Dasatinib is synergistic with cetuximab and cisplatin in triple-negative breast cancer cells
Keywords: Triple-negative breast cancer; Dasatinib; Cisplatin; Cetuximab; Src; EGFR
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Imaging specificity of MR-optical imaging agents following the masking of surface charge by poly(ethylene glycol)
Keywords: EGFR; Erbitux; MnMEIO; MRI; Nanocarrier
The Changing Face of Percutaneous Image-guided Biopsy: Molecular Profiling and Genomic Analysis in Current Practice
Keywords: EGFR; epidermal growth factor receptor; FISH; fluorescence in situ hybridization; FNA; fine-needle aspiration; H&E; hematoxylin and eosin; HCC; hepatocellular carcinoma; IHC; immunohistochemistry; MMR; mismatch repair; NSCLC; non-small-cell lung cancer;
Personalized Oncology in Interventional Radiology
Keywords: ATP; adenosine triphosphate; ALK; analplastic lymphoma factor; BCR-ABL; breakpoint cluster region/the Abelson tyrosine; BRAF; v-raf murine sarcoma viral oncogene; CD-20; clusters of differentiation-20 (antigen of B-cells); c-KIT; tyrosine-protein kinase k
Epidermal growth factor receptor expression and KRAS and BRAF mutations: study of 39 sinonasal intestinal-type adenocarcinomas
Keywords: EGFR; EGFR amplification; EGFR copy number gain; EGFR immunohistochemistry; Sinonasal intestinal-type adenocarcinoma
Design, synthesis and characterization of peptidomimetic conjugate of BODIPY targeting HER2 protein extracellular domain
Keywords: BODIPY; Breast cancer; EGFR; Protein–protein interactions; HER2; Peptidomimetic; Phosphorylation
Validation of the IASLC/ATS/ERS Lung Adenocarcinoma Classification for Prognosis and Association with EGFR and KRAS Gene Mutations: Analysis of 440 Japanese Patients
Keywords: Lung adenocarcinoma; Classification; EGFR; KRAS; Prognosis.
Prognostic Role of Human Epidermal Growth Factor Receptor in Gastric Cancer: A Systematic Review and Meta-analysis
Keywords: Gastric cancer; Human epidermal growth factor receptor; EGFR; HER2; Meta-analysis
Lung cancer in never smokers: Disease characteristics and risk factors
Keywords: Lung cancer; Smoking; Never smokers; NSCLC; EGFR
Interleukin-8 as a modulator of response to bevacizumab in preclinical models of head and neck squamous cell carcinoma
Keywords: HNSCC, head and neck squamous cell carcinoma; IL-8, interleukin-8; IL-1α, interleukin-1α; VEGF, vascular endothelial growth factor; FGF-a, fibroblast growth factor-a; TNF-α, tumor necrosis factor-α; VEGFR, vascular endothelial growth factor receptor; EGFR
Combined Use of the Novel Biomarkers High-Sensitivity Troponin T and ST2 for Heart Failure Risk Stratification vs Conventional Assessment
Keywords: ACEI; angiotensin-converting enzyme inhibitor; AIC; Akaike information criterion; ARB; angiotensin II receptor blocker; AUC; area under the receiver operating characteristic curve; BIC; Bayesian information criterion; eGFR; estimated glomerular filtration
Novel compound PS-101 exhibits selective inhibition in non-small-cell lung cancer cell by blocking the EGFR-driven antiapoptotic pathway
Keywords: PS-101; Inhibition selectivity; EGFR; Antiapoptotic pathway; Non-small cell lung cancer
Molecular phenotype predicts sensitivity of squamous cell carcinoma of the head and neck to epidermal growth factor receptor inhibition
Keywords: EGFR; Gefitinib; Head and neck squamous cell carcinoma; AKT; PIK3CA mutationsSCCHN, squamous cell carcinoma of the head and neck; EGFR, Epidermal Growth Factor Receptor; RECIST, Response Evaluation Criteria in Solid Tumors; NSCLC, non-small cell lung canc
A targeted adenovirus vector displaying a human fibronectin type III domain-based monobody in a fiber protein
Keywords: Adenovirus vector; Monobody; Knobless fiber; Targeted gene delivery; EGFR; VEGFR2
Study on TRPV1-mediated mechanism for the hypersecretion of mucus in respiratory inflammation
Keywords: TRPV1; Capsaicin; HNE; EGFR; PI3K; PKC; HIF-1α; MUC5AC
Genetics and pharmacogenomics of diffuse gliomas
Keywords: Companion diagnostics; Glioma; 1p/19q co-deletion; IDH1; Pharmacogenomics; EGFRvIII; CGH; comparative genomic hybridization; CNA; copy number aberrations; CRC; colorectal carcinoma; CML; chronic myeloid leukemia; EGFR; epidermal growth factor receptor; FF
EGFR-driven up-regulation of decoy receptor 3 in keratinocytes contributes to the pathogenesis of psoriasis
Keywords: Decoy receptor 3; Keratinocyte; Psoriasis; EGFR; NF-κB; TNF-α
Mechanisms for oncogenic activation of the epidermal growth factor receptor
Keywords: EGFR; Cancer; Mechanism; Oncogenesis; Mutation; Transactivation; Signaling; Downregulation
Lycopene modulates growth and survival associated genes in prostate cancer
Keywords: TGFβ-2; Transforming growth factor beta-2; CDK-9; cyclin dependent kinase-9; EGFR; epidermal growth factor receptor; BCL-2; B-cell lymphoma-2; BCL2L1; B-cell lymphoma-2 like 1; IGF1R; insulin-like growth factor 1 receptor; CDK-7; cyclin dependent kin
Affibody modified and radiolabeled gold–Iron oxide hetero-nanostructures for tumor PET, optical and MR imaging
Keywords: Au-Fe3O4; Hetero-nanoparticles; Affibody; EGFR; PET; MRI
EGRF conjugated PEGylated nanographene oxide for targeted chemotherapy and photothermal therapy
Keywords: Nanographene oxide; Tumor targeting; Chemotherapy; Photothermal therapy; Growth signal blocking; EGFR
EGFR dependent subcellular communication was responsible for morphine mediated AC superactivation
Keywords: MOR, mu opioid receptor; GPCR, G protein coupled receptor; HA, hemagglutinin; TCA, trichloroacetic acid; FACS, fluorescence-activated cell sorting; PP2, 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine; PTX, pertussis toxinMOR; EGFR; AC sup
Computer-aided identification of EGFR tyrosine kinase inhibitors using ginsenosides from Panax ginseng
Keywords: Panax ginseng; Ginsenosides; EGFR; Pharmacophore; ADME; Insilco
Cellular Immunotherapy for Carcinoma Using Genetically Modified EGFR-Specific T Lymphocytes
Keywords: EGFR; epidermal growth factor receptor; ACT; adoptive cell therapy; CAR; chimeric antigen receptor;
Multitargeted Low-Dose GLAD Combination Chemoprevention: A Novel and Promising Approach to Combat Colon Carcinogenesis
Keywords: DFMO; α-difluoromethylornithine; GLAD; gefitinib, licofelone, atorvastatin, and DFMO; EGFR; epidermal growth factor receptor; HMGR; 3-hydroxy-3-methylglutaryl CoA reductase; COX; cyclooxygenase;
Differences in growth properties of endometrial cancer in three dimensional (3D) culture and 2D cell monolayer
Keywords: Endometrial cancer; 3D cell model; VEGF; Glut-1; Polarity; EGFR
CB1 cannabinoid receptors promote maximal FAK catalytic activity by stimulating cooperative signaling between receptor tyrosine kinases and integrins in neuronal cells
Keywords: 2-AG; 2-arachidonoylglycerol; BSA; bovine serum albumin; CB1; CB1 cannabinoid receptor; Csk; C-terminal Src kinase; DAGL; diacylglycerol lipase; DTT; dithiothreitol; ECM; extracellular matrix; ERK1/2; extracellular signal-regulated kinases 1 and 2; EGFR;
Kardionkologia - odpowiedź na wyzwania wspóÅczesnej terapii
Keywords: antracykliny; biomarkery; chemioterapia; kardioprotekcja; kardiotoksycznoÅÄ; Anthracyclines; Biomarkers; Cardioprotection; Cardiotoxicity; Chemotherapy; ACEI; (Angiotensin Converting Enzyme Inhibitor) ihibitory konwertazy angiotensyny; AML; (Acute Myelo
The least of 3 evils: Exposure to red blood cell transfusion, anemia, or both?
Keywords: CPB; cardiopulmonary bypass; eGFR; estimated glomerular filtration rate; HCT; hematocrit; LOS; length of stay; RBC; red blood cell;
Applications and limitations of oncogene mutation testing in clinical cytopathology
Keywords: Cytology; Aspiration; PCR; c-KIT; BRAF; EGFR; KRAS; NRAS
A patient tumor transplant model of squamous cell cancer identifies PI3K inhibitors as candidate therapeutics in defined molecular bins
Keywords: Head and neck cancer; Xenografts; Human papillomavirus; EGFR; PI3K; NOTCH1
Inhibition of the Growth of Patient-Derived Pancreatic Cancer Xenografts with the MEK Inhibitor Trametinib Is Augmented by Combined Treatment with the Epidermal Growth Factor Receptor/HER2 Inhibitor Lapatinib
Keywords: EGFR; epidermal growth factor receptor; MRI; magnetic resonance imaging; RTKs; receptor tyrosine kinases; MAPKs; mitogen-activated protein kinases; SMAD4; SMAD family member 4 gene;
Flavopiridol Synergizes with Sorafenib to Induce Cytotoxicity and Potentiate Antitumorigenic Activity in EGFR/HER-2 and Mutant RAS/RAF Breast Cancer Model Systems
Keywords: BC; breast cancer; CDKs; cyclin-dependent kinases; CI; combination index; EGFR; epidermal growth factor receptor; FFPE; formalin fixed and paraffin embedded; FISH; fluorescence in situ hybridization; FPD; flavopiridol; HER-2; ErbB2/epidermal growth factor
The N550K/H Mutations in FGFR2 Confer Differential Resistance to PD173074, Dovitinib, and Ponatinib ATP-Competitive Inhibitors
Keywords: EGFR; epidermal growth factor receptor; FGFR; fibroblast growth factor receptor; RTK; receptor tyrosine kinase; SDM; site-directed mutagenesis;
Intrahepatic Cholangiocarcinoma: Management Options and Emerging Therapies
Keywords: AJCC; American Joint Committee on Cancer; EGFR; epidermal growth factor receptor; HBV; hepatitis B virus; HCC; hepatocellular carcinoma; HCV; hepatitis C virus; IBD; inflammatory bowel disease; ICC; intrahepatic cholangiocarcinoma; LN; lymph node; PSC; pr
Cutaneous manifestations of gastrointestinal disease
Keywords: Bannayan-Riley-Ruvalcaba syndrome; Cowden syndrome; Cronkhite-Canada syndrome; cutaneous manifestations; gastrointestinal disorders; hamartomatous polyposis syndrome; hereditary and nonhereditary gastrointestinal malignancies; Lynch syndrome; Muir-Tor
Cancer Concepts and Principles: Primer for the Interventional Oncologist-Part II
Keywords: AFP; α-fetoprotein; AJCC; American Joint Committee on Cancer; BCLC; Barcelona Clinic Liver Cancer; CapeOx; capecitabine/oxaliplatin; CRC; colorectal cancer; DEB; drug-eluting bead; DEBIRI; drug-eluting beads with irinotecan; EASL; European Association fo
PDGFRB Promotes Liver Metastasis Formation of Mesenchymal-Like Colorectal Tumor Cells
Keywords: CRC; colorectal cancer; CRP; collagen-related peptide; DAPI; 4â²,6-diamidino-2-phenylindole; DFS; disease-free survival; ECM; extracellular matrix; EGFR; epithelial growth factor receptor; EMT; epithelial-to-mesenchymal transition; FCS; fetal calf serum;
Oncoapoptotic signaling and deregulated target genes in cancers: Special reference to oral cancer
Keywords: Oral cancer; Oncogenes; Tumor suppressor genes; Bcl2 family proteins; EGFR; TNF receptors
Novel Colonoscopic Imaging
Keywords: CE; chromoendoscopy; CRC; colorectal cancer; EGFR; epidermal growth factor receptor; FICE; Fuji Intelligent Chromo Endoscopy; GI; gastrointestinal; HD-WLE; high-definition white-light endoscope; IBD; inflammatory bowel disease; NBI; narrow-band imaging; p
Two distinct mechanisms by which phospholipase C-γ1 mediates epidermal growth factor-induced keratinocyte migration and proliferation
Keywords: EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; Cai; intracellular calcium; NHK; normal human keratinocytes; PLC; phospholipase C; PLC-β1; phospholipase C-β1; PLC-γ1; phospholipase C-γ1; PLC-δ1; phospholipase C-δ1; PI3K; phosph
Synthesis and biological evaluation of a series of novel salicylanilides as inhibitors of EGFR protein tyrosine kinases
Keywords: Salicylanilides; EGFR; HER2; Tyrosine kinase inhibitor
A comparison of in vitro methods for determining the membrane receptor expression in cell lines
Keywords: EGFR; KEX method; Receptor number; In vitro
Plasminogen activator inhibitor-1 is associated with renal dysfunction independent of BMI and serum lipid levels in patients with type 2 diabetes
Keywords: PAI-1; eGFR; Type 2 diabetes;
Rapid biochemical synthesis of 11C-labeled single chain variable fragment antibody for immuno-PET by cell-free protein synthesis
Keywords: PET; positron emission tomography; EGFRvIII; epidermal growth factor receptor variant III; scFv; single chain Fv; l-[methyl-11C]methionine; [11C]Met; CT; computed tomography; [18F]FDG; 2-[18F]-fluoro-2-deoxy-d-glucose; MWCO; molecular weight cut-off; Cell
A fluorescent reporter of ATP binding-competent receptor kinases
Keywords: ERBB2; EGFR; Kinase inhibitors; Fluorescent probes; Quinazoline;
Plasma copeptin in the assessment of febrile neutropenia
Keywords: ACTH; adrenocorticotropic hormone; ASCT; autologous stem cell transplant; AVP; arginine vasopressin; CRP; C-reactive protein; CV; coefficient of variation; EDTA; ethylenediaminetetraacetic acid; eGFR; estimated glomerular filtration rate; ICU; intensive c
Impact of age on epidermal growth factor receptor mutation in lung cancer
Keywords: Lung cancer; EGFR; Age; Adenocarcinoma; Sex; Smoking
Chronic Kidney Disease Staging in Nursing Home and Community Older Adults: Does the Choice of Cockcroft-Gault, Modification of Diet in Renal Disease Study, or the Chronic Kidney Disease Epidemiology Collaboration Initiative Equations Matter?
Keywords: Stages of CKD; Cockcroft-Gault equation; MDRD equation; CKD-EPI equation; estimation of kidney function in older adults; measuring renal function in older adults; creatinine clearance; eGFR; GFR;
Ethanol-induced oxidative stress is associated with EGF receptor phosphorylation in MCF-10A cells overexpressing CYP2E1
Keywords: Breast cancer; Ethanol; ROS; Oxidative stress; EGFR; CYP2E1