Neuronal nicotinic receptors: A perspective on two decades of drug discovery research
Keywords: کشف مواد مخدر; nAChR; Drug discovery; Nicotine
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Use of competition dialysis in the discovery of G-quadruplex selective ligands
Keywords: کشف مواد مخدر; G-quadruplex DNA; Binding; Dialysis; Drug discovery; Structural selectivity;
The next generation of PPAR drugs: Do we have the tools to find them?
Keywords: کشف مواد مخدر; PPAR; Safety; Drug discovery; TZD
Evaluation of a basic physiologically based pharmacokinetic model for simulating the first-time-in-animal study
Keywords: کشف مواد مخدر; PBPK; Predictive models; In silico models; Drug discovery; Drug candidate; Preclinical development
Phytochemistry and pharmacognosy
Keywords: کشف مواد مخدر; Phytochemistry; Pharmacognosy; Natural products chemistry; Biological activities; Medicinal plants; Drug discovery;
Small molecule intercalation with double stranded DNA: Implications for normal gene regulation and for predicting the biological efficacy and genotoxicity of drugs and other chemicals
Keywords: کشف مواد مخدر; Double stranded DNA; DNA intercalation; Drug discovery; Nuclear receptors; Gene regulation; Genotoxicity
NMR methods for the determination of protein-ligand dissociation constants
Keywords: کشف مواد مخدر; NMR spectroscopy; Protein-ligand interactions; Binding affinity; Quantitative methods; Drug discovery;
Bioactive natural products from marine cyanobacteria for drug discovery
Keywords: کشف مواد مخدر; Marine cyanobacteria; Alkaloids; Polyketide-nonribosomal polypeptide; Drug discovery;
Clinical attrition due to biased preclinical assessments of potential efficacy
Keywords: کشف مواد مخدر; Bias; Expectancy; Drug discovery; Productivity; Efficacy; Preclinical assessments;
Ligand- and substrate-based 19F NMR screening: Principles and applications to drug discovery
Keywords: کشف مواد مخدر; ALARM; a La assay to detect reactive molecules; BEI; binding efficiency index; CPMG; Carr-Purcell-Meiboom-Gill; CSA; chemical shift anisotropy; ERETIC; electronic reference to access in vivo concentrations; FA; fluorescence anisotropy; FABS; fluorin
Using epidemiology and archaeology to unearth new drug targets for rheumatoid arthritis therapy
Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; arthritis; tuberculosis; drug targets; evolution; epidemics;
Selective optimization of side activities: the SOSA approach
Keywords: کشف مواد مخدر; Pharmaceutical Science; Drug Discovery; Biochemistry; Techniques & MethodsSelective Optimization; Side Activities; Drug Libraries; Old drugs; SOSA Approach
'Venomics' or: The venomous systems genome project
Keywords: کشف مواد مخدر; Bioinformatics; Database; Drug discovery; Envenomation; Evolution; Genetics; Genomics; Proteomics; Transcriptomics; Toxinology; Venom; Venom gland; Venomous animals; Venomous function;
Utility of human/human-derived reagents in drug discovery and development: An industrial perspective
Keywords: کشف مواد مخدر; Human reagents; Drug discovery; In silico ADME; Drug–drug interactions (DDI)
A role for physicians in ethnopharmacology and drug discovery
Keywords: کشف مواد مخدر; Physician; Ethnopharmacology; Traditional medicine; Drug discovery
Emerging chemical and biological approaches for the preparation of discovery libraries
Keywords: کشف مواد مخدر; Bioinformatics; Chemical Biology; Pharmaceutical Science; Drug Discovery; Biochemistrycombinatorial chemistry; library design; solid phase organic synthesis; diversity oriented synthesis; microwave; continuous flow; phage display
Optimizing the use of open-source software applications in drug discovery
Keywords: کشف مواد مخدر; Drug Discovery; Bioinformaticsmolecular modeling; molecular descriptors; chemical visualization; computer; internet; free programs
Improving the hit-to-lead process: data-driven assessment of drug-like and lead-like screening hits
Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Techniques & Methodshit-to-lead process; HTS; ADME-Tox; hits; leads
Defining and maintaining a high quality screening collection: the GSK experience
Keywords: کشف مواد مخدر; Drug Discovery; BiotechnologyHTS; GlaxoSmithKline; array; platelookup; data mining
Comparative efficacy of HgCl2 with candidate aquaporin-1 inhibitors DMSO, gold, TEA+ and acetazolamide
Keywords: کشف مواد مخدر; AQP1; Water transport; Water channel; Inhibitor; Drug discovery
Evaluation of the chemiluminescent nitrogen detector for solubility determinations to support drug discovery
Keywords: کشف مواد مخدر; Chemiluminescent nitrogen detection; Solubility; Drug discovery
New drug candidates and therapeutic targets for tuberculosis therapy
Keywords: کشف مواد مخدر; Biochemistry; Drug Discovery; Pharmaceutical Sciencetuberculosis; drug targets; drug development; treatment
The potential impact of structural genomics on tuberculosis drug discovery
Keywords: کشف مواد مخدر; Biochemistry; Drug Discovery; Pharmaceutical ScienceX-ray crystallography; NMR; structural genomics; drug design; TB; antibiotics
Dual-action peptides: a new strategy in the treatment of diabetes-associated neuropathy
Keywords: کشف مواد مخدر; Drug Discovery; Neurobiologyneurotrophin; peptide; therapy; peripheral neuropathy; erythropoietin; INGAP
Harnessing in vivo siRNA delivery for drug discovery and therapeutic development
Keywords: کشف مواد مخدر; Drug Discovery; Cell biologyRNA interference; plasmid; adenovirus; siRNA; systemic
Electrophysiological characterization of 14-benzoyltalatisamine, a selective blocker of the delayed rectifier K+ channel found in virtual screening
Keywords: کشف مواد مخدر; 14-Benzoyltalatisamine; Channel blocker; Delayed rectifier K+ channel; Drug discovery; Tetraethylammonium; Virtual screening
Immunomics: discovering new targets for vaccines and therapeutics
Keywords: کشف مواد مخدر; Drug Discovery; ImmunologyImmunome; Immunomics; Immunoinformatics; Computational Immunology; Vaccine; Deimmunization; T-cell epitope
The role of molecular modelling in biomedical research
Keywords: کشف مواد مخدر; Protein modelling; Drug discovery; Antibodies; Leptin; Hepatitis C virus
Restoring p53-mediated apoptosis in cancer cells: New opportunities for cancer therapy
Keywords: کشف مواد مخدر; p53; Apoptosis; Transcription; Mitochondria; Cancer therapeutic; Drug discovery
New directions in kinetic high information content assays
Keywords: کشف مواد مخدر; Drug Discovery; Cell biology; High content screening; biosensors; multielectrode arrays; Ca2+ oscillations; networks; intercellular communication;
Leishmania tarentolae: Purification and characterization of tubulin and its suitability for antileishmanial drug screening
Keywords: کشف مواد مخدر; Leishmania; Tubulin; Dinitroaniline; Drug discovery; DEAE, diethylaminoethyl; DMSO, dimethyl sulfoxide; EGTA, ethyleneglycol-bis(β-aminoethyl ether); GB-II-5, N1-phenyl-3,5-dinitro-N4,N4-di-n-propylsulfanilamide; GB-II-150, N1-phenyl-3,5-dinitro-N4,N4-di-
Isolation and cloning of exendin precursor cDNAs from single samples of venom from the Mexican beaded lizard (Heloderma horridum) and the Gila monster (Heloderma suspectum)
Keywords: کشف مواد مخدر; Lizard; Venom; Exendin; cDNA cloning; Biodiversity; Drug discovery
SAGE and related approaches for cancer target identification
Keywords: کشف مواد مخدر; Pharmaceutical Science; Drug Discovery; Cancer biology; Chemical Biology; gene expression; genomic; SAGE; digital karyotyping; epigenome;
Antibacterial drug discovery—Then, now and the genomics future
Keywords: کشف مواد مخدر; Antibacterials; Antibiotics; Antibiotic synergy; Drug discovery; Genomics; Pathogen response – antibiotics; Resistance
Studies of small molecule interactions with protein phosphatases using biosensor technology
