دانلود مقالات ISI درباره کشف مواد مخدر + ترجمه فارسی

Discovery of novel A3 adenosine receptor ligands based on chromone scaffold

Keywords: کشف مواد مخدر; [3H]CCPA; [3H](2R,3R,4S,5R)-2-[2-chloro-6-(cyclopentylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol; [3H]HEMADO; [3H] 2-(1-Hexynyl)-N6-methyladenosine; [3H]NECA; [3H]adenosine-5′-(N-ethylcarboxamide); AR; Adenosine receptor; Arg; arginine; Asn; as

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Toponome imaging system: multiplex biomarkers in oncology

Keywords: کشف مواد مخدر; toponome imaging system (TIS); multiplex biomarker; heterogeneity; drug discovery; microenvironment; cancer stem cells; early cancer diagnosis

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Inter-individual Variability of In Vivo CYP2D6 Activity in Different Genotypes

Keywords: کشف مواد مخدر; inter-individual variability; CYP2D6; Monte Carlo simulation; physiologically based pharmacokinetics; pharmacogenetics; dextromethorphan; drug discovery;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Early rapid identification of in vivo rat metabolites of AN6414, a novel boron-containing PDE4 inhibitor by QTRAP LC/MS/MS to support drug discovery

Keywords: کشف مواد مخدر; In vivo metabolite identification; QTRAP LC/MS/MS; Drug discovery; Boron containing compound; PDE4 inhibitor;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

PerspectiveA model for improving the treatment and care of Alzheimer's disease patients through interdisciplinary research

Keywords: کشف مواد مخدر; Drug discovery; Biomarkers; Clinical trial design; Continuity of care; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Placing supercritical fluid chromatography one step ahead of reversed-phase high performance liquid chromatography in the achiral purification arena: A hydrophilic interaction chromatography cross-linked diol chemistry as a new generic stationary phase

Keywords: کشف مواد مخدر; Supercritical fluid chromatography; Generic stationary phases; HILIC; Analytical screen; Achiral purification; Drug Discovery

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

From snake venom toxins to therapeutics – Cardiovascular examples

Keywords: کشف مواد مخدر; Toxins to therapeutics; Toxins to drugs; Drug discovery; Drug design; Antithrombotic agents; Anti-hypertensive agents; Anti-cancer

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Is chemical synthetic accessibility computationally predictable for drug and lead-like molecules? A comparative assessment between medicinal and computational chemists

Keywords: کشف مواد مخدر; De novo design; Drug discovery; Synthetic accessibility; Synthesis design; Virtual screening; MDFNKONIJQYFPS-UHFFFAOYSA-N; BEXLGYMADAVLBV-MRXNPFEDSA-N; BEXLGYMADAVLBV-INIZCTEOSA-N; WLFMJHYSRBZBMY-UHFFFAOYSA-N; LLPGJMNCBYZYOZ-GOSISDBHSA-N; KSEKHDPSPJWLQE-U

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Evaluation of laser diode thermal desorption (LDTD) coupled with tandem mass spectrometry (MS/MS) for support of in vitro drug discovery assays: Increasing scope, robustness and throughput of the LDTD technique for use with chemically diverse compound lib

Keywords: کشف مواد مخدر; Laser diode thermal desorption (LDTD); Drug discovery; High-throughput; Cytochrome P450; Ambient ionization

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Metastatic disease: A drug discovery perspective

Keywords: کشف مواد مخدر; GEMM; genetically engineered mouse models; ADME; absorption, distribution, metabolism and excretion; PK; pharmacodynamics; ECM; extracellular matrix; EMT; epithelial-mesenchymal transition; MET; mesenchymal-epithelial transition; NSCLC; non-small cell

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Innovative therapy for Classic Galactosemia - Tale of two HTS

Keywords: کشف مواد مخدر; Classic Galactosemia; Small molecule inhibitors; High-throughput screening; Drug discovery; Galactokinase; Anti-cancer therapy;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents

Keywords: کشف مواد مخدر; Cyclin-dependent kinase; RNA polymerase II; Anti-tumour activity; Induction of apoptosis; Mcl-1 anti-apoptotic protein; Drug discovery; Cancer therapy;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Behavioral profiling of zebrafish embryos exposed to a panel of 60 water-soluble compounds

Keywords: کشف مواد مخدر; Zebrafish embryo; Behavior; Toxicology; Safety pharmacology; Predictive model; Drug discovery

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Fitting the complexity of GPCRs modulation into simple hypotheses of ligand design

Keywords: کشف مواد مخدر; Drug design; Chemoinformatics; Structure–activity relationships; G-protein coupled receptors; Drug discovery

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Human cytosolic glutathione transferases: structure, function, and drug discovery

Keywords: کشف مواد مخدر; drug metabolism; glutathione transferases; crystal structure; drug discovery

