Critical comments for roles of biomarkers in the diagnosis and treatment of cancer
Keywords: Biomarker; KRAS; EGFR; Prognostic factor; Predictive factor; Pharmacogenomics
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Lung Adenocarcinomas with HER2-Activating Mutations Are Associated with Distinct Clinical Features and HER2/EGFR Copy Number Gains
Keywords: HER2; Lung adenocarcinoma; Mutation; Copy number; EGFR; KRAS
Les biomarqueurs à rechercher en 2012 et dans le futur proche dans les cancers bronchiques non à petites cellules (CBNPC)
Keywords: Cancer bronchiques non à petites cellules (CBNPC); Thérapeutiques ciblées; Biomarqueurs; EGFR; ALK; AMM conditionnée; Non Small Cell Lung Cancer (NSCLC); Targeted therapies; Biomarkers; EGFR; Molecularconditoned registration;
The surgeon's role in molecular biology
Keywords: ALK; anaplastic lymphoma kinase; EGFR; epidermal growth factor receptor; NSCLC; non-small cell lung cancer; 10; 29;
Outcomes of Patients with Surgically Treated Bilateral Renal Masses and a Minimum of 10 Years of Followup
Keywords: kidney; carcinoma, renal cell; nephrectomy; reoperation; genetic diseases, inborn; BRM; bilateral renal mass; eGFR; estimated glomerular filtration rate; FRC; familial renal cancer; NCI; National Cancer Institute; NSS; nephron sparing surgery; OS; overall
Discovery of novel 5-alkynyl-4-anilinopyrimidines as potent, orally active dual inhibitors of EGFR and Her-2 tyrosine kinases
Keywords: Kinase inhibitor; EGFR; Her-2; BT474; N87; Pyrimidine; Antitumor efficacy;
N4-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors
Keywords: RTK; receptor tyrosine kinase; EGFR; epidermal growth factor receptor; VEGFR; vascular endothelial growth factor receptor; CSF-1; colony stimulating factor; PDGFR; platelet-derived growth factor receptors; Pyrrolo[2,3-d]pyrimidines; Receptor tyrosine kina
Decrease of serum chemerin concentration in patients with end stage renal disease after successful kidney transplantation
Keywords: ESRD; end stage renal disease; BUN; blood urea nitrogen; CRP; C-reactive protein; eGFR; estimated glomerular filtration rate; TIG2; tazarotene-induced gene 2 protein; RARRES2; retinoic acid receptor responder protein 2; CMKLR1; chemokine-like receptor 1;
A new screening method for proteinuria using Erythrosin B and an automated analyzer-Rapid, sensitive and inexpensive determination
Keywords: PR-Mo; Pyrogallol Red-molybdenum (PR-Mo) method; TIA; turbidimetric immunoassay; ESKD; end-stage kidney disease; CKD; chronic kidney disease; eGFR; estimated glomerular filtration rate; JCCLS; Japanese Committee for Clinical Laboratory Standards; THP; Tam
Do cardiac risk factors affect the homocysteine and asymmetric dimethylarginine relationship in patients with coronary artery diseases?
Keywords: ADMA; asymmetric dimethylarginine; BMI; Body mass index; CAD; coronary artery disease; DDAH; dimethylaminohydrolase; eGFR; estimated glomerular filtration rate; ELISA; enzymeâlinked immunosorbent assay; eNOS; endothelial nitric oxide synthase; Hcy; homo
Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae - A review
Keywords: Bax; Bcl-2-associated x protein; Bcl-xL; B-cell lymphoma-extra large; Bcl-2; B-cell lymphoma 2; COX-2; cyclooxygenase-2; EGFR; epidermal growth factor receptor; ER-α; estrogen receptor-α; ERK; extracellular signal-regulated kinase; HER-2; human epiderma
Long-Term Impact of Laparoscopic Cyst Decortication on Renal Function, Hypertension and Pain Control in Patients with Autosomal Dominant Polycystic Kidney Disease
Keywords: polycystic kidney, autosomal dominant; laparoscopy; ADPKD; adult dominant polycystic kidney disease; ATI; antihypertensive therapeutic index; BP; blood pressure; CKD; chronic kidney disease; CrCl; creatinine clearance; eGFR; estimated glomerular filtratio
Enterocyte expression of epidermal growth factor receptor is not required for intestinal adaptation in response to massive small bowel resection
Keywords: EGFR; Adaptation; Small bowel resection; Enterocytes;
A Potential New Method to Estimate Tissue Cystine Content in Nephropathic Cystinosis
Keywords: CC; Cystine crystal; CC-GD; Mean CC counts, calculated from stomach and duodenum combined; CC-5H; Mean CC load from the 5 histiocytes with the highest number of crystal was also calculated; eGFR; Estimated glomerular filtration rate; GI; Gastrointestinal;
Protein-encapsulated bio-nanocapsules production with ER membrane localization sequences
Keywords: DDS; drug delivery system; BNC; bio-nanocapsule; HBV; hepatitis B virus; HBsAg; hepatitis B virus surface antigen; ER; endoplasmic reticulum; IgG; immunoglobulin G; HER2; human EGFR-related 2; EGFR; epidermal growth factor receptor; MLS; membrane localiza
Monitoring of Circulating Tumor Cells and Their Expression of EGFR/Phospho-EGFR During Combined Radiotherapy Regimens in Locally Advanced Squamous Cell Carcinoma of the Head and Neck
Keywords: Circulating tumor cells; Head and neck cancer; Pharmacodynamic biomarker; EGFR; Radiotherapy;
STAT3 expression in activating EGFR-driven adenocarcinoma of the lung
Keywords: Non-small cell lung cancer; Bronchioloalveolar carcinoma; Adenocarcinoma; STAT3; EGFR; JAK2;
Discovery of 6-substituted 4-anilinoquinazolines with dioxygenated rings as novel EGFR tyrosine kinase inhibitors
Keywords: EGFR; Kinase inhibitor; 4-Aminoquinazolines;
Discovery of novel EGFR tyrosine kinase inhibitors by structure-based virtual screening
Keywords: EGFR; Docking; Inhibitor; Virtual screening; Drug discovery;
Isolation of miRNAs that target EGFR mRNA in human lung cancer
Keywords: EGFR; Lung cancer; miR-542-5p;
EGF receptor inhibitors increase ErbB3 mRNA and protein levels in breast cancer cells
Keywords: EGF; epidermal growth factor; EGFR; EGF receptor; Erk; extracellular signal-regulated kinase; FAS; (TNF receptor superfamily, member 6); FoxO3a; forkhead box O3a; Ki-67; (antigen KI-67); MEK-1; MAPK/Erk kinase 1; PI3K; phosphatidylinositol 3-kinase; EGFR
Absence of evidence for epidermal growth factor receptor and human homolog of the Kirsten rat sarcoma-2 virus oncogene mutations in breast cancer
Keywords: Breast cancer; EGFR; Gene mutation; KRAS; RT-PCR;
Impact of specific mutant KRAS on clinical outcome of EGFR-TKI-treated advanced non-small cell lung cancer patients with an EGFR wild type genotype
Keywords: EGFR; Erlotinib; EGFR-TKI; Gefitinib; KRAS; Non-small cell lung cancer;
Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer
Keywords: NSCLC; Hsp90; AUY922; EGFR; EGFR-TKI; Mesothelioma;
Characteristics of lung cancer in women: Importance of hormonal and growth factors
Keywords: Lung cancer; EGFR; K-Ras; Estrogen receptor; Prognosis;
Discovery of novel selective inhibitors for EGFR-T790M/L858R
Keywords: EGFR; T790M/L858R; Virtual screening; Kinase inhibitors; Selective inhibitors; Dual-effective inhibitors
Analysis of EGFR, KRAS and P53 mutations in lung cancer using cells in the curette lavage fluid obtained by bronchoscopy
Keywords: EGFR; KRAS; P53; Mutation; Direct sequencing; Curette lavage fluid; L747S;
Synthesis, molecular modeling and biological evaluation of 2-(benzylthio)-5-aryloxadiazole derivatives as anti-tumor agents
Keywords: Oxadiazole; Anti-tumor; EGFR
CD95 death receptor and epidermal growth factor receptor (EGFR) in liver cell apoptosis and regeneration
Keywords: Apoptosis; CD95; Fas; Liver regeneration; EGFR; JNK
NOK/STYK1 has a strong tendency towards forming aggregates and colocalises with epidermal growth factor receptor in endosomes
Keywords: NOK/STYK1; Subcellular localisation; Endosome; EGFR
Epidermal growth factor receptor (EGFR) gene copy number in colorectal adenoma-carcinoma progression
Keywords: EGFR; fluorescence in situ hybridization; gene copy number; colorectal cancer;
Combined inhibition of EGFR and CK2 augments the attenuation of PI3K-Akt-mTOR signaling and the killing of cancer cells
Keywords: EGFR; CK2; Erlotinib; CX-4945
Effective suppression of breast tumor growth by an anti-EGFR/ErbB2 bispecific antibody
Keywords: ErbB2; EGFR; Breast cancer; Bispecific; Monoclonal antibody
Renal Function and Oncologic Outcomes of Parenchymal Sparing Ureteral Resection Versus Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma
Keywords: carcinoma; transitional cell; kidney failure; chronic; ureter; eGFR; estimated glomerular filtration rate; GFR; glomerular filtration rate; PSUR; parenchymal sparing ureteral resection; RNU; radical nephroureterectomy; UC; urothelial carcinoma; UTUC; uppe
Detection of EML4-ALK fusion genes in a few cancer cells from transbronchial cytological specimens utilizing immediate cytology during bronchoscopy
Keywords: EML4-ALK; EGFR; Bronchoscopy; RT-PCR; Cytological sample; Immediate cytology; Rapid diagnosis; Ultrafast Papanicolaou
Metastatic brain tumors from non-small cell lung cancer with EGFR mutations: Distinguishing influence of exon 19 deletion on radiographic features
Keywords: EGFR; Mutation; Miliary; Brain metastases; Brain edema; Lung cancer; Exon 19
Correlation between EGFR Y1068 tyrosine phosphorylation and AP-1 activation by tumor promoter 12-O-tetradecanoylphorbol-13-acetate in mouse skin
Keywords: Mouse skin; Carcinogenesis; EGFR; AP-1; JNK; TPA
Competitive allele specific TaqMan PCR for KRAS, BRAF and EGFR mutation detection in clinical formalin fixed paraffin embedded samples
Keywords: CAST-PCR; KRAS; BRAF; EGFR; Mutation; Targeted therapy
Rapid improvement of renal function in patients with acute pulmonary embolism indicates favorable short term prognosis
Keywords: renal failure; mortality; eGFR; prognosis; pulmonary embolism
Phase II study of gefitinib adaptive dose escalation to skin toxicity in recurrent or metastatic squamous cell carcinoma of the head and neck
Keywords: Gefitinib; EGFR; Head and neck cancer; Tyrosine kinase inhibitor
Difference in expression of EGFR, pAkt, and PTEN between oropharyngeal and oral cavity squamous cell carcinoma
Keywords: EGFR; Akt; PTEN; Human papillomavirus; Head and neck cancer
Epidermal growth factor receptor (EGFR) in salivary gland carcinomas: Potentials as therapeutic target
Keywords: EGFR; Salivary gland; Adenoidcystic carcinoma; Adenocarcinoma (NOS); Salivary gland carcinoma
Molecularly targeted therapies in head and neck cancers
Keywords: Head and neck cancers; Molecularly targeted therapy; Monoclonal antibodies; EGFR; VEGFR; Cetuximab; nowotwory gÅowy i szyi; terapia ukierunkowana molekularnie; przeciwciaÅa monoklonalne; EGFR; VEGFR; cetuksymab;
The burning question: Why is smoking a risk factor for pancreatic cancer?
Keywords: Smoking; Pancreatic cancer; Fibrosis; Inflammation; cAMP; cyclic AMP; EGFR; epidermal growth factor receptor; ECM; extracellular matrix protein; IL-1β; interleukin 1 beta; MIP-1α; macrophage inflammatory protein 1 alpha; MMPs; matrix metalloproteinases;
Applying estimated glomerular filtration rate to an ageing population: are we in danger of becoming ageist?
Keywords: eGFR; Elderly; Nephrology outpatients; Chronic Kidney disease
L1 cell adhesion molecule and epidermal growth factor receptor activation confer cisplatin resistance in intrahepatic cholangiocarcinoma cells
Keywords: EGFR; L1CAM; Cisplatin resistance; Intrahepatic cholangiocarcinoma
EGF promotes the shedding of soluble E-cadherin in an ADAM10-dependent manner in prostate epithelial cells
Keywords: sE-cad, soluble E-cadherin; pA10, pro form of ADAM10; mA10, mature form of ADAM10; INC, ADAM10 inhibitor INCB8765; BIO, ADAM10 prodomain; OPT, 1,10-Phenanthroline; AREG, amphiregulinADAM10; EGFR; Soluble E-cadherin
A novel calmodulin-β-PIX interaction and its implication in receptor tyrosine kinase regulation
Keywords: β-PIX; β-p21-activated kinase interacting exchange factor; Ca2 +; calcium; CaM; calmodulin; c-Cbl; casitas B-cell lymphoma; CC; coiled-coil; CD; circular dichroism; DH; diffuse B-cell lymphoma homology; EGFR; epidermal growth factor receptor; GEF; guan
Rab21 attenuates EGF-mediated MAPK signaling through enhancing EGFR internalization and degradation
Keywords: Rab21; EGFR; Degradation; Internalization; MAPK signaling
Strongly amphiphilic photosensitizers are not substrates of the cancer stem cell marker ABCG2 and provides specific and efficient light-triggered drug delivery of an EGFR-targeted cytotoxic drug
Keywords: ABCG2; Photochemical internalization; Drug delivery; Cancer stem cells; MDR; EGFR