The mechanism of axonal degeneration after perikaryal excitotoxic injury to the retina
Keywords: اکسید سمیت; Excitotoxicity; Wallerian; Neurodegeneration
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Unusual increase in lumbar network excitability of the rat spinal cord evoked by the PARP-1 inhibitor PJ-34 through inhibition of glutamate uptake
Keywords: اکسید سمیت; Excitotoxicity; Motoneurons; Fictive locomotion; 5-HT; 5-hydroxytryptamine; ANOVA; analysis of variance; CCF; cross correlation factor; CNQX; 6-cyano-7-nitroquinoxaline-2,3-dione; CV; coefficient of period variation; DAPI; 4â²,6-diamidino-2-phenylindole;
Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice
Keywords: اکسید سمیت; NMDA receptor; GluN2A; GluN2B; Huntington's disease; Neurodegeneration; Striatal medium spiny neuron; Excitotoxicity; Glutamate; Extrasynaptic; Corticostriatal; Coculture; pCREB; Microfluidic isolation chamber; Electrophysiology; YAC128; Striatum;
p53 Mediates autophagy activation and mitochondria dysfunction in kainic acid-induced excitotoxicity in primary striatal neurons
Keywords: اکسید سمیت; p53; kainic acid; excitotoxicity; autophagy; mitochondriaEDTA, Ethylenediaminetetraacetic acid; KA, Kainic acid; LC3, light chain 3; LDH, lactate dehydrogenase; PFT-α, pifithrin-alpha; PFT-μ, pifithrin-mu; PIGs, p53-induced genes; 3-MA, 3-methyladenine; R
The molecular basis of retinal ganglion cell death in glaucoma
Keywords: اکسید سمیت; Glaucoma; Retinal ganglion cell; Optic nerve; Neuroprotection; Apoptosis; Neurotrophic factor; Excitotoxicity; Oxidative stress; Reactive gliosis; Dendritic remodeling; Synaptic loss
Structure–activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators
Keywords: اکسید سمیت; Excitatory amino acid transporter 2; Glutamate; Pyridazines; Excitotoxicity
P2X7 receptor as a double-edged sword: Neurotrophic and neurotoxic effects
Keywords: اکسید سمیت; ATP; endoplasmic reticulum; excitotoxicity; mitochondria; neuron; P2X7 receptor; proliferation;
Identification of complexin II in astrocytes: A possible regulator of glutamate release in these cells
Keywords: اکسید سمیت; Vesicular release; SNARE; Cell culture; Excitotoxicity; Neurotransmitter; Exocytosis;
Brief communicationPerinatal exposure to environmental polychlorinated biphenyls sensitizes hippocampus to excitotoxicity ex vivo
Keywords: اکسید سمیت; Excitotoxicity; Non-coplanar PCBs; Picrotoxin; Hippocampus; Hippocampal slice; GABAA receptor; Seizure activity; Microelectrode array;
Excitotoxicity by kainate-induced seizure causes diacylglycerol kinase ζ to shuttle from the nucleus to the cytoplasm in hippocampal neurons
Keywords: اکسید سمیت; Diacylglycerol kinase; Kainate; Excitotoxicity; Hippocampus; Translocation; Immunohistochemistry
Insulin increases glutamate transporter GLT1 in cultured astrocytes
Keywords: اکسید سمیت; Glutamate transporter; GLT1; Astrocyte; Insulin; Excitotoxicity; Growth factor; Akt
Comparison between PACAP- and enriched environment-induced retinal protection in MSG-treated newborn rats
Keywords: اکسید سمیت; Environmental enrichment; Excitotoxicity; Neurotrophic factor; Development; Retinoprotection;
Increased vesicular glutamate transporter expression causes excitotoxic neurodegeneration
Keywords: اکسید سمیت; VGLUT; Glutamate; Excitotoxicity; Drosophila; Neurodegeneration; Disease model
The excitatory neurotransmitter glutamate stimulates DNA repair to increase neuronal resiliency
Keywords: اکسید سمیت; Glutamate; Excitotoxicity; Oxidative DNA damage; APE1; Neurodegenerative diseases
Modulation of the Ca2+ permeability of human endplate acetylcholine receptor-channel
Keywords: اکسید سمیت; ACh; acetylcholine; AChR; ACh receptor; [Ca2+]i; intracellular free Ca2+ concentration; CMS; congenital myasthenic syndromes; IACh; ACh-evoked whole-cell current; Pf; fractional Ca2+ current; QACh; total electrical charge entering the cell through the act
Beneficial effects of an innovative exercise model on motor and oxidative disorders induced by haloperidol in rats
Keywords: اکسید سمیت; Exercise; Oral dyskinesia; Haloperidol; Oxidative stress; Excitotoxicity;
HIF-1α expression in the hippocampus and peripheral macrophages after glutamate-induced excitotoxicity
Keywords: اکسید سمیت; Hippocampus; Macrophages; HIF-1 alpha; VEGF; EPO; Excitotoxicity;
Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis
Keywords: اکسید سمیت; Anandamide; EAE; EPSC; Excitotoxicity; FAAH; Neurodegeneration;
Suppressing inflammatory cascade by cyclo-oxygenase inhibitors attenuates quinolinic acid induced Huntington's disease-like alterations in rats
Keywords: اکسید سمیت; Excitotoxicity; Mitochondrial dysfunction; Huntington's disease; Oxidative stress; Quinolinic acid
Neuroglial interactions mediated by purinergic signalling in the pathophysiology of CNS disorders
Keywords: اکسید سمیت; ADK, adenosine kinase; EAE, experimental autoimmune encephalomyelitisEpilepsy; Ischemia; Multiple sclerosis; Excitotoxicity; ATP; Adenosine
Bilirubin facilitates depolarizing GABA/glycinergic synaptic transmission in the ventral cochlear nucleus of rats
Keywords: اکسید سمیت; Bilirubin; Excitotoxicity; Calcium; PKA; Reversal potential; Patch clamp;
SP-8203 shows neuroprotective effects and improves cognitive impairment in ischemic brain injury through NMDA receptor
Keywords: اکسید سمیت; Cerebral ischemia; Earth worms; Excitotoxicity; Memory; Neuronal death; NMDA;
Decreased myeloperoxidase expressing cells in the aged rat brain after excitotoxic damage
Keywords: اکسید سمیت; Aging; Striatum; Excitotoxicity; Neutrophil; MPO; Inflammation
Adaptation to moderate hypoxia protects cortical neurons against ischemia-reperfusion injury and excitotoxicity independently of HIF-1α
Keywords: اکسید سمیت; Hypoxia; Adaptation; Ischemia; Reperfusion; Neuroprotection; Hypoxia-inducible factor; Prolyl hydroxylase; Excitotoxicity; Glutamate;
Management of moderate to severe Alzheimer’s disease: Focus on memantine
Keywords: اکسید سمیت; Alzheimer’s disease; Excitotoxicity; IRES; Memantine; NMDA receptors
A decrease in phosphorylation of cAMP-response element-binding protein (CREBP) promotes retinal degeneration
Keywords: اکسید سمیت; retina; CREBP; excitotoxicity; apoptosis; ganglion cells; amacrine cells; retinal degenerationGCL, ganglion cell layer; INL, inner nuclear layer; KA, Kainic acid; TUNEL, TdT-mediated dUTP nick-end labeling; CRE, cAMP-response element; CREBP, cAMP-response
Ghrelin protects spinal cord motoneurons against chronic glutamate-induced excitotoxicity via ERK1/2 and phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3β pathways
Keywords: اکسید سمیت; Ghrelin; Neuroprotection; Akt; Excitotoxicity; Motoneuron; Organotypic spinal cord cultures;
2-(Cyclohexylamino)-1-(4-cyclopentylpiperazin-1-yl)-2-methylpropan-1-one, a novel compound with neuroprotective and neurotrophic effects in vitro
Keywords: اکسید سمیت; Neuroprotection; Neurotrophic effects; Sigma-1; Excitotoxicity; Oxidative stress; Neurite outgrowth
Impaired striatal GABA transmission in experimental autoimmune encephalomyelitis
Keywords: اکسید سمیت; EAE; Excitotoxicity; IPSC; Multiple sclerosis; Neurodegeneration; Parvalbumin; Striatum; MEA
Neurodegeneration, Neuroprotection, and Disease-Oriented NeuroscienceResearch PaperDelayed neuroprotection by riluzole against excitotoxic damage evoked by kainate on rat organotypic spinal cord cultures
Keywords: اکسید سمیت; spinal cord injury; motoneuron; kainic acid; neuroprotection; excitotoxicity; glutamate; ALS; amyotrophic lateral sclerosis; ANOVA; analysis of variance; DAPI; 4',6-diamidino-2-phenylindole; DIV; days in vitro; DME/HIGH; Dulbecco's modified Eagle's medium
Parallel high throughput neuronal toxicity assays demonstrate uncoupling between loss of mitochondrial membrane potential and neuronal damage in a model of HIV-induced neurodegeneration
Keywords: اکسید سمیت; Neuroinflamation; Neurotoxicity; Excitotoxicity; Mitochondria; Calpain; Neurovirology;
Kainic acid-induced neurodegeneration and activation of inflammatory processes in organotypic hippocampal slice cultures: Treatment with cyclooxygenase-2 inhibitor does not prevent neuronal death
Keywords: اکسید سمیت; Developing brain; Hippocampus; Excitotoxicity; Inflammation; Neuroprotection
TNF-α potentiates glutamate-induced spinal cord motoneuron death via NF-κB
Keywords: اکسید سمیت; Excitotoxicity; Glutamate transporter 1; Motoneuron; Nuclear factor-kappaB; Oxidative stress; Tumor necrosis factor-alpha;
Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease
Keywords: اکسید سمیت; alternative splicing; Alzheimer's disease; excitatory amino acid transporter 2; excitotoxicity; glutamate uptake; splice variant;
Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity
Keywords: اکسید سمیت; Brain injury; Calcium; Excitotoxicity; Ion channels; Neuroprotection; Glutamate
Calcium preconditioning triggers neuroprotection in retinal ganglion cells
Keywords: اکسید سمیت; excitotoxicity; neuroprotection; retinal ganglion cells; preconditioning; calcium; nicotinic AChRACh, acetylcholine; Akt, protein kinase B; AM, membrane permeable form; ANOVA, analysis-of-variance; Bcl2, B-cell lymphoma protein 2 [Ca+2]i, intracellular ca
Research ReportAn organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges
Keywords: اکسید سمیت; Excitotoxicity; Stroke; Glutamate; Patch clamp electrophysiology; Rat; AE; acquired epilepsy; SRED; spontaneous recurrent epileptiform discharges; OHSC; organotypic hippocampal slice culture; AED; anti-epileptic drug;
Functional reduction of SK3-mediated currents precedes AMPA-receptor-mediated excitotoxicity in dopaminergic neurons
Keywords: اکسید سمیت; Dopaminergic; SK channels; Apamin; 1-Ebio; CyPPA; NS8593 AMPA; Excitotoxicity; NeuroprotectionSK, small-conductance calcium-activated potassium channels; ISK, SK channel-mediated current; IAHP, afterhyperpolarization; VDCC, voltage-dependent calcium chann
Neurodegeneration, Neuroprotection, and Disease-Oriented NeuroscienceResearch PaperExposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing
Keywords: اکسید سمیت; ADAR2; excitotoxicity; RNA editing; amyotrophic lateral sclerosis (ALS); AMPA receptors; calpain activation; ADAR2; adenosine deaminase dependent on RNA 2; ALS; amyotrophic lateral sclerosis; APV; 2-amino-5-phosphonopentanoic acid; CNQX; 6-cyano-7-nitroqu
Excitotoxic neuroprotection and vulnerability with CaMKII inhibition
Keywords: اکسید سمیت; Excitotoxicity; Aberrant calcium signaling; Ischemia; Kinase inhibitors; Cortical neurons; CaMKII inactivation
Deficient mitochondrial Ca2+ buffering in the Cln8mnd mouse model of neuronal ceroid lipofuscinosis
Keywords: اکسید سمیت; Neurodegeneration; Neuronal ceroid lipofuscinosis (NCL); Excitotoxicity; Photolysis of caged calcium; Patch clamp
Sex differences in effects of excitotoxic spinal injury on below-level pain sensitivity
Keywords: اکسید سمیت; Spinal cord injury; Quisqualic acid; Central pain; Excitotoxicity; SCI pain;
Cleavage of the vesicular glutamate transporters under excitotoxic conditions
Keywords: اکسید سمیت; Brain ischemia; Calpains; Excitotoxicity; Oxygen and glucose deprivation; Vesicular glutamate transporters
Modeling neurodegenerative disease pathophysiology in thiamine deficiency: Consequences of impaired oxidative metabolism
Keywords: اکسید سمیت; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AQP-4; aquaporin-4; ATP; adenosine triphosphate; Aβ; amyloid-β peptide; APP; amyloid precursor protein; BBB; blood-brain barrier; BCSFB; blood-cerebrospinal fluid barrier; CT; computed tom
The unsolved puzzle of neuropathogenesis in glutaric aciduria type I
Keywords: اکسید سمیت; 3-OHGA; 3-hydroxyglutaric acid; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; APV; D-2-amino-5-phophonovalerate; BBB; blood-brain barrier; BCB; blood-cerebrospinal fluid barrier; CAT; catalase; CHO; Chinese hamster ovary; CK; creatine k
A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death
Keywords: اکسید سمیت; Amyotrophic lateral sclerosis; Motor neuron; Astrocyte; Excitotoxicity; Metabotropic glutamate receptor 5; MPEP; BDNF;
Post-ischemic administration of nimodipine following focal cerebral ischemic-reperfusion injury in rats alleviated excitotoxicity, neurobehavioural alterations and partially the bioenergetics
Keywords: اکسید سمیت; [Ca]i; intracellular calcium; ANOVA; Analysis of Variance; ANSA; 1-amino-2- napthol-4-sulphonic acid; ATP; adenosine triphosphate; BHT; butylated hydroxyl toluene; CA1; cornu ammonis; VDCC; voltage dependent calcium channel; CCB; calcium channel blockers;
HIV-Tat elicits microglial glutamate release: Role of NAPDH oxidase and the cystine-glutamate antiporter
Keywords: اکسید سمیت; Excitotoxicity; Glia; Inflammation; Morphine; HIV-associated neurocognitive disorders; Oxidative stress;
Retinal blood vessels are damaged in a rat model of NMDA-induced retinal degeneration
Keywords: اکسید سمیت; Endothelial cells; Excitotoxicity; Retinal degeneration; Retinal blood vessel
Mild as well as severe insults produce necrotic, not apoptotic, cells: Evidence from 60-min seizures
Keywords: اکسید سمیت; Apoptosis; Caspase-3; Excitotoxicity; Necrosis; Programmed cell death; Status epilepticus;