دانلود مقالات ISI درباره کشف مواد مخدر + ترجمه فارسی

Compounds for the prevention and treatment of noise-induced hearing loss

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Biotechnology; Hearing; Noise; Otoprotection; Presbycusis; Aging;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

High-throughput target discovery using cell-based genetics

Keywords: کشف مواد مخدر; Pharmaceutical Science; Drug Discovery; Techniques & Methods; Biochemistry; Target screens; Loss-of-function genetics; RNA modulation; Protein inhibition; Gain-of-function genetics; Angiogenesis;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Strategies for producing faster acting antidepressants

Keywords: کشف مواد مخدر; Drug Discovery; Neurobiology; depression; antidepressant; 5HT receptor; serotonin; NK1 receptor; corticotrophin-releasing factor; glutamate; cAMP;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Phenotype-first screening for the identification of novel drug targets

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Biochemistry; Chemical Biology; Genetics; Mutagenesis; Model organisms; Chemical genetics; RNAi;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Using imaging biomarkers to accelerate drug development and clinical trials

Keywords: کشف مواد مخدر; Drug Discovery; magnetic resonance; computed tomography; positron emission tomography; PET;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Drug design using the example of the complement system inhibitors' development

Keywords: کشف مواد مخدر; Pharmaceutical Science; Drug Discovery; Biotechnology; Biochemistry; Chemical Biology; Complement system; inhibitor; drug design; phage display; Combinatorial chemistry; HTS;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Bioinformatic methods for integrating whole-genome expression results into cellular networks

Keywords: کشف مواد مخدر; Drug Discovery; Genomics; Cell Biology; Bioinformatics; Genetics; Biochemical Pathway; Cellular Networks; Regulatory Gene Networks; Systems Biology; Gene Expression; Microarray Data Analysis;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Incretin mimetics and DPP-IV inhibitors for the treatment of type 2 diabetes

Keywords: کشف مواد مخدر; Pharmaceutical Science; Drug Discovery; Incretin mimetic; Exenatide; Liraglutide; DPP-IV Inhibitor; Type 2 Diabetes;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Measurements of binding thermodynamics in drug discovery

Keywords: کشف مواد مخدر; Pharmaceutical Science; Drug Discovery; Biophysics; Thermodynamics; ligand binding; calorimetry; protein stability; isothermal titration calorimetry; ITC; differential scanning calorimetry; DSC;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Metabolomics: from pattern recognition to biological interpretation

Keywords: کشف مواد مخدر; Pharmaceutical Science; Drug Discovery; Biochemistry; metabolomics; proteomics; shotgun proteomics; multivariate data analysis; PCA; ICA; unsupervised; systems biology;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

FT-ICR mass spectrometry in the drug discovery process

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Techniques & Methods; Target validation; Proteomics; Noncovalent complexes; Lead optimization; Natural products;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

cGMP-dependent protein kinases in drug discovery

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Biochemistry; Chemical Biology; Nitric oxide; cGMP kinase activators; cGMP kinase inhibitors; Smooth muscle tone; latelet aggregation; Learning; Nociception;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Tinnitus: neurobiological substrates

Keywords: کشف مواد مخدر; Anatomy; Drug Discovery; Pharmaceutical Science; Neurobiology; tinnitus; animal studies; spontaneous firing rate; GABA; NMDA; glycine; AMPA; plasticity;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

The transcriptome's drugable frequenters

Keywords: کشف مواد مخدر; Drug Discovery; genomics; microarray; transcriptome; drug target; gene frequency;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Kinomics: characterizing the therapeutically validated kinase space

Keywords: کشف مواد مخدر; Drug Discovery; clinical information; kinase dendrogram; selectivity; chemogenomics; disease mapping; Kinomics; target selection; target annotation;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Analyzing and mining image databases

Keywords: کشف مواد مخدر; Bioinformatics; Drug Discovery; Pharmaceutical Science; Image databases; Image mining; High content screening; Segmentation; Object classification;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Combinatorial biomarkers: From early toxicology assays to patient population profiling

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Biotechnology; Chemical Biology; High content analysis; Systems biology; Toxicogenomics; Toponomics; Proteomics;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Local inner-ear drug delivery and pharmacokinetics

Keywords: کشف مواد مخدر; Pharmacology; Pharmaceutical Science; Drug Discovery; Biotechnology; Anatomy; hearing disorders; cochlear; implantable pumps; pharmacokinetic; controlled-release; deafness;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Therapeutics of hearing loss: expectations vs reality

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Genetics; Pharmacology; deafness; Hearing loss; inner ear; cochlea; hair cells; mouse models; gene therapy; stem cells; cell cycle; regulatory genes;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

From genome to antivirals: SARS as a test tube

Keywords: کشف مواد مخدر; Drug Discovery; Virology; Pharmaceutical Science; HIV; Entry inhibitors; RNA polymerase; Membrane fusion;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Global properties of biological networks

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Bioinformatics; Genetic networks; Protein networks; Protein interactions; Metabolic networks; Gene expression;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Thalidomide as a novel therapeutic agent: new uses for an old product

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Biochemistry; Chemical Biology; Lenalidomide; Immunomodulation; IMiD®s; Analogues; Anticancer; Cytokine; Myelodysplastic syndrome; Multiple myeloma;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Botanical immunodrugs: scope and opportunities

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Chemical Biology; Systems biology; Traditional medicine; Bioprospecting; Immunomodulation; Immunostasis; Ayurveda;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Targeting DHFR in parasitic protozoa

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Biochemistry; Chemical Biology; Structure-based drug design; Malaria; Toxoplasmosis; Cryptosporidiosis; Enzyme inhibitors;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Target-based drug discovery: is something wrong?

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Genetics; Biochemistry; Management; Risk; Strategy; Physiology; Genomics;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Dendrimers and dendritic polymers in drug delivery

Keywords: کشف مواد مخدر; Pharmaceutical Science; Drug Discovery; Biochemistry; Cancer biology; Boron neutron capture therapy; Biocompatible; Dendrimer-drug conjugates; Cancer; Photodynamic therapy;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Computer prediction of drug resistance mutations in proteins

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Bioinformatics; Cell biology; Decision tree; Drug-receptor interaction; Molecular dynamics; Ligand-protein interaction; Neural networks; Machine learning; Molecular mechanics;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Keynote review: Is declining innovation in the pharmaceutical industry a myth?

Keywords: کشف مواد مخدر; Drug Discovery; innovation; management; pharmaceutical industry; strategy;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Dopamine D3 receptor antagonists as therapeutic agents

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Neurobiology; Schizophrenia; limbic system; cocaine; extrapyramidal; cognition; positive symptoms;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Functional genomics in antibacterial drug discovery

Keywords: کشف مواد مخدر; Pharmaceutical Science; Drug Discovery; Biochemistry; Microbiology; proteomics; transcriptome analysis; expression profiling; bacteria; antibiotic;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Aquaporins as targets for drug discovery

Keywords: کشف مواد مخدر; Pharmaceutical Science; Cell biology; Drug Discovery; Structural Biology; Water transport; Channels; Kidney; Eye; Respiratory tract; Central nervous system;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Progress in protein and antibody microarray technology

Keywords: کشف مواد مخدر; Pharmaceutical Science; Drug Discovery; Biotechnology; Microarray coatings; Multiple spotting technique; Rolling circle amplification; Tyramide signal amplification;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

A novel high-throughput automated chip-based nanoelectrospray tandem mass spectrometric method for PAMPA sample analysis

Keywords: کشف مواد مخدر; ADME; absorption, distribution, metabolism, elimination; DMSO; di-methyl sulphoxide; IAM; immobilized artificial membrane; LC/MS; liquid chromatography/mass spectrometry; HPLC; high pressure liquid chromatography; MDCK; mardin darby canine kidney cells; N

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Delivery options for contraceptives

Keywords: کشف مواد مخدر; Drug Discovery; contraceptive; drug delivery;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Construction of a virtual combinatorial library using SMILES strings to discover potential structure-diverse PPAR modulators

Keywords: کشف مواد مخدر; Virtual combinatorial library; SMILES; PPAR; Virtual screening; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

MALDI mass spectrometric imaging of biological tissue sections

Keywords: کشف مواد مخدر; Mass spectrometry imaging; MALDI-TOF; Amyloid beta peptides; Tissue imaging; Drug imaging; Drug discovery; Molecular scanner;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Therapies for rheumatoid arthritis: hope springs eternal

Keywords: کشف مواد مخدر; Pharmaceutical Science; Drug Discovery; Immunology; Cell biology; Molecular Medicine; Rheumatoid arthritis; Disease modifying drugs; Anti-inflammatory drugs; COX-2 inhibitors; Combination therapy; Gene therapy;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Representativity of target families in the Protein Data Bank: impact for family-directed structure-based drug discovery

Keywords: کشف مواد مخدر; Pharmaceutical Science; Drug Discovery; Bioinformatics; Structural Biology; Protein Data Bank; enzymes; chemogenomics; structural genomics; homology modeling; structure-based design;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Novel and emerging therapies for asthma

Keywords: کشف مواد مخدر; Pharmaceutical Science; Drug Discovery; Immunology; Molecular Medicine; Asthma therapy; Allergic diseases; Cytokines; IgE; Immunomodulation;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

From ligand design to therapeutic efficacy: the challenge for nicotinic receptor research

Keywords: کشف مواد مخدر; Pharmaceutical Science; Drug Discovery; Bioinformatics; Molecular Medicine; nicotine; epibatidine; cytisine; nicotinic acetylcholine receptor; nicotinic drug;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Evaluation of online extraction/mass spectrometry for in vivo cassette analysis

Keywords: کشف مواد مخدر; Sample preparation; Bioanalysis; Drug discovery; TFC; Online extraction; Pharmacokinetics;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Conformational sampling of the botulinum neurotoxin serotype a light chain: implications for inhibitor binding

Keywords: کشف مواد مخدر; BoNT, botulinum neurotoxin; BoNT/A, botulinum neurotoxin serotype A; BoNT/B, botulinum neurotoxin serotype B; LC, light chain; HC, heavy chain; Rmsd, rms deviation; Bioterrorism; Botulinum neurotoxin; Drug discovery; Inhibitors; Molecular dynamics; Molecu

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Therapeutic scope of modulation of non-voltage-gated cation channels

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Biochemistry; Chemical Biology; Ion channels; Non-voltage gated cation channels; Electrophysiology; Hydroxytryptamine receptors; Sulfonylurea;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Not all viruses are bad guys: the case for reovirus in cancer therapy

Keywords: کشف مواد مخدر; Drug Discovery; reovirus; cancer therapy; Ras signalling; oncolysis;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Peroxidases: a role in the metabolism and side effects of drugs

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Chemical Biology; Cell biology; Chemical carcinogenesis; Hypochlorite; Kupffer cells; Inflammation; Hepatitis; Idiosyncratic drug reactions; Prostaglandin-endoperoxide H synthase; Myeloperoxidase;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Staphylococcus aureus: the search for novel targets

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Microbiology; Cell biology; Antibiotic; Antimicrobial; MRSA; Immunologicals; Prophylaxis;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

In silico strategies for modeling membrane transporter function

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Bioinformatics; Biochemistry; 3D-QSAR; Comparative modeling; Glucose transporter 1; ATP-binding cassette transporters; Monoamine transporters; Nucleoside transporters;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Formulation strategies for absorption windows

Keywords: کشف مواد مخدر; Drug Discovery; absorption window; gastrointestinal tract; bioadhesion; gastroretention; chitosan;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Discovery and development of biomarkers of neurological disease

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Biochemistry; Chemical Biology; Metabolomics; Neurodegeneration; Alzheimer's disease; Parkinson's disease; Genomics; Proteomics;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Cell culture-based models for intestinal permeability: A critique

Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Biochemistry; Chemical Biology; Cell monolayers; Passive transport; Absorption; High-throughput; In vitro models; Caco-2 cells;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه