Isolation of miRNAs that target EGFR mRNA in human lung cancer

► EGFR is major targets for new therapeutics such as monoclonal antibodies and tyrosine kinase inhibitors. ► To identify miRNAs that target EGFR, we performed a bioinformatics analysis. ► We found that miR-542-5p down-regulates EGFR expression in human lung cancer cells. ► miR-542-5p inhibited the growth of human lung cancer cells.