Keywords: کشف مواد مخدر; Surface plasmon resonance; Protein phosphatase inhibitors; Drug discovery; Methodology; Binding rate constants; Biosensor
MRI-guided immunotherapy development for multiple sclerosis in a primate
Keywords: کشف مواد مخدر; Drug Discovery; Immunology; NeurobiologyImmunotherapy; common marmoset; EAE; preclinical model; MRI
Targeting N-type and T-type calcium channels for the treatment of pain
Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Cell biology; Neurobiologyneuron; calcium channel; ion channel; inflammation; Prialt; Gabapentin; nociception
The promise of a virtual lab in drug discovery
Keywords: کشف مواد مخدر; Drug DiscoveryVirtual laboratory; e-science; e-bioscience; Grid; information management; data sharing; collaborative experimentation; problem-solving environment; drug discovery; systems biology
Development of a novel bioavailable inhibitor of the calmodulin-regulated protein kinase MLCK: A lead compound that attenuates vascular leak
Keywords: کشف مواد مخدر; Myosin light chain kinase; Barrier dysfunction; Genetic knockout; Inflammatory disorder; Drug discovery; Structure–activity relationship
The impact of microwave-assisted organic synthesis in drug discovery
Keywords: کشف مواد مخدر; Drug Discovery; Pharmaceutical Science; Techniques & MethodsMicrowave Assisted; MAOS; Drug Discovery; Solid supported reagents
Role of pharmacologically active metabolites in drug discovery and development
Keywords: کشف مواد مخدر; Pharmaceutical Science; Drug Discovery; Pharmacology; EndocrinologyRole; formation; structure-activity relationship; detection of pharmacologically active metabolites
What makes a good anti-inflammatory drug target?
Keywords: کشف مواد مخدر; Immunology; Pharmaceutical Science; Drug Discovery; Biochemistry; BiotechnologyGPCR; inflammation; cytokine; interleukin; adhesion molecules
Discovery of novel sodium channel inhibitors—A gene family-based approach
Keywords: کشف مواد مخدر; Sodium channel; Gene family; Subtype profiling; Inhibitors; Drug discovery; Splice variants; Ribonuclease protection assay
The proteasome as a potential target for novel anticancer drugs and chemosensitizers
Keywords: کشف مواد مخدر; Drug resistance; Chemosensitizer; Proteasome inhibitor; Molecular target; Natural product; Drug discovery; Anticancer
The challenge of drug discovery of a GPCR target: Analysis of preclinical pharmacology of histamine H3 antagonists/inverse agonists
Keywords: کشف مواد مخدر; H3 receptor; Histamine; GPCR; Drug discovery; Cognition; Antagonist/inverse agonist
Development and characterization of LLC-PK1 cells containing Sprague–Dawley rat Abcb1a (Mdr1a): Comparison of rat P-glycoprotein transport to human and mouse
Keywords: کشف مواد مخدر; Drug discovery; Human; LLC-PK1; Membrane transport; Methods; Mouse; P-glycoprotein; Rat
Keynote review: Allosterism in membrane receptors
Keywords: کشف مواد مخدر; Biochemistry; Biotechnology; Drug Discovery; Pharmaceutical Science; G protein-coupled receptors; ligand-gated ion channel; tyrosine kinase receptors; allosteric enhancer; guanylate cyclase receptor; transmembrane helix;
Liquid chromatography–mass spectrometry/mass spectrometry method development for drug metabolism studies: Examining lipid matrix ionization effects in plasma
Keywords: کشف مواد مخدر; LC–MS/MS; Plasma; Phospholipids; Lecithin; Glycerophosphocholines; Matrix suppression; Drug discovery; Pharmaceutical analysis; Electrospray mass spectrometry; Matrix effects
Keynote review: Chromatin control and cancer-drug discovery: realizing the promise
Keywords: کشف مواد مخدر; Cancer biology; Pharmaceutical Science; Drug Discovery; GeneticsHistone deacetylase; Methylation; Acetylation; Cell Cycle; Chromatin; Cancer Therapy
The role of neuroinflammation in neuropathic pain: mechanisms and therapeutic targets
Keywords: کشف مواد مخدر; Neurobiology; Drug Discovery; Biochemistry; Pharmaceutical Scienceinflammation; CNS; cytokine; glial cells; Schwann cells