دانلود مقالات ISI درباره Erk2 + ترجمه فارسی

جلوگیری از آسیب تابشی توسط محصولات طبیعی

Prevention from radiation damage by natural products

Keywords: Cancer; Phytochemical; Radiotherapy; Radioprotection; Side effects; AP-1; activator protein-1; Bax; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma 2; CAPE; caffeic acid phenylethylester; CAT; chloramphenicol acetyltransferase; CBMN; cytokinesis block

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

زمان اقامت و تجزیه و تحلیل کارایی جنبشی مهار کننده های کیناز 2 تنظیم شده توسط سیگنال خارج سلولی

Residence time and kinetic efficiency analysis of extracellular signal-regulated kinase 2 inhibitors

Keywords: Structure–kinetic relationship; Kinetic efficiency; ERK2; Time-dependent inhibition; Off-rate; Residence time

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

بینش اخیر در پاتوفیزیولوژی مولکولی تشکیل قطرات چربی در سلولهای کبدی

Recent insights into the molecular pathophysiology of lipid droplet formation in hepatocytes

Keywords: ACAT; acyl-CoA cholesterol acyltransferase; ACC; acetyl CoA carboxylases; ACLY; ATP citrate lyases; ACSL; acyl CoA synthetases long chain family; ADRP; adipose differentiation related protein; AGP; advanced glycation end products; AGPAT; acylglycerophosph

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2014 سفارش ترجمه

A combination of 19F NMR and surface plasmon resonance for site-specific hit selection and validation of fragment molecules that bind to the ATP-binding site of a kinase

Keywords: SPR; surface plasmon resonance; ERK2; MAP kinase extracellular regulated kinase 2; FBDD; fragment-based drug discovery; HTS; high-throughput screening; ITC; isothermal titration calorimetry; 19F NMR; Surface plasmon resonance (SPR); Drug screening; Fragme

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Inflammation, insulin signaling and cognitive function in aged APP/PS1 mice

Keywords: Aβ; Amyloid-β; AD; Alzheimer's disease; ERK2; extracellular signal-regulated kinase 2; IKKβ; Inhibitor of NF-κB kinase β; IRS-1 pSer616; Insulin receptor substrate-1 phosphorylated at serine residue 616; MAPK; mitogen-activated protein kinase; mTOR

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2018 سفارش ترجمه

Leukotriene B4 induces EMT and vimentin expression in PANC-1 pancreatic cancer cells: Involvement of BLT2 via ERK2 activation

Keywords: LTB4; BLT2; Vimentin; EMT; Comp A; ERK2;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Anxa5 mediates the in vitro malignant behaviours of murine hepatocarcinoma Hca-F cells with high lymph node metastasis potential preferentially via ERK2/p-ERK2/c-Jun/p-c-Jun(Ser73) and E-cadherin

Keywords: Anxa5; Hepatocarcinoma; Malignant behaviour; ERK2; c-Jun; E-cadherin;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Role of XPD in cellular functions: To TFIIH and beyond

Keywords: ANT2; an adenine nucleotide translocase that exchanges mitochondrial ATP with cytosolic ADP; CDK; cyclin dependent kinase; CAK; CDK-activating kinase complex; CIA; cytoplasmic FeS assembly; CIA01/2; cytosolic iron-sulfur assembly component ½; CS; Cockayn

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2016 سفارش ترجمه

Phosphorylated TandeMBP: A unique protein substrate for protein phosphatase assay

Keywords: Phosphatase assay; Protein phosphatase; Protein substrate; Myelin basic protein; Malachite green assay; CaMKIδ; Ca2+/calmodulin-dependent protein kinase Iδ; CK1δ; casein kinase 1δ; DCLK; doublecortin-like protein kinase; DYRK1A; dual-specificity tyros

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2016 سفارش ترجمه

Toll-like receptor-3 mediates HIV-1 transactivation via NFκB and JNK pathways and histone acetylation, but prolonged activation suppresses Tat and HIV-1 replication

Keywords: TLR3; HIV; Viral transactivation; LTR; NFκB; JNK; STAT1; Histone acetylation; Epigenetics; Human monocyte-derived macrophages; TZM-bl; U38 cells; AP-1; activator protein-1; B2M; beta-2-microglobulin; BCA; bicinchoninic acid; CAT; chloramphenicol acetyltr

دانلود رایگان متن کامل مقاله ISI 56 صفحه سال انتشار : 2016 سفارش ترجمه

Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors

Keywords: ERK2; Pyrrolopyrazine; Fragment-based; Extracellular-regulated kinase;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

RIP140 contributes to foam cell formation and atherosclerosis by regulating cholesterol homeostasis in macrophages

Keywords: LDL; low density lipoprotein; HDL; high density lipoprotein; RIP140; receptor interacting protein 140; ABCA1; ATP-binding membrane cassette transporter A-1; ABCG1; ATP-binding membrane cassette transporter G-1; RCT; reverse cholesterol transport; oxLDL; o

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Cyclophilin D and myocardial ischemia-reperfusion injury: A fresh perspective

Keywords: ANT; adenine nucleotide translocator; ATP; adenosine triphosphate; ATP5G; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9); BAK; BCL2-antagonist/killer; BAX; BCL2-associated X protein; BCL-2; B cell lymphoma protein 2; C1QBP

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Identification and expression profiles of ERK2 and ERK5 in large yellow croaker (Larimichthys crocea) after temperature stress and immune challenge

Keywords: ERK2; ERK5; Large yellow croaker; Subcellular localization; Temperature stress; Immune challenge

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Monitoring changes in proteome during stepwise adaptation of a MDCK cell line from adherence to growth in suspension

Keywords: 2-D DIGE; two dimensional differential gel electrophoresis; aq; aqueous; BHK; baby hamster kidney; BR; biological replicate; CDM; chemically defined medium; CHO; Chinese hamster ovary; GMEM; glasgow minimal essential medium; ERK2; extracellular signal-reg

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Platinum-induced kidney damage: Unraveling the DNA damage response (DDR) of renal tubular epithelial and glomerular endothelial cells following platinum injury

Keywords: ApG; adenine-guanine; ATM; Ataxia telangiectasia mutated; ATR; ATM and Rad3 related kinase; Bax; Bcl2-associated X protein; Bcl2; B-cell CLL/lymphoma 2; EdU; 5-ethynyl-2′-deoxyuridine; CarboPt; carboplatin; CENP-F; centromere protein F; Chk1; checkpoint

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Tranilast: A review of its therapeutic applications

Keywords: ARH; aryl hydrocarbon receptor; bFGF; basic fibroblast growth factor; cAMP; cyclic AMP; CDK; cyclin-dependent kinase; COX-2; cyclooxsygenase-2; CTGF; connective tissue growth factor; CXCL; CX chemokine ligand; CXCR; CX chemokine receptor; EMT; epithelial-

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition

Keywords: Methylseleninic acid (PubChem CID: 161597); Sodium selenite (PubChem CID: 24934); Cisplatin (PubChem CID: 441203); LY294002 (PubChem CID: 3973); MSA; methylseleninic acid; Se; selenium; PPP; pentose phosphate pathway; TCA; tricarboxylic acid; ROS; reactiv

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2015 سفارش ترجمه

Close teamwork between Nrf2 and peroxiredoxins 1 and 6 for the regulation of prostaglandin D2 and E2 production in macrophages in acute inflammation

Keywords: AA; arachidonic acid; AP-1; activator protein-1; ARE; antioxidant-response element; BMDM; bone marrow-derived macrophage; COX-2; cyclooxygenase-2; DEX; dexamethasone; 15d-PGJ2; 15-deoxy-Δ12,14-prostaglandin J2; ERK2; extracellular-regulated kinase 2; GST

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells

Keywords: 1,5-Naphthyridine; Kinase inhibitor; ERK2; Aurora B; Antitumor activity;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

ERK2 small interfering RNAs prevent epidural fibrosis via the efficient inhibition of collagen expression and inflammation in laminectomy rats

Keywords: FBSS; failed back surgery syndrome; EF; epidural fibrosis; RNAi; RNA interference; ERK2; extra-cellular signal-regulated kinase 2; siRNAs; small interfering RNAs; TGF-β1; transforming growth factor-β1; IL6; interleukin 6; GFP; green fluorescent protein;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

In silico screening and study of novel ERK2 inhibitors using 3D QSAR, docking and molecular dynamics

Keywords: ERK2; 3D QSAR pharmacophore; HypoGen; Molecular docking; LigandFit; Molecular dynamics

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Depletion of ERK2 but not ERK1 abrogates oncogenic Ras-induced senescence

Keywords: OIS; oncogene-induced senescence; MEF; mouse embryonic fibroblast; ERK; extracellular signal-regulated kinase; MEK; mitogen-activated protein kinase kinase; PI3K; phosphatidylinositol 3-kinase; pRb; retinoblastoma tumor suppressor protein; SA-β-Gal; sene

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

The involvement of ERK/CREB/Bcl-2 in depression-like behavior in prenatally stressed offspring rats

Keywords: Prenatal stress; Depression; ERK2; CREB; Bcl-2

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells

Keywords: HGF; Nobiletin; Invasion; Migration; c-Met; ERK2; Akt

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Sex differences in social interaction behaviors in rats are mediated by extracellular signal-regulated kinase 2 expression in the medial prefrontal cortex

Keywords: ANOVA; one-way or two-way analysis of variance; ERK2; extracellular signal regulated kinase 2; HSV; herpes simplex virus; mPFC; medial prefrontal cortex; MAPK; mitogen activated protein kinase; NADH; nicotinamide adenine dinucleotide dehydrogenase; wtERK2

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Extracellular Signal-Regulated Kinase 2 Signaling in the Hippocampal Dentate Gyrus Mediates the Antidepressant Effects of Testosterone

Keywords: 17β-estradiol; depression; ERK2; hippocampus; neurogenesis; testosterone;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Perspectives des thérapies ciblées dans le cancer du sein métastatique

Keywords: thérapie ciblée; cancer du sein métastatique; HER-2; anti-angiogénèse; étude clinique; targeted therapy; metatstatic breast cancer; HER-2; anti-agiogenesis; clinical trial; ADCC; cytotoxicité à médiation cellulaire anticorps-dépendante; Akt; pro

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

XGef influences XRINGO/CDK1 signaling and CPEB activation during Xenopus oocyte maturation

Keywords: Signal transduction; Meiosis; ERK2

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

PKC promotes the migration of colon cancer cells by regulating the internalization and recycling of integrin αvβ6

Keywords: Integrin αvβ6; ERK2; Protein kinase C; Colon cancer

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Neurodegeneration, Neuroprotection, and Disease-Oriented NeuroscienceResearch PaperGenetic inactivation of Pleiotrophin triggers amphetamine-induced cell loss in the substantia nigra and enhances amphetamine neurotoxicity in the striatum

Keywords: neurotoxicity; methamphetamine; MDMA; RPTPβ/ζ; ERK1/2; Fyn; DA; dopamine; DAT; dopamine transporter; ERK1/2; extracellular-signal regulated kinase 1/2; ERK1; p44 ERK; ERK2; p42 ERK; GFAP; glial-fibrillary acidic protein; MDMA; 3,4-methylenedioxymethamph

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

MAP kinases have different functions in Dictyostelium G protein-mediated signaling

Keywords: MAPK, MAP kinase or mitogen-activated protein kinase; MAP2K, MAP kinase kinase; ERK, extracellular-signal regulated kinase; SDS, sodium dodecyl sulfate; cAMP, cyclic adenosine monophosphate; cGMP, cyclic guanine monophosphateMAP kinase; ERK1; ERK2; G prot

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

Low level exposure to monomethyl arsonous acid-induced the over-production of inflammation-related cytokines and the activation of cell signals associated with tumor progression in a urothelial cell model

Keywords: ErbB2; epidermal growth factor receptor B2; Erk2; extracellular signal-regulated kinase 2; HIF-a; hypoxia factor 1-α; iNOS; inducible nitric oxide sintetase; IL-; Interleukin; MAPKs; mitogen-activated protein kinases; MIP-2; macrophage inflammatory prote

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

ERK2 dependent signaling contributes to wound healing after a partial-thickness burn

Keywords: Partial-thickness burn; ERK2; Knockout mice; Proliferation; Skin; Phosphorylation; Epithelization; Keratinocytes

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Efficient inhibition of fibroblast proliferation and collagen expression by ERK2 siRNAs

Keywords: Joint adhesion; Fibroblast; Small interfering RNA; ERK2; TGF-β1; FGF-2;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Detection of two novel mutations and relatively high incidence of H-RAS mutations in Vietnamese oral cancer

Keywords: Oral carcinoma; H-RAS mutation; ERK2; Oncogene; OSCC; Vietnam

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

MAP kinase: It’s been longer than fifteen minutes

Keywords: MAP kinase; Cell cycle; MEK1; MEK2; ERK1; ERK2

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Feedback regulation of DUSP6 transcription responding to MAPK1 via ETS2 in human cells

Keywords: DUSP6; MKP-3; MAPK; ERK2; ETS; Promoter; Chromatin immunoprecipitation; Transcriptional factor; Feedback; Pancreatic cancer

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Identification of novel inhibitors of extracellular signal-regulated kinase 2 based on the structure-based virtual screening

Keywords: Virtual screening; Docking; ERK2; Inhibitor; Anticancer agents

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

ERK2-binding domain is required for phosphorylation of EBITEIN1, a potential downstream interactor of ERK2

Keywords: EBITEIN; EB domain; Protein–protein interaction; Binding protein; Binding domain; Phosphorylation; Electrophoretic mobility; Testis; ERK2; Spermatogenesis

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Molecular modeling and crystal structure of ERK2–hypothemycin complexes

Keywords: ERK, extracellular regulated kinase; RAL, resorcylic acid lactone; MM, molecular mechanics; MD, molecular dynamicsHypothemycin; ERK2; Resorcylic acid lactones; Molecular modeling; Crystal structure

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

The mechanism of anti-platelet activity of davallialactone: Involvement of intracellular calcium ions, extracellular signal-regulated kinase 2 and p38 mitogen-activated protein kinase

Keywords: Davallialactone; Inonotus xeranticus; Platelet aggregation; Thrombin; Collagen; ADP; ERK2; p38 MAPK; [Ca2+]i

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Functional modulation of the ATP-sensitive potassium channel by extracellular signal-regulated kinase-mediated phosphorylation

Keywords: Katp channel; MAPK; ERK2; single-channel; patch clamp; transfectionANOVA, analysis of variance; ERK, extracellular signal-regulated kinase; cGMP, cyclic guanosine monophosphate; HEK, human embryonic kidney; IC50, the half-maximal inhibitory concentration;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation

Keywords: ERK1; ERK2; MAPK; Cell migration; Epiboly; Gastrulation; Development

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2008 سفارش ترجمه

Nurr1 is phosphorylated by ERK2 in vitro and its phosphorylation upregulates tyrosine hydroxylase expression in SH-SY5Y cells

Keywords: Nurr1; ERK2; Phosphorylation; Tyrosine hydroxylase; Parkinson's disease

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Ghrelin stimulates angiogenesis in human microvascular endothelial cells: Implications beyond GH release

Keywords: Ghrelin; GHS-R—growth hormone secretagogue receptor; Angiogenesis; Endothelial cells; Proliferation; Migration; ERK2

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Regulation of protein phosphorylation within the MKK1-ERK2 complex by MP1 and the MP1•P14 heterodimer

Keywords: MAPK kinase; ERK2; Fluorescence; Anisotropy; MP1; P14; MKK1;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Application of hydrogen/deuterium exchange mass spectrometry to study protein tyrosine phosphatase dynamics, ligand binding, and substrate specificity

Keywords: H/D exchange; Mass spectrometry; Protein tyrosine phosphatases (PTPs); Dynamics; Ligand binding; Substrate specificity; MKP3; ERK2; Protein-protein interaction;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

The expression and purification of the N-terminal activation domain of the transcription factor c-Myc: A model substrate for exploring ERK2 docking interactions

Keywords: MAPK kinase; ERK2; c-Myc

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Crystal structure of human ERK2 complexed with a pyrazolo[3,4-c]pyridazine derivative

Keywords: ERK2; X-ray; Structural change

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2006 سفارش ترجمه