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Driving forces of technological change in medicine: Radical innovations induced by side effects and their impact on society and healthcare

Keywords: کشف مواد مخدر; I10; O33Radical innovation; Incremental innovation; Breast cancer; Oral contraceptive pill; Side effects; Adverse effects; Medicine; Healthcare; Technological change; Drug discovery

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Aquaporins in drug discovery and pharmacotherapy

Keywords: کشف مواد مخدر; Aquaporin (AQP); Drug discovery; Pharmacotherapy; Imaging;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Computational NeuroscienceAutomated multi-slice extracellular and patch-clamp experiments using the WinLTP data acquisition system with automated perfusion control

Keywords: کشف مواد مخدر; Automated perfusion; Multi-slice; Brain slices; Protocol scripting; Drug discovery; Long-term potentiation (LTP);

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Recent developments in microfluidic devices for in vitro cell culture for cell-biology research

Keywords: کشف مواد مخدر; Cell biology; Cell culture; Cell immobilization; Cell migration; Co-culture; Drug discovery; Gradient generator; Microfluidics; Micropatterning; Single cell

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Improving the prediction of the brain disposition for orally administered drugs using BDDCS

Keywords: کشف مواد مخدر; BDDCS, Biopharmaceutics drug disposition classification system; BBB, Blood–brain barrier; Pgp, P-glycoprotein; CNS, Central nervous systemBrain disposition; Data mining; Drug discovery; Rules of thumb

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Recent advances in pharmaceutical separations with supercritical fluid chromatography using chiral stationary phases

Keywords: کشف مواد مخدر; Achiral separation; Chiral separation; Chiral stationary phase (CSP); Drug discovery; Enantioseparation; Packed column; Preparative chromatography; Screening strategy; Supercritical fluid chromatography (SFC); Tandem column

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2012 سفارش ترجمه

From cancer metabolism to new biomarkers and drug targets

Keywords: کشف مواد مخدر; Cancer; Metabolism; NMR; Mass spectrometry; PET; Drug discovery; Systems biology

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2012 سفارش ترجمه

Nanopores: A journey towards DNA sequencing

Keywords: کشف مواد مخدر; Nanopores; Nanotechnology; DNA sequencing; Drug discovery; Single-molecule biophysics

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2012 سفارش ترجمه

Growth inhibition of Escherichia coli and methicillin-resistant Staphylococcus aureus by targeting cellular methionine aminopeptidase

Keywords: کشف مواد مخدر; Antibiotic; Drug resistance; Drug discovery; Enzyme inhibition; Hydrolase; Metalloenzyme

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis and biological evaluation of salicylate-based compounds as a novel class of methionine aminopeptidase inhibitors

Keywords: کشف مواد مخدر; Salicylic acid; Metalloenzyme; Inhibition; Antibacterial; Drug discovery

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Traditional Medicine Collection Tracking System (TM-CTS): A database for ethnobotanically driven drug-discovery programs

Keywords: کشف مواد مخدر; Database; Traditional Chinese Medicine; High throughput screening; Ethnobotany; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Two methionine aminopeptidases from Acinetobacter baumannii are functional enzymes

Keywords: کشف مواد مخدر; MetAP, methionine aminopeptidase; AbMetAP, A. baumannii methionine aminopeptidase; EcMetAP, E. coli methionine aminopeptidase; Met-AMC, methionyl aminomethylcoumarinMetalloenzyme; Drug resistance; Gram-negative bacteria; Drug discovery; Antibiotics; Metal

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors

Keywords: کشف مواد مخدر; Drug discovery; Inhibitor; Structure–activity relationship; Benzodiazepine; Peptidomimetics

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis of potential drug metabolites by a modified Udenfriend reaction

Keywords: کشف مواد مخدر; Metabolites; Biomimetic oxidation; Aromatic hydroxylation; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening

Keywords: کشف مواد مخدر; SHP2 inhibitor; Protein tyrosine phosphatase (PTP); Virtual screening; Molecular dynamics simulation; Drug discovery

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Chiral separation of potent corticotropin-releasing factor-1 receptor antagonists by supercritical fluid chromatography

Keywords: کشف مواد مخدر; Enantiomeric separation; Supercritical fluid chromatography; Pyrazinone; CRF1 antagonist; Drug discovery

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

High-performance thin layer chromatography: A powerful analytical technique in pharmaceutical drug discovery

Keywords: کشف مواد مخدر; Drug discovery; HPTLC; natural products; planar chromatography;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Principles of strategic drug delivery to the brain (SDDB): Development of anorectic and orexigenic analogs of leptin

Keywords: کشف مواد مخدر; Leptin; Blood–brain barrier; Obesity; Anorexia; Drug discovery; Drug delivery

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Impact of enzyme concentration and residence time on apparent activity recovery in jump dilution analysis

