Keywords: متوسط تاشو; Bromodomain; Protein folding; Folding intermediate;
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The βγ-crystallins: Native state stability and pathways to aggregation
Keywords: متوسط تاشو; Crystallin; Stability; Aggregation; Folding intermediate; Amyloid; Domain swapping
The fluorescence detected guanidine hydrochloride equilibrium denaturation of wild-type staphylococcal nuclease does not fit a three-state unfolding model
Keywords: متوسط تاشو; Folding intermediate; Linear extrapolation; Residual structure; Protein stability;
Protein l-isoaspartyl-O-methyltransferase of Vibrio cholerae: Interaction with cofactors and effect of osmolytes on unfolding
Keywords: متوسط تاشو; Methyltransferase; Folding intermediate; Osmolytes; Protein modeling and simulation; AdoMet; S-adenosyl methionine; AdoHcy; S-adenosyl homocysteine; bis-ANS; 4,4â²-dianilino-1,1â²-binaphthyl-5,5â²-disulfonic acid; CD; circular dichroism; DLS; dynamic l
Glu434 is an important amino acid residue for the activity, structure and stability of tyrosine hydroxylase of the silkworm, Bombyx mori
Keywords: متوسط تاشو; l-DOPA, 3,4-dihydroxyphenylalanine; BH4, tetrahydrobiopterin; GdnHCl, guanidine hydrochlorideTyrosine hydroxylase; Silkworm; Bombyx mori; Aggregation; Folding intermediate; Structural stability
The how’s and why’s of protein folding intermediates
Keywords: متوسط تاشو; Protein folding; Protein stability; Intermediate; Folding intermediate; Protein engineering
A combined single-molecule FRET and tryptophan fluorescence study of RNase H folding under acidic conditions
Keywords: متوسط تاشو; Protein folding; RNase H; Single molecule fluorescence resonance energy transfer (smFRET); Tryptophan fluorescence; Folding intermediate;
Mutational analysis of cysteine 328 and cysteine 368 at the interface of Plasmodium falciparum adenylosuccinate synthetase
Keywords: متوسط تاشو; AdSS; Adenylosuccinate synthetase; PfAdSS; P. falciparum adenylosuccinate synthetase; WtAdSS; wildtype adenylosuccinate synthetase; IMP; inosine monophosphate; GTP; guanosine triphosphate; IAA; iodoacetate; P. falciparum; Adenylosuccinate synthetase; Inte
The cross-road between the mechanisms of protein folding and aggregation; study of human stefin B and its H75W mutant
Keywords: متوسط تاشو; Amyloid fibril formation; Kinetics of protein folding; Folding intermediate; Molten globule; ANS fluorescence; Cystatins stefin B;
Temporal Development of Protein Structure during S100A11 Folding and Dimerization Probed by Oxidative Labeling and Mass Spectrometry
Keywords: متوسط تاشو; protein folding; dimerization; hydroxyl radical; folding intermediate; covalent labeling·OH, hydroxyl radical; ESI, electrospray ionization; HDX, hydrogen/deuterium exchange; MS, mass spectrometry; NOL, normalized oxidation level; t, folding time; LC, liq
Kinetic Folding Mechanism of an Integral Membrane Protein Examined by Pulsed Oxidative Labeling and Mass Spectrometry
Keywords: متوسط تاشو; folding kinetics; folding intermediate; covalent labeling; hydroxyl radical; stopped-flow spectroscopyBR, bacteriorhodopsin; BO, bacterioopsin (BR without retinal chromophore); Chaps, 3-[(3-cholamidopropyl)dimethylammonio]propanesulfonic acid; DMPC, l-α-1
Structural Analysis of an Equilibrium Folding Intermediate in the Apoflavodoxin Native Ensemble by Small-Angle X-ray Scattering
Keywords: متوسط تاشو; SAXS, small-angle X-ray scattering; MD, molecular dynamics; FMN, flavin mononucleotide; PCA, principal component analysis; MCR, multivariate curve resolution; ALS, alternating least squares; rMD, restrained MDprotein folding; folding intermediate; small-a
Cold destabilization and temperature jump of the murine prion protein mPrP(23–231)
Keywords: متوسط تاشو; PrP, prion protein; ID50, median infectious dose; cT-jump, continuous-wave probed laser-induced temperature jump; CD, circular dichroism; NATA, N-acetyltryptophanamidePrion protein; Folding intermediate; Cold denaturation; Structural stability; Laser-indu
Reversible unfolding of dimeric phosphofructokinase-2 from Escherichia coli reveals a dominant role of inter-subunit contacts for stability
Keywords: متوسط تاشو; Pfk-2; phosphofructokinase-2; GdnHCl; guanidine hydrochloride; ANS; 8-anilino-1-naphthalene sulfonic acid; DTT; dithiotreitol; SEC; size exclusion chromatography; CD; circular dichroism spectroscopy; DLS; dynamic light scattering; Cm; guanidine hydrochlor
Blocking creatine kinase refolding by trace amounts of copper ions
Keywords: متوسط تاشو; Creatine kinase; Protein misfolding and aggregation; Copper ion; Folding intermediate; Neurodegenerative disease
Effects of the single point genetic mutation D54G on muscle creatine kinase activity, structure and stability
Keywords: متوسط تاشو; ANS; 1-anilinonaphtalene-8-sulfonate; CK; creatine kinase; BB-CK; brain CK; MM-CK; muscle CK; CD; circular dichroism; GdnHCl; guanidine hydrochloride; Emax; emission maximum wavelength of the intrinsic fluorescence; MG; molten globule intermediate; PCr; p
Folding Mechanism of an Ankyrin Repeat Protein: Scaffold and Active Site Formation of Human CDK Inhibitor p19INK4d
Keywords: متوسط تاشو; ANK, ankyrin repeat; CDK, cyclin D-dependent kinase; H/D, hydrogen/deuterium; HSQC, heteronuclear single quantum coherenceankyrin repeat; protein folding; p19INK4d; folding intermediate; folding kinetics
Surprisingly High Correlation between Early and Late Stages in Non-two-state Protein Folding
Keywords: متوسط تاشو; protein folding; folding kinetics; non-two-state protein; folding intermediate; backbone topologykI, the rate constant for the formation of the folding intermediate in non-two-state proteins; kN, the rate constant for the formation of the native state in
Protein topology affects the appearance of intermediates during the folding of proteins with a flavodoxin-like fold
Keywords: متوسط تاشو; Protein folding; Topology; Flavodoxin; CheY; Cutinase; Folding intermediate;
Two distinct intermediates of trigger factor are populated during guanidine denaturation
Keywords: متوسط تاشو; Chaperone; Folding intermediate; Pre-molten globule; Prolyl isomerase; Protein folding; Trigger factor; ANS; 1-anilininonaphthalene-8-sulfonate; DSS; disuccinimidyl suberate; GuHCl; guanidine hydrochloride; MG; molten globule; PPIase; peptidyl-prolyl ci
Pathways of tau fibrillization
Keywords: متوسط تاشو; Alzheimer's disease; Neurofibrillary tangle; Tau; Folding intermediate; Aggregation; Kinetics;