کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10814975 | 1058438 | 2016 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
EZH2, an on-off valve in signal network of tumor cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Enhancer Zeste 2 (EZH2) is a histone methyltransferase catalyzing histone H3K27me3 to mediate gene silence. It is implicated in governing various biological behaviors of human malignancies. In this review, we over-review EZH2 serves as an “on-off valve”-not only as a critical epigenetic repressor, but as a brand-new activator for specific downstream targets as well. Time and space it “switching on-off” depends on the context and its cellular type. Moreover, EZH2 could act as a Tumor-Defender under certain circumstances. Moreover, the “Mutual-Inhibition” relationship between EZH2 and microRNAs is elaborated. In addition, we focus on different functions of phosphorylatied EZH2 in tumor cells. Finally, EZH2 inhibitors are summarized and newly-discovered strategies of targeting-EZH2 treatment are prospected.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 28, Issue 5, May 2016, Pages 481-487
Journal: Cellular Signalling - Volume 28, Issue 5, May 2016, Pages 481-487
نویسندگان
Shanshan Sun, Feng Yu, Lun Zhang, Xuan Zhou,