دانلود مقالات ISI درباره کشف مواد مخدر + ترجمه فارسی

Affinity characterization-mass spectrometry methodology for quantitative analyses of small molecule protein binding in solution

Keywords: کشف مواد مخدر; Thermodynamics; Ligand binding; Mass spectrometry; Thymidylate synthetase; DNA primase; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assay

Keywords: کشف مواد مخدر; Adenosine; A2A; JNK; IKK; CXCR3; Microglia; Neurodegeneration; Neuroprotection; Biolistics; Brain slice; Drug discovery; Inflammation;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Discovery of cytotoxic and pro-apoptotic compounds against leukemia cells: Tert-butyl-4-[(3-nitrophenoxy) methyl]-2,2-dimethyloxazolidine-3-carboxylate

Keywords: کشف مواد مخدر; Apoptosis; Drug discovery; Hit compound; Scaffold; Anti-cancer;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Drosophila as a model system for studying lifespan and neuroprotective activities of plant-derived compounds

Keywords: کشف مواد مخدر; Drosophila; Model organism; Life span; Neurodegenerative disease; Oxidative stress; Drug discovery

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Phylogenetic selection of target species in Amaryllidaceae tribe Haemantheae for acetylcholinesterase inhibition and affinity to the serotonin reuptake transport protein

Keywords: کشف مواد مخدر; Acetylcholinesterase; Amaryllidaceae; Drug discovery; Internal transcribed spacer; Phylogeny; Serotonin-reuptake-transport-protein; trnL-F

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Development of Vaccinia reporter viruses for rapid, high content analysis of viral function at all stages of gene expression

Keywords: کشف مواد مخدر; Orthopoxvirus; Antiviral; Gene expression; High-throughput; Drug discovery

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

The properties of thermostabilised G protein-coupled receptors (StaRs) and their use in drug discovery

Keywords: کشف مواد مخدر; G protein-coupled receptor; Thermostability; Receptor kinetics; Drug discovery

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

The development of a whole-cell based medium throughput screening system for the discovery of human aldosterone synthase (CYP11B2) inhibitors: Old drugs disclose new applications for the therapy of congestive heart failure, myocardial fibrosis and hyperte

Keywords: کشف مواد مخدر; CYP11Bs; Hyperaldosteronism; Hypertension; Heart failure; Myocardial fibrosis; Screening system; Drug discovery; Drug recycling

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Using a private desktop grid system for accelerating drug discovery

Keywords: کشف مواد مخدر; Desktop grid; Service grid; Science gateway; Boinc; Cloud; Drug discovery

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Supercritical fluid chromatography in research laboratories: Design, development and implementation of an efficient generic screening for exploiting this technique in the achiral environment

Keywords: کشف مواد مخدر; Supercritical Fluid Chromatography; Analytical screen; Achiral purification; Drug Discovery

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

QSAR-based permeability model for drug-like compounds

Keywords: کشف مواد مخدر; Chemical space; Computational chemistry; Drug discovery; Quantitative structure–activity relationships (QSAR); Permeability

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Evaluation of spontaneous propulsive movement as a screening tool to detect rescue of Parkinsonism phenotypes in zebrafish models

Keywords: کشف مواد مخدر; Zebrafish; Parkinsonism; Motor function; Dopamine; MPP+; Chlorpromazine; Haloperidol; Apomorphine; Ropnirole; Spontaneous movement; Automated behavior measurement; Drug discovery

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Intestinal drug solubility estimation based on simulated intestinal fluids: Comparison with solubility in human intestinal fluids

Keywords: کشف مواد مخدر; TPGS; Solubilizing capacity; Solubility estimation; Human intestinal fluids; Simulated intestinal fluids; Drug discovery

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Isolation of functional mitochondria from rat kidney and skeletal muscle without manual homogenization

Keywords: کشف مواد مخدر; Mitochondria; Barocycler; Hydrostatic pressure; Kidney; Muscle; Drug discovery; Toxicology

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation

Keywords: کشف مواد مخدر; Dihydroquinoline; African trypanosomiasis; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

New antimicrobial agents on the horizon

Keywords: کشف مواد مخدر; Antibiotic; Antibiotic resistance; Drug discovery; Clinical trial; Bacterial target

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Allosteric modulation of G protein-coupled receptors: A pharmacological perspective

Keywords: کشف مواد مخدر; Allosteric modulator; Drug discovery; Functional selectivity; G protein-coupled receptor; Stimulus-bias; Structure–function

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Developing predictive CSF biomarkers—A challenge critical to success in Alzheimer's disease and neuropsychiatric translational medicine

Keywords: کشف مواد مخدر; Alzheimer's disease; CSF biomarkers; Schizophrenia; Depression; Parkinson's disease; Drug discovery

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Cassette Dosing for Pharmacokinetic Screening in Drug Discovery: Comparison of Clearance, Volume of Distribution, Half-Life, Mean Residence Time, and Oral Bioavailability Obtained by Cassette and Discrete Dosing in Rats

Keywords: کشف مواد مخدر; clearance; cassette dosing; N-in-one dosing; pharmacokinetics; drug discovery; volume of distribution at steady state; half-life; oral bioavailability; liquid chromatography—tandem mass spectrometry

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Renal fibrosis and proteomics: Current knowledge and still key open questions for proteomic investigation

Keywords: کشف مواد مخدر; CKD; Fibrosis; Proteomics; Drug discovery; Myofibroblast; Kidney;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2011 سفارش ترجمه

Protein kinase biochemistry and drug discovery

Keywords: کشف مواد مخدر; Protein kinase; Phosphorylation; Drug discovery; Enzyme mechanism; Irreversible inhibition; Phosphotransfer

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2011 سفارش ترجمه

Metabolite identification by liquid chromatography-mass spectrometry

Keywords: کشف مواد مخدر; Drug development; Drug discovery; Early stage drug discovery; Liquid chromatography-mass spectrometry (LC-MS); Mass spectrometer; Metabolism; Metabolite identification (Met ID); Pharmacologically active; Pharmacologically toxic; Reactive metabolite

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2011 سفارش ترجمه

PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration-time profiles in human by using the physiologically‐based pharmacokinetic modeling approach

Keywords: کشف مواد مخدر; animal alternative; computational ADME; drug discovery; drug development; absorption; distribution; disposition; in vitro-in vivo correlation; pharmacokinetics; PBPK modeling;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2011 سفارش ترجمه

Natural products: An evolving role in future drug discovery

Keywords: کشف مواد مخدر; Natural products; Clinical development; Drug discovery; Approved drugs

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis and characterization of a cellular membrane affinity chromatography column containing histamine 1 and P2Y1 receptors: A multiple G-protein coupled receptor column

Keywords: کشف مواد مخدر; Affinity chromatography; Drug discovery; Receptor screening; Anti-histamines; Membrane receptors

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Development of novel inhibitors targeting HIF-1α towards anticancer drug discovery

Keywords: کشف مواد مخدر; Hypoxia; HIF-1α; Small molecule; Anticancer; Antiproliferative; Drug discovery; Pyridylpyrimidine

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Unusual antimalarial meroditerpenes from tropical red macroalgae

Keywords: کشف مواد مخدر; Callophycus serratus; Amphiroa crassa; Natural product; Drug discovery; Red macroalgae

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Beyond the signaling effect role of amyloid-β42 on the processing of APP, and its clinical implications

Keywords: کشف مواد مخدر; Aging; Alzheimer's disease; Amyloid beta peptide; Clinical trial; Dementia; Drug discovery; Gene regulation; Molecular pharmacology; Signaling; Transcription factor; Treatment

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Synthesis and structure–activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents

Keywords: کشف مواد مخدر; Anti-cancer agents; Drug discovery; Synthesis; Structure–activity relationship

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

High-throughput sequencing for the identification of binding molecules from DNA-encoded chemical libraries

Keywords: کشف مواد مخدر; DNA-encoded chemical library; High-throughput sequencing; Illumina; 454; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

The synthesis and characterization of cellular membrane affinity chromatography columns for the study of human multidrug resistant proteins MRP1, MRP2 and human breast cancer resistant protein BCRP using membranes obtained from Spodoptera frugiperda (Sf9)

Keywords: کشف مواد مخدر; Sf9; Affinity chromatography; Drug discovery; Receptor screening; ABC transporters; P-glycoprotein; MRP1; MRP2; BCRP; Membrane receptors

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Assessment of the blood-brain barrier in CNS drug discovery

Keywords: کشف مواد مخدر; Blood-brain barrier; Drug disposition; Drug discovery; CNS; Permeability; Free-fraction; Pharmacokinetics/pharmacodynamics;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Discovery of substituted benzyl tetrazoles as histamine H3 receptor antagonists

Keywords: کشف مواد مخدر; Histamine; H3R; Antagonists; CNS; GPCR; Drug discovery

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors

Keywords: کشف مواد مخدر; Drug discovery; Inhibitors; Structure–activity relationships; Growth factor; Receptor

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Identification of the first non-peptidic small molecule inhibitor of the c-Abl/14-3-3 protein–protein interactions able to drive sensitive and Imatinib-resistant leukemia cells to apoptosis

Keywords: کشف مواد مخدر; 14-3-3 Proteins; Leukemia; Drug discovery; Molecular modeling; Non-peptidic compounds; Protein–protein interactions

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Cancer as a reprogramming-like disease: Implications in tumor development and treatment

Keywords: کشف مواد مخدر; Cancer; Stem cells; Cancer stem cells; Reprogramming; Mouse models; Drug discovery

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

ES and iPS cell research for cardiovascular regeneration

Keywords: کشف مواد مخدر; Induced pluripotent stem cells; Heart; Blood vessel; Regeneration; Drug discovery

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Evaluation of the Mycobacterium smegmatis and BCG models for the discovery of Mycobacterium tuberculosis inhibitors

Keywords: کشف مواد مخدر; Drug discovery; Chemical library; Tuberculosis; BCG; Smegmatis

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Discovery of veterinary antiparasitic agents in the 21st Century: A view from industry

Keywords: کشف مواد مخدر; Drug discovery; Animal health

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Cytotoxic effect of amide derivatives of trifluoromethionine against the enteric protozoan parasite Entamoeba histolytica

Keywords: کشف مواد مخدر; Drug discovery; Sulphur-containing amino acid metabolism; Methionine γ-lyase; Protozoan parasite

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Design of comprehensive Alzheimer's disease centers to address unmet national needs

Keywords: کشف مواد مخدر; Alzheimer's disease; Neurodegenerative diseases; Basic science; Prevention; Neuroimaging; Clinical trials; Drug discovery; Health care policy; Health services;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Prediction of blood–brain barrier penetration of poorly soluble drug candidates using surface activity profiling

Keywords: کشف مواد مخدر; Surface activity profiling; Drug discovery; Maximum surface pressure; Cross-sectional area; Blood–brain barrier; Gibbs adsorption isotherms

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Maintained activity of glycogen synthase kinase-3β despite of its phosphorylation at serine-9 in okadaic acid-induced neurodegenerative model

Keywords: کشف مواد مخدر; GSK3β inhibitor; β-Catenin; CRMP2; Drug discovery

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Antitumor activity of novel fluoro-substituted (–)-epigallocatechin-3-gallate analogs

Keywords: کشف مواد مخدر; Breast cancer; Proteasome inhibitor; Drug discovery; Cancer prevention; Tea polyphenol

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity

Keywords: کشف مواد مخدر; T. cruzi; TIM; Massive screening; Drug discovery

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Tau-directed drug discovery for Alzheimer's disease and related tauopathies: A focus on tau assembly inhibitors

Keywords: کشف مواد مخدر; Alzheimer's disease; Tau; Neurofibrillary tangles; Drug discovery

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Influence of selective estrogen receptor modulators on interleukin-6 expression in human retinal pigment epithelial cells (ARPE-19)

Keywords: کشف مواد مخدر; Age-related macular degeneration; Retinal pigment epithelium; Selective estrogen receptor modulator; 17β-estradiol; Drug discovery; Inflammation

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

QSAR-based solubility model for drug-like compounds

Keywords: کشف مواد مخدر; Chemical space; Computational chemistry; Drug discovery; Quantitative structure–activity relationships (QSAR); Solubility

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

AnalysisThe pharmaceutical value of marine biodiversity for anti-cancer drug discovery

Keywords: کشف مواد مخدر; Resource valuation; Ecosystem service; Drug discovery; Cancer; Marine biodiversity; Marine natural products;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Modulation of 11β-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles

Keywords: کشف مواد مخدر; 11β-Hydroxysteroid dehydrogenase type 1; 11β-HSD1; Drug discovery; Metabolic syndrome;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه