Keywords: Aib; α-aminoisobutyric acid; Fmoc; fluorenylmethyloxycarbonyl; HPLC; high-performance liquid chromatography; HBM; Hepes-buffered medium; Peptide stapling; Pseudopeptide; Orexin; G protein-coupled receptor;
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Keywords: BBB; blood brain barrier; BK; bradykinin; Boc; t-butyloxycarbonyl; BR; bradykinin receptor; CNS; central nervous system; DALKD; [des-Arg10, Leu9]-kallidin; DIPEA; diisopropylethylamine; DMF; N,N-dimethylformamide; Dyn A; dynorphin A; Fmoc; fluorenylmethyl
Keywords: Fmoc; fluorenylmethyloxycarbonyl; FPGS; folylpoly-gamma glutamase synthase; MSNT; 1-(2- mesitylenesulfonyl)-3-nitro-1H-1,2,4-triazole; PMTX; pemetrexed; PMTXPG1; Pemetrexed-monoglutamic acid; PMTXPG2; pemetrexed-diglutamic acid; PMTXPG3; pemetrexed-triglu
Keywords: Diversity-oriented synthesis; Imidazoheterocyclic; Groebke-Blackburn-Bienayme reaction; Fused imidazole; Lewis acid; Ugi type; Ac; acetyl; Aq; aqueous; Ar; aryl; Bn; benzyl; Boc; tert-butoxycarbonyl; BDMS; bromodimethylsulfonium bromide; CDK; cyclin-d
Keywords: 1AA; 1-aminoanthracene; CAT; carnitine acetyltransferase; CE; capillary electrophoresis; CSP; chiral stationary phase; CV; coefficient of variation; CZE; capillary zone electrophoresis; DM; dry matter; DTNB; 5,5â²-dithiobis-2-nitrobenzoate; EDAC; 1-ethyl
Substrate-derived triazolo- and azapeptides as inhibitors of cathepsins K and S
Keywords: Azapeptide; Bradykinin; Cathepsin; 1,2,3-triazole heterocycle; Protease; Protease inhibitor; Abz; o-aminobenzoic acid; Ahx; 6-aminohexanoic acid; AEBSF; 4-(2-aminoethyl) benzenesulfonyl fluoride hydrochloride; AMC; 7-amino-4-methyl coumarin; BK; bradykini
Biopolymer nanogels improve antibacterial activity and safety profile of a novel lysine-based α-peptide/β-peptoid peptidomimetic
Keywords: Antimicrobial peptides; Peptidomimetics; Drug delivery; Nanogel; Infection; Pseudomonas aeruginosa; AMP; antimicrobial peptide; ASM; artificial sputum medium; CFU; colony forming unit; DCM; dichloromethane; DMEM; Dulbecco's modified Eagle's medium; DM
NMR structures in different membrane environments of three ocellatin peptides isolated from Leptodactylus labyrinthicus
Keywords: BHK; 21 baby hamster kidney cells; CD; circular dichroism; DD K; dermadistinctin K; DPC; dodecylphosphorylcholine; DPC-d38; dodecylphosphorylcholine-d38; DSS; sodium 2,2-dimethyl-2-silapentane-5-sulfonate; Fmoc; fluorenylmethyloxycarbonyl; Gly; glycine; 1
New insights about the peculiar role of the 28-38 C-terminal segment and some selected residues in PACAP for signaling and neuroprotection
Keywords: ACN; acetonitrile; BBB; bloodbrain barrier; Bip; biphenylalanine; Boc; tert-butoxycarbonyl; BOP; (benzotriazol-1-yloxy)tris(dimethylamino) phosphonium hexafluorophosphate; BRET; bioluminescence resonance energy transfer; CHO cells; Chinese hamster ovary c
Characterization of potent and selective iodonium-class inhibitors of NADPH oxidases
Keywords: NOX; NADPH oxidase; DUOX; dual oxidase; ROS; reactive oxygen species; DPI; diphenylene iodonium; DTI; di-2-thienyliodonium chloride; DMSO; dimethyl sulfoxide; FMOC; fluorenylmethyloxycarbonyl; IC50; inhibitory concentration 50%; RLU; relative light units;
A mode of action of glucosinolate-derived isothiocyanates: Detoxification depletes glutathione and cysteine levels with ramifications on protein metabolism in Spodoptera littoralis
Keywords: Glucosinolate; Isothiocyanate; Detoxification; Generalist herbivore; Protein metabolism; Sulforaphane; Glutathione; GSH; l-glutathione (reduced); ITC; Isothiocyanate; 4msob; 4-Methylsulfinylbutyl; CysGly; Cysteinylglycine; Cys; Cysteine; FMOC; Fluorenylme
Antimicrobial and host cell-directed activities of Gly/Ser-rich peptides from salmonid cathelicidins
Keywords: Antimicrobial peptide; Trout cathelicidin; Antibacterial activity; Immunomodulation; Head kidney leukocytes; AMP; Antimicrobial peptide; BSA; Bovine serum albumin; CD; Circular dichroism; CFU; Colony forming units; DCM; Dichloromethane; DIPEA; Diisopropyl
Ultrashort cationic lipopeptides and lipopeptoids: Evaluation and mechanistic insights against epithelial cancer cells
Keywords: AMP; antimicrobial peptide; USCL; ultrashort cationic lipopeptide; Fmoc; fluorenylmethyloxycarbonyl; MBHA; 4-methylbenzhydrylamine; TFA; trifluoroacetic acid; DMEM; Dulbecco's Modified Eagle's Medium; FBS; fetal bovine serum; MTS; (3-(4,5-dimethylthia
Blood-brain transfer and antinociception of linear and cyclic N-methyl-guanidine and thiourea-enkephalins
Keywords: Blood-brain barrier (BBB) transport (influx/efflux); Antinociceptive activity; Linear/cyclic enkephalin analogs; In vivo mouse models; AUC; area under the curve; Alloc; allyloxycarbonyl; BBB; blood-brain barrier; Boc; tertButyloxycarbonyl; BSA; bovine
Structure-activity relationship studies of pyrimidine-2,4-dione derivatives as potent P2X7 receptor antagonists
Keywords: P2X7 receptor; Antagonists; KN-62; Structure-activity relationships; IL-1β; Inflammation; AcCl; acetyl chloride; ACN; acetonitrile; ATP; adenosine-5â²-triphosphate; BzATP; 2â²(3â²)-O-(4-benzoylbenzoyl)-ATP; DCM; dichloromethane; DMEM; Dulbecco's Mod
An improved d-α-tocopherol-based nanocarrier for targeted delivery of doxorubicin with reversal of multidrug resistance
Keywords: Fluorenylmethyloxycarbonyl; Drug-interactive motif; Nanomedicine; Reversal of multidrug resistance; Chemotherapeutics;
Differences in the inhibition of coagulation factor XIII-A from animal species revealed by Michael Acceptor- and thioimidazol based blockers
Keywords: Abz; ortho-aminobenzoic acid; CAD; cadaverine; DNP; 2,4-dinitrophenyl; tBu; tert-butyl ester; Trt; trityl; Fmoc; Fluorenylmethyloxycarbonyl; DMF; Dimethylformamide; TBTU; O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; HOBt; Hydroxyb
Cyanoacetamide-based oxime carbonates: an efficient, simple alternative for the introduction of Fmoc with minimal dipeptide formation
Keywords: Amino acids; 9-Fluorenylmethyloxycarbonyl; Oxime; N-Protecting group; Peptide synthesis; Boc; tert-butoxycarbonyl; DCM; dichloromethane; ESI-MS; electrospray ionization mass spectrometry; Fmoc; fluorenylmethyloxycarbonyl; NMR; nuclear magnetic resonance;
Structure-activity relationships for the binding of polymyxins with human α-1-acid glycoprotein
Keywords: ANS; 1-anilino-8-naphthalene sulfonic acid; AO; Auramine O; AGP; human α-1-acid glycoprotein; CAPs; cationic antimicrobial peptides; CMS; colistin methanesulfonate; Fmoc; fluorenylmethyloxycarbonyl; Dab; diaminobutyric-acid; ITC; isothermal titration cal
Biological and conformational evaluation of angiotensin II lactam bridge containing analogues
Keywords: AAA; Amino acid analysis; ACN; Acetonitrile; AII; angiotensin II; BOP; (Benzotriazol-1-yl-oxy)tris(dimethylamino)phosphonium hexafluorophosphate; BSA; bovine serum albumin; CD; Circular Dichroism; CE; Capillary Electrophoresis; CHO; Chinese hamster ovary;
Effects of positively charged arginine residues on membrane pore forming activity of Rev-NIS peptide in bacterial cells
Keywords: CD; circular dichroism; diSC35; 3,3â²-dipropylthiadicarbocyanine iodide; FITC; fluorescein isothiocyanate; FD; FITC-dextran; AMP; antimicrobial peptide; NIS; nuclear entry inhibitory signal; TFE; 2,2,2-trifluoroethanol; SDS; sodium dodecyl sulfate; MIC;
Conformationally restricted analogs of the direct thrombin inhibitor FM 19
Keywords: DTI; direct thrombin inhibitor; HOBt; hydroxybenzotriazole; HBTU; O-benzotriazole-N,N,Nâ²,Nâ²-tetramethyl-uroniumhexafluorophosphate; DIEA; N,N-diisopropylethylamine; Oic; (2S,3aS,7aS)-octahydroindole-2-carboxylic acid; Phe(p-Me); p-methyl phenylalanine