPE; cytopathic effect; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; FBS; fetal bovine serum; HA; hemagglutinin; MDCK; Madin-Darby canine kidney cells; MOI; multiplicity of infection;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Classification of nervous system withdrawn and approved drugs with ToxPrint features via machine learning strategies

Keywords: کشف مواد مخدر; Machine learning; Support vector machine; Drug discovery; ToxPrint chemotypes; Approved & withdrawn drug;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Dual Inhibition of Mnk2 and FLT3 for potential treatment of acute myeloid leukaemia

Keywords: کشف مواد مخدر; Mnk inhibitor; FLT3 inhibitor; Dual inhibitor; AML; Drug discovery; Anti-leukaemic agent; AML; acute myeloid leukaemia; CDK; cyclin-dependent kinase; eIF; eukaryotic initiation factor; Erk; extracellular signal-regulated kinase; FLT3; Fms-like tyrosine ki

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1)

Keywords: کشف مواد مخدر; NRF2; Antioxidant; Biochemical methods; KEAP1; Neurodegeneration; Drug discovery; Protein-protein interaction;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91

Keywords: کشف مواد مخدر; GPR91; SUCNR1; Metabolite receptor; GPCR; Drug discovery; Virtual screening; Chemical design;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Using Zebrafish for High-Throughput Screening of Novel Cardiovascular Drugs

Keywords: کشف مواد مخدر; drug discovery; high-throughput screening; translational medicine; zebrafish;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Polar aromatic periphery increases agonist potency of spirocyclic free fatty acid receptor (GPR40) agonists inspired by LY2881835

Keywords: کشف مواد مخدر; Drug discovery; FFA1 agonists; Antidiabetic agents; Spirocyclic motifs; Hydrophobic interactions; π−π stacking;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

The role of chromatographic and chiroptical spectroscopic techniques and methodologies in support of drug discovery for atropisomeric drug inhibitors of Bruton's tyrosine kinase

Keywords: کشف مواد مخدر; Atropisomer; Bruton's tyrosine kinase; Drug discovery; Chiral separation; Circular dichroism; Interconversion;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and evaluation of modified chalcone based p53 stabilizing agents

Keywords: کشف مواد مخدر; Chalcones; Antitumor; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Recent advances on the encoding and selection methods of DNA-encoded chemical library

Keywords: کشف مواد مخدر; DNA-encoded library; Drug discovery; High throughput screening; Combinatorial chemistry; Dynamic combinatorial library;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Reviving the guardian of the genome: Small molecule activators of p53

Keywords: کشف مواد مخدر; AML; acute myelogenous leukemia; CML; chronic myelogenous leukemia; INZ; inauhzin; p53; Small molecules; MDM2; MDMX; Drug discovery; Inauhzin;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Neurofibromatosis as a gateway to better treatment for a variety of malignancies

Keywords: کشف مواد مخدر; NF; neurofibromatoses; NF1; neurofibromatosis type 1; NF2; neurofibromatosis type 2; WHO; World Health Organization; PN; plexiform neurofibromas; MPNST; malignant peripheral nerve sheath tumors; FTase; farnesyl transferase; TTP; time-to-progression; OPG;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Diospyros, an under-utilized, multi-purpose plant genus: A review

Keywords: کشف مواد مخدر; Diospyros; Phytochemicals; Pharmacological uses; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Structure of a Myeloid cell leukemia-1 (Mcl-1) inhibitor bound to drug site 3 of Human Serum Albumin

Keywords: کشف مواد مخدر; Mcl-1; Myeloid cell leukemia 1; HSA; Human Serum Albumin; BSA; Bovine Serum Albumin; FBS; Fetal Bovine Serum; FITC; fluorescein isothiocyanate; TR-FRET; time resolved fluorescence energy transfer; Human Serum Albumin; Free fraction; Apoptosis; Cancer; Mcl

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2017 سفارش ترجمه

Beyond mouse cancer models: Three-dimensional human-relevant in vitro and non-mammalian in vivo models for photodynamic therapy

Keywords: کشف مواد مخدر; 3D cell culture model; Non-mammalian model; Photodynamic therapy; Drug discovery; Cancer research;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2017 سفارش ترجمه

FLIP: An assisting software in structure based drug design using fingerprint of protein-ligand interaction profiles

Keywords: کشف مواد مخدر; Drug discovery; Structure-based drug design; Interaction fingerprints; Molecular interactions; Scoring function;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2017 سفارش ترجمه

Enabling faster Go/No-Go decisions through secondary screens in anti-mycobacterial drug discovery

Keywords: کشف مواد مخدر; Tuberculosis; Anti-mycobacterials; Drug discovery; Secondary screens; Phenotypic screens;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2017 سفارش ترجمه

High content analysis of phagocytic activity and cell morphology with PuntoMorph

Keywords: کشف مواد مخدر; Phagocytosis; High content analysis; Image processing; Phenotypic screening; Microglia; Drug discovery; Morphometry;

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2017 سفارش ترجمه

Molecular dynamics simulations of Zika virus NS3 helicase: Insights into RNA binding site activity

Keywords: کشف مواد مخدر; Zika virus; Flavivirus; NS3 helicase; Molecular dynamics; FTMap; Drug discovery; ZIKV; Zika virus; NS; non-structural; NS3h; NS3 helicase; PrM; membrane precursor; MD; molecular dynamics; RMSF; root mean square fluctuation; PDB; protein data bank; VMD; Vi

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2017 سفارش ترجمه

An alkaloid-like 3-azabicyclo[3.3.1]non-3-ene library obtained from the bridged Ritter reaction

Keywords: کشف مواد مخدر; Bridged Ritter reaction; Alkaloid-like; 3-Aza-bicyclo[3.3.1]nonane; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

An impedance-based approach using human iPSC-derived cardiomyocytes significantly improves in vitro prediction of in vivo cardiotox liabilities

Keywords: کشف مواد مخدر; Cardiotoxicity; Impedance; Cardiomyocytes; iPSC; In vitro; Drug discovery; CiPA; comprehensive in vitro proarrhythmia assay; hIPSC-CMs; human induced pluripotent stem cell cardiomyocytes; HDAC; histone deacetylase inhibitors;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

Identification of compounds with cytotoxic activity from the leaf of the Nigerian medicinal plant, Anacardium occidentale L. (Anacardiaceae)

Keywords: کشف مواد مخدر; Cancer; Lead compound; Nigerian medicinal plants; Drug discovery; Cytotoxicity;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Scaling machine learning for target prediction in drug discovery using Apache Spark

Keywords: کشف مواد مخدر; Drug discovery; Apache Spark; Machine learning; Target prediction;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?

Keywords: کشف مواد مخدر; G-triplex; G-quadruplex; Ligand; Anticancer agents; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of nanomolar ligands with novel scaffolds for the histamine H4 receptor by virtual screening

Keywords: کشف مواد مخدر; Histamine; Virtual screening; H4 receptor; Homology model; Docking; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

Identifying novel factor XIIa inhibitors with PCA-GA-SVM developed vHTS models

Keywords: کشف مواد مخدر; Factor XIIa; Virtual high-throughput screening; Data mining; QSAR; Drug discovery; Signature;

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2017 سفارش ترجمه