Galacto-N-biose is neuroprotective against glutamate-induced excitotoxicity in vitro
Keywords: اکسید سمیت; GNB; Excitotoxicity; Glutamate; Cortical neuron;
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Mitochondrial dysfunction and lipid peroxidation in rat frontal cortex by chronic NMDA administration can be partially prevented by lithium treatment
Keywords: اکسید سمیت; NMDA; Lipid peroxidation; Mitochondria; Excitotoxicity; Lithium;
Learning impairment by minimal cortical injury in a mouse model of Alzheimer׳s disease
Keywords: اکسید سمیت; Brain injury; Excitotoxicity; BK channel; Morris water maze; DNA microarray
Characterization of brevetoxin (PbTx-3) exposure in neurons of the anoxia-tolerant freshwater turtle (Trachemys scripta)
Keywords: اکسید سمیت; Harmful algal bloom; Red tide; Excitotoxicity; Tetrodotoxin; NMDA receptor; Glutamate;
Exploring neuroprotective potential of Withania somnifera phytochemicals by inhibition of GluN2B-containing NMDA receptors: An in silico study
Keywords: اکسید سمیت; N-methyl-d-aspartate receptors; Excitotoxicity; Neurodegenerative diseases; Withania somnifera; Allosteric inhibition
Dexamethasone-induced acute excitotoxic cell death in the developing brain
Keywords: اکسید سمیت; Dexamethasone; c-Fos; Excitotoxicity; Apoptosis; Caspase-3; DNA fragmentation; Memantine; Hippocampus; Subiculum; Neonatal;
Oxygen-glucose deprivation increases firing of unipolar brush cells and enhances spontaneous EPSCs in Purkinje cells in the vestibulo-cerebellum
Keywords: اکسید سمیت; Cerebellum; Unipolar brush cells; Ischemia; Oxygen-glucose deprivation; Vestibulo-cerebellar lobules; Excitotoxicity; NMDA;
Post-treatment with prolactin protects hippocampal CA1 neurons of the ovariectomized female rat against kainic acid-induced neurodegeneration
Keywords: اکسید سمیت; ANOVA; analysis of variance; BDNF; brain-derived neurotrophic factor; BrdU; 5-bromo-2-deoxyuridine; DCX; doublecortin; ELISA; enzyme-linked immunosorbent assay; KA; kainic acid; KPBS; potassium phosphate buffer; NOR; novel object recognition; OVX; ovariec
Proteomic analysis of PSD-93 knockout mice following the induction of ischemic cerebral injury
Keywords: اکسید سمیت; Proteomic analysis; PSD-93; Excitotoxicity; Ischemic stroke;
Neuropathophysiology of Brain Injury
Keywords: اکسید سمیت; Mechanisms of ischemic brain injury; Excitotoxicity; Oxidative stress; Neuroinflammation; Apoptosis; Synaptic plasticity; Neurovascular unit; Translation;
Neuroprotection against glutamate-induced excitotoxicity and induction of neurite outgrowth by T-006, a novel multifunctional derivative of tetramethylpyrazine in neuronal cell models
Keywords: اکسید سمیت; Alzheimer's disease; Tetramethylpyrazine derivative; Excitotoxicity; Neuroprotection; Neurite outgrowthTMP, tetramethylpyrazine; ROS, reactive oxygen species; RNS, reactive nitrogen species; CGN, cerebellar granule neuron; ERK, extracellular signal-regula
Neuroprotection by GH against excitotoxic-induced cell death in retinal ganglion cells
Keywords: اکسید سمیت; Growth hormone (GH); Insulin-like growth factor (IGF)-1; Glutamate; Buthionine sulfoxamide (BSO); Excitotoxicity; Apoptosis
Mechanisms of tau and Aβ-induced excitotoxicity
Keywords: اکسید سمیت; Alzheimer׳s disease; Excitotoxicity; Amyloid beta; Tau; Group 1 metabotropic glutamate receptors; Kainate receptors
Rat intra-hippocampal NMDA infusion induces cell-specific damage and changes in expression of NMDA and GABAA receptor subunits
Keywords: اکسید سمیت; Excitotoxicity; NMDA receptor; GABA A receptor; Hippocampus; Neuroinflammation; Neurodegeneration; Interneurons; Spatial learning; Carousel maze;
Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges
Keywords: اکسید سمیت; CypD; SOD2; ROS; mPTP; mitochondria; excitotoxicity; neurodegeneration; voluntary exercise
Bilirubin-Induced Neurotoxicity in the Preterm Neonate
Keywords: اکسید سمیت; Kernicterus; Excitotoxicity; Low-bilirubin kernicterus; Auditory neuropathy; Cerebellum; Hypoalbuminemia;
Associate Editor: J. TurgeonA beacon of hope in stroke therapy-Blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies
Keywords: اکسید سمیت; Excitotoxicity; Stroke; Neuron death; NMDAR; Calpain; nNOS; AIF; Apoptosis-inducing factor; AMPA; α-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid; Aβo; amyloid β oligomers; Bax; Bcl-2-associated X-protein; CaMKIV; Calcium-calmodulin-dependent kin
Glutamate excitotoxicity and Ca2+-regulation of respiration: Role of the Ca2+ activated mitochondrial transporters (CaMCs)
Keywords: اکسید سمیت; ATP-Mg/Pi carrier; Aspartate/glutamate carrier; Aralar; Calcium; Excitotoxicity; Mitochondria; PARP-1; SCaMC-3;
MDMA decreases glutamic acid decarboxylase (GAD) 67-immunoreactive neurons in the hippocampus and increases seizure susceptibility: Role for glutamate
Keywords: اکسید سمیت; MDMA; Glutamate; GABA; Excitotoxicity;
Combined neuroprotective action of adenosine A1 and cannabinoid CB1 receptors against NMDA-induced excitotoxicity in the hippocampus
Keywords: اکسید سمیت; Adenosine A1 receptor; Cannabinoid CB1 receptor; Excitotoxicity; Hippocampus
Astroglial NMDA receptors inhibit expression of Kir4.1 channels in glutamate-overexposed astrocytes in vitro and in the brain of rats with acute liver failure
Keywords: اکسید سمیت; Kir4.1; Astrocytic NMDA receptors; Glutamate; Excitotoxicity; Hepatic encephalopathy; Oxidative/nitrosative stress
Impaired retinal vasodilator response to acetylcholine in a rat model of NMDA-induced retinal degeneration
Keywords: اکسید سمیت; Endothelial cell; Excitotoxicity; Retinal neuronal cell; Retinal blood vessel; Vasodilation
Experimental evidence that overexpression of NR2B glutamate receptor subunit is associated with brain vacuolation in adult glutaryl-CoA dehydrogenase deficient mice: A potential role for glutamatergic-induced excitotoxicity in GA I neuropathology
Keywords: اکسید سمیت; Glutaric aciduria type I; Glutamate receptors; Glutamate transporter; Excitotoxicity;
Regular ArticleTransient mitochondrial permeability transition mediates excitotoxicity in glutamate-sensitive NSC34D motor neuron-like cells
Keywords: اکسید سمیت; Glutamate; Excitotoxicity; Mitochondrial calcium uniporter; Transient mitochondrial permeability transition; Superoxide flashes; Neuron death;
Tideglusib protects neural stem cells against NMDA receptor overactivation
Keywords: اکسید سمیت; Excitotoxicity; Tideglusib; Neuroprotection; Neural stem cell
Adenosine A3 receptor activation is neuroprotective against retinal neurodegeneration
Keywords: اکسید سمیت; A3 adenosine receptor; Retinal ganglion cell; Neuroprotection; Excitotoxicity; Ischemia-reperfusion; Axon injury; A3R; A3 receptor; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; CTZ; cyclothiazide; DARC; Detection of Apoptosing Retinal Cell
Neuronal erythropoietin overexpression protects mice against age-related hearing loss (presbycusis)
Keywords: اکسید سمیت; Age-related hearing loss (ARHL); Excitotoxicity; Neuroprotection; Cochlea; Spiral ganglion; ABR;
PBT2 inhibits glutamate-induced excitotoxicity in neurons through metal-mediated preconditioning
Keywords: اکسید سمیت; Excitotoxicity; Zinc; Calcium flux; Huntington's disease (HD); Alzheimer's disease (AD);
Role of adaptor protein MyD88 in TLR-mediated preconditioning and neuroprotection after acute excitotoxicity
Keywords: اکسید سمیت; Excitotoxicity; Toll-like receptors; MyD88; Microglia; Preconditioning; Neuroprotection;
The L-type voltage-gated calcium channel modulates microglial pro-inflammatory activity
Keywords: اکسید سمیت; [Ca2+]i; intracellular calcium concentration; DAB; diaminobenzidine; DG; dentate gyrus; FBS; fetal bovine serum; GFAP; glial fibrillary acidic protein; IB4; isolectin B4; IFNγ; interferon-gamma; IL-1β; interleukin-1β; KW; Kruskal-Wallis; LPS; lipopol
Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy
Keywords: اکسید سمیت; APV; (2R)-amino-5-phosphonovaleric acid; C7; 7-chlorokynurenic acid; CCCP; carbonyl cyanide m-chlorophenyl hydrazone; DCF; 2â²,7â²-dichlorofluorescien; DIV; day in vitro; ER; endoplasmic reticulum; GFP-Sec61β; green fluorescent protein-tagged Sec61beta
Synthetic and endogenous cannabinoids protect retinal neurons from AMPA excitotoxicity in vivo, via activation of CB1 receptors: Involvement of PI3K/Akt and MEK/ERK signaling pathways
Keywords: اکسید سمیت; Cannabinoids; CB1 receptors; Retina; Excitotoxicity; Neuroprotection; Amacrine cells; PI3K/Akt signaling pathway; MEK/ERK1/2 signaling pathwayAMPA, (RS)-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid hydrobromide; AEA, anandamide, N-arachidonoyl eth
Dual role of Src kinase in governing neuronal survival
Keywords: اکسید سمیت; Src kinase; Excitotoxicity; NMDA receptor; Calpain; Akt
CDK5 knockdown in astrocytes provide neuroprotection as a trophic source via Rac1
Keywords: اکسید سمیت; CDK5; cyclin-dependent kinase; GLU; glutamate; AD; Alzheimer's disease; DIV; day in vitro; ROS; reactive oxygen species; BDNF; brain-derived neurotrophic factor; ROCK; Rho kinase; LDH; lactate dehydrogenase; G-LISA; GTP enzyme-linked immunosorbent assay;
Dopamine midbrain neurons in health and Parkinson's disease: Emerging roles of voltage-gated calcium channels and ATP-sensitive potassium channels
Keywords: اکسید سمیت; D2-AR; D2-autoreceptor; DA; dopamine; DBS; deep brain stimulation; DHPs; dihydropyridines; ER; endoplasmic reticulum; ETC; electron transfer chain; K-ATPs; ATP-sensitive potassium channels; LC; locus coeruleus; LTCCs; L-type calcium channels; mNOS; mitoch
Delayed treatments with pharmacological modulators of pre- and postsynaptic mGlu receptors rescue the hippocampus from kainate-induced neurodegeneration
Keywords: اکسید سمیت; Excitotoxicity; Kainic acid; Hippocampus; MPEP; LY354740; Fluoro-Jade;
Pre- and postsynaptic type-1 cannabinoid receptors control the alterations of glutamate transmission in experimental autoimmune encephalomyelitis
Keywords: اکسید سمیت; EAE; EPSC; Excitotoxicity; GABA; Glutamate; Multiple sclerosis; Striatum;
Downregualtion of dynamin-related protein 1 attenuates glutamate-induced excitotoxicity via regulating mitochondrial function in a calcium dependent manner in HT22 cells
Keywords: اکسید سمیت; Excitotoxicity; Apoptosis; Drp-1; Calcium; Mitochondria;
Neuroprotective effects of C3 exoenzyme in excitotoxic retinopathy
Keywords: اکسید سمیت; glaucoma; neuroprotection; C3; excitotoxicity;
Co-activation of synaptic and extrasynaptic NMDA receptors by neuronal insults determines cell death in acute brain slice
Keywords: اکسید سمیت; Glutamate; Synaptic NMDA receptors; Extrasynaptic NMDA receptors; Excitotoxicity; Brain slice;
Thiamine deficiency results in release of soluble factors that disrupt mitochondrial membrane potential and downregulate the glutamate transporter splice-variant GLT-1b in cultured astrocytes
Keywords: اکسید سمیت; Excitotoxicity; Vitamin B1; Wernicke’s encephalopathy; GLT-1; NF-κB; Mitochondrial membrane potential
Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degeneration
Keywords: اکسید سمیت; LRRK2; leucine rich repeat kinase 2; LRRK2-3HA; C-terminal 3Ã-hemagglutinin tagged LRRK2; cDNA; complementary deoxyribonucleic acid; mEPSC; miniature excitatory postsynaptic current; PD; Parkinson's disease; AMPA; (2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-
Excitotoxic glutamate insults block autophagic flux in hippocampal neurons
Keywords: اکسید سمیت; CaMKII; Glutamate; Excitotoxicity; Autophagy; Neuronal cell death;
Neurotoxicity of methamphetamine and 3,4-methylenedioxymethamphetamine
Keywords: اکسید سمیت; Methamphetamine; 3-4-Methylenedioxymethamphetamine; Neurotoxicity; Excitotoxicity; Oxidative stress; Psychosis
Alpha II Spectrin breakdown products in immature Sprague Dawley rat hippocampus and cortex after traumatic brain injury
Keywords: اکسید سمیت; Controlled cortical impact; Apoptosis; Excitotoxicity; Cell death; Developmental
Possible involvement of VEGF signaling system in rescuing effect of endogenous acetylcholine on NMDA-induced long-lasting hippocampal cell damage in organotypic hippocampal slice cultures
Keywords: اکسید سمیت; Rescuing/protecting activity; Excitotoxicity; Endogenous acetylcholine; PKC; VEGF-A-VEGFR-2 signaling; Organotypic hippocampal slice cultures
Regular ArticleThe sigma-1 receptor agonist 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) protects against newborn excitotoxic brain injury by stabilizing the mitochondrial membrane potential in vitro and inhibiting microglial activation in vivo
Keywords: اکسید سمیت; AIF; anti-apoptosis inducing factor; NMDA; N-methyl-d-aspartate; PI; propidium iodide; PPBP; 4-phenyl-1-(4-phenylbutyl) piperidine; TMRM; tetramethylrhodamine methyl ester; WGA; wheat germ agglutinin; Excitotoxicity; Sigma receptor agonist; Brain damage;
Basic NeuroscienceAutomated immunohistochemical method to quantify neuronal density in brain sections: Application to neuronal loss after status epilepticus
Keywords: اکسید سمیت; DAPI; 4â²,6â²-diamidino-2-phenylindole; NeuN; neuronal nuclei; PBS; phosphate buffered saline; SE; status epilepticus; Excitotoxicity; Epilepsy; Quantification; ImageJ; Neuroanatomy; Microscopy;
The role of the glutamatergic NMDA receptor in nanosilver-evoked neurotoxicity in primary cultures of cerebellar granule cells
Keywords: اکسید سمیت; Nanosilver; Nanotoxicity; Excitotoxicity; MK-801; Calcium homeostasis; Reactive oxygen species;
GLT-1 transporter: An effective pharmacological target for various neurological disorders
Keywords: اکسید سمیت; Glutamate; Excitotoxicity; GLT-1; Neurological disorders;