Keywords: کشف مواد مخدر; Drug target residence time; Tight-binding inhibition; Jump dilution analysis; Drug discovery

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Single-label time-resolved luminescence assay for estrogen receptor–ligand binding

Keywords: کشف مواد مخدر; Drug discovery; Time-resolved luminescence; Nuclear receptors; Steroids; Homogeneous assay

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase

Keywords: کشف مواد مخدر; Tuberculosis; Arylamine N-acetyltransferase; β-Amino alcohols; Enzyme inhibition; Drug discovery

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Surface plasmon resonance imaging (SPRi) as an alternative technique for rapid and quantitative screening of small molecules, useful in drug discovery

Keywords: کشف مواد مخدر; Surface plasmon resonance imaging (SPRi); Drug discovery; Quadruplex binding

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Investigating combinatorial approaches in virtual screening on human inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3): A case study for small molecule kinases

Keywords: کشف مواد مخدر; Drug discovery; Computational biology; Software evaluation molecular docking; Enrichment factors; 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase; Small molecule kinases; Glycolysis; PFKFB3; Cancer; Warburg; Fructose-2,6-bisphosphate;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Combined SVM-based and docking-based virtual screening for retrieving novel inhibitors of c-Met

Keywords: کشف مواد مخدر; c-Met inhibitor; Drug discovery; Molecular docking; Support vector machine; Virtual screeningSVM, support vector machine; VS, virtual screening; SB-VS, SVM-based virtual screening; DB-VS, molecular docking-based virtual screening; HGFR, hepatocyte growth

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Structural basis of CX-4945 binding to human protein kinase CK2

Keywords: کشف مواد مخدر; Cancer; CK2α; Protein kinase; Drug discovery; X-ray crystallography; CK2; protein kinase CK2; DMAT; 2-dimethylamino-4,5,6,7-tetrabromo-benzimidazole; ATP; adenosine-5′-triphosphate; DMSO; dimethyl sulfoxide; HEPES; N-(2-hydroxyethyl) piperazine-N′-(2

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Multiparametric luminescence method for quantitative cell surface protein expression analysis and imaging

Keywords: کشف مواد مخدر; Protein expression analysis; Immunocytochemistry; Drug discovery; Time-resolved luminescence; Adhesion molecules; Cell-based assay;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Methylglyoxal metabolism in trypanosomes and leishmania

Keywords: کشف مواد مخدر; GLO1; glyoxalase I; GLO2; glyoxalase II; T[SH]2; trypanothione, N1,N8-bis(glutathionyl)spermidine; GSH; glutathione; LADH; lactaldehyde dehydrogenase; Trypanosoma; Leishmania; Methylglyoxal; Glyoxalase; Trypanothione; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

The global need for effective antibiotics—A summary of plenary presentations

Keywords: کشف مواد مخدر; Drug resistance; Microbial; Anti-Bacterial agents; Communicable disease; Emerging; Surveillance; Poverty; Delivery of health care; Drug discovery; Drug regulations; Globalization

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Discovering new antimicrobial agents

Keywords: کشف مواد مخدر; Drug discovery; New antimicrobials; Antibacterial targets; Bacterial genomics; Membrane-active drugs

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Open source drug discovery– A new paradigm of collaborative research in tuberculosis drug development

Keywords: کشف مواد مخدر; Open source; Drug Discovery; Tuberculosis; Malaria; Neglected diseases; Generics

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity

Keywords: کشف مواد مخدر; Drug discovery; Indoles; Prion disease; Structure–activity relationships; ZebrafishBSE, bovine spongiform encephalopathy; CJD, Creutzfeldt–Jakob disease; CWD, chronic wasting disease; FFI, familial fatal insomnia; GSS, Gerstmann–Sträussler–Scheinker syndr

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Exploratory analysis of kinetic solubility measurements of a small molecule library

Keywords: کشف مواد مخدر; Aqueous solubility; Physicochemical properties; High-throughput screening; Medicinal chemistry; Drug discovery

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

A modified fluorescent intercalator displacement assay for RNA ligand discovery

Keywords: کشف مواد مخدر; FID; ESI-MS; RNA; Ribosome; Drug discovery

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

High-throughput 3-D cell-based proliferation and cytotoxicity assays for drug screening and bioprocess development

Keywords: کشف مواد مخدر; High throughput screening; Three-dimensional cell culture; Microplate; Green fluorescent protein; Cytotoxicity; Drug discovery

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Discovery of cytotoxic and pro-apoptotic compounds against leukemia cells: Tert-butyl-4-[(3-nitrophenoxy) methyl]-2,2-dimethyloxazolidine-3-carboxylate

Keywords: کشف مواد مخدر; Apoptosis; Drug discovery; Hit compound; Scaffold; Anti-cancer;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه