Keywords: Antibody; Antibody drug conjugate; Maytansinoid; EGFRvIII;
مقالات ISI (ترجمه نشده)
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Keywords: Brain neoplasm; Clinical trials; Glioblastoma; Immunotherapeutic; Immunotherapy; Vaccine; APC; Antigen-presenting cell; APVAC; Actively personalized vaccination; BBB; Blood-brain barrier; CMV; Cytomegalovirus; CNS; Central nervous system; CSF; Cerebrosp
Keywords: AA; arachidonic acid; COX; cyclooxygenase; cPGES; cytoplasmic prostaglandin E synthase; CREB; carbohydrate response element binding protein; CYP450; CYP450 epoxygenase; DAG; diacylglycerol; EGFR; epidermal growth factor receptor; EGFRvIII; epidermal growt
Keywords: BBB; blood brain barrier; CAR; chimeric antigen receptor; CNS; central nervous system; CRS; cytokine release syndrome; EGFR; epidermal growth factor receptor; EGFRvIII; variant 3 of epidermal growth factor receptor; epha2; erythropoietin producing hepatoc
Keywords: EVs; extracellular vesicles; MVBs; multivesicular bodies; ESCRT; exosomal sorting complex required for transport; DCs; dendritic cells; lncRNA; long non-coding RNA; miRNA; microRNA; MMP; matrix metalloproteinases; EGFRvIII; epidermal growth factor recepto
Keywords: AEX; anion exchange chromatography; CID; collision induced dissociation; DHB; 2,5-dihydroxybenzoic acid; ECD; electron capture dissociation; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EGFRvIII; epidermal growth factor receptor v
Keywords: Glioblastoma; Treatment; Review; Pharmacology; Targeted therapy; Stem cell; AKT; protein kinase B; BBB; blood-brain barrier; BCNU; carmustin; CCNU; lomustin; c-MET; hepatocyte growth factor receptor; EGF(R); epidermal growth factor (receptor); EGFRvIII; e
A Pre-Clinical Assessment of the Pan-ERBB Inhibitor Dacomitinib in Pediatric and Adult Brain Tumors
Keywords: 4HPC; 4-hydroperoxycyclophosphamide; CC3; cleaved caspase-3; CI; combination index; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EGFRvIII; constitutively active mutant form of the epidermal growth factor receptor; SMO; ND2:SmoA1 t
Identification and suppression of epidermal growth factor receptor variant III signaling in fibroblast-like synoviocytes from aggressive rheumatoid arthritis by the mimotope
Keywords: EGFR; Epidermal Growth Factor Receptor; EGFRvIII; EGFR variant III; FLS; fibroblast-like synoviocytes; RA; rheumatoid arthritis; CFA/IFA; complete Freund adjuvant/incomplete Freund adjuvant; LEMIA; linked EGFR mimotope-induced antibodies; CPIA; the contro
Evaluation of targeted curcumin (CUR) loaded PLGA nanoparticles for in vitro photodynamic therapy on human glioblastoma cell line
Keywords: CUR; Curcumin; NPs; Nanoparticles; PLGA NPs; Poly (D, l-lactic-co-glycolic acid) Nanoparticles; CUR-PLGA NPs; Curcumin loaded PLGA Nanoparticles; PEMA; Poly(ethylene-alt-maleic anhydride); PVA; Polyvinyl alcohol; FITC; Fluorescein isothiocyanate; Blank PL
Antibody-drug conjugates (ADCs): Potent biopharmaceuticals to target solid and hematological cancers- an overview
Keywords: Antibody-drug conjugates; Monoclonal antibodies; Anticancer; Drug resistance; Solid tumors; Hematological tumors; ADC; Antibody-Drug Conjugate; ALCL; Anaplastic Large Cell Lymphoma; ALL; Acute Lymphoblastic Leukemia; AML; Acute Myeloid Leukemia; BCMA; B C
Reformation in chimeric antigen receptor based cancer immunotherapy: Redirecting natural killer cell
Keywords: NK cell; natural killer cell; IFN-γ; interferon-γ; IL; interleukin; TNF-α; tumor necrosis factor-α; CCL; C-C motif ligand; GM-CSF; granulocyte-macrophage colony-stimulating factor; ADCC; antibody dependent cell-mediated cytotoxicity; TRAIL; TNF-relate
Mini-reviewTargeting EGFRvIII for glioblastoma multiforme
Keywords: Glioblastoma; EGFRvIII; Vaccine; CAR T-cell therapy;
Original ArticleEGFR/EGFRvIII remodels the cytoskeleton via epigenetic silencing of AJAP1 in glioma cells
Keywords: AJAP1; Cytoskeleton; MK2206; EGFR pathway; Glioblastoma; EGFR; epidermal growth factor receptor; EGFRvIII; the ligand-independent activated EGFR mutation; GBM; glioblastoma; AJAP1; adherens junctional associated protein-1 (also known as Shrew1); CNAs; cop
Recruitment of RNA molecules by connexin RNA-binding motifs: Implication in RNA and DNA transport through microvesicles and exosomes
Keywords: Cxs; connexins; Cx26; connexin26; Cx43; connexin43; CL; cytoplasmic loop; CTD; C-terminal domain; EGFRvIII; epidermal growth factor receptor variant III; E1-E2; extracellular loops; GJs; gap junctions; GJIC; gap junction intercellular communication; MVs;
Original ArticleEGFL7 is an intercellular EGFR signal messenger that plays an oncogenic role in glioma
Keywords: Glioblastoma; Heterogeneity; Angiogenesis; EGFL7; EGFRvIII;
The EGFR variant III mutant as a target for immunotherapy of glioblastoma multiforme
Keywords: EGFRvIII; EGFR; Glioblastoma; Immunotherapy; Rindopepimut vaccine; Monoclonal antibody;
Invert biopanning: A novel method for efficient and rapid isolation of scFvs by phage display technology
Keywords: Phage display; Single chain antibody; Biopanning; Nonspecific binding; EGFRvIII;
Nuclear EGFRvIII resists hypoxic microenvironment induced apoptosis via recruiting ERK1/2 nuclear translocation
Keywords: Glioblastoma; EGFRvIII; ERK1/2; Hypoxia; Nuclear translocation;
F25P preproinsulin abrogates the secretion of pro-growth factors from EGFRvIII cells and suppresses tumor growth in an EGFRvIII/wt heterogenic model
Keywords: EGFRvIII; F25P preproinsulin; External secretion; Glioblastoma;
Chimeric antigen receptor-modified T cells for the treatment of solid tumors: Defining the challenges and next steps
Keywords: CAIX; Carbonic anhydrase IX; CAR; Chimeric antigen receptor; EGFR; Epidermal growth factor receptor; EGFRvIII; Epidermal growth factor receptor variant III; HSV-tk; Herpes simplex thymidine kinase; IDO; Indoleamine 2,3 dioxygenase; IL; Interleukin; MHC; M
A wide spectrum of EGFR mutations in glioblastoma is detected by a single clinical oncology targeted next-generation sequencing panel
Keywords: Glioblastoma; Next-generation sequencing; EGFRvIII; EGFR; Glioma;
Alteration of major vault protein in human glioblastoma and its relation with EGFR and PTEN status
Keywords: EGFR; epidermal growth factor receptor; EGFRvIII; EGFR variant III mutation; FISH; fluorescent in situ hybridization; GBM; glioblastoma; GFAP; glial fibrillary acidic protein; HPFs; high-power fields; KPS; Karnofsky performance status; MLPA; multiplex lig
ReviewPharmacogenomics and targeted therapy of cancer: Focusing on non-small cell lung cancer
Keywords: ALDH; aldehyde dehydrogenase; ALK; anaplastic lymphoma kinase; BRAF; v-Raf murine sarcoma viral oncogene homolog B1; CSC; cancer stem cell; EGFR; epidermal growth factor receptor; EGFR-TKIs; EGFR tyrosine kinase inhibitors; EGFRvIII; EGFR variant III; EML
humMR1, a highly specific humanized single chain antibody for targeting EGFRvIII
Keywords: EGFRvIII; Humanization; Single chain antibody; Specificity;
The monoclonal antibody CH12 augments 5-fluorouracil-induced growth suppression of hepatocellular carcinoma xenografts expressing epidermal growth factor receptor variant III
Keywords: EGFR; epidermal growth factor receptor; EGFRvIII; epidermal growth factor receptor variant III; HCC; hepatocellular carcinoma; 5-FU; 5-fluorouracil; DPYD; dihydrouracil dehydrogenase; OPRT; orotate phosphoribosyltransferase; TS; thymidylate synthase; Epid
Genetics and pharmacogenomics of diffuse gliomas
Keywords: Companion diagnostics; Glioma; 1p/19q co-deletion; IDH1; Pharmacogenomics; EGFRvIII; CGH; comparative genomic hybridization; CNA; copy number aberrations; CRC; colorectal carcinoma; CML; chronic myeloid leukemia; EGFR; epidermal growth factor receptor; FF
Rapid biochemical synthesis of 11C-labeled single chain variable fragment antibody for immuno-PET by cell-free protein synthesis
Keywords: PET; positron emission tomography; EGFRvIII; epidermal growth factor receptor variant III; scFv; single chain Fv; l-[methyl-11C]methionine; [11C]Met; CT; computed tomography; [18F]FDG; 2-[18F]-fluoro-2-deoxy-d-glucose; MWCO; molecular weight cut-off; Cell
Overcoming resistance to EGFR inhibitor in head and neck cancer: A review of the literature
Keywords: EGFR inhibitor resistance; Head and neck squamous cell carcinoma; ErbB; Aurora kinase; EGFRvIII; PI3K/Akt; MET; VEGF;
Pathology: Commonly Monitored Glioblastoma Markers: EFGR, EGFRvIII, PTEN, and MGMT
Keywords: EGFR; EGFRvIII; PTEN; MGMT; Glioblastoma;
Landscape of EGFR signaling network in human cancers: Biology and therapeutic response in relation to receptor subcellular locations
Keywords: EGFR; EGFRvIII; HER2; Cancer; Gene regulation; Proliferation; Apoptosis; Survival; Radioresistance
Radioimmunotargeting of malignant glioma by monoclonal antibody D2C7 reactive against both wild-type and variant III mutant epidermal growth factor receptors
Keywords: Epidermal growth factor receptor; EGFRvIII; Glioblastoma multiforme; Monoclonal antibody;
Evaluation of 4-[18F]fluorobenzoyl-FALGEA-NH2 as a positron emission tomography tracer for epidermal growth factor receptor mutation variant III imaging in cancer
Keywords: Targeting peptides; Fluorine-18 labelling; EGFRvIII; PET; Molecular imaging; Cancer; Tumours;
CXCR4 suppression attenuates EGFRvIII-mediated invasion and induces p38 MAPK-dependent protein trafficking and degradation of EGFRvIII in breast cancer cells
Keywords: EGFR; EGFRvIII; CXCR4; Growth; Invasion;
Identification of an Exon 4-Deletion Variant of Epidermal Growth Factor Receptor with Increased Metastasis-Promoting Capacity
Keywords: de4 EGFR; the exon 4 deletion variant of EGFR; EGFR; epidermal growth factor receptor; EGFRvIII; epidermal growth factor receptor variant III; ERK; extracellular signal-regulated kinase; EGFRwt; wild type EGFR;
Maintenance of EGFR and EGFRvIII expressions in an in vivo and in vitro model of human glioblastoma multiforme
Keywords: EGFR; EGFRvIII; Stem cells; Glioblastoma multiforme
The effect of epidermal growth factor receptor variant III on glioma cell migration by stimulating ERK phosphorylation through the focal adhesion kinase signaling pathway
Keywords: EGFRvIII; FAK; ERK1/2; Tyrosine phosphorylation; Cell migration;
EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity
Keywords: EGFR; EGFRvIII; Glioblastoma; Apoptosis; PUMA; Chemoresistance
Binding of cetuximab to the EGFRvIII deletion mutant and its biological consequences in malignant glioma cells
Keywords: EGFRvIII; Cetuximab; Targeted therapy; Glioma; Radiotherapy;
The deletion mutant EGFRvIII significantly contributes to stress resistance typical for the tumour microenvironment
Keywords: Epidermal growth factor receptor (EGFR); EGFRvIII; Tumour; Microenvironment; Hypoxia
The EGFRvIII variant in glioblastoma multiforme
Keywords: EGFRvIII; Signalling; Glioma; Therapy
Detection of humoral response in patients with glioblastoma receiving EGFRvIII-KLH vaccines
Keywords: EGFRvIII; Magnetic; Beads; KLH; PEPIII; Glioblastoma; Humoral response
Development and evaluation of a cetuximab-based imaging probe to target EGFR and EGFRvIII
Keywords: Cetuximab; EGFR; EGFRvIII; Imaging probe evaluation
Expression of EGFR variant vIII promotes both radiation resistance and hypoxia tolerance
Keywords: EGFRvIII; Radiation resistance; Radiotherapy; Hypoxia tolerance; Targeted therapy
c-Myc is required for transformation of FDC-P1 cells by EGFRvIII
Keywords: wtEGFR; wild-type growth factor receptor; EGFRvIII; epidermal growth factor receptor variant III; tTA; tetracycline-regulated transactivator protein; siRNA; small interfering RNA; VEGF2R; vascular endothelial growth factor receptor; EGFRvIII; c-Myc; Trans
Molecular detection of EGFRvIII-positive cells in the peripheral blood of breast cancer patients
Keywords: EGFRvIII; Breast cancer; Occult systemic disease
Clinico-Pathological and Biological Significance of Tyrosine Kinase Domain Gene Mutations and Overexpression of Epidermal Growth Factor Receptor for Lung Adenocarcinoma
Keywords: Lung cancer; Epidermal growth factor receptor; Mutation; EGFRvIII; Overexpression
Antiepidermal growth factor variant III scFv fragment: effect of radioiodination method on tumor targeting and normal tissue clearance
Keywords: Radioiodination; Monoclonal antibody; EGFRvIII; Growth factor receptor;