Keywords: G پروتئین همراه با پروتئین; HMG-CoA; 3-hydroxy-3-methyl glutaryl-coenzyme A; BUN; Blood urea-nitrogen; BMI; Body mass index; BCAAs; Branched-chain amino acids; CMD; Cardiometabolic disorders; CD; Cardiovascular disease; CKD; Chronic kidney diseases; CRP; C reactive protein; DMA; Dim
مقالات ISI G پروتئین همراه با پروتئین (ترجمه نشده)
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Keywords: G پروتئین همراه با پروتئین; CRD; Cysteine-rich domain; GPCR; G protein coupled receptors; GTs; Glycosylated terpenoids; mGluR3; Metabotropic glutamate receptor 3; MPA; MultiPoint Attachment model; PDB; Protein data bank; QSAR; Quantitative Structure-Analysis Relationship; SG; Stevio
Keywords: G پروتئین همراه با پروتئین; Cannabinoids; Phytocannabinoids; Endocannabinoids; Therapeutic agents; AEA; Arachidonylethanolamine or Anandamide; 2-AG; 2-arachidonylglycerol; CB1; Cannabinoid receptor type 1; CB2; Cannabinoid receptor type 2; CBD; Cannabidiol; CBG; Cannabigerol; CBL; C
Keywords: G پروتئین همراه با پروتئین; G protein coupled receptors; Endothelin; ETA; ETB; Biased agonism; Biased antagonism; β-Arrestin; Bosentan; Pathway selectivity; IRL1620;
Keywords: G پروتئین همراه با پروتئین; BM; bone marrow; CCL2; chemokine (C-C motif) ligand 2; COX2; cyclooxygenase-2; CXCR4; C-X-C chemokine receptor type 4; DC; dendritic cells; ECM; extracellular matrix; FKBP51; FK506 binding protein 51; G-MDSCs; granulocytic MDSCs; GPCRs; G protein coupled
Keywords: G پروتئین همراه با پروتئین; AC; adenylyl cyclase; CCK; cholecystokinin; CFTR; cystic fibrosis transmembrane regulator; CREBs; cAMP response element binding proteins; EGF; epidermal growth factor; Epac; Exchange protein directly activated by cAMP; GDP; guanosine diphosphate; GEF; gua
Keywords: G پروتئین همراه با پروتئین; Calcitonin; Evolution; G protein coupled receptors; Promoter analysis; Synteny
Keywords: G پروتئین همراه با پروتئین; ACh; acetylcholine; AAV; adeno-associated virus; AgRP; agouti-related protein; ArchT; archaerhodopsin; BAC; bacterial artificial chromosomes; ChRs; channelrhodopsins; DBS; deep brain stimulation; DREADDs; designer receptors exclusively activated by design
Keywords: G پروتئین همراه با پروتئین; AC; adenylyl cyclase; BAT; brown adipose tissue; BMP; bone morphogenetic protein; BST; bed nucleus of the stria terminalis; CB1R; cannabinoid receptor type 1; CNS; central nervous system; CREB; cAMP-response element binding protein; DRN; dorsal raphe nucl
Keywords: G پروتئین همراه با پروتئین; Angiogenesis; Antiangiogenic agents; Angiogenic cytokines/peptides; EC; endothelial cells; VEGF; vascular endothelial growth factor; VEGF Receptor; VEGFR; FGF; fibroblast growth factor; EGF; epidermal growth factor; epidermal growth factor receptor; EGFR;
Gi protein functions in thalamic neurons to decrease orofacial nociceptive response
Keywords: G پروتئین همراه با پروتئین; VP; ventroposterior thalamic complex; Gi; inhibitory G protein; DREADD; designer receptor exclusively activated by a designer drug; LFP; Local field potentials; GIRK; Gi-coupled inwardly-rectifying potassium channels; VGLUT2; glutamate vesicular transport
Structure-activity relationship studies and pharmacological characterization of N5-heteroarylalkyl-substituted-2-(2-furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine-based derivatives as inverse agonists at human A2A adenosine receptor
Keywords: G پروتئین همراه با پروتئین; G protein coupled receptors; A2A adenosine receptors; Inverse agonists; Thiazolopyrimidine derivatives; Bicyclic heteroaromatic system; AR; adenosine receptor; cAMP; 3â²,5â²-cyclic adenosine monophosphate; CHO; chinese hamster ovary; DPCPX; 8-cyclopenty
Quaternary structure of the yeast pheromone receptor Ste2 in living cells
Keywords: G پروتئین همراه با پروتئین; G protein coupled receptors; Optical spectroscopy; Membrane protein interactions; Fluorescence; Förster resonance energy transfer (FRET); Light microscopy;
Therapeutic journey of 2,4-thiazolidinediones as a versatile scaffold: An insight into structure activity relationship
Keywords: G پروتئین همراه با پروتئین; Thiazolidinedione; PPARγ; Antihyperglycemic; Anticancer; Antimicrobial; AI-2; Auto inducer-2; ATP; Adenosine triphosphate; ALR; Aldose reductase; COX; Cyclooxygenase; EC50; Half maximal effective concentration; ED50; Median effective dose; FFAR1; Free fa
RGS2 modulates the activity and internalization of dopamine D2 receptors in neuroblastoma N2A cells
Keywords: G پروتئین همراه با پروتئین; Dopamine D2 receptors; RGS2; Gαi/o signaling; Internalization; β-arrestin; D2Rs; dopamine D2 receptors; RGS2; regulators of G protein signaling protein 2; GPCRs; G protein coupled receptors; ERK; extracellular signal-regulated kinases; AP2; adaptor prot
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment
Keywords: G پروتئین همراه با پروتئین; PDE4D inhibitors; cAMP enhancers; Memory behavior test; Pharmacokinetic analyses; Molecular dynamics simulation; In silico ADMET properties; AD; Alzheimer Disease; cAMP; cyclic adenosine monophosphate; CR3; conserved region 3; CREB; cAMP response element-
New therapeutic opportunities for 5-HT2C receptor ligands in neuropsychiatric disorders
Keywords: G پروتئین همراه با پروتئین; 5-HT receptors; mRNA editing; G protein coupled receptors; Receptor oligomers; Dopamine; GABA5-HT2C receptor, serotonin2C receptor; DRN, dorsal raphe nucleus; MRN, medial raphe nucleus; DA, Dopamine; 6-OHDA, 6-hydroxydopamine; MPTP, 1-methyl-4-phenyl-1,2,
RGS2 and RGS4 proteins: New modulators of the κ-opioid receptor signaling
Keywords: G پروتئین همراه با پروتئین; 293Â F; cell line of human embryonic kidney origin; 6ÃÂ His; hexahistidine; aa; amino acids; AC; adenylyl cyclase; AR; adrenergic receptors; AT1; Angiotensin Receptor 1; CT; carboxyl terminus; ÎÎRGS4; RGS4 lacking its N-terminal domain; DAMGO; [d-Ala2,
Targeting G protein coupled receptor-related pathways as emerging molecular therapies
Keywords: G پروتئین همراه با پروتئین; G protein coupled receptors; Signaling pathway; Molecular therapy; Potential target
5-HT1A receptor-mediated phosphorylation of extracellular signal-regulated kinases (ERK1/2) is modulated by regulator of G protein signaling protein 19
Keywords: G پروتئین همراه با پروتئین; GPCRs; G protein coupled receptors; RGS; regulator of G protein signaling; GAP; GTPase accelerating protein; RH; RGS homology domain; shRNA; short hairpin RNA; GFP; green fluorescent protein; IBMX; 3-isobutyl-1-methylxanthine; MAPK; mitogen-activated prot
Peripheral prostaglandin E2 prolongs the sensitization of nociceptive dorsal root ganglion neurons possibly by facilitating the synthesis and anterograde axonal trafficking of EP4 receptors
Keywords: G پروتئین همراه با پروتئین; CFA; complete Freud's adjuvant; COX2; cyclooxygenase-2; DMEM; Dulbecco's Modified Eagle Medium; dmPGE2; 16,16-dimethyl PGE2; DRG; dorsal root ganglion; FBS; fetal bovine serum; GDNF; glia-derived neurotrophic factor; GPCR; G protein coupled receptors; HBS
ReviewTransitioning pharmacoperones to therapeutic use: In vivo proof-of-principle and design of high throughput screens
Keywords: G پروتئین همراه با پروتئین; GPCRs; G protein coupled receptors; V2R; vasopressin type 2 receptor; GnRHR; gonadotropin releasing hormone receptor; QCS; quality control system; ER; endoplasmic reticulum; PM; plasma membrane; GnRH; gonadotropin releasing hormone; LH; luteinizing hormon
Fluorescent approaches for understanding interactions of ligands with G protein coupled receptors
Keywords: G پروتئین همراه با پروتئین; G protein coupled receptors; Fluorescence; Fluorescence Resonance Energy Transfer; FRET; Ligands; Pheromone receptors;
D5 dopamine receptor carboxyl tail involved in D5-D2 heteromer formation
Keywords: G پروتئین همراه با پروتئین; G protein coupled receptors; D5 and D2 dopamine receptor; Nuclear localization; Protein structure; Heteromer; Interacting amino acids.;
Adenosine A1 receptors heterodimerize with β1- and β2-adrenergic receptors creating novel receptor complexes with altered G protein coupling and signaling
Keywords: G پروتئین همراه با پروتئین; GPCR; G protein-coupled receptors; A1AR; A1 adenosine receptor; β1R & β2R; β-adrenergic receptor subtypes; HEK-293; human embryonic kidney cells; IP; immunoprecipitation; IB; immunoblotting; IF; immunofluorescence; cAMP; cyclic adenosine monophosphate;
Schizophrenia and Parkinson’s disease: Selected therapeutic advances beyond the dopaminergic etiologies
Keywords: G پروتئین همراه با پروتئین; G protein coupled receptors; Schizophrenia; Parkinson’s disease; Potential target
Understanding the balance and integration of volume and synaptic transmission. Relevance for psychiatry
Keywords: G پروتئین همراه با پروتئین; Volume transmission; Schizophrenia; G protein coupled receptors; Receptor–receptor interactions; Neuroinflammation; Toxoplasma gondii
Disruption of the mu-delta opioid receptor heteromer
Keywords: G پروتئین همراه با پروتئین; G protein coupled receptors; Mu and delta opioid receptor; Nuclear localization; Protein structure; Heteromer; Interacting amino acids; G protein; Dimers;
Two amino acids in each of D1 and D2 dopamine receptor cytoplasmic regions are involved in D1–D2 heteromer formation
Keywords: G پروتئین همراه با پروتئین; G protein coupled receptors; Dopamine receptor; Nuclear localization; Protein structure; Heteromer; Interacting amino acids
Differential expression of muscarinic acetylcholine receptor subtypes in Jurkat cells and their signaling
Keywords: G پروتئین همراه با پروتئین; Muscarinic acetylcholine receptors; Lymphocytes; G protein coupled receptors; Signal transduction; Immunopharmacology
Associate Editor: V.J. WattsRegulation of stem cell pluripotency and differentiation by G protein coupled receptors
Keywords: G پروتئین همراه با پروتئین; G protein coupled receptor; GPCR; Pluripotency; Stem cell; Differentiation; EB; Embryoid body; ES cells; Embyronic stem cells; FZD; Frizzled; GPCRs; G protein coupled receptors; GSK3; Glycogen synthase kinase 3; hATSCs; Human adipose tissue-derived mesenc
A serine point mutation in the adenosine A2AR C-terminal tail reduces receptor heteromerization and allosteric modulation of the dopamine D2R
Keywords: G پروتئین همراه با پروتئین; Dopamine D2 receptor; Adenosine A2 receptor; Heteromerization; G protein coupled receptors; Allosteric modulation; Protein-protein interaction;
Characterization of the A2AR–D2R interface: Focus on the role of the C-terminal tail and the transmembrane helices
Keywords: G پروتئین همراه با پروتئین; Dopamine D2 receptor; Adenosine A2A receptor; Heteromerization; G protein coupled receptors; Transmembrane segments; Protein–protein interaction
Brain volume regulation: osmolytes and aquaporin perspectives
Keywords: G پروتئین همراه با پروتئین; glutamate; G protein coupled receptors; ischemia; hyposmolarity; astrocytes9-AC, anthracene-9 carboxylate; BKCa, large conductance Ca2+-activated K+ channels; CaMK, calcium/calmodulin-dependent protein kinase; CKII, casein kinase II; DCPIB, 4-[(2-Butyl-6,
Physiological and pharmacological implications of beta-arrestin regulation
Keywords: G پروتئین همراه با پروتئین; G protein coupled receptors; Seven transmembrane spanning receptors; GRK; Beta-arrestin; Functional selectivity; Knockout mouse models; Drug discovery; Receptor regulation; PhysiologyΔ9-THC, Δ9-tetrahydrocannabinol; DOI, 2,5-dimethoxy-4-iodoamphetamine; C
Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: Measurement and mathematical modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 activation
Keywords: G پروتئین همراه با پروتئین; Computational simulations of signaling pathways; G protein coupled receptors; Systems biology; Receptors of hallucinogenic drugs of abuse; Serotonin receptors; MAPK phosphorylation cascade
Association of RGS2 and RGS5 variants with schizophrenia symptom severity
Keywords: G پروتئین همراه با پروتئین; Genetics; Candidate gene; Pharmacogenetics; G protein coupled receptors; Regulator of G-protein signaling; Cerebral cortex;
A role of RGS proteins in drug addiction
Keywords: G پروتئین همراه با پروتئین; G protein coupled receptors; Signal transduction; Scaffolding protein; Receptor desensitization; Opiate receptors; Dopamine receptors
Synthesis and evaluation of homo-bivalent GnRHR ligands
Keywords: G پروتئین همراه با پروتئین; G protein coupled receptors; Gonadotropin-releasing hormone receptor; Bivalent ligands; Huisgen 1,3-cycloaddition; Imidazopyrimidinone
Contribution of the kinetics of G protein dissociation to the characteristic modifications of N-type calcium channel activity
Keywords: G پروتئین همراه با پروتئین; GPCR; G protein coupled receptors; DAMGO; d-Ala2,Me-Phe4,glycinol5)-enkephalin; Calcium channel; N-type channel; G protein regulation; μ-Opioid receptor; β-Subunit; Prepulse facilitation; Channel reluctance;
Phospholipase C is involved in the adenosine-activated signal transduction pathway conferring protection against iodoacetic acid-induced injury in primary rat neuronal cultures
Keywords: G پروتئین همراه با پروتئین; Ado-STP; adenosine-induced signal transduction pathway; GPCR; G protein coupled receptors; IAA-R; iodoacetate-“reperfusion”; KATP channels; ATP sensitive potassium channels; PKC; protein kinase C; PLC; phospholipase C; R-PIA; N6-(R)-phenylisopropylade
Expression and localization of an exogenous G protein-coupled receptor fused with the rhodopsin C-terminal sequence in the retinal rod cells of knockin mice
Keywords: G پروتئین همراه با پروتئین; rhodopsin biosynthesis; rhodopsin transport; photoreceptor cells; knockin mice; G protein coupled receptors;
Neuronal Kir3.1/Kir3.2a channels coupled to serