دانلود مقالات ISI درباره کشف مواد مخدر + ترجمه فارسی

Determination of tumour marker genes from gene expression data

Keywords: کشف مواد مخدر; Drug Discovery; microarray; gene analysis; gene selections; tumour classification; marker genes; tumour diagnostics; feature analysis; feature selection;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Computer prediction of drug resistance mutations in proteins

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Bioinformatics; Cell biology; Decision tree; Drug-receptor interaction; Molecular dynamics; Ligand-protein interaction; Neural networks; Machine learning; Molecular mechanics;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Progress in protein and antibody microarray technology

Keywords: کشف مواد مخدر; Pharmaceutical Science; Drug Discovery; Biotechnology; Microarray coatings; Multiple spotting technique; Rolling circle amplification; Tyramide signal amplification;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Modelling enzyme reaction mechanisms, specificity and catalysis

Keywords: کشف مواد مخدر; Pharmaceutical Science; Drug Discovery; Bioinformatics; Chemical Biology; QM/MM; molecular dynamics; transition state; drug metabolism; polymorphism; Cytochrome P450; pharmacogenomics;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Reengineering the pharmaceutical industry by crash-testing molecules

Keywords: کشف مواد مخدر; Biotechnology; Drug Discovery; Pharmaceutical Science; in silico; targets; computational; clinical trials; computer-aided design;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Keynote review: Medicinal chemistry strategies to CB1 cannabinoid receptor antagonists

Keywords: کشف مواد مخدر; Drug Discovery; rimonabant; therapeutic applications; scaffold hopping; bioisosterism; pharmacophore; conformational constraint; CB1 receptor modeling;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Biological networks and analysis of experimental data in drug discovery

Keywords: کشف مواد مخدر; Bioinformatics; Drug Discovery; Pharmaceutical Science; Biotechnology; Protein interactions; Network modules; Substructure search; Network topology; Metabonomics;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Keynote review: Progress in targeting HIV-1 entry

Keywords: کشف مواد مخدر; Pharmaceutical Science; Drug Discovery; Virology; Structural Biology; Chemical Biology; HIV-1 entry; entry inhibitors; Protein disulfide isomerase; PDI; gp120; disulfide bonds; conformational changes; CD4; gp41 activation; virus-cell fusion;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Embryonic stem cells: Understanding their history, cell biology and signalling

Keywords: کشف مواد مخدر; Embryonic; Stem cell; History; Biology; Signalling; Review; Drug discovery; Toxicology; Cell therapy;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Bacterial surface display library screening by target enzyme labeling: Identification of new human cathepsin G inhibitors

Keywords: کشف مواد مخدر; Autodisplay; Peptide libraries; Labeling; Screening; Cathepsin G; FACS; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Kinetic studies of small molecule interactions with protein kinases using biosensor technology

Keywords: کشف مواد مخدر; Surface plasmon resonance; Protein kinase inhibitors; Drug discovery; Methodology; Binding rate constants; Biosensor;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Systems and integrative biology as alternative guises for pharmacology: Prime time for an iPharm concept?

Keywords: کشف مواد مخدر; Pharmacology; Drug discovery; Integrative biology; Null hypothesis; iPharm;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

New perspectives on natural products in TB drug research

Keywords: کشف مواد مخدر; Drug discovery; Natural products; Mycobacterium tuberculosis; Dormancy; Bioassay-guided fractionation;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Chemical complementation: A definitive phenotypic strategy for identifying small molecule inhibitors of elusive cellular targets

Keywords: کشف مواد مخدر; Chemical complementation; Forward Pharmacology; Reverse Pharmacology; High-content screening; Cell-based assay; Drug discovery; Erk; extracellular signal-regulated kinase; GFP; green fluorescent protein; HTS; high-throughput screening; MAPK; mitogen-activ

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Disruption of the interactions between the subunits of herpesvirus DNA polymerases as a novel antiviral strategy

Keywords: کشف مواد مخدر; DNA polymerase; drug discovery; herpesviruses; polymerisation interactions; protein-protein interactions; review;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Identification of non-cross-resistant platinum compounds with novel cytotoxicity profiles using the NCI anticancer drug screen and clustered image map visualizations

Keywords: کشف مواد مخدر; DACH; diaminocyclohexane; FBS; fetal bovine serum; Platinum; Drug discovery; Drug screen; Chemotherapy; Bioinformatics; NCI-60; Cisplatin; Carboplatin; Oxaliplatin;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Trypanothione biosynthesis in Leishmania major

Keywords: کشف مواد مخدر; GSH; glutathione; GspS; glutathionylspermidine synthetase; TryS; trypanothione synthetase; TCEPtris(2-carboxyethyl)phosphine; Trypanothione metabolism; Evolution; Drug discovery; Enzymology;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Lipocalins in drug discovery: From natural ligand-binding proteins to 'anticalins'

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Biochemistry; Chemical Biology; Bilin-binding protein; Calycin; Hapten; Retinol-binding protein; Plasma protein; Protein engineering;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Stable isotope methods for high-precision proteomics

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Techniques & Methods; Mass defect; ICAT; iTRAQ; GIST; IDBEST; Biomarkers; Target validation;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Integration of supercritical fluid chromatography into drug discovery as a routine support tool

Keywords: کشف مواد مخدر; Supercritical fluid chromatography; Enantiomer separation; Gradient screening; Chiral; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Integration of supercritical fluid chromatography into drug discovery as a routine support tool

Keywords: کشف مواد مخدر; Supercritical fluid chromatography; Batch purification; Fast gradient screening; Achiral; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Synthetic heparin derivatives as new anticoagulant drugs

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Biochemistry; Chemical Biology; Thrombosis; Oligosaccharide; Factor Xa; Dual inhibitor; Peptidomimetic; Thrombocytopenia;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Foundation Review: Transgenic animals and their impact on the drug discovery industry

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Cell biology; Chemical Biology; Transgenic mice; Animal biotechnology; Bioreactors; Genetic engineering; Gene transfer;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors

Keywords: کشف مواد مخدر; Biotechnology; Cell biology; Drug Discovery; G-protein-coupled receptor; ligand binding; nonpeptide; calcitonin; parathyroid hormone; incretin; secretin; glucagon; corticotropin releasing-hormone; calcitonin gene-related peptide;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Translational Research in Central Nervous System Drug Discovery

Keywords: کشف مواد مخدر; CNS; drug discovery; translational research; biomarkers; proteomics; imaging;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه

Keynote review: The adipocyte as a drug discovery target

Keywords: کشف مواد مخدر; Pharmaceutical Science; Drug Discovery; Cell biology; Adipocyte; Obesity; Insulin resistance; Inflammation; Adiponectin; Thiazolidinedione; PPAR alpha; Leptin; Resistin;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه

Keynote review: Recent advances in biomarkers for cancer diagnosis and treatment

Keywords: کشف مواد مخدر; Drug Discovery; Biomarkers; Cancer; Early Detection; Diagnosis; Development; Validation; High throughput;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه

Keynote review: Mammalian carboxylesterases: From drug targets to protein therapeutics

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Cell biology; Chemical Biology; Transesterification; Xenobiotic processing; Specificity; Prodrug activation; Cholesterol homeostasis;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2005 سفارش ترجمه

Protein structure similarity clustering and natural product structure as guiding principles in drug discovery

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Chemical Biology; Structural Biology; Bioinformatics; Combinatorial synthesis; Ligand-sensing core; Compound library development; Protein domains;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2005 سفارش ترجمه

Keynote review: Structural biology and drug discovery

Keywords: کشف مواد مخدر; Techniques & Methods; Structural Biology; Drug Discovery; Pharmaceutical Science; X-ray crystallography; structural genomics; structure-based drug design; virtual screening; fragments;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2005 سفارش ترجمه

Keynote review: Intestinal Peyer's patch M cells and oral vaccine targeting

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Peyer's patches; follicle-associated epithelium; M cells; oral vaccination; mucosal immunity; targeting ligands;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2005 سفارش ترجمه

Keynote review: In vitro safety pharmacology profiling: an essential tool for successful drug development

Keywords: کشف مواد مخدر; Pharmacology; Drug Discovery; safety pharmacology; radioligand binding; multi-parallel screening; adverse drug reaction; bioprint;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2005 سفارش ترجمه

ES cell technology: An introduction to genetic manipulation, differentiation and therapeutic cloning

Keywords: کشف مواد مخدر; Lineage selection; Gene targeting; Differentiation; Drug discovery; Cell therapy;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2005 سفارش ترجمه

Perspectives for cytokine antagonist therapy in COPD

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Biochemistry; Chemical Biology; Tumor necrosis factor-alpha; Signal transduction; Transcription; CCL2; CCR2; CXCL8; CXCR2;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2005 سفارش ترجمه

Keynote review: The auditory system, hearing loss and potential targets for drug development

Keywords: کشف مواد مخدر; Biotechnology; Drug Discovery; Pharmacology; Anatomy; WHO; RNID; deafness; cochlear; inner ear; organ of Corti; hair cells;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2005 سفارش ترجمه

Imaging mass spectrometry: fundamentals and applications to drug discovery

Keywords: کشف مواد مخدر; Drug Discovery; mass spectrometry; MALDI; SIMS; imaging; chemical image; ion microscope;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2005 سفارش ترجمه

Keynote review: Histamine H3 receptor antagonists reach out for the clinic

Keywords: کشف مواد مخدر; Pharmaceutical Science; Drug Discovery; Chemical Biology; histamine receptor; histaminergic drug; medicinal chemistry; imidazole-containing ligands; pharmacophore;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2005 سفارش ترجمه

An estrogen receptor chimera senses ligands by nuclear translocation

Keywords: کشف مواد مخدر; ER; estrogen receptor; GR; glucocorticoid receptor; GFP; green fluorescent protein; Tet; tetracycline; LBD; ligand binding domain; Dex; dexamethasone; E2; 17-β-estradiol; PPT; 4,4′,4″-(4-propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol; DES; diethylstilbe

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2005 سفارش ترجمه

Screening approach for chiral separation of pharmaceuticals

Keywords: کشف مواد مخدر; Supercritical fluid chromatography; Screening strategy; High-throughput chiral separations; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2005 سفارش ترجمه

Imaging addiction with PET: is insight in sight?

Keywords: کشف مواد مخدر; Drug Discovery; Neurobiology; neuroimaging; pharmacotherapy; dependence; relapse; neurotransmitter interactions;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2005 سفارش ترجمه

Keynote review: Phosphodiesterase-4 as a therapeutic target

Keywords: کشف مواد مخدر; Pharmaceutical Science; Drug Discovery; Biochemistry; Chemical Biology; Structural Biology; phosphodiesterase-4; rolipram; chronic obstructive pulmonary disease; COPD; asthma; cancer; depression; cyclic AMP;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2005 سفارش ترجمه

Pharmaceutical applications of embryonic stem cells

Keywords: کشف مواد مخدر; Embryonic stem cells; Pharmaceutical applications; Differentiation; Drug discovery; Low molecular weight drugs; Drug screening;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2005 سفارش ترجمه

An Evaluation of the Utility of Physiologically Based Models of Pharmacokinetics in Early Drug Discovery

Keywords: کشف مواد مخدر; pharmacokinetics; physiological model; simulations; computational ADME; absorption; GastroPlus; drug discovery;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2005 سفارش ترجمه

Protein kinases as targets for antimalarial intervention: Kinomics, structure-based design, transmission-blockade, and targeting host cell enzymes

Keywords: کشف مواد مخدر; CamK; calmodulin kinase; CDK; cyclin-dependent kinase; CDPK; calcium-dependent protein kinase; CK1; casein kinase 1; CQ; chloroquine; EPK; eukaryotic protein kinase domain; ERK; extracellular signal-regulated kinase; GSK3; glycogen synthase kinase 3; Hb;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2005 سفارش ترجمه

Cell-based and biochemical screening approaches for the discovery of novel HIV-1 inhibitors

Keywords: کشف مواد مخدر; beta-Gal; beta-galactosidase; CAT; chloramphenicol acetyltransferase; CHO; Chinese Hamster Ovary; CV-N; cyanovirin-N; dsDNA; double-stranded DNA; Ec; ecdysone; EIA; enzyme immunoassay; ELISA; enzyme-linked immunosorbent assay; Env; envelope; FLIPR; Fluoro

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2005 سفارش ترجمه

Optical imaging in drug discovery and diagnostic applications

Keywords: کشف مواد مخدر; Optical imaging; Fluorescent dyes; Reporter probes; Drug discovery; Animal imaging; Near-infrared dyes; NIR; GFP; Luciferase;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2005 سفارش ترجمه

Green fluorescent proteins in receptor research: An emerging tool for drug discovery

Keywords: کشف مواد مخدر; Aequorea; Drug discovery; Expression vectors; Flow cytometry; Fluorescence microscopy; Fluorescence resonance energy transfer; Green fluorescent protein; Methods; Orphan receptors; Receptor research;

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2005 سفارش ترجمه

Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action

Keywords: کشف مواد مخدر; Gene expression; Microarray; Contextual database; Chemogenomics; Drug discovery; Toxicogenomics; Lead optimization; Carmustine; Bile duct hyperplasia;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2005 سفارش ترجمه

Anticancer metal compounds in NCI's tumor-screening database: putative mode of action

Keywords: کشف مواد مخدر; Data mining; NCI tumor screen; Metal compounds; Mechanism of action; Drug discovery; Cancer;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2005 سفارش ترجمه