کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5905468 | 1159895 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lineage-specific loss of FGF17 within the avian orders Galliformes and Passeriformes
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کلمات کلیدی
WntMCMCFGF8WGDFGF18LRTFGFRBayesian posterior probabilitiesFGFBPPRT-PCRSSDcDNA - cDNADNA complementary to RNA - DNA مکمل RNALikelihood ratio test - آزمون نسبت احتمالGene loss - از دست دادن ژنcoding sequence - توالی کدگذاریGenome duplication - تکثیر ژنومwhole genome duplication - تکثیر ژنوم کلMaximum likelihood - حداکثر احتمالMarkov chain Monte Carlo - زنجیره مارکف مونت کارلوfibroblast growth factor - فاکتور رشد فیبروبلاستBMP - مدیریت فرایند کسب و کارmegabase - مگابایتیmya - میاmillion years ago - میلیون سال پیشIndels - هندلReverse transcriptase-polymerase chain reaction - واکنش زنجیره ای واکنش زنجیره ای واکنش زنجیره ایBone morphogenetic protein - پروتئین مورفوژنیک استخوانCdS - کادمیم سولفید، سولفید کادمیمfibroblast growth factor receptor - گیرنده فاکتور رشد فیبروبلاست
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The genomic and developmental complexity of vertebrates is commonly attributed to two rounds of whole genome duplications which occurred at the base of the vertebrate radiation. These duplications led to the rise of several, multi-gene families of developmental proteins like the fibroblast growth factors (FGFs); a signaling protein family which functions at various stages of embryonic development. One of the major FGF assemblages arising from these duplications is the FGF8 subfamily, which includes FGF8, FGF17, and FGF18 in tetrapods. While FGF8 and FGF18 are found in all tetrapods and are critical for embryonic survival, genomic analyses suggest putative loss of FGF17 in various lineages ranging from frogs and fish, to the chicken. This study utilizes 27 avian genomes in conjunction with molecular analyses of chicken embryos to confirm the loss of FGF17 in chicken as a true, biological occurrence. FGF17 is also missing in the turkey, black grouse, Japanese quail and northern bobwhite genomes. These species, along with chicken, form a monophyletic clade in the order Galliformes. Four additional species, members of the clade Passeroidea, within the order Passeriformes, are also missing FGF17. Additionally, analysis of intact FGF17 in other avian lineages reveals that it is still under strong purifying selection, despite being seemingly dispensable. Thus, FGF17 likely represents a molecular spandrel arising from a genome duplication event and due to its high connectivity with FGF8/FGF18, and potential for interference with their function, is retained under strong purifying selection, despite itself not having a strong selective advantage.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 563, Issue 2, 1 June 2015, Pages 180-189
Journal: Gene - Volume 563, Issue 2, 1 June 2015, Pages 180-189
نویسندگان
John Abramyan,