Keywords: مکانیزم آنزیم; Isothermal titration calorimetry; Human chitinase; Inhibition; Enzyme mechanism;
مقالات ISI مکانیزم آنزیم (ترجمه نشده)
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Keywords: مکانیزم آنزیم; Zinc; Copper; Lethal factor; Proteases; Metal substitution; Enzyme mechanism;
Keywords: مکانیزم آنزیم; GK; glycerol kinase; LC-MS/MS; liquid chromatography tandem mass spectrometry; G3P; glycerol 3-phosphate; Pi; inorganic phosphate; Tbg; Trypanosoma brucei gambiense; Tbr; Trypanosoma brucei rhodesiense; pNPP; paranitrophenyl phosphate; WHO; World Health O
Keywords: مکانیزم آنزیم; ALDH, aldehyde dehydrogenase; Ct-FDH, carboxyl terminal domain of 10-formyltetrahydrofolate dehydrogenase; THF, tetrahydrofolateFolate metabolism; ALDH1L enzymes; Mitochondria; Aldehyde dehydrogenases; Enzyme mechanism; Evolution
Keywords: مکانیزم آنزیم; Enzyme kinetics; Ester hydrolysis; Pre-steady-state kinetics; Spectrophotometrically blind substrates; Enzyme mechanism; Activation energies;
Keywords: مکانیزم آنزیم; Isothermal titration calorimetry; Human chitinase; Inhibition; Enzyme mechanism;
Keywords: مکانیزم آنزیم; hPGK; human phosphoglycerate kinase; 3PG; 3-phosphoglycerate; 1,3BPG; bisphosphoglycerate; Enzyme mechanism; Phosphoryl transfer; SAXS;
Keywords: مکانیزم آنزیم; Phosphatase; Catalytic promiscuity; Enzyme mechanism; Sulfate transfer; Sulfatase; Linear-free energy relationship;
Keywords: مکانیزم آنزیم; Cyclopropane fatty acid synthase; Mycolic acid methyltransferase; Fatty acid methyl ester; Enzyme mechanism; AdoHcy; S-adenosyl-l-homocysteine; AdoMet; S-adenosyl-l-methionine; CS; cyclopropane synthase; CFAS; cyclopropane fatty acid synthase; CMAS; cyclo
Ferrochelatase Ï-helix: Implications from examining the role of the conserved Ï-helix glutamates in porphyrin metalation and product release
Keywords: مکانیزم آنزیم; Protoporphyrin ferrochelatase; Heme; Porphyrin; Enzyme mechanism; Erythropoiesis; Metalloenzyme; MOPS; 3-[N-morpholino]propanesulfonic acid; PIPBS; piperazine-N,Nâ²-bis(4-butanesulfonic acid); PPIX; protoporphyrin IX;
Modelling of polyhydroxyalkanoate synthase from Aquitalea sp. USM4 suggests a novel mechanism for polymer elongation
Keywords: مکانیزم آنزیم; PHA synthase; Enzyme mechanism; Homology modelling; Substrate specificity;
Study of the Cys-His bridge electron transfer pathway in a copper-containing nitrite reductase by site-directed mutagenesis, spectroscopic, and computational methods
Keywords: مکانیزم آنزیم; wt SmNir; wild type nitrite reductase from Sinorhizobium meliloti 2011; SmPaz; pseudoazurin from Sinorhizobium meliloti 2011; Rs; Rhodobacter sphaeroides 2.4.3; Ax; Alcaligenes xylosoxidans; Af; Alcaligenes faecalis S6; MV; methyl viologen; QM/MM; quantum
Mathematical determination of kinetic parameters for assessing the effect of the organic solvent on the selectivity of peptide synthesis with immobilized α-chymotrypsin
Keywords: مکانیزم آنزیم; Peptide synthesis; α-Chymotrypsin; Kyotorphin; Enzyme mechanism; Kinetic control;
Penicillin acylase and O-aryloxycarbonyl hydroxamates: Two acyl-enzymes, one leading to hydrolysis, the other to inactivation
Keywords: مکانیزم آنزیم; Penicillin acylase; N-terminal hydrolase; O-Aryloxycarbonyl hydroxamates; Enzyme kinetics; Enzyme inactivation; Enzyme mechanism;
The VAO/PCMH flavoprotein family
Keywords: مکانیزم آنزیم; Enzyme mechanism; Flavoprotein; Oxidoreductase; Phylogeny; Protein family; 4PO; 4-phenol oxidizing; ADPS; alkyl-dihydroxyacetone phosphate synthase; AldO; alditol oxidase; ALO; d-arabinono-1,4-lactone oxidase; BBE; berberine bridge enzyme; ChoX; cholester
NMR studies of the non-haem Fe(II) and 2-oxoglutarate-dependent oxygenases
Keywords: مکانیزم آنزیم; 2OG; 2-Oxoglutarate; BBOX; γ-Butyrobetaine hydroxylase; CODD; C-terminal oxygen-dependent degradation domain; COSY; Correlation spectroscopy; DSBH; Double-stranded β-helix; EFE; Ethylene-forming enzyme; FIH; Factor-inhibiting hypoxia-inducible factor; H
Hopeahainol A binds reversibly at the acetylcholinesterase (AChE) peripheral site and inhibits enzyme activity with a novel higher order concentration dependence
Keywords: مکانیزم آنزیم; Acetylcholinesterase; Hopeahainol A; Peripheral site; Natural product inhibitors; Enzyme mechanism; A; absorbance; AChE; acetylcholinesterase; BSA; bovine serum albumin; DTNB; 5,5â²-dithiobis-(2-nitrobenzoic acid);
Roles of active site residues in LodA, a cysteine tryptophylquinone dependent ε-lysine oxidase
Keywords: مکانیزم آنزیم; Enzyme mechanism; Posttranslational modification; Quinoprotein; Amine oxidase; Cofactor; Redox enzyme
Coenzyme A-free activity, crystal structure, and rational engineering of a promiscuous β-ketoacyl thiolase from Ralstonia eutropha
Keywords: مکانیزم آنزیم; Thiolase; In vitro biocatalysis; Crystal structure; Enzyme mechanism; Rational engineering
1.55Â Ã
-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis
Keywords: مکانیزم آنزیم; Protein crystallography; Terpene cyclase; Enzyme mechanism; Gibberellin biosynthesis;
A straightforward kinetic evidence for coexistence of “induced fit” and “selected fit” in the reaction mechanism of a mutant tryptophan indole lyase Y72F from Proteus vulgaris
Keywords: مکانیزم آنزیم; TIL, tryptophan indole-lyase (tryptophanase) [EC 4.1.99.1]; TPL, tyrosine phenol-lyase [EC 4.1.99.2]; PLP, pyridoxal-51-phosphate; OIA, oxindolyl-l-alanineTryptophan indole-lyase; Pyridoxal-51-phosphate; Enzyme mechanism; Kinetics; Enzyme-substrate fit
Acyl transfer mechanisms of tissue transglutaminase
Keywords: مکانیزم آنزیم; Enzyme mechanism; Acyl transfer; Transglutaminase; Transamidation
Sweet siblings with different faces: The mechanisms of FBP and F6P aldolase, transaldolase, transketolase and phosphoketolase revisited in light of recent structural data
Keywords: مکانیزم آنزیم; Enzyme mechanism; Structure; Crystallography; Intermediate; Catalysis; Schiff base; Thiamin diphosphate; Phosphosugar; Aldolase; Transaldolase; Transketolase; Phosphoketolase; Ring opening; Strain; Bond cleavage
A mutational analysis of active site residues in trans-3-chloroacrylic acid dehalogenase
Keywords: مکانیزم آنزیم; Hydrolytic dehalogenation; Tautomerase superfamily; trans-3-Chloroacrylic acid dehalogenase; Enzyme mechanism;
Kinetic mechanism and energetics of binding of phosphoryl group acceptors to Mycobacterium tuberculosis cytidine monophosphate kinase
Keywords: مکانیزم آنزیم; Cytidine monophosphate kinase; Mycobacterium tuberculosis; Enzyme mechanism; Isothermal titration calorimetry; Proton linkage; Intrinsic binding enthalpy;
The roles of active site residues in the catalytic mechanism of methylaspartate ammonia-lyase
Keywords: مکانیزم آنزیم; Methylaspartate ammonia-lyase; Deamination; Enzyme mechanism; Amino acid; Mutagenesis
The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue
Keywords: مکانیزم آنزیم; Antibiotics; Biosynthesis; Enzyme mechanism; Metalloenzymes; Non-heme iron oxidase; Penicillin
Cytochrome P450cin (CYP176A1) D241N: Investigating the role of the conserved acid in the active site of cytochrome P450s
Keywords: مکانیزم آنزیم; Cytochrome P450; Cineole; Citrobacter braakii; Enzyme mechanism
Supporting role of lysine 13 and glutamate 16 in the acid–base mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae
Keywords: مکانیزم آنزیم; Lysine biosynthesis; Saccharopine dehydrogenase; Site-directed mutagenesis; Isotope effects; pH-rate profiles; Enzyme mechanism
Mechanisms and inhibition of uracil methylating enzymes
Keywords: مکانیزم آنزیم; Uracil methylation; Thymidylate synthase; Flavin; Enzyme mechanism
First crystal structure of an endo-inulinase, INU2, from Aspergillus ficuum: Discovery of an extra-pocket in the catalytic domain responsible for its endo-activity
Keywords: مکانیزم آنزیم; Endo-inulinase; Glycoside hydrolase; Crystal structure; Enzyme mechanism; Molecular modelling;
Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease
Keywords: مکانیزم آنزیم; TREX1; Autoimmune disease; Protein structure; Enzyme mechanism; Lupus; Exonuclease;
Adenosylcobalamin enzymes: Theory and experiment begin to converge
Keywords: مکانیزم آنزیم; Coenzyme B12; Free radical; Enzyme mechanism
The crystal structure of isopenicillin N synthase with δ-(l-α-aminoadipoyl)-l-cysteinyl-d-methionine reveals thioether coordination to iron
Keywords: مکانیزم آنزیم; Antibiotics; Biosynthesis; Enzyme mechanism; Metalloenzymes; Non-heme iron oxidase; Penicillin
Structure and catalysis by carbonic anhydrase II: Role of active-site tryptophan 5
Keywords: مکانیزم آنزیم; Carbon dioxide; Carbonic anhydrase; Enzyme mechanism; Proton transfer; Bicarbonate
The enzymatic reaction-induced configuration change of the prosthetic group PQQ of methanol dehydrogenase
Keywords: مکانیزم آنزیم; MEDH; methanol dehydrogenase; PQQ; pyrroloquinoline quinone; MEDH-WA; methanol dehydrogenase from Methylophilus W3A1; MWA-A, MWA-B and MWA-C; crystals of MEDH-WA in forms A, B and C, respectively, grown in the presence of methanol at low concentration; MW
Molecular enzymology of 5-Aminolevulinate synthase, the gatekeeper of heme biosynthesis
Keywords: مکانیزم آنزیم; Pyridoxal-5'-phosphate; Aminolevulinate synthase; Enzyme mechanism; Catalysis; Heme biosynthesis
The role of the active site residues in human galactokinase: Implications for the mechanisms of GHMP kinases
Keywords: مکانیزم آنزیم; Active site base; Protein stability; GHMP kinase; Galactosemia; Galactokinase; Enzyme mechanism
Mechanism of the aromatic aminotransferase encoded by the Aro8 gene from Saccharomyces cerevisiae
Keywords: مکانیزم آنزیم; Enzymes; Pyridoxal phosphate; Aminotransferase; Spectral studies; Enzyme mechanism; pH studies
Investigation of Streptomyces antibioticus tyrosinase reactivity toward chlorophenols
Keywords: مکانیزم آنزیم; Tyrosinase; Copper; Oxygen; Chlorophenols; Enzyme specificity; Enzyme mechanism; Molecular modeling
Oxygen activation by P450cin: Protein and substrate mutagenesis
Keywords: مکانیزم آنزیم; Cytochrome P450; Cineole; Camphane; Terpene; Citrobacter braakii; Enzyme mechanism
Molecular, kinetic, thermodynamic, and structural analyses of Mycobacterium tuberculosishisD-encoded metal-dependent dimeric histidinol dehydrogenase (EC 1.1.1.23)
Keywords: مکانیزم آنزیم; Histidinol dehydrogenase; Mycobacterium tuberculosis; Metalloenzyme; Thermodynamic binding parameters; Enzyme mechanism; Molecular model;
Mechanisms and structures of vitamin B6-dependent enzymes involved in deoxy sugar biosynthesis
Keywords: مکانیزم آنزیم; Vitamin B6 coenzyme; Deoxy sugar; Aminosugar; Biosynthesis; Deoxygenation; Enzyme mechanism
NMR-Based Substrate Analog Docking to Escherichia coli Peptidyl-tRNA Hydrolase
Keywords: مکانیزم آنزیم; tRNA; fidelity of translation; substrate recognition; enzyme mechanism; enzyme specificityIF, initiation factor; Pth, peptidyl-tRNA hydrolase; 3D, three-dimensional; HSQC, heteronuclear single-quantum coherence; TOCSY, total correlated spectroscopy; NOESY
Protein kinase biochemistry and drug discovery
Keywords: مکانیزم آنزیم; Protein kinase; Phosphorylation; Drug discovery; Enzyme mechanism; Irreversible inhibition; Phosphotransfer
Insight into the reaction mechanism of the Escherichia coli cyclopropane fatty acid synthase: Isotope exchange and kinetic isotope effects
Keywords: مکانیزم آنزیم; Fatty acid cyclopropane synthase; Isotope exchange; Kinetic isotope effect; Ultra high resolution mass spectrometry; Enzyme mechanism
The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism
Keywords: مکانیزم آنزیم; Thymidine phosphorylase; Transition state analog; Enzyme mechanism; Inhibition kinetics
Flavin-dependent thymidylate synthase: A novel pathway towards thymine
Keywords: مکانیزم آنزیم; Thymidylate; Biosynthesis; Thymidylate synthase; Flavin; Enzyme mechanism
A study of cytochrome bo3 in a tethered bilayer lipid membrane
Keywords: مکانیزم آنزیم; Ubiquinol oxidase; Cytochrome c oxidase; Electrochemistry; Tethered bilayer lipid membrane; Enzyme mechanism
Molecular basis of inhibition of substrate hydrolysis by a ligand bound to the peripheral site of acetylcholinesterase
Keywords: مکانیزم آنزیم; AChE; acetylcholinesterase; ATMA; 3-(acetamido)-N,N,N-trimethylanilinium; DTNB; 5,5â²-dithiobis-(2-nitrobenzoic acid); M7C; N-methyl(7-dimethylcarbamoxy)quinolinium iodide; TcAChE; AChE from Torpedo californica; Acetylcholinesterase; Peripheral site; Thi