Fibroblast activation protein (FAP) as a novel metabolic target
Keywords: FAP; FGF21; DPP4; Metabolic regulation; Obesity; Diabetes;
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Mapping the response of human fibroblast growth factor 21 (FGF21) promoter to serum availability and lipoic acid in HepG2 hepatoma cells
Keywords: ACTB; β-actin; CPT1A; carnitine palmitoyltransferase 1α; CBP; CREB binding factor; CREB; cAMP response element-binding protein; DHLA; DL-α-dihydrolipoic acid; Elk-1; ETS domain-containing Elk-1; Elk-4; ETS domain-containing Elk-4 (aka SAP-1); ENCODE; e
FGF21 improves cognition by restored synaptic plasticity, dendritic spine density, brain mitochondrial function and cell apoptosis in obese-insulin resistant male rats
Keywords: FGF21; Obese; Insulin resistance; Cognition; Brain mitochondria;
FGF21 represses cerebrovascular aging via improving mitochondrial biogenesis and inhibiting p53 signaling pathway in an AMPK-dependent manner
Keywords: FGF21; Aging; p53; Mitochondrial biogenesis; AMPK
The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress
Keywords: Mitochondria; Stress response; Metabolic stress; Obesity; FGF21
BMP-9 enhances fibroblast growth factor 21 expression and suppresses obesity
Keywords: ALT; BMP-9; FGF21; Obesity; Stem cell; UCP1;
The role of mitochondrial DNA damage in the development of atherosclerosis
Keywords: AMPK; AMP activated protein kinase; cGAS; cyclic GMP-AMP synthase; DAMP; damage-associated molecular pattern; Drp1; dynamin-related protein 1; FGF21; fibroblast growth factor 21; IFN; interferon; MOMP; mitochondrial outer membrane permeabilisation; MPTP;
Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis
Keywords: DIO; diet induced obesity; FGF; fibroblast growth factor; FGFR; fibroblast growth factor receptor; UCP1; uncoupling protein 1; KO; knockout; CNS; central nervous system; SNA; sympathetic nerve activity; ICV; intracerebroventricular; ChREBP; carbohydrate r
Curcumin induces brown fat-like phenotype in 3T3-L1 and primary white adipocytes
Keywords: ACC; acyl-CoA carboxylase; AMPK; AMP-activated protein kinase; Brite; brown in white; BAT; brown adipose tissue; CYT C; cytochrome C; C/EBP/Cebp; CCAAT/enhancer-binding protein/encoding gene; CPT; carnitine palmitoyltransferase; Fgf21; gene encoding fibro
Up-regulation of Nrf2 is involved in FGF21-mediated fenofibrate protection against type 1 diabetic nephropathy
Keywords: Diabetic nephropathy; PPARα agonist; FGF21; Nrf2; Type 1 diabetes; Oxidative stress; Antioxidants;
Genomics of human fatty liver disease reveal mechanistically linked lipid droplet-associated gene regulations in bland steatosis and nonalcoholic steatohepatitis
Keywords: ACACB; acetyl-CoA carboxylase beta acetyl-CoA carboxylase beta; ACAT1; acetyl-CoA acetyltransferase 1; ACLY; ATP citrate lyase; AMPK; 5â²AMP-activated protein kinase; ASCL1; acyl-CoA synthetase long-chain family member 1; ACSL4; acyl CoA synthetases long
Ingestion of eicosapentaenoic acid in the early stage of social isolation reduces a fibroblast growth factor 21 resistant state independently of body weight in KKAy mice
Keywords: EPA; FGF21; GLP-1; Hyperglycemia; Hypertriglyceridemia; ChREBP; SREBP1c; Periostin; gp78; Notch; Lipogenesis;
FGF21, energy expenditure and weight loss – How much brown fat do you need?
Keywords: FGF21; UCP1; Brown fat; Energy expenditure
Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion
Keywords: FGF21; UCP1; Thermogenesis; BAT; iWAT; Obesity
Growth differentiation factor 11 is a protective factor for osteoblastogenesis by targeting PPARgamma
Keywords: GDF11; growth differentiation factor 11; PPAR-γ; peroxisome proliferator-activated receptor γ; MSC; mesenchymal stem cell; ELISA; enzyme linked immunosorbent assay; FGF21; fibroblast growth factor 21; ERα; estrogen-related receptor α; PGC-1β; PPAR-ga
Fructose ingestion acutely stimulates circulating FGF21 levels in humans
Keywords: FGF21; Fructose; ChREBP; Metabolic syndrome
Fibroblast growth factor 21 (FGF21) ameliorates collagen-induced arthritis through modulating oxidative stress and suppressing nuclear factor-kappa B pathway
Keywords: RA; rheumatoid arthritis; FGF21; fibroblast growth factor 21; CIA; collagen-induced arthritis; IL-1β; interleukin-1β; TNF-α; tumor necrosis factor; IL-6; interleukin-6; IFN-γ; interferon-γ; MMP-3; matrix metalloproteinase-3; IL-10; interleukin-10; DE
FGF21 Revolutions: Recent Advances Illuminating FGF21 Biology and Medicinal Properties
Keywords: FGF21; FGFR; KLB; metabolic regulation; hormones; drug development
Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex
Keywords: Brown adipose tissue; Therapeutic antibody; Thermogenesis; Adipose tissue browning; Humanized antibody; Adiponectin; FGF21; FGF19; FGFR1; betaKlotho; UCP1; Bispecific antibody; Insulin resistance; Obesity; Type 2 diabetes; Hepatosteatosis; NASH
Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR-YY1-PGC1α pathway
Keywords: CS; citrate synthase; ECAR; extracellular acidification rate; FGF21; fibroblast growth factor; MELAS; mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes; mtDNA; mitochondrial DNA; mTOR; mammalian target of rapamycin; mTORC; mTOR co
B-cell-activating factor deficiency attenuates high-fat diet-induced glucose intolerance by potentiating adipose tissue function
Keywords: B-cell-activating factor; Glucose tolerance; Brown adipose tissue; FGF21; Leptin; IL-10;
The modulating effect of Persea americana fruit extract on the level of expression of fatty acid synthase complex, lipoprotein lipase, fibroblast growth factor-21 and leptin - A biochemical study in rats subjected to experimental hyperlipidemia and obesit
Keywords: Hyperlipidemia; Fatty acid synthase; Leptin; Fibroblast growth factor-21; Adiponectin; Lipoprotein lipase; HFEA; hydroalcoholic fruit extract of avocado; HFD; high fat diet; FGF21; fibroblast growth factor 21; FASN; fatty acid synthase; LPL; lipoprotein l
1-Benzyl-4-phenyl-1H-1,2,3-triazoles improve the transcriptional functions of estrogen-related receptor γ and promote the browning of white adipose
Keywords: ERR; estrogen-related receptor; WAT; white adipose tissue; BAT; brown adipose tissue; PET; positron-emission-tomography; FGF21; fibroblast growth factor 21; MOA; mechanisms of action; UCP1; uncoupling protein 1; SHP; small heterodimer partner; ATP5b; ATP
Alpha lipoic acid induces hepatic fibroblast growth factor 21 expression via up-regulation of CREBH
Keywords: FGF21; Alpha lipoic acid; CREBH; Liver;
Research ArticleSerum FGF21 increases with hepatic fat accumulation in pediatric onset intestinal failure
Keywords: IF; intestinal failure; PN; parenteral nutrition; IFALD; intestinal failure associated liver disease; FGF21; fibroblast growth factor 21; LDL; low-density lipoprotein; HDL; high-density lipoprotein; GT; glutamyl transferase; ALT; alanine aminotransferase;
Inventing new medicines: The FGF21 story
Keywords: FGF21; LY2405319; Metabolism; Drug discovery
Hydrodynamic delivery of FGF21 gene alleviates obesity and fatty liver in mice fed a high-fat diet
Keywords: Hydrodynamic gene delivery; FGF21; Obesity; Diabetes; Fatty liver; Thermogenesis
Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH)
Keywords: ATGL; adipose triglyceride lipase; ACC1; acetyl-CoA carboxylase; ACSL1; long-chain fatty-acid-coenzyme A ligase; ap2/FABP4; adipocyte protein 2/fatty acid binding protein 4; ATP5B; ATP synthase, HÂ + transporting mitochondrial F1 complex, beta subunit; BA
Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21
Keywords: Liver-Specific Disruption of Sirt1; Hepatocyte-Derived Hormone; Metabolic Homeostasis; Obesity; Ad; adenovirus; BAT; brown adipose tissue; CPT1α; carnitine palmitoyltransferase 1α; FAS; fatty acid synthase; FGF21; fibroblast growth factor 21; MCAD; medi
Thermogenic adipocytes: From cells to physiology and medicine
Keywords: ATP; adenosine triphosphate; BAT; brown adipose tissue; BMI; body mass index; Bmp; bone morphogenetic protein; cPGI2; carbaprostacyclin; cAMP; cyclic adenosine monophosphate; C/EBPβ; CCAAT/enhancer binding protein β; cGMP; cyclic guanosine monophosphate
Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation
Keywords: Metformin; FGF21; ATF4; AMPK; Diabetes;
Transcriptional profiling in rats and an ex vivo analysis implicate novel beneficial function of egg shell membrane in liver fibrosis
Keywords: α-Sma; smooth muscle-α-actin; BHLHB2; basic helix-loop-helix domain containing class B2; COL1A1; collagen, type I, alpha 1; COL1A2; collagen, type I, alpha 2; CYP7A1; cytochrome P450 Family 7 Subfamily A Polypeptide 1; DMEM; Dulbecco's modified eagleâ
Artemisia scoparia extract attenuates non-alcoholic fatty liver disease in diet-induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of FGF21 pathway
Keywords: FGF21; Fibroblast growth factor 21; FGFR; Fibroblast growth factor receptor, NAFLD, nonalcoholic fatty liver disease; IPGTT; intraperitoneal glucose tolerance test. AMPK, AMP-activated protein kinase; Obesity; Insulin resistance; NAFLD; FGF21; AMPK;
Bone marrow mesenchymal stem cells: Fat on and blast off by FGF21
Keywords: Bone marrow mesenchymal stem cell; Osteoblast; Adipocyte; FGF21; PPARγ
Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice
Keywords: FGF21; Insulin resistance; Hyperinsulinemic–euglycemic clamp; Diabetes; Mouse
The cell adhesion molecule L1 regulates the expression of FGF21 and enhances neurite outgrowth
Keywords: Neurite outgrowth; L1; FGF21; FGFR;
Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones
Keywords: FGF21; Rosiglitazone; PPARγ; Metabolism; Adiponectin
Protective effect of FGF21 on type 1 diabetes-induced testicular apoptotic cell death probably via both mitochondrial- and endoplasmic reticulum stress-dependent pathways in the mouse model
Keywords: FGF21; Testicular apoptosis; Type 1 diabetes; Bax/Bcl2; Endoplasmic reticulum stress; Mitochondrial cell death
Oral bezafibrate induces daily torpor and FGF21 in mice in a PPAR alpha dependent manner
Keywords: Core body temperature; Torpor; Hibernation; PPARα; FGF21;
Research ArticleNon-invasive diagnosis of non-alcoholic steatohepatitis by combined serum biomarkers
Keywords: AFABP; adipocyte fatty acid binding protein; ALT; alanine aminotransferase; AUROC; area under the receiver operating characteristic curve; BMI; body mass index; CK-18; cytokeratin-18 fragments; FGF21; fibroblast growth factor 21; LDL; low density lipoprot
Allelic and phenotypic spectrum of plasma triglycerides
Keywords: ABL; abetalipoproteinemia; ANGPTL3; angiopoietin-like 3; ANGPTL4; angiopoietin-like 4; APOA4; apolipoprotein A-IV; APOA5; apolipoprotein A-V; APOB; apolipoprotein B; APOC2; apolipoprotein C-II; APOC3; apolipoprotein C-III; APOE; apolipoprotein E; CAD; cor
Hormone-like fibroblast growth factors and metabolic regulation
Keywords: FGF19; FGF21; FGF23; Klotho; βKlotho; Metabolic regulation
The link between fibroblast growth factor 21 and sterol regulatory element binding protein 1c during lipogenesis in hepatocytes
Keywords: FGF21; Lipogenesis; SREBP1c; Promoter; Hepatocyte
The Peptidic GHS-R antagonist [D-Lys3]GHRP-6 markedly improves adiposity and related metabolic abnormalities in a mouse model of postmenopausal obesity
Keywords: BAT; brown adipose tissue; DIO; diet-induced obesity; E2; 17β-estradiol-3-benzoate; FGF21; fibroblast growth factor 21; GHS-R; ghrelin receptor; HF; high fat (diet); OVX; ovariectomized; PPAR; alpha peroxisome proliferator-activated receptor alpha; SC; s
Hepatosteatosis in peroxisome deficient liver despite increased β-oxidation capacity and impaired lipogenesis
Keywords: Hepatosteatosis; Fatty acid oxidation; Fatty acid uptake; PPARα; ACC; acetyl-CoA carboxylase; ACLY; ATP citrate lyase; Acox1; acyl-CoA oxidase; Adfp; adipose differentiation related protein; Apo; apolipoprotein; Cpt; carnitine palmitoyltransferase; DHA;
The FGFR D3 Domain Determines Receptor Selectivity For Fibroblast Growth Factor 21
Keywords: FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor; pERK, phospho-ERK; MSD, Meso Scale Discoveryfibroblast growth factor; FGF19; FGF21; FGFR1c; FGFR4
Circadian expression of FGF21 is induced by PPARα activation in the mouse liver
Keywords: Circadian rhythm; FGF21; Fibrate; PDK4; Fasting; PPARα
PPARα is a key regulator of hepatic FGF21
Keywords: Diabetes; Fasting; Fibrates; Fibroblast growth factor 21; FGF21; ob/ob Mice; Peroxisome proliferator-activated receptor α; PPARα; Wy-14,643
The fasting polypeptide FGF21 can enter brain from blood
Keywords: FGF21; Blood–brain barrier; Metabolism