کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5557652 1560927 2017 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reviving the guardian of the genome: Small molecule activators of p53
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Reviving the guardian of the genome: Small molecule activators of p53
چکیده انگلیسی

The tumor suppressor p53 is one of the most important proteins for protection of genomic stability and cancer prevention. Cancers often inactivate it by either mutating its gene or disabling its function. Thus, activating p53 becomes an attractive approach for the development of molecule-based anti-cancer therapy. The past decade and half have witnessed tremendous progress in this area. This essay offers readers with a grand review on this progress with updated information about small molecule activators of p53 either still at bench work or in clinical trials.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 178, October 2017, Pages 92-108
نویسندگان
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