کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6055094 1198784 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Overcoming resistance to EGFR inhibitor in head and neck cancer: A review of the literature
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Overcoming resistance to EGFR inhibitor in head and neck cancer: A review of the literature
چکیده انگلیسی
Head and neck squamous cell carcinoma (HNSCC) affects over half a million people worldwide. Despite advances in therapy, only half of the patients are alive in 5 years. Epidermal growth factor receptor (EGFR) is overexpressed in approximately 90% of the tumors, and it is correlated with poor response to treatment and worse outcome. Multiple therapies targeting this pathway have been tested. Cetuximab is the only EGFR inhibitor approved in HNSCC, but response rates are low. More recently, significant interest has focus on identifying mechanisms of acquired and de novo EGFR blockage resistance. Here we review some of these mechanisms and describe strategies to overcome that resistance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Oncology - Volume 48, Issue 11, November 2012, Pages 1085-1089
نویسندگان
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