کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065531 1580475 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association of an EAAT2 polymorphism with higher glutamate concentration in relapsing multiple sclerosis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Association of an EAAT2 polymorphism with higher glutamate concentration in relapsing multiple sclerosis
چکیده انگلیسی

Glutamate excitotoxicity contributes to oligodendrocyte and tissue damage in multiple sclerosis (MS). Here, we have examined if glutamate homeostasis is altered in plasma from MS patients. We initially observed that plasma glutamate levels are elevated in MS patients as compared to control subjects. In addition, we have studied the presence of a polymorphism sited in the promoter of the glutamate transporter EAAT2 whose mutant genotype results in lower transporter expression. We found that the polymorphism is not associated with the risk to develop MS. However, it is associated with higher glutamate plasma levels during the course of a relapse. These findings suggest that glutamate homeostasis is compromised in MS and that carrying this mutation may contribute to this alteration in relapsing MS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 195, Issues 1–2, March 2008, Pages 194–198
نویسندگان
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