Keywords: EAAT1; EAAT2; GLAST; GLT-1; Diet-induced obesity;
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Keywords: 5HT; serotonin; 5HIAA; 5-hydroxyindoleacteic acid; DA; dopamine; DAT; dopamine transporter; DOPAC; 3,4-dihydroxyphenylacetic acid; EAAT2; excitatory amino acid transporter 2; ELISA; enzyme-linked immunosorbent assay; GFAP; glial fibrillary acidic protein;
Keywords: 2-AI; 2-aminoindane; 2C-B; 2,5-dimethoxy-4-bromophenethylamine; 5-IAI; 5-iodo-2-aminoindane; COMT; catechol-O-methyl transferase; CPP; conditioned place preference; DAT; dopamine transporter; DIO; diet-induced obese; DMT; N,N-dimethyltryptamine; EAAT2; ex
Keywords: (I-R); ischemia-reperfusion injury; IPC; ischemia preconditioning; ROS; reactive oxygen species; RNS; reactive nitrogen species; (ONOOâ); peroxynitrite; PI3K; phosphatidylinositol 3-kinase; PIP3; phosphatidyl-inositol 3,4,5-triphosphate; PIP2; phosp
Keywords: Essential tremor; Cerebellum; Neurodegenerative; GFAP; EAAT2; Excitotoxicitiy; AD; Alzheimer's disease; CERAD; the Consortium to establish a Registry for Alzheimer's disease; GFAP; glial fibrillary acidic protein;
Keywords: Epilepsy; Cortical malformation; Glutamate; Glutamate transport; GLT-1; GLAST; EAAT1; EAAT2; Membrane resistance; Glial development;
Keywords: Neuromyelitis optica; Aquaporin 4; EAAT2; NMDA receptor; Astrocyte; Intrathecal passive transfer;
Keywords: 3D; three-dimension; ACSF; artificial cerebrospinal fluid; AQP4; aquaporin-4; BSCB; blood-spinal cord barrier; CCI; chronic constriction injury; CNS; central nervous system; EAAT2; excitatory amino acid transporter 2; EB; Evans Blue; GFAP; glial fibrill
Keywords: EAAT2; excitatory amino acid (glutamate) transporter 2; 5-HT; serotonin; HEF; formerly high explorer; HE; high explorer; LE; low explorer; PDC; l-trans-pyrrolidine-2,4-dicarboxylic acid; Glutamate; Exploratory behaviour; Individual differences; Depression
Keywords: Astroglia; Microglia; Oligodendroglia; Inflammation; Excitotoxicity; RNA; Transporters; EAAT2; C9ORF72; MCT1;
The tetrapartite synapse: a key concept in the pathophysiology of schizophrenia
Keywords: ADAMS; a disintegrin and matrix metalloproteases; ADAMTS; ADAMS with a thrombospondin domain; AMPAR; α amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; ATP; adenosine trisphosphate; C4; complement component 4; CS; chondroitin sulfate; CSPG; C
The influence of peroxisome proliferator-activated receptor γ (PPARγ) ligands on cancer cell tumorigenicity
Keywords: Cancer cells; PPARγ agonist; PPARγ antagonist; Therapeutic agents; Tumorigenicity; ACC; Acetyl-CoA carboxylase; AKR1B10; Alde-keto reductase 1B10; Alpha-ESA; Alpha-eleostreac acid; ACLY; ATP citrate lyase; BADGE; Bisphenol-A-diglycidyl-etter; CSCs; Canc
Pyridazine-derivatives Enhance Structural and Functional Plasticity of Tripartite Synapse Via Activation of Local Translation in Astrocytic Processes
Keywords: Ank2; ankyrin-2; AP-2; adaptor complex 2 subunit; APP; amyloid precursor protein; AUC; area under the curve; BDNF/NT-3; brain-derived neurotrophic factor and neurotrophin-3 receptor; CDS; coding sequence; CLTB; clathrin light-chain B; EAAT1/GLAST; excitat
Original articleAntidepressant-like activity of icariin mediated by group I mGluRs in prenatally stressed offspring
Keywords: Depression; Icariin; Prenatal restraint stress; Group I mGluR receptors; EAAT2;
Research PaperMutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS
Keywords: Excitotoxicity; Glutamate; Astrocyte; Amyotrophic lateral sclerosis; EAAT2; GLT-1; SOD1;
Effects of ceftriaxone on ethanol, nicotine or sucrose intake by alcohol-preferring (P) rats and its association with GLT-1 expression
Keywords: Acb; accumbens; CEF; ceftriaxone; EtOH; ethanol; GLT-1; glutamate transporter 1; HRP; horseradish peroxidase; NIC; nicotine; NMDA; N-methyl-d-aspartate; PFC; prefrontal cortex; pVTA; posterior ventral tegmental area; SUC; sucrose; addiction; alcohol; ceft
Excitotoxicity in ALS: Overstimulation, or overreaction?
Keywords: ALS; Motor neuron disease; Glutamate; GABA; Glycine; Interneuron; EAAT2; Excitability
Neuronal vs glial glutamate uptake: Resolving the conundrum
Keywords: Glutamate uptake; EAAT2; Glutamate transporter; Conditional knockout; Synaptosomes; Axon-terminalsCre, Cyclization recombinase (Le and Sauer, 2000); EAAC1, glutamate transporter (EAAT3, slc1a1, Kanai and Hediger, 1992, Bjørås et al., 1996); EAAT, excitato
Ceftriaxone reverses ketamine-induced lasting EEG and astrocyte alterations in juvenile mice
Keywords: Ketamine; Mouse; EEG; Glia; EAAT2;
Effects of ampicillin, cefazolin and cefoperazone treatments on GLT-1 expressions in the mesocorticolimbic system and ethanol intake in alcohol-preferring rats
Keywords: ALDH2; aldehyde dehydrogenase-2; AMP; ampicillin; ANOVA; analysis of variance; CSF; cerebrospinal fluid; CZN; cefazolin; CPZ; cefoperazone; EDTA; ethylenediaminetetraacetic acid; GLM; General Linear Model; GLT-1; glutamate transporter 1; HPLC; high-perfor
Effect of glutamate transporter EAAT2 gene variants and gray matter deficits on working memory in schizophrenia
Keywords: Schizophrenia; EAAT2; Glutamate; Working memory; Structural imagingEAAT, Excitatory amino-acid transporter
Reduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expression in the cerebellum of fragile X mental retardation gene 1 premutation carriers with fragile X-associated tremor/ataxia syndrome
Keywords: FMR1; FMRP; Premutation; Fragile X tremor/ataxia syndrome; FXTAS; Glu transporters; EAAT1; EAAT2; mGluR5;
Intractable Nausea and Vomiting From Autoantibodies Against a Brain Water Channel
Keywords: Diagnosis; Chronic Nausea and Vomiting; Central Nervous System; Aquaporin-4 Antibody; AQP4; aquaporin-4; AQP4-IgG; immunoglobulin G against AQP4; CT; computed tomography; EAAT2; excitatory amino acid transporter 2; LETM; longitudinally extensive transvers
Chronic brain ischemia induces the expression of glial glutamate transporter EAAT2 in subcortical white matter
Keywords: APC; adenomatous polyposis coli; CBF; cerebral blood flow; EAAT; excitatory amino acid transporter; GFAP; glial-fibrillary acidic protein; GSTÏ; glutathione-S-transferase pi; LBCCA; ligation of bilateral common carotid arteries; MCAO; middle cerebral art
Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus
Keywords: Excitotoxicity; Glutamate transporter; EAAT2; Temporal lobe epilepsy; Pilocarpine; Epileptogenesis
Valproic acid mediates the synaptic excitatory/inhibitory balance through astrocytes - A preliminary study
Keywords: BDNF; brain derived neurotrophic factor; CAM; cell adhesion molecules; E/I; excitatory/inhibitory; EAAT2; excitatory amino acid transporter 2; ECM; extracellular matrix; GDNF; glial derived neurotrophic factor; GSK; glycogen synthase kinase; HDAC; histone
Neuromyelitis optica: Aquaporin-4 based pathogenesis mechanisms and new therapies
Keywords: ADCC; antibody-dependent cellular cytotoxicity; AQP; aquaporin; AQP4; aquaporin-4; AQP4-IgG; anti-AQP4 immunoglobulin NMO autoantibody; BN-PAGE; blue-native polyacrylamide gel electrophoresis; CDC; complement-dependent cytotoxicity; CNS; central nervous s
Unusual increase in lumbar network excitability of the rat spinal cord evoked by the PARP-1 inhibitor PJ-34 through inhibition of glutamate uptake
Keywords: Excitotoxicity; Motoneurons; Fictive locomotion; 5-HT; 5-hydroxytryptamine; ANOVA; analysis of variance; CCF; cross correlation factor; CNQX; 6-cyano-7-nitroquinoxaline-2,3-dione; CV; coefficient of period variation; DAPI; 4â²,6-diamidino-2-phenylindole;
Regulation of ethanol-sensitive EAAT2 expression through adenosine A1 receptor in astrocytes
Keywords: EAAT2; Glutamate; Adenosine A1 receptor; Adenylate cyclase; Astrocytes; Alcoholism
Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression
Keywords: Harmine; GLT-1; EAAT2; Glutamate transporter; Astroglia; ALS
Research ReportChronic electrographic seizure reduces glutamine and elevates glutamate in the extracellular fluid of rat brain
Keywords: Glutamate; Glutamine; Extracellular; Kainate; Seizure; Epilepsy; EAAT2; excitatory amino acid transporter subtype 2; ECF; extracellular fluid; GLU; glutamate; GLN; glutamine; GS; glutamine synthetase; HYP; hypersynchronous; KA; kainic acid; LVF; low-volta
Epigallocatechin-3-gallate protects motor neurons and regulates glutamate level
Keywords: ALS; amyotrophic lateral sclerosis; EAAT2; excitatory amino acid transporter 2; EGCG; epigallocatechin-3-gallate; GTP; green tea polyphenol; NAC; N-acetyl-l-cysteine; TBARS; thiobarbituric acid-reactive substances; THA; threohydroxyaspartate; Green tea po
Cancer cells release glutamate via the cystine/glutamate antiporter
Keywords: CNS; central nervous system; EAAT1; excitatory amino acid transporter 1; EAAT2; excitatory amino acid transporter 2; GLAST-1; glutamate/aspartate transporter 1; GLT-1; glutamate transporter 1; VGLUT1; vesicular glutamate transporter 1; xCT; light-chain su
Bromocriptine, an ergot alkaloid, inhibits excitatory amino acid release mediated by glutamate transporter reversal
Keywords: Bromocriptine; Glutamate transporter; GLT-1; EAAT2; Ischemia
Molecular NeuroscienceResearch PaperThe effects of alcoholism on the human basolateral amygdala
Keywords: brain; gene expression; glutamate; addiction; AMPARs; AMPA receptors; BLA; basolateral amygdala; CB1; cannabinoid receptor 1; CeA; central nucleus of the amygdala; EAAT1; excitatory amino acid transporter 1 (protein name); EAAT2; excitatory amino acid tra
Association of an EAAT2 polymorphism with higher glutamate concentration in relapsing multiple sclerosis
Keywords: Glutamate; Multiple sclerosis; EAAT2; Polymorphism; Relapse
Selective overexpression of excitatory amino acid transporter 2 (EAAT2) in astrocytes enhances neuroprotection from moderate but not severe hypoxia-ischemia
Keywords: hypoxia; ischemia; glutamate transport; ceftriaxone; EAAT2; BSS; balanced salt solution; DHK; dihydrokainic acid; EAAT; excitatory amino acid transport; EAAT2; excitatory amino acid transporter 2; GFAP; glial fibrillary acidic protein; gp; genomic particl
Research ReportEffects of chronic unpredictable stress and methamphetamine on hippocampal glutamate function
Keywords: Meth; methamphetamine; EAAT2; excitatory amino acid transporter 2; VGLUT1; vesicular glutamate transporter 1; 5HT; serotonin; CUS; chronic unpredictable stress; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; Stress; Glutamate; Hippocampus; Methamphetami
High-affinity glycine and glutamate transport in pig forebrain white and gray matter: A quantitative study
Keywords: EAAT2; excitatory amino acid transporter 2; GABA; γ-aminobutyric acid; GLYT (1 or 2); glycine transporter 1 or 2; HPLC; high performance liquid chomatography; NMDA receptor; N-methyl-d-aspartate receptor; High-affinity transport; Glycine; Glutathione; N-
Analysis of multiple exon-skipping mRNA splice variants using SYBR Green real-time RT-PCR
Keywords: Glutamate transporter; Absolute quantification; EAAT2; Human brain; Alternative splicing;
Intrathecal infusion of a Ca2+-permeable AMPA channel blocker slows loss of both motor neurons and of the astrocyte glutamate transporter, GLT-1 in a mutant SOD1 rat model of ALS
Keywords: Amyotrophic lateral sclerosis; G93A; Excitotoxicity; EAAT2; Motor neuron; 3-Nitrotyrosine; 1-Naphthyl acetylspermine
A quantitative regional expression profile of EAAT2 known and novel splice variants reopens the question of aberrant EAAT2 splicing in disease
Keywords: Quantitative RT-PCR; Alternative splicing; Gene expression; GLT1; EAAT2
Late appearance of glutamate transporter defects in a murine model of ALS–parkinsonism dementia complex
Keywords: ALS–PDC; GLT-1; EAAT2; Sterol glucoside; Cycad; Excitotoxicity; ALS; ApoE
Subcellular localization of the glutamate transporters GLAST and GLT at the neuromuscular junction in rodents
Keywords: EAAT1; EAAT2; skeletal muscle; mammalian; neurotransmitterACh, acetylcholine; AChR, acetylcholine receptor; Cy3, carboxymethylindocyanine; EAAT1, excitatory amino acid transporter 1; EDL, musculus extensor digitorum longus; GLAST, glutamate aspartate tran
Increased glutamine synthetase but normal EAAT2 expression in platelets of ALS patients
Keywords: ALS, amyotrophic lateral sclerosis; EAAT, excitatory amino acid transporter; GS, glutamine synthetase; PRP, platelet-rich plasmaALS; Glutamate transport; EAAT2; Glutamine synthetase (GS); Blood platelets
Quantitative analysis of glutamate transporter mRNA expression in prefrontal and primary visual cortex in normal and schizophrenic brain
Keywords: quantitative PCR; EAAT2; GLT1; gene expression; antipsychotic; RT-PCRALS, amyotrophic lateral sclerosis; ANCOVA, analysis of covariance; Ct, threshold cycle; DLPFC, dorsolateral prefrontal cortex; Eaac1, excitatory amino acid carrier 1; EAAT, excitatory a
Selective up-regulation of the glial Na+-dependent glutamate transporter GLT1 by a neuroimmunophilin ligand results in neuroprotection
Keywords: Glutamate; ALS; Transport; GLT1; EAAT2; Motor neuron; Neuroprotection; Neuroimmunophilin
Hypothesis: Minimal changes in neural transmission in schizophrenia: Decreased glutamatergic and GABAergic functions in the prefrontal cortex
Keywords: AMPA; α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid; EAAT2; excitatory amino acid transporter 2; hGAT-1; human GABA transporter-1; HPLC; high-pressure liquid chromatography; KA; kainic acid; mGluRs; metabotrophic glutamate receptors; NMDA; N-methy
Thrombin-stimulated glutamate uptake in human platelets is predominantly mediated by the glial glutamate transporter EAAT2
Keywords: CNS; central nervous system; EAAT; excitatory amino acid transporter; PRP; platelet-rich plasma; Glutamate transport; EAAT2; Blood platelets; Thrombin;
Ncm-d-aspartate: A novel caged d-aspartate suitable for activation of glutamate transporters and N-methyl-d-aspartate (NMDA) receptors in brain tissue
Keywords: Glutamate transporter; NMDA receptor; Astrocyte; Hippocampus; GLT-1; GLAST; EAAT2; EAAT1; EAAT4; NMDA; N-methyl-d-aspartate; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; TBOA; dl-threo-β-benzyloxyaspartic acid; Ncm-d-aspartate; N-[(6-nit