Sodium Channel Blockers for the Treatment of Neuropathic Pain
Keywords: کشف مواد مخدر; Sodium channel; subtype; selectivity; neuropathic pain; drug discovery;
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In vivo, in vitro and in silico methods for small molecule transfer across the BBB
Keywords: کشف مواد مخدر; blood-brain barrier; in vitro model; in vivo model; in silico modeling; CNS; permeability; passive diffusion; active transport; drug discovery; molecular descriptors;
Plant cell-based processes for cyclotides production
Keywords: کشف مواد مخدر; Oldenlandia affinis; In vitro cultures; Cyclotides; Kalata B1 production; Morphogenesis; Drug discovery
Natural Compound Curcumin-a Channel Potentiator Rather Than a Corrector of the Defective Intracellular Processing of ÎF508 Mutant Cystic Fibrosis Transmembrane Conductance Regulator
Keywords: کشف مواد مخدر; Cystic fibrosis; CFTR; Mutation; Natural compound; Drug discovery;
Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency
Keywords: کشف مواد مخدر; Migrastatin; Iso-migrastatin; Cell migration; Metastasis; Macrolide; 14-Membered; Scratch wound-healing (SWH); Semi-synthesis; Biosynthesis; Structure–activity relationship; Drug discovery
2-Oxo-tetrahydro-1,8-naphthyridines as selective inhibitors of malarial protein farnesyltransferase and as anti-malarials
Keywords: کشف مواد مخدر; Malaria; P. falciparum; Anti-malarials; Protein farnesyltransferase; Drug discovery; Rational drug design
High-speed solubility screening assay using ultra-performance liquid chromatography/mass spectrometry in drug discovery
Keywords: کشف مواد مخدر; Physicochemical screening; Solubility; Drug discovery; Ultra-performance liquid chromatography (UPLC); Mass spectrometry (MS); LC–MS
Peptide-based fluorescent sensors of protein kinase activity: Design and applications
Keywords: کشف مواد مخدر; Signal transduction; Sensor; Fluorescent peptide; Assay; Inhibitor; Drug discovery
A radiochemical technique with potential for revealing novel fungal metabolites according to expression of specific biosynthetic activities
Keywords: کشف مواد مخدر; Autoradiography; Drug discovery; Fungal natural products; Micro-scale fermentation; Secondary metabolites; Structural analogues
Phylogenetic selection of Narcissus species for drug discovery
Keywords: کشف مواد مخدر; Alzheimer's disease; Amaryllidaceae; Daffodils; Drug discovery; trnL-F; Narcissus; ndhF; Selection
Towards a molecular characterisation of pathological pathways
Keywords: کشف مواد مخدر; Systems pathology; Protein–protein interaction; Network modelling; Biological pathway; Drug discovery
SSM-based electrophysiology
Keywords: کشف مواد مخدر; Solid supported membrane; Lipid membrane; Vesicle; Proteoliposome; Assay technique; Transport protein; Solution exchange; Capacitive coupling; Drug discovery
Separation of maxi-K channel opening 3-substitued-4-arylquinolinone atropisomers by enantioselective supercritical fluid chromatography
Keywords: کشف مواد مخدر; Atropisomer separation; Supercritical fluid chromatography; 3-substitued-4-arylquinolinone; Maxi-K channel opener; Drug discovery
A new approach for drug discovery from glycobiology and phage-displayed peptide library technology
Keywords: کشف مواد مخدر; Phage displayed peptide library; Glyco-replica peptide; Glycolipid; Ganglioside; Angiogenesis; Melanoma; Drug discovery; Glycobiology; Metastasis; Molecular mimicry;
Drug development and regulation
Keywords: کشف مواد مخدر; clinical trial; drug development; drug discovery; European Clinical Trials Directive; licensing authority
Design and utilization of the drug–excipient chemical compatibility automated system
Keywords: کشف مواد مخدر; Excipient compatibility; Automation; Oral dosage form; Chemical stability; Drug discovery
Large-scale prediction of drug–target relationships
Keywords: کشف مواد مخدر; Drug–target interaction; Small-molecule network; Drug discovery; Target prediction
Drugs from hidden bugs: their discovery via untapped resources
Keywords: کشف مواد مخدر; Metagenomics; Environmental DNA extraction; Drug discovery; High throughput screening
PerspectivePartnership between academia and industry for drug discovery in Alzheimer's disease
Keywords: کشف مواد مخدر; Alzheimer's disease; Drug development; Drug discovery; Collaboration; Pharmaceutical industry; Academia;
Pharao: Pharmacophore alignment and optimization
Keywords: کشف مواد مخدر; Drug discovery; Pharmacophore; Virtual screening; Clustering
PcrA/UvrD/Rep DNA helicases in bacterial genomes
Keywords: کشف مواد مخدر; PcrA; UvrD; Rep; DNA helicases; PURL; Drug discovery
A screening study of ChirBase molecular database to explore the expanded chiral pool derived from the application of chiral chromatography
Keywords: کشف مواد مخدر; Chirbase database; Chiral HPLC; Chiral combinatorial library; Diversity analysis; Drug discovery; Druglike; Leadlike distribution
Screening of tobacco smoke condensate for nicotinic acetylcholine receptor ligands using cellular membrane affinity chromatography columns and missing peak chromatography
Keywords: کشف مواد مخدر; Natural products screening; α3β4 Nicotinic receptor; Affinity chromatography; Nicotine derivatives; Tobacco smoke fingerprinting; Drug discovery
Multi-channel counter-current chromatography for high-throughput fractionation of natural products for drug discovery
Keywords: کشف مواد مخدر; Counter-current chromatography; Multi-channel; High-throughput; Natural products; Drug discovery; Fractionation; Metabolomics
High-throughput screening of cell responses to biomaterials
Keywords: کشف مواد مخدر; High-throughput screening; Biomaterial; Tissue engineering; Biocompatibility; Cell culture; Microarray; Microfluidics; Drug discovery
Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discovery
Keywords: کشف مواد مخدر; Mycobacterium tuberculosis; Cell division; FtsZ; Septum inhibition; Drug discovery
A support vector machines approach for virtual screening of active compounds of single and multiple mechanisms from large libraries at an improved hit-rate and enrichment factor
Keywords: کشف مواد مخدر; Computer aided dug design; Drug discovery; High-throughput screening; Lead discovery; Machine learning method; Virtual screening
Computer-aided drug discovery and development (CADDD): In silico-chemico-biological approach
Keywords: کشف مواد مخدر; Drug discovery; Drug development; Molecular modeling; Virtual screening; Computational modeling; In silico drug design; QSAR/QSPR; Predictive toxicology
Experimental Therapeutics for Dystonia
Keywords: کشف مواد مخدر; Dystonia; animal models; drug discovery; pathogenesis; therapy;
Inactivation of the medial prefrontal cortex of the rat impairs strategy set-shifting, but not reversal learning, using a novel, automated procedure
Keywords: کشف مواد مخدر; Prefrontal cortex; Set-shifting; Reversal learning; Perseveration; Drug discovery; Rat
N-in-1 Dosing Pharmacokinetics in Drug Discovery: Experience, Theoretical and Practical Considerations
Keywords: کشف مواد مخدر; N-in-1 dosing; cassette doing; pharmacokinetics; drug discovery; drug-drug interactions;
Targeting ubiquitin specific proteases for drug discovery
Keywords: کشف مواد مخدر; Ubiquitin; Drug discovery; Ubiquitin specific proteases; De-ubiquitination; Inhibitor
Cytochrome P450s in the development of target-based anticancer drugs
Keywords: کشف مواد مخدر; Recombinant P450; CYP; Expression; Pharmacokinetics; Drug discovery
Human embryonic stem cells: Current technologies and emerging industrial applications
Keywords: کشف مواد مخدر; Human embryonic stem cells; Differentiation; Cardiomyocytes; Hepatocytes; Drug discovery; Toxicology; Regenerative medicine
Toxicogenomic predictive modeling: Emerging opportunities for more efficient drug discovery and development
Keywords: کشف مواد مخدر; Drug Discovery; R&D productivity; Toxicogenomics; Technology Integration; Predictive modeling; Biotechnology; Technology Roadmapping
Campylobacter jejuni proteomics for new travellers’ diarrhoea vaccines
Keywords: کشف مواد مخدر; Travellers’ diarrhoea; Campylobacter jejuni; Proteomics; Vaccine; Drug discovery
Virtual screening application of a model of full-length HIV-1 integrase complexed with viral DNA
Keywords: کشف مواد مخدر; HIV-1 integrase strand transfer inhibitors; Computer-aided drug design; Virtual screening; Drug discovery
Carnitine palmitoyltransferase 2: Analysis of membrane association and complex structure with a substrate analog
Keywords: کشف مواد مخدر; Type 2 diabetes mellitus; Drug discovery; Membrane proteinβOG, β-octylglucoside; CACT, carnitine/acylcarnitine translocase; CPT, carnitine palmitoyltransferase; LCFA, long-chain fatty acid; T2D, type 2 diabetes mellitus
From diatomics to drugs and dividends
Keywords: کشف مواد مخدر; Computational chemistry; Drug discovery; Grid computing; Commercialisation
Quantifying trifluoroacetic acid as a counterion in drug discovery by 19F NMR and capillary electrophoresis
Keywords: کشف مواد مخدر; Trifluoroacetate; 19F nuclear magentic resonance; Capillary electrophoresis; Indirect UV; Quantitation; Drug discovery
Molecular aspects of phytoestrogen selective binding at estrogen receptors
Keywords: کشف مواد مخدر; hormones; drug design; drug discovery; molecular structure; functional groups;
Chemical proteomics for drug discovery based on compound-immobilized affinity chromatography
Keywords: کشف مواد مخدر; Affinity chromatography; Drug discovery; Proteomics
Headless splice variant acting as dominant negative calcitonin receptor
Keywords: کشف مواد مخدر; CTR; Hormone-binding domain; GPCR-regulation; RAMP; Drug discovery;
Measurements with fluorescent probes in primary neural cultures; improved multiwell techniques
Keywords: کشف مواد مخدر; Cerebellar granule cells; Drug discovery; Fluorescence; Methods; NMDA; Calcium; Rat; MK-801; Ion channel block; Fura-2
Development of an in silico model for predicting efflux substrates in Caco-2 cells
Keywords: کشف مواد مخدر; P-gp substrates; Efflux; In silico model; Caco-2 cell; Drug discovery
Enhanced cardiac allograft survival by Vav1-Rac signaling blockade in a mouse model
Keywords: کشف مواد مخدر; T cells; Transplantation; Immunosuppression; Drug discovery; Vav1-Rac
Rational development of solvent system families in counter-current chromatography
Keywords: کشف مواد مخدر; CCC; HSCCC; GUESSmix; GUESS; G.U.E.S.S.; Bioassay-guided fractionation; Metabolomics; Solvent system mapping; Metabolome analysis; Natural products; Drug discovery
Analytical approaches to determine cytochrome P450 inhibitory potential of new chemical entities in drug discovery
Keywords: کشف مواد مخدر; In vitro cytochrome P450 inhibition assay; LC–MS/MS; DDI; Cocktail DDI analysis; Bioanalysis; CYP3A4; CYP2D6; CYP2C19; CYP2C9; CYP1A2; High-throughput analysis; Drug discovery
Multi-Target Recognition in Intracellular Regulation Networks
Keywords: کشف مواد مخدر; cell cycle; constrained state feedback; drug discovery; intracellular regulation network; Monte-Carlo method; uniform distribution;
Allosteric approaches to the targeting of G-protein-coupled receptors for novel drug discovery: A critical assessment
Keywords: کشف مواد مخدر; Drug discovery; G-protein-coupled receptor; Allosteric; Orthosteric;