Down-regulation of EZH2 expression in myelodysplastic syndromes
Keywords: Myelodysplastic syndromes; EZH2; Histone methylation; Epigenetics;
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Expression of DNA methyltransferases 1 and 3B correlates with EZH2 and this 3-marker epigenetic signature predicts outcome in glioblastomas
Keywords: DNMT1; DNMT3A; DNMT3B; EZH2; GBM; Survival;
Research papermiR-340 impedes the progression of laryngeal squamous cell carcinoma by targeting EZH2
Keywords: LSCC; laryngeal squamous cell carcinoma; EZH2; enhancer of zest homolog; qRT-PCR; quantitative real-time-polymerase chain reaction; ATCC; American Type Culture Collection; BrdU; 5-bromo-2â²-deoxyuridine; DMEM; Dulbecco modified Eagle medium; FBS; fetal b
BCR/ABL increases EZH2 levels which regulates XIAP expression via miRNA-219 in chronic myeloid leukemia cells
Keywords: EZH2; BCR/ABL; XIAP; miR-219
MicroRNAs in CD4+ T cell subsets are markers of disease risk and T cell dysfunction in individuals at risk for type 1 diabetes
Keywords: Type 1 diabetes; miRNA; nTreg; miR-26a; EZH2; FOXP3; TIGIT;
ASC-J9®, and not Casodex or Enzalutamide, suppresses prostate cancer stem/progenitor cell invasion via altering the EZH2-STAT3 signals
Keywords: Prostate cancer; Stem/progenitor cell; Androgen deprivation therapy; EZH2; ASC-J9®
miR-214 protects erythroid cells against oxidative stress by targeting ATF4 and EZH2
Keywords: ATF-4; activating transcription factor 4; Bim; BCL2-like 11; EZH2; enhancer of zeste 2 polycomb repressive complex 2 subunit; eIF2; eukaryotic initiation factor-2; Fe-NTA; ferric nitrilotriacetate; Hri; eukaryotic translation initiation factor 2 alpha kin
Cancer development, chemoresistance, epithelial to mesenchymal transition and stem cells: A snapshot of IL-6 mediated involvement
Keywords: Cytokine; IL-6; Cancer stem cell; Chemoresistance and EMT; MAPK; mitogen-activated protein kinases; STAT3; signal transducer and activator of transcription 3; gp130; glycoprotein 130; C/EBP; CCAAT/enhancer-binding protein; JAK; Janus kinase; PI3K; phospho
S-adenosylhomocysteine induces inflammation through NFkB: A possible role for EZH2 in endothelial cell activation
Keywords: S-adenosylhomocysteine; Endothelial activation; Adhesion molecules; NFkB; Methylation; EZH2
Theanine from tea and its semi-synthetic derivative TBrC suppress human cervical cancer growth and migration by inhibiting EGFR/Met-Akt/NF-κB signaling
Keywords: TBrC; ethyl 6-bromocoumarin-3-carboxylyl l-theanine; BrC; ethyl 6-bromocoumarin-3-carboxylic acid; NF-κB; nuclear factor κB; HGF; hepatocyte growth factor; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EZH2; enhancer of zeste hom
Aberrant differential expression of EZH1 and EZH2 in Polycomb repressive complex 2 among B- and T/NK-cell neoplasms
Keywords: EZH2; EZH1; EED; SUZ12; Polycomb group
EZH2, an on-off valve in signal network of tumor cells
Keywords: EZH2; Double facet; Signaling; Histone modulation; Tumor;
MicroRNA-126 increases chemosensitivity in drug-resistant gastric cancer cells by targeting EZH2
Keywords: miR-126; Chemosensitivity; EZH2; Gastric cancer;
Common and differentially expressed long noncoding RNAs for the characterization of high and low grade bladder cancer
Keywords: (lncRNAs); long non-coding RNAs; (DEGs); differentially expressed genes; (eukaryotic translation initiation factor 3, subunit E); EIF3E; (UC); urothelial carcinoma; (Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit); EZH2; (metastasis associated
EZH2 promotes invasion and metastasis of laryngeal squamous cells carcinoma via epithelial-mesenchymal transition through H3K27me3
Keywords: EZH2; H3K27me3; Laryngeal squamous cells carcinoma; Metastasis; Epithelial-mesenchymal transition;
MYC amplification in multiple marker chromosomes and EZH2 microdeletion in a man with acute myeloid leukemia
Keywords: Acute myeloid leukemia; Genetic abnormality; MYC; EZH2; Marker chromosomes
SAH derived potent and selective EZH2 inhibitors
Keywords: EZH2; SAH; Nucleoside; Homology model
The emergence of long non-coding RNAs in the tumorigenesis of hepatocellular carcinoma
Keywords: lncRNA; long non-coding RNA; HCC; hepatocellular carcinoma; HBV; hepatitis B virus; miRNA; microRNA; MALAT1; lincRNA metastasis associated lung adenocarcinoma transcript 1; H19; gene comes from colon pH19; Hotair; HOX antisense intergenic RNA; EZH2; enhan
Overexpression of EZH2 associates with a poor prognosis in chronic lymphocytic leukemia
Keywords: Chronic lymphocytic leukemia; EZH2; Histone methyltransferase; Gene expression; Cytogenetic;
Transcriptome and H3K27 tri-methylation profiling of Ezh2-deficient lung epithelium
Keywords: Ezh2; Lung; Development; RNA-seq; ChIP-seq
Discovery, design, and synthesis of indole-based EZH2 inhibitors
Keywords: EZH2; PRC2; Histone methyltransferase; Epigenetics; Pyridone
New polycomb group protein enhancer of zeste homolog (EZH) 2-derived peptide with the potential to induce cancer-reactive cytotoxic T lymphocytes in prostate cancer patients with HLA-A3 supertype alleles
Keywords: Prostate cancer; EZH2; CTL; Peptide; HLA-A3 supertype allele
DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis
Keywords: EZH2; Human colon cancer HCT116 cells; DZNep; Anti-cancer mechanisms
A new kinetochore component CENP-W interacts with the polycomb-group protein EZH2 to promote gene silencing
Keywords: PRC2; EZH2; CENP-W; Kinetochore; Gene silencing; Oncogene; PRC2; polycomb repressive complex 2; CENP-W; centromere protein W; EZH2; enhancer of zeste homolog 2; SUZ12; suppressor of zeste 12; CENP-T; centromere protein T; HDAC; histone deacetylase; HOXA9;
Non-coding RNAs in gastric cancer
Keywords: ncRNAs; non-coding RNAs; sncRNAs; small ncRNAs; lncRNAs; long ncRNAs; snoRNAs; small nucleolar RNAs; piRNAs; Piwi-associated RNAs; miRNAs; microRNAs; tiRNAs; transcription initiation RNAs; lincRNAs; long intergenic ncRNAs; GC; gastric cancer; nts; nucleot
EZH2 is a negative prognostic factor and exhibits pro-oncogenic activity in glioblastoma
Keywords: Glioblastoma; EZH2; Prognostic biomarker; Tumor progression;
Clinical and prognostic relevance of EZH2 in breast cancer: A meta-analysis
Keywords: EZH2; Breast cancer; Prognosis; Overall survival; Meta-analysis
DNMT1 and EZH2 mediated methylation silences the microRNA-200b/a/429 gene and promotes tumor progression
Keywords: Histone modifications; DNA methylation; miR-200; DNMT; EZH2
Enhancer of zeste homolog-2 (EZH2) methyltransferase regulates transgelin/smooth muscle-22α expression in endothelial cells in response to interleukin-1β and transforming growth factor-β2
Keywords: Endothelial cell; EZH2; SM22α; Inflammation; Fibrosis; Chromatin;
Enhancer of zeste homolog 2 depletion induces cellular senescence via histone demethylation along the INK4/ARF locus
Keywords: PcG; polycomb group; EZH2; enhancer of zeste homolog 2; shRNA; short hairpin RNA; Rb; retinoblastoma; MDM2; murine double minute 2; CDKIs; cyclin-dependent kinase inhibitors; PRC1; polycomb repressive complex 1; PRC2; polycomb repressive complex 2; H3K27m
The Bmi-1 helix-turn and ring finger domains are required for Bmi-1 antagonism of (â) epigallocatechin-3-gallate suppression of skin cancer cell survival
Keywords: Bmi-1; B-cell-specific Moloney murine leukemia virus integration site 1; HT; helix-turn; RF; ring finger; Ezh2; enhancer of zeste homolog 2; PcG; polycomb group; H2AK119ub; histone H2A ubiquitinated on lysine 119; H3K27me3; histone H3 trimethylation on
Whole genome and transcriptome analysis of a novel AML cell line with a normal karyotype
Keywords: NK-AML cell line; RNA-seq; Cytokines; GATA2; EZH2;
Research ArticleHotair mediates hepatocarcinogenesis through suppressing miRNA-218 expression and activating P14 and P16 signaling
Keywords: Bmi-1; B lymphoma mouse Moloney leukemia virus insertion region 1; CDS; the coding sequence; ceRNA; competitive endogenous RNAs; EZH2; Enhancer of zeste homolog 2; HCC; hepatocellular carcinoma; Hotair; Hox transcript antisense intergenic RNA; lncRNAs; Lo
Polycomb recruitment at the Class II transactivator gene
Keywords: PRC2; polycomb repressive complex 2; EZH2; enhancer of zeste homolog 2; JARID2; jumonji, AT rich interactive domain 2; YY1; Yin-Yang 1; CIITA pIV; class II transactivator promoter IV; MHC; major histocompatibility complex; lncRNA; long non-coding RNA; HOT
Translational implications of the β-cell epigenome in diabetes mellitus
Keywords: Arx; arista-less-related homeobox protein; CDK5; cyclin-dependent kinase 5; CpG; Cytosine-phosphodiester-bond-guanine; DM; diabetes mellitus; EZH2; enhancer of zeste homolog 2; GLP-1; glucagonlike peptide 1; GWAS; genomewide association study; H3-K4; Lys-
Germline-derived DNA methylation and early embryo epigenetic reprogramming: The selected survival of imprints
Keywords: 5mC; 5-methylcytosine; ES cells; embryonic stem cells; SAM; S-adenosyl-methionine; Dnmt; DNA methyltransferase; Uhrf1; Ubiquitin-like, containing PHD and RING finger domains 1; H3K; Histone H3 lysine; Cfp1; CXXC finger protein 1; Ezh2; enhancer of zeste h
Research ArticleA CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients
Keywords: HCC; hepatocellular carcinoma; HBV; hepatitis B virus; E2F1; E2F transcription factor 1; EZH2; enhancer of zeste homolog 2; PRC2; polycomb repressive complex 2; H3K27me3; trimethylation of lysine 27 at histone H3; AR; androgen receptor; CCRK; cell cycle-r
Genome methylation patterns in male breast cancer - Identification of an epitype with hypermethylation of polycomb target genes
Keywords: Male breast cancer; Methylation; Epitype; EZH2; Polycomb target genes; JARID1B;
Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications
Keywords: Short chain fatty acids; SIRT1; EZH2; P-TEFb; HIV-1 transactivation;
The histone chaperone HJURP is a new independent prognostic marker for luminal A breast carcinoma
Keywords: Chromatin; Epigenetics; Biomarkers; Prognosis; MKI67; CENP-A; AFA; Adaptive Focused Acoustics; ASF1; anti-silencing function 1; BCSS; breast cancer specific survival; BLC; basal-like cancer; CAF-1; chromatin assembly factor 1; CENP-A; centromere protein A
Canonical and non-canonical roles of the histone methyltransferase EZH2 in mammary development and cancer
Keywords: EZH2; Histone methyltransferase; Breast;
Reactive oxygen species contribute to arsenic-induced EZH2 phosphorylation in human bronchial epithelial cells and lung cancer cells
Keywords: Arsenic; Oxidative stress; EZH2; Akt; Phosphorylation; Cytoplasmic translocation
Biological evaluation of tanshindiols as EZH2 histone methyltransferase inhibitors
Keywords: EZH2; enhancer of zeste homologue 2; ELISA; enzyme-linked immunosorbent assay; IC50; half maximal inhibitory concentration; GI50; half maximal growth-inhibitory concentration; Ki; dissociation constant of the enzyme-inhibitor complex; EED; embryonic ect
EZH2, a Potential Regulator of Dental Pulp Inflammation and Regeneration
Keywords: Cell proliferation; EZH2; human dental pulp cells; inflammation; regeneration
FOXA1 antagonizes EZH2-mediated CDKN2A repression in carcinogenesis
Keywords: FOXA1; EZH2; CDKN2A; Carcinogenesis
Research ArticleThe functional and mechanistic relatedness of EZH2 and menin in hepatocellular carcinoma
Keywords: HCC; hepatocellular carcinoma; PcG; polycomb group; H3K27me3; histone 3 lysine 27 trimethylation; EZH2; enhancer of zeste homolog 2; SUZ12; suppressor of zeste 12; TrxG; trithorax group; MLL; mixed-lineage leukemia proteins; MEN1; multiple endocrine neopl
Huaier suppresses proliferation and induces apoptosis in human pulmonary cancer cells via upregulation of miR-26b-5p
Keywords: miR-26b-5p; Huaier; Lung cancer; EZH2; Proliferation; Apoptosis;
Identification and characterization of microRNAs in the crab-eating macaque (Macaca fascicularis) using transcriptome analysis
Keywords: miRNAs; microRNAs; M. fascicularis; Macaca fascicularis; SMC; skeletal muscle cell; ES; embryonic stem; HF; heart failure; RCC; renal cell carcinoma; MFE; minimal folding free energy; MFEI; minimal folding free energy index; DEPC; diethylpyrocarbonate; PB
Activating mutations of the oncogene EZH2 in cutaneous melanoma revealed by next generation sequencing
Keywords: EZH2; Melanoma; Transcriptome sequencing; Lymphoma
Cardiac hypertrophy and dysfunction induced by overexpression of miR-214 in vivo
Keywords: microRNA; Cardiac hypertrophy; EZH2; Transgenic mouse; Therapeutic target