Keywords: PAR2; protease-activated receptor2; TF; tissue factor; FVIIa; activated factor VII; MMP-2; matrix metalloproteinase-2; rMMP-2; recombinant MMP-2; HSP27; heat shock protein 27; RT-PCR; reverse transcriptase-polymerase chain reaction; NF-ĸBI; NF-ĸB inhibi
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Keywords: asTF; alternatively spliced Tissue Factor; ECRF; immortalized human umbilical vein endothelial cells; ER; endoplasmic reticulum; FVIIa; activated coagulation factor VII; FXa; activated coagulation factor X; flTF; full length Tissue Factor; HUVEC; human um
Keywords: Blood coagulation; Tissue factor; Thrombin; Platelets; Protease-activated receptors; Metastasis; AT; antithrombin; BMI; body mass index; CA-125; cancer antigen 125; CCC; clear cell carcinoma; CD; cluster of differentiation; CG; control group; DVT; deep ve
Keywords: APC; antigen-presenting cells; BcR; B cell receptor; EMA; European Medicines Agency; Fc; crystallizable fragment; FcγR; receptor for IgG Fc portion; FcRn; neonatal Fc receptor; FVIIa; activated factor VII; FVIII; factor VIII; GLP-1; glucagon-like peptide
Keywords: FV; Factor V; FVIIa; Factor VIIa; FX/FXa; Factor X/Factor Xa; IgG; immunoglobulin; LPS; lipopolysaccharide; PCA; procoagulant activity; PMA; phorbol myristate acetate; PRP; platelet rich plasma; PS; phosphatidylserine; PSGL-1; P-selectin glycoprotein liga
Keywords: fVII; factor VII; fVIIa; activated factor VII; fXa; activated factor X; HNSCC; head and neck squamous cell carcinoma; LMWH; low molecular weight heparin; MM; multiple myeloma; MP; microparticles; PCA; procoagulant activity; PE; phosphatidylethanolamine; P
Keywords: TF; tissue factor; FVII; factor VII; FVIIa; factor VIIa; Cys; cysteine; FX; factor X; FXase; extrinsic factor Xase; PS; phosphatidylserine; PC; phosphotidylcholine; PCPS; synthetic vesicles of (1,2-dioleoyl-sn-glycero-3-phosphocholine) and (1,2-dioleoyl-s
FVIIa prevents the progressive hemorrhaging of a brain contusion by protecting microvessels via formation of the TF-FVIIa-FXa complex
Keywords: APC; anticoagulant protein C/activated protein C; CCI; controlled cortical impact; CT; computed tomography; ELISA; enzyme-linked immunosorbent assay; EPCR; endothelial cell protein C receptor; FVII; factor VII; GPCR; G protein-coupled receptor; HUVECs; hu
The M358R variant of α1-proteinase inhibitor inhibits coagulation factor VIIa
Keywords: FVIIa; Alpha-1 proteinase inhibitor; Antithrombin; Serpins; Heparin; Blood coagulation;
Colocalization of neutrophils, extracellular DNA and coagulation factors during NETosis: Development and utility of an immunofluorescence-based microscopy platform
Keywords: NETs; neutrophil extracellular traps; FXII; factor XII; FXI; factor XI; FX; factor X; FX-GD; Gla-less FX; FVIIa; factor VIIa; APC; Activated protein C; APC-GD; Gla-less APC; PMA; phorbol 12-myristate 13-acetate; PKC; protein kinase C; Gla-domain; γ-carbo
Amblyomin-X having a Kunitz-type homologous domain, is a noncompetitive inhibitor of FXa and induces anticoagulation in vitro and in vivo
Keywords: PT; prothrombin time; aPTT; activated partial thromboplastin time; MS/MS; tandem mass spectrometry; FVa; active factor V; FVIIa; active factor VII; FII; prothrombin; PRP; Human platelet-rich plasma; ER; endoplasmic reticulum; ROS; reactive oxygen species;
Synthesis, evaluation and structure-activity relationship of new 3-carboxamide coumarins as FXIIa inhibitors
Keywords: Coumarins; Factor XIIa; Factor XII; FXII; Antithrombotic agents; Benzopyrans; ADME; absorption, distribution, metabolism and excretion; FXIIa; activated coagulation factor XII; FXa; activated coagulation factor X; THR; thrombin; FVIIa; activated factor VI
Enhanced Pharmacokinetics of Factor VIIa as a Monomeric Fc Fusion
Keywords: TF; tissue factor; sTF; soluble tissue factor; FVIIa; factor VIIa; FVIII; factor VIII, FIX, factor IX; FX; factor X; Recombinant FVIIa; rFVIIa; Bypass therapy; Prophylaxis; Hemophilia;
Pro- and anti-inflammatory effects of histamine on tissue factor and TNFα expression in monocytes of human blood
Keywords: ASA; acetylsalicylic acid; FV; Factor V; FVIIa; activated Factor VII; FXa; activated Factor X; LPS; lipopolysaccharide; TF; tissue factor; PMA; phorbol myristate acetate; PKC; protein kinase C; PKD; protein kinase D; PSGL-1; P-selectin glycoprotein-1; TNF
Regular ArticleInhibitory effects of LDL-associated tissue factor pathway inhibitor
Keywords: BSA; bovine serum albumin; CAT; calibrated automated thrombogram; dPT; diluted prothrombin time; FVIIa; activated factor VII; FX; factor X; FXa; activated factor X; GPI; glycosyl phosphatidyl inositol; HBS; hepes buffered saline; IP; immuno pull down; KI;
Recombinant fusion protein linking factor VIIa with albumin (rVIIaÂFP): Tissue distribution in rats
Keywords: AUC; area under the curve; FVIIa; activated factor VII; HPLC; high-performance liquid chromatography; ITI; immune tolerance induction; LMW; low molecular weight; NSP; NÂsuccinimidyl[2,3-3H]propionate; QWBA; quantitative whole-body autoradiography; rFVIIa
Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor
Keywords: FVIIa; Coagulation factor VIIa; Inhibitor; Thrombosis; Antithrombotic; Anticoagulant; Tetrahydroquinoline; Povarov annulation; Benzamidine;
Activated protein C plasma levels in the fasting and postprandial states among patients with previous unprovoked venous thromboembolism
Keywords: APC; Activated protein C; AUCi; incremental area under the curve; BMI; Body mass index; DVT; Deep vein thrombosis; FVIIa; Activated factor VII; HMG-CoA; 3-hydroxy-3-methylglutaryl-coenzyme A; MI; Myocardial infarction; PE; pulmonary embolism; PC; Protein
Pharmacokinetics, distribution, and excretion of 125I-labeled human plasma-derived-FVIIa and -FX with MC710 (FVIIa/FX mixture) in rats
Keywords: Hemophilia; Inhibitor; FVIIa; FX; Bypassing agents
Hypercoagulability in Patients With Chronic Noncirrhotic Portal Vein Thrombosis
Keywords: Hemostatic Disorders; Portal Hypertension; vWF; Ristocetin Cofactor; CLT; ADAMTS-13; a disintegrin and metalloprotease with thrombospondin type 1 motifs 13 antigen; aPTT; activated partial thromboplastin time; CLT; clot lysis time; ELISA; enzyme-linked im
Global haemostasis assays, from bench to bedside
Keywords: α; angle that assesses rate of clot formation; α2M; α2-macroglobulin; AMC; 7-amino-4-methylcoumarine; AT; antithrombin; AUC; area under the curve; APC; activated protein C; aPTT; activated partial thromboplastin time; A10; the amplitude after ten minut
Effects on the conformation of FVIIa by sTF and Ca2+ binding: Studies of fluorescence resonance energy transfer and quenching
Keywords: EGF; epidermal growth factor-like domain; FVIIa; activated coagulation factor VII; Fl; fluorescein FPR-chloromethyl ketone; Gla; γ-carboxyglutamic acid; PD; protease domain; sTF; soluble tissue factor (residues 1-219); TF; tissue factor; TMR; tetramethyl
Leptin and resistin induce increased procoagulability in diabetes mellitus
Keywords: DM; diabetes mellitus; DMSO; dimethyl sulfoxide; FVIIa; factor VIIa; FX; factor X; HUVECs; human umbilical endothelial cells; PAI; plasminogen activator inhibitor 1; SD; standard deviation; SEM; standard error of the mean; TF; tissue factor; TFPI; tissue
Recombinant Activated Factor VII Increases Stroke in Cardiac Surgery: A Meta-analysis
Keywords: bleeding; cardiac surgery; FVIIa; recombinant factor VII; stroke; surgical revision; anesthesia
Heparin affinity of factor VIIa: Implications on the physiological inhibition by antithrombin and clearance of recombinant factor VIIa
Keywords: FVIIa; Factor VIIa; TF; Tissue Factor; rFVIIa; recombinant FVIIa; LMWH; Low molecular weight heparin; UHF; Unfractionated heparin; SPR; Surface Plasmon resonance; TFPI; Tissue factor pathway inhibitor; RU; Response units;
Tissue Factor/ FVIIa prevents the extrinsic pathway of apoptosis by regulation of the tumor suppressor Death-Associated Protein Kinase 1 (DAPK1)
Keywords: Tissue factor; FVIIa; Apoptosis; DAPK1; PAR2; Caspase-8
Tissue Factor–Factor VIIa complex induces cytokine expression in coronary artery smooth muscle cells
Keywords: Tissue Factor; FVIIa; PAR-2; Smooth muscle cells; Inflammation
Combining FVIIa and FX into a mixture which imparts a unique thrombin generation potential to hemophilic plasma: an in vitro assessment of FVIIa/FX mixture as an alternative bypassing agent
Keywords: FVIIa; FX; hemophilia; bypassing agents; inhibitors; APCC
Purified thromboplastin causes haemostatic abnormalities but not overt DIC in an experimental rabbit model
Keywords: ISTH; International Society on Thrombosis and Haemostasis; DIC; disseminated intravascular coagulation; FDP; fibrin degradation product; PT; prothrombin time; AT; antithrombin; TAT; thrombin-antithrombin; PC; protein C; TEG; thromboelastography; FVIIa; ac
Protein disulfide isomerase has no stimulatory chaperone effect on factor X activation by factor VIIa-soluble tissue factor
Keywords: FVIIa; activated factor VII; FX; factor X; FXa; activated factor X; Gla; γ-carboxyglutamic acid; PDI; protein disulfide isomerase; sTF; soluble tissue factor; TF; tissue factor; Factor X activation; Protein disulfide isomerise; Factor VIIa; Tissue factor
Simvastatin induces apoptosis in human breast cancer cells in a NFκB-dependent manner and abolishes the anti-apoptotic signaling of TF/FVIIa and TF/FVIIa/FXa
Keywords: Statins; Apoptosis; NFκB; Tissue factor; FVIIa; Cell signaling
Discovery of novel heterocyclic factor VIIa inhibitors
Keywords: Factor VIIa; Inhibitor; fVIIa; Heterocyclic; 5-aminopyrrolo[3,2-b]pyridine; Factor VIIa crystal structure; Anticoagulant
Factor VIIa inhibitors: Chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model
Keywords: Factor VIIa; fVIIa; Tissue factor; TF; Coagulation; Antithrombotic; Baboon thrombosis model; Pharmacokinetics; Pharmacodynamics; Serine protease; Thrombin; Factor Xa
Efecto de la dieta mediterránea en los valores plasmáticos de factor VII activado en personas sanas
Keywords: Dieta mediterránea; Factor VII activado; Enfermedad cardiovascular; Mediterranean diet; Activated factor VII; Cardiovascular risk; cHDL; colesterol ligado a lipoproteÃnas de alta densidad; cLDL; colesterol ligado a lipoproteÃnas de baja densidad; FVII;
Effect of the Mediterranean Diet on Fasting Concentrations of Activated Factor VII in Healthy Persons
Keywords: Mediterranean diet; Activated factor VII; Cardiovascular risk; Dieta mediterránea Factor VII activado; Enfermedad cardiovascular; HDL; high-density lipoprotein; LDL; low-density lipoprotein; FVII; factor VII; FVIIc; factor VII clotting; FVIIa; activated
The influence of the â401G/T and â402G/A polymorphisms of the coagulation FVII promoter on plasma levels of FVII
Keywords: CVD; cardiovascular disease; FVII; coagulation factor FVII; FVIIa; activated FVII; FVIIag; FVII antigen; FVIIc; FVII coagulant activity; FFQ; food frequency questionnaire; MI; myocardial infarction; PCR; polymerase chain reaction; RFLP; restriction fragme
Characterization of recombinant murine factor VIIa and recombinant murine tissue factor: a human-murine species compatibility study
Keywords: TF; tissue factor; FVII; factor VII; FVIIa; factor VIIa; FFR-FVIIa; FVIIa blocked in the active site with phenylalanyl-phenylalanyl-arginyl-chloromethyl ketone; FX; factor X; FIX; factor IX; PCR; polymerase chain reaction; EDTA; ethylenediaminetetraacetic
Stability of solvent/detergent-treated plasma and single-donor fresh-frozen plasma during 48Â h after thawing
Keywords: APTT; activated partial thromboplastin time; FFP; fresh-frozen plasma; FVIIa; activated factor VIIa; HLA; human lymphocyte antigen; RT; room temperature; SD; solvent/detergent; TNBP; Tri(n-butyl)phosphate; TTP; thrombotic thrombocytopenic purpura; SD plas