دانلود مقالات ISI درباره Egfr + ترجمه فارسی

Exploiting Synthetic Lethality and Network Biology to Overcome EGFR Inhibitor Resistance in Lung Cancer

Keywords: SCLC; small cell lung cancer; NSCLC; non-small cell lung cancer; EGFR; epidermal growth factor receptor; EGFRi; EGFR inhibitor; PFS; progression-free survival; ORR; objective response rate; HER2; human epidermal growth factor receptor 2; EMT; epithelialâ€

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2017 سفارش ترجمه

A Phase 1/2 Trial of Ruxolitinib and Erlotinib in Patients with EGFR-Mutant Lung Adenocarcinomas with Acquired Resistance to Erlotinib

Keywords: EGFR; Acquired resistance; Ruxolitinib; Erlotinib; JAK; STAT;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2017 سفارش ترجمه

Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition

Keywords: Total Parenteral Nutrition; EGF; GLP-2; EGFR; PI3K; Mucosal Atrophy; bp; base pair; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; GLP-2; glucagon-like peptide 2; GLP2R; glucagon-like peptide 2 receptor; GLP-2 (3-33); glucagon-like

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents

Keywords: Multiple receptor tyrosine kinase inhibitors; Antiangiogenic agents; Pyrimido[4,5-b]indole synthesis; Thymidylate synthase inhibitors; Combination chemotherapeutic potential in single agents; RTK; receptor tyrosine kinases; VEGF; vascular endothelial grow

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of Benzo[g]quinazolin benzenesulfonamide derivatives as dual EGFR/HER2 inhibitors

Keywords: Benzo[g]quinazolin; Acetamide; Benzenesulfonamide; EGFR; HER2;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2017 سفارش ترجمه

Virologic, Clinical, and Immune Response Outcomes of Patients With Hepatitis C Virus-Associated Cryoglobulinemia Treated With Direct-Acting Antivirals

Keywords: Cryoglobulinemic Vasculitis; Hepatitis C; DAA; Antiviral Therapy; ACC; asymptomatic circulating cryoglobulins; BVAS.v3; Birmingham Vasculitis Activity Score version 3; C4; complement 4 fraction; CH50; 50% hemolytic complement activity; CV; cryoglobulinemi

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2017 سفارش ترجمه

Pseudomonas aeruginosa increases MUC1 expression in macrophages through the TLR4-p38 pathway

Keywords: MUC1; Membrane-tethered mucin; Macrophage; Inflammation; Pseudomonas aeruginosa; aa; amino acid; AEC; airway epithelial cell; AM; alveolar macrophage; CF7; control peptide 7; EGFR; epidermal growth factor receptor; ERK1/2; extracellular signal-regulated k

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2017 سفارش ترجمه

Clinical and prognostic value of spot urinary creatinine in chronic heart failure-An analysis from GISSI-HF

Keywords: BMI; Body mass index; CV; Cardiovascular; DEXA; Dual-energy x-ray absorptiometry; eGFR; Estimated glomerular filtration rate; HR; Hazard ratio; KIM; kidney injury molecule (KIM)-1; NAG; N-acetyl-β-d-glucosaminidase; NGAL; Neutrophil gelatinase-associated

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2017 سفارش ترجمه

Modulation of Biomarker Expression by Osimertinib: Results of the Paired Tumor Biopsy Cohorts of the AURA Phase I Trial

Keywords: Osimertinib; Biomarker; T790M; EGFR; NSCLC;

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2017 سفارش ترجمه

Design and discovery of 4-anilinoquinazoline-urea derivatives as dual TK inhibitors of EGFR and VEGFR-2

Keywords: 4-Anilinoquinazoline-urea; EGFR; VEGFR-2; Tyrosine kinase inhibitor; Antitumor;

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2017 سفارش ترجمه

The 99th percentile and imprecision of point-of-care cardiac troponin I in comparison to central laboratory tests in a large reference population

Keywords: AMI; acute myocardial infarction; cTn; cardiac troponin; URL; upper reference limit; POCT; point-of-care test; TAT; turn-around-time; CLT; central laboratory test; CK; creatine kinase; eGFR; estimated glomerular filtration rate; LoD; limit of detection; C

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2017 سفارش ترجمه

Potential mechanisms of CD133 in cancer stem cells

Keywords: CD133; Cancer stem cells (CSCs); Autophagy; Lipid metabolism; Reactive oxygen species (ROS); PI3K; Src; EGFR;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2017 سفارش ترجمه

Hippo effector YAP directly regulates the expression of PD-L1 transcripts in EGFR-TKI-resistant lung adenocarcinoma

Keywords: PD-L1; YAP1; EGFR; Adenocarcinoma; Immunotherapy;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2017 سفارش ترجمه

Activation of the Tor/Myc signaling axis in intestinal stem and progenitor cells affects longevity, stress resistance and metabolism in drosophila

Keywords: AKH; adipokinetic hormone; CAFE; capillary feeding assay; DILP; Drosophila insulin-like peptide; EB; enteroblast; EC; enterocyte; EE; enteroendocrine cell; EGFR; epidermal growth factor receptor; ISC; intestinal stem cell; JAK/STAT; Janus kinase and signa

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2017 سفارش ترجمه

MAN2A1-FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice

Keywords: Fusion Gene; Driver; Biomarker; Ectopic Activation; EGFR; epidermal growth factor receptor; HCC; hepatocellular carcinoma; PCR; polymerase chain reaction; SCID; severe combined immunodeficient;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

Recent advances in the design, development, and targeting mechanisms of polymeric micelles for delivery of siRNA in cancer therapy

Keywords: AFM; atomic force microscopy; AMD; age-related macular degeneration; ANG; Angiopep-2; apoB; apolipoprotein B; ATP; adenosine triphosphate; AURKA; Aurora A kinase; BMA; butylmethacrylate; BPEI; branched PEI; BSA; bovine serum albumin; CCP; charge-conversio

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2017 سفارش ترجمه

Renal Mass and Localized Renal Cancer: AUA Guideline

Keywords: kidney neoplasms; kidney diseases; nephrectomy; ablation techniques; watchful waiting; AHRQ; Agency for Healthcare Research and Quality; AS; active surveillance; AUA; American Urological Association; CKD; chronic kidney disease; CT; computerized tomograph

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2017 سفارش ترجمه

Bilirubin concentration is positively associated with haemoglobin concentration and inversely associated with albumin to creatinine ratio among Indigenous Australians: eGFR Study

Keywords: Bilirubin; eGFR; ACR; Diabetes; Indigenous; Cardiovascular risk;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

Biomarker Development in COPD

Keywords: biomarkers; COPD; personalized medicine; ALK; anaplastic lymphoma kinase; CRP; C-reactive protein; EGFR; epidermal growth factor receptor; FDA; Food and Drug Administration; NSCLC; non-small cell lung cancer;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

Conflicting interactions of apolipoprotein A and high density lipoprotein cholesterol with microvascular complications of type 2 diabetes

Keywords: AER; albumin excretion rate; Apo A; apolipoprotein A; ApoB; apolipoprotein B-100; BMI; body mass index; DBP; diastolic blood pressure; DNS; diabetic neuropathy symptom; eGFR; estimated glomerular filtration rate; FPG; fasting plasma glucose; FPI; fasting

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

Gefitinib and pyrrolidine dithiocarbamate decrease viral replication and cytokine production in dengue virus infected human monocyte cultures

Keywords: Dengue virus; Gefitinib; Cytokines; EGFR; NOD receptor;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

Higher serum albumin was related with diabetes incidence and the impact of BMI changes: Based on cohort study of 18,384 Chinese male elderly

Keywords: ALB; albumin; ALT; alanine aminotransferase; BMI; body mass index; CI; confidence interval; DBP; diastolic blood pressure; eGFR; estimate glomerular filtration rate; FBG; fasting blood glucose; HDL-C; high density lipoprotein cholesterol; IFG; impaired fa

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells

Keywords: AEBSF; 4-(2-aminoethyl)-benzolsulfonylfluorid; DMEM; Dulbecco's modified Eagle's medium; EGFR; epidermal growth factor receptor; Epo; erythropoietin; EpoR; erythropoietin receptor; Erk; extracellular signal regulated kinase; FCS; fetal calf serum; Gab1; G

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Characteristics and Outcomes of Patients with Lung Cancer Harboring Multiple Molecular Alterations: Results from the IFCT Study Biomarkers France

Keywords: NSCLC; Single mutation; Multiple mutations; Biomarkers France; KRAS; EGFR;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Real-World EQ5D Health Utility Scores for Patients With Metastatic Lung Cancer by Molecular Alteration and Response to Therapy

Keywords: ALK; EGFR; HUS; NSCLC; SCLC;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2017 سفارش ترجمه

Estrogen receptor beta as epigenetic mediator of miR-10b and miR-145 in mammary cancer

Keywords: ECM; extracellular matrix; EGFR; epidermal growth factor receptor; EMT; epithelial-to-mesenchymal-transition; ER; estrogen receptor; ERK; extracellular signal-regulated kinase; IGF-IR; insulin-like growth factor receptor type I; miR; microRNA; MMP; matrix

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

Systemic analysis of different colorectal cancer cell lines and TCGA datasets identified IGF-1R/EGFR-PPAR-CASPASE axis as important indicator for radiotherapy sensitivity

Keywords: GEO; Gene Expression Omnibus; Colorectal cancer; Radiotherapy; qRT-PCR; Flow cytometry; TCGA; IGF-1R; EGFR;

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

High Prevalence of Concomitant Oncogene Mutations in Prospectively Identified Patients with ROS1-Positive Metastatic Lung Cancer

Keywords: Lung adenocarcinoma; ROS1; Concomitant mutations; EGFR; Pemetrexed;

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

Sphingosine kinase 1 (SK1) allosteric inhibitors that target the dimerization site

Keywords: SK; sphingosine kinase; S1P; sphingosine-1-phosphate; PKC-α; protein kinase C alpha; MAPK; mitogen-activated protein kinase; PI3K; phosphatidylinositol kinase; CKII; casein kinase II; EGFR; epidermal growth factor receptor; sphingosine kinase 1; alloster

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

Driven by Mutations: The Predictive Value of Mutation Subtype in EGFR-Mutated Non-Small Cell Lung Cancer

Keywords: Lung cancer; Targeted therapy; EGFR; Mutation subtype;

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2017 سفارش ترجمه

Clearance of cardiac troponin T with and without kidney function

Keywords: cTnT; cardiac troponin T; MI; myocardial infarction; cTnI; cardiac troponin I; hs-cTnT; high-sensitivity cTnT; EDTA; ethylenediaminetetraacetic acid; FITC-; fluorescein-isothiocyanate; GFR; glomerular filtration rate; 51Cr-EDTA; chromium ethylenediaminete

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and evaluation of azaacridine derivatives as dual-target EGFR and Src kinase inhibitors for antitumor treatment

Keywords: EGFR; Src; Azaacridine derivatives; Antitumor; Invasion; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

Choline Kinase α Mediates Interactions Between the Epidermal Growth Factor Receptor and Mechanistic Target of Rapamycin Complex 2 in Hepatocellular Carcinoma Cells to Promote Drug Resistance and Xenograft Tumor Progression

Keywords: Liver Cancer; Signal Transduction; Tumorigenesis; Oncogene; AKT; v-akt murine thymoma viral oncogene homolog; CHKA; choline kinase α; EGFR; epidermal growth factor receptor; ERK; extracellular regulated kinase; GFP; green fluorescent protein; HCC; hepato

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

EGFR, HER2 target based molecular docking analysis, in vitro screening of 2, 4, 5-trisubstituted imidazole derivatives as potential anti-oxidant and cytotoxic agents

Keywords: Imidazole; HER2; EGFR; Molecular docking; Anti-cancer activity; Anti-oxidant activity;

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2017 سفارش ترجمه

Dual role of MUC1 mucin in kidney ischemia-reperfusion injury: Nephroprotector in early phase, but pro-fibrotic in late phase

Keywords: AKI; acute kidney injury; ATN; acute tubular necrosis; CD; collecting ducts; CDT; convoluted distal tubule; CKD; chronic kidney disease; DFG; delay graft function; eGFR; estimated glomerular filtration rate; EMT; epithelial-mesenchymal transition; EV; emp

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2017 سفارش ترجمه

Recombinant EGFR/MMP-2 bi-targeted fusion protein markedly binding to non-small-cell lung carcinoma and exerting potent therapeutic efficacy

Keywords: EGFR; epidermal growth factor receptor; MMPs; matrix metalloproteinases; Ec; EGF derived oligopeptide; TIMP2; tissue inhibitor of matrix metalloproteinase 2; LDM; lidamycin; LDP; lidamycin apoprotein; AE; active enediyne; NSCLC; non-small-cell lung carcin

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

Hyper-methylation of the upstream CpG island shore is a likely mechanism of GPER1 silencing in breast cancer cells

Keywords: GPER1; G-protein coupled Estrogen Receptor; COBRA; Combined Bisulfite and Restriction Analysis; RT-PCR; Reverse Transcriptase Polymerase Chain Reaction; TBE-PAGE; Tris Borate EDTA Polyacrylamide Gel Electrophoresis; cAMP; cyclic adenosine monophosphate; P

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

Counter regulation of ECRG4 gene expression by hypermethylation-dependent inhibition and the Sp1 transcription factor-dependent stimulation of the c2orf40 promoter

Keywords: Sp1 transcription factor; Hypermethylation; Promoter; Jurkat cells; RACE; C2orf40; chromosome 2 open reading frame number 40; ECRG4; Esophageal Cancer Related Gene-4; Sp1; specific protein-1; RACE; Rapid Amplification of cDNA Ends; ChIP; Chromatin immunop

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

The roles of subcellularly located EGFR in autophagy

Keywords: AMPK; AMP-activated protein kinase; ATG; autophagy-related; BCL2; B-cell lymphoma 2; BCL2L1; BCL2 like 1; BNIP3; BCL2/Adenovirus E1B-binding protein Nip3; CME; clathrin-mediated endocytosis; cytoSTAT3; cytoplasmic STAT3; Dsbs; double strand breaks; ECD; e

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2017 سفارش ترجمه

Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling

Keywords: Mitochondrial Uncoupler; Treatment; Liver Cancer; Big Data; AFP; α-fetoprotein; CDC37; cell division cycle 37; CCLE; Cancer Cell Line Encyclopedia; CMap; Connectivity Map; EGFR; epidermal growth factor receptor; FDA; Food and Drug Administration; GEO; Ge

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2017 سفارش ترجمه

A crosstalk between muscarinic and CRF2 receptors regulates cellular adhesion properties of human colon cancer cells

Keywords: AJ; adherens junctions; ctn; catenin; CRC; colorectal cancer; CRF2; corticotrophin releasing factor receptor 2; ECM; extracellular matrix; EGFR; epidermal growth factor receptor; EMT; epithelial-mesenchymal transition; FAK; focal adhesion kinase; GPRC; G

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2017 سفارش ترجمه

IRE1α links Nck1 deficiency to attenuated PTP1B expression in HepG2 cells

Keywords: ATF6; activating transcription factor 6; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; HNF4α; hepatocyte nuclear factor 4α; GAP; GTPase-activating protein; HFD; high fat diet; IL-4; interleukin-4; IRE1α; inositol-requiring enzyme 1

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2017 سفارش ترجمه

Leptomeningeal carcinomatosis in non-small cell lung cancer patients: A continuing challenge in the personalized treatment era

Keywords: Neoplastic; Meningitis; Lung; Intrathecal; EGFR; ALK; Metastasis;

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2017 سفارش ترجمه

Microvascular NADPH oxidase in health and disease

Keywords: ROS; reactive oxygen species; NADPH; nicotinamide-adenine-dinucleotide phosphate; Nox; NADPH oxidase; BBB; blood-brain barrier; Ang II; angiotensin II; TRP channels; transient receptor potential channels; DPI; diphenyleneiodonium; PKC; protein kinase C; M

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2017 سفارش ترجمه

WT1 ameliorates podocyte injury via repression of EZH2/β-catenin pathway in diabetic nephropathy

Keywords: BUN; blood urea nitrogen; Ccr; creatinine clearance rate; ChIP; chromatin immunoprecipitation; CTNNB1; β-catenin 1; DAPI; 4,6-diamidino-2-phenylindole; DCFH-DA; 2′, 7′-dichlorodihydrofluorescein diacetate; DMSO; dimethyl sulphoxide; DN; diabetic neph

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2017 سفارش ترجمه

Heat shock protein 22 (HSPB8) reduces the migration of hepatocellular carcinoma cells through the suppression of the phosphoinositide 3-kinase (PI3K)/AKT pathway

Keywords: HSP; heat shock protein; HCC; hepatocellular carcinoma; TGF; transforming growth factor; HGF; hepatocyte growth factor; PI3K; phosphoinositide 3-kinase; EGFR; epidermal growth factor receptor; ERK; extracellular signal-regulated kinase; siRNA; small inter

دانلود رایگان متن کامل مقاله ISI 51 صفحه سال انتشار : 2017 سفارش ترجمه

G protein-coupled receptor 35 contributes to mucosal repair in mice via migration of colonic epithelial cells

Keywords: DAI; disease activity index; DSS; dextran sulphate sodium salt; EGFR; epidermal growth factor receptor; ERK; extracellular signal-regulated kinase; GPR; G protein-coupled receptor; IEC-6; intestinal epithelial cell line No. 6; MPO; myeloperoxidase; PA; pa

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2017 سفارش ترجمه

Src-family tyrosine kinases and the Ca2 + signal

Keywords: 5-HT6; serotonin receptor 6; A23187; 5-(methylamino)-2-({(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxylic acid; ADPR; ADP-ribose; AMPA; α-amino-3-hydr

دانلود رایگان متن کامل مقاله ISI 57 صفحه سال انتشار : 2017 سفارش ترجمه

Anaplastic lymphoma kinase (ALK) inhibitors in the treatment of ALK-driven lung cancers

Keywords: Alectinib: (PubMED CID: 49806720); Brigatinib: (PubMED CID: 68165256); Ceritinib: (PubMED CID: 57379345); Crizotinib (PubMED CID: 11626560); Entrectinib: (PubMED CID: 25141092); Lorlatinib: (PubMed CID: 71731823); ALK+-NSCLC; ALK-positive non-small cell l

دانلود رایگان متن کامل مقاله ISI 60 صفحه سال انتشار : 2017 سفارش ترجمه

Downregulations of TRPM8 expression and membrane trafficking in dorsal root ganglion mediate the attenuation of cold hyperalgesia in CCI rats induced by GFRα3 knockdown

Keywords: TRPM8; transient receptor potential melastatin 8; CCI; chronic constriction injury; DRG; dorsal root ganglion; GFRα3; glial cell line-derived neurotrophic factor family receptor alpha3; siRNA; small interfering RNA; TRP; transient receptor potential; dsR

دانلود رایگان متن کامل مقاله ISI 64 صفحه سال انتشار : 2017 سفارش ترجمه