دانلود مقالات ISI درباره Fgfr + ترجمه فارسی

Recent advances of RAF (rapidly accelerated fibrosarcoma) inhibitors as anti-cancer agents

Keywords: MAPK; RAF inhibitors; Anti-cancer agents; Abl; Abelson murine leukemia viral oncogene; ATP; Adenine triphosphate; Bcl-2; B-cell lymphoma; CNS; Central nervous system; COX-2; Cyclo-oxygenase enzyme-2; CR; Conserved region; CRD; Cysteine-rich domain; DFG; A

دانلود رایگان متن کامل مقاله ISI 57 صفحه سال انتشار : 2018 سفارش ترجمه

MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma

Keywords: Organoid; AUY922; Bile Duct Cancer; DNAJB5; CCA; cholangiocarcinoma; DMSO; dimethyl sulfoxide; FFPE; formalin-fixed paraffin-embedded; FGFR; fibroblast growth factor receptor; GI; growth inhibition; HSP; heat shock protein; HTS; high-throughput screen; iC

دانلود رایگان متن کامل مقاله ISI 59 صفحه سال انتشار : 2018 سفارش ترجمه

Role of RET protein-tyrosine kinase inhibitors in the treatment RET-driven thyroid and lung cancers

Keywords: ARTN; artemin; AS; activation segment; CD; cadherin-like domain; CDK; cyclin-dependent protein kinase; CL; catalytic loop; CS or C-spine; catalytic spine; CTT; carboxyterminal tail; EGFR; epidermal growth factor receptor; FGFR; fibroblast growth factor re

دانلود رایگان متن کامل مقاله ISI 70 صفحه سال انتشار : 2018 سفارش ترجمه

The role of small molecule platelet-derived growth factor receptor (PDGFR) inhibitors in the treatment of neoplastic disorders

Keywords: Axitinib: (PubMED CID: 6450551); Dasatinib: (PubMED CID: 3062316); Imatinib: (PubMED CID: 5291); Lenvatinib: (PubMED CID: 9823820); Nilotinib: (PubMed CID: 644241); Nintedanib: (PubMed CID: 9809715); Ponatinib: (PubMed CID: 24826799); Sorafenib: (PubMed C

دانلود رایگان متن کامل مقاله ISI 71 صفحه سال انتشار : 2018 سفارش ترجمه

Cell adhesion and matricellular support by astrocytes of the tripartite synapse

Keywords: β (Greek Small Letter Beta): 03B2; α (Greek Small Letter Alpha): 03B1; δ (Greek Small Letter Delta): 03B4; γ (Greek Small Letter Gamma): 03B3; ACM; astrocyte-conditioned medium; AMIGO; adhesion molecule with IG-like domain; AMOG; A Molecule On Glia; A

دانلود رایگان متن کامل مقاله ISI 75 صفحه سال انتشار : 2018 سفارش ترجمه

Optimization of 1H-indazol-3-amine derivatives as potent fibroblast growth factor receptor inhibitors

Keywords: FGFR; Inhibitors; Cellular activity; Fluorine;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

A Functional Genetic Screen Identifies the Phosphoinositide 3-kinase Pathway as a Determinant of Resistance to Fibroblast Growth Factor Receptor Inhibitors in FGFR Mutant Urothelial Cell Carcinoma

Keywords: FGFR; Bladder cancer; PI3K; Synergy;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Apert syndrome with S252W FGFR2 mutation and characterization using Phenomizer: An Indian case report

Keywords: FGFR; fibroblast growth factor receptor; BKT; Binet Kamat intelligence test; ADHD; attention deficit hyperactivity disorder; Craniosynostosis; Apert syndrome; FGFR2; Phenomizer; Genetic diagnosis;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Docosahexaenoic acid induces glial cell-line derived neurotrophic factor release in C6 glioma cells: Implications of antidepressant effects for docosahexaenoic acid

Keywords: DHA; GDNF; ERK; PKC; FGFR; Antidepressant;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Dental issues in lacrimo-auriculo-dento-digital syndrome

Keywords: Dental enamel; caries; salivary glands; genetics; Sjögren disease; ADHD; Attention deficit hyperactivity disorder; d; Died; dx; Diagnosis; FGF; Fibroblast growth factor; FGFR; Fibroblast growth factor receptor; LADD; Lacrimo-auriculo-dento-digital; SVT;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Comparative analysis of the neurula transcriptomes of two species of flatfishes: Platichthys stellatus and Paralichthys olivaceus

Keywords: BMP; Bone Morphogenetic Protein; BMPR; Bone Morphogenetic Protein Receptor; BLAST; Basic Local Alignment Search Tool; ERBB; Erb-b2 Receptor Tyrosine Kinase; FGF; Fibroblast Growth Factor; FGFR; Fibroblast Growth Factor Receptor; FZ; Frizzled; HOXB1B; Home

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Vascular calcification in CKD-MBD: Roles for phosphate, FGF23, and Klotho

Keywords: CAVD; calcific aortic valve disease; CKD; chronic kidney disease; CKD-MBD; CKD-mineral and bone disorder; ESKD; endstage kidney disease; FGF23; fibroblast growth factor 23; FGFR; fibroblast growth factor receptor; Pi; phosphate; PTH; parathyroid hormone;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

TMDOCK: An Energy-Based Method for Modeling α-Helical Dimers in Membranes

Keywords: 3D; three-dimensional; APP; amyloid precursor protein; Eph; ephrin receptor; EFDOCK-TM; Evolutionary-guided Fold and Dock of TransMembrane proteins; FGFR; fibroblast growth factor receptor; FMAP; folding of membrane-associated peptides; MD; molecular dyna

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

FGFR a promising druggable target in cancer: Molecular biology and new drugs

Keywords: Cancer; FGF; FGFR; FGFR inhibitors;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Strategies for development of optogenetic systems and their applications

Keywords: AU1; Aureochrome 1; BLUF; blue-light-utilizing FAD; BphP1; bacterial bathy phytochrome 1; BV; biliverdin IXα; COP1; constitutively photomorphogenic 1; CRY2; cryptochrome 2; CIB1; cryptochrome interacting basic-helix-loop-helix protein 1; CPH1; cyanobacte

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Impact of chemotherapy-induced neutropenia (CIN) and febrile neutropenia (FN) on cancer treatment outcomes: An overview about well-established and recently emerging clinical data

Keywords: ABCC1/MRP; ATP binding cassette subfamily C member 1/ multidrug resistance protein; ABVD; doxorubicine-bleomycin-vinblastine-dacarbazine; AC; doxorubicin-cyclophosphamide; ANC; absolute neutrophil count; ASCO; American Society of Clinical Oncology; AUC; a

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Management of Muscle-Invasive Urothelial Cancer and the Emerging Role of Immunotherapy in Advanced Urothelial Cancer

Keywords: AKT; AKT serine/threonine kinase 1; BCG; bacillus Calmette-Guérin; CTLA4; cytotoxic T-lymphocyte-associated protein 4; EGFR; epidermal growth factor receptor; FDA; Food and Drug Administration; FGFR; fibroblast growth factor receptor; GC; gemcitabine p

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2017 سفارش ترجمه

Mutation of a putative MAP kinase consensus site regulates NCAM endocytosis and NCAM-dependent neurite outgrowth

Keywords: ERK; extracellular regulated kinase; FGFR; fibroblast growth factor receptor; MAP; mitogen-activated protein; NCAM; neural cell adhesion molecule; Human NCAM140; Endocytosis; ERK phosphorylation; Neurite outgrowth;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of novel Ponatinib analogues for reducing KDR activity as potent FGFRs inhibitors

Keywords: FGFR; KDR; Inhibitor; Anticancer; Ponatinib;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

ARQ 087 inhibits FGFR signaling and rescues aberrant cell proliferation and differentiation in experimental models of craniosynostoses and chondrodysplasias caused by activating mutations in FGFR1, FGFR2 and FGFR3

Keywords: ARQ 087; Fibroblast growth factor receptor; FGFR; Skeletal dysplasia; Achondroplasia; Craniosynostosis; Inhibitor;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

Loss of discoidin domain receptor 1 (DDR1) via CpG methylation during EMT in epithelial ovarian cancer

Keywords: DDR1; discoidin domain receptor 1; DDR2; discoidin domain receptor 2; EMT; epithelial-mesenchymal transition; EOC; epithelial ovarian cancer; RT-qPCR; reverse transcription quantitative polymerase chain reaction; ELISA; enzyme-linked immunosorbent assay;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

The structure property and endothelial protective activity of fucoidan from Laminaria japonica

Keywords: MMW; medium molecular weight; LMW; low molecular weight; vWF; von Willebrand Factor; TNF-α; tumor necrosis factor α; HUVEC; human umbilical vein endothelial cell; EMPs; endothelial microparticles; FGF; fibroblast growth factor; FGFR; fibroblast growth f

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2017 سفارش ترجمه

2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors

Keywords: FGFR; 2-Oxo-3,4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives; Irreversible inhibitor;

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2017 سفارش ترجمه

An overview of the binding models of FGFR tyrosine kinases in complex with small molecule inhibitors

Keywords: FGFR; Small molecule inhibitor; Crystal structure; DFG-in/out; Irreversible; Pharmacological activity;

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2017 سفارش ترجمه

Effects of Klotho on fibrosis and cancer: A renal focus on mechanisms and therapeutic strategies

Keywords: ACE; angiotensin converting enzyme; ADAM; a disintegrin and metalloproteinase; AKI; acute kidney injury; ANGII; angiotensin II; AT1; angiotensin II receptor type 1; AMPKα; AMP-activated protein kinase α; α-SMA; α-smooth muscle actin; CKD; chronic kidn

دانلود رایگان متن کامل مقاله ISI 82 صفحه سال انتشار : 2017 سفارش ترجمه

Fibroblast growth factors (FGFs) in cancer: FGF traps as a new therapeutic approach

Keywords: CAF; Cancer associated fibroblast; ECM; Extracellular matrix; EGF; Epidermal growth factor; FGF; Fibroblast growth factor; FGFR; Fibroblast growth factor receptor; GAG; Glycosaminoglycan; HS; Heparan sulfate; HSPG; Heparan sulfate proteoglycans; MAPK; Mit

دانلود رایگان متن کامل مقاله ISI 82 صفحه سال انتشار : 2017 سفارش ترجمه

Exenatide treatment decreases fasting fibroblast growth factor 21 levels in patients with newly diagnosed type 2 diabetes mellitus

Keywords: FGF21; fibroblast growth factor 21; T2DM; type 2 diabetes mellitus; HOMA-IR; homoeostasis model assessment for insulin resistance; HOMA-B; homoeostasis model assessment for β-cell function; FGFR; fibroblast growth factor receptor; BMI; body mass index; T

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Nintedanib in patients with idiopathic pulmonary fibrosis: Combined evidence from the TOMORROW and INPULSIS® trials

Keywords: Forced vital capacity; Acute exacerbations; Disease progression; Quality of life; Mortality; bid; twice daily; FGFR; fibroblast growth factor receptor; FVC; forced vital capacity; HR; hazard ratio; IPF; idiopathic pulmonary fibrosis; MedDRA; Medical Dicti

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Discovery of an artificial peptide agonist to the fibroblast growth factor receptor 1c/βKlotho complex from random peptide T7 phage display

Keywords: Peptide; Agonist; FGFR; βKlotho; FGF21; Phage display; FGFR; fibroblast growth factor receptor; KLB; βKlotho; FGF21; fibroblast growth factor 21; PEG; polyethyleneglycol; Egr-1; early growth response protein-1; RTK; receptor tyrosine kinase;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Sinapine reverses multi-drug resistance in MCF-7/dox cancer cells by downregulating FGFR4/FRS2α-ERK1/2 pathway-mediated NF-κB activation

Keywords: Sinapine; Doxorubicin; MCF-7/dox; P-glycoprotein; NF-κB; FGFR4; FGFR; fibroblast growth factor receptor; FRS2α; FGFR substrate protein-2α; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; NF-κB; nuclear factor kappa-light-chain-enhancer of activated B

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Cutaneous skeletal hypophosphatemia syndrome (CSHS) is a multilineage somatic mosaic RASopathy

Keywords: congenital melanocytic nevus; cutaneous skeletal hypophosphatemia syndrome; epidermal nevus; fibroblast growth factor-23; mosaicism; nevus syndrome; rickets; CSHS; cutaneous skeletal hypophosphatemia syndrome; FGF; fibroblast growth factor; FGFR; fibrobla

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

CommunicationsPathogenic Cysteine Removal Mutations in FGFR Extracellular Domains Stabilize Receptor Dimers and Perturb the TM Dimer Structure

Keywords: FGF; fibroblast growth factor; FGFR; fibroblast growth factor receptor; TM; transmembrane; EC; extracellular; RTK; receptor tyrosine kinase; QI-FRET; quantitative imaging FRET; I-FRET; intrinsic FRET; IC; intracellular; YFP; yellow fluorescent protein; FG

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Fgf regulates dedifferentiation during skeletal muscle regeneration in adult zebrafish

Keywords: EdU; 5-ethynyl-2′-deoxyuridine; EOM; extraocular muscle; hpi; hours post injury; dpi; days post injury; Fgf; fibroblast growth factor; Fgfr; fibroblast growth factor receptor; LR; lateral rectus; Tc; cell cycle length; Ts; length of S-phase; MAPK; mitog

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Efficient regulation of branching morphogenesis via fibroblast growth factor receptor 2c in early-stage embryonic mouse salivary glands

Keywords: SG; salivary gland; FGF; fibroblast growth factor; FGFR; fibroblast growth factor receptor; EMT; epithelial mesenchymal transition; PBS; phosphate-buffered saline; RT; reverse transcriptase; NA; neutral antibody; ERK; extracellular signal-regulated kinase

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Mapping the response of human fibroblast growth factor 21 (FGF21) promoter to serum availability and lipoic acid in HepG2 hepatoma cells

Keywords: ACTB; β-actin; CPT1A; carnitine palmitoyltransferase 1α; CBP; CREB binding factor; CREB; cAMP response element-binding protein; DHLA; DL-α-dihydrolipoic acid; Elk-1; ETS domain-containing Elk-1; Elk-4; ETS domain-containing Elk-4 (aka SAP-1); ENCODE; e

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Research ReportPossible involvement of basic FGF in the upregulation of PDGFRβ in pericytes after ischemic stroke

Keywords: CNS; central nervous system; BBB; blood-brain barrier; PDGF; platelet-derived growth factor; PDGFRβ; platelet-derived growth factor receptor β; bFGF; basic fibroblast growth factor; FGFR; fibroblast growth factor receptor; MCA; middle cerebral artery;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

ADAMs family and relatives in cardiovascular physiology and pathology

Keywords: ADAM; A disintegrin and metalloproteinase; ADAM-TS; ADAM with thrombospondin domains; APP; amyloid precursor protein; APPsα; α-secretase-released N-terminal APP domain; C-domain; cysteine-rich domain; COMP; cartilage oligomeric matrix protein; DCM; dila

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Blocking the FGF/FGFR system as a â¿¿two-compartmentâ¿¿ antiangiogenic/antitumor approach in cancer therapy

Keywords: Angiogenesis; Cancer; Cancer therapy; FGF; FGFR; Stroma; Therapeutic target;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Expression and localization of fibroblast growth factor (FGF) family in corpus luteum during different stages of estrous cycle and synergistic role of FGF2 and vascular endothelial growth factor (VEGF) on steroidogenesis, angiogenesis and survivability of

Keywords: Fibroblast growth factor; FGF; Vascular endothelial growth factor; VEGF; Corpus luteum; CL; Progesterone; P4; Fibroblast growth factor receptor; FGFR; Steroidogenic acute regulatory protein; StAR; Cytochrome P45011A1; CYP11A1; 3-beta-hydroxysteroid dehydr

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2016 سفارش ترجمه

FGFR antagonist induces protective autophagy in FGFR1-amplified breast cancer cell

Keywords: Breast cancer; FGFR; PD166866; Autophagy; mTOR;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2016 سفارش ترجمه

The activation of the NF-κB-JNK pathway is independent of the PI3K-Rac1-JNK pathway involved in the bFGF-regulated human fibroblast cell migration

Keywords: bFGF; basic Fibroblast Growth Factor; NF-κB; nuclear factor kappa B; c-JNK; Jun N-terminal kinase; PI3 K; phosphatidylinositol 3-kinase; FGFR; fibroblast growth factor receptor; RNA-Seq; RNA-Sequencing; IκB-α; inhibitor of nuclear factor kappa B-alpha;

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2016 سفارش ترجمه

Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis

Keywords: DIO; diet induced obesity; FGF; fibroblast growth factor; FGFR; fibroblast growth factor receptor; UCP1; uncoupling protein 1; KO; knockout; CNS; central nervous system; SNA; sympathetic nerve activity; ICV; intracerebroventricular; ChREBP; carbohydrate r

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2016 سفارش ترجمه

Design, synthesis and preliminary biological evaluation of C-8 substituted guanine derivatives as small molecular inhibitors of FGFRs

Keywords: FGFR; Guanine; Antitumor activity; Kinase inhibitor

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Regulatory effects of fibroblast growth factor-8 and tumor necrosis factor-α on osteoblast marker expression induced by bone morphogenetic protein-2

Keywords: ALK; activin receptor-like kinase; ActRII; activin type-II receptor; ALP; alkaline phosphatase; BMP; bone morphogenetic protein; BMPRII; BMP type-II receptor; ERK; extracellular signal-regulated kinase; FGF; fibroblast growth factor; FGFR; FGF receptor; M

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Inhibition of the insulin-like growth factor 1 receptor by CHM-1 blocks proliferation of glioblastoma multiforme cells

Keywords: EGFR; epidermal growth factor receptor; FGFR; fibroblast growth factor receptor; GBM; glioblastoma multiforme; IGF-1R; insulin-like growth factor-1 receptor; IR; insulin receptor; PDGFR; platelet-derived growth factor receptor; PI3K; phosphatidylinositol

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors

Keywords: Cell signaling; Transmembrane receptors; Signal to noise; FGFR; MET receptor;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Region-specific regulation of cell proliferation by FGF receptor signaling during the Wolffian duct development

Keywords: Fgfr; Ret; Receptor tyrosine kinase; Cell proliferation; Wolffian duct; Ureteric bud;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Autophagy in zebrafish

Keywords: 3MA; 3-methyladenin; AC; adenylyl cyclase; AMPK; adenosine monophosphate-dependent kinase; Atg; autophagy related gene; BafA1; Bafilomycin A1; CMV; cytomegalovirus; CQ; chloroquine; dpa; days post amputation; dpf; days post fertilization; ERK; extracellul

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Lineage-specific loss of FGF17 within the avian orders Galliformes and Passeriformes

Keywords: BMP; bone morphogenetic protein; Bpp; Bayesian posterior probabilities; cDNA; DNA complementary to RNA; CDS; coding sequence; FGF; fibroblast growth factor; FGFR; fibroblast growth factor receptor; indels; insertions/deletion; LRT; likelihood ratio test;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

FGF21 Revolutions: Recent Advances Illuminating FGF21 Biology and Medicinal Properties

Keywords: FGF21; FGFR; KLB; metabolic regulation; hormones; drug development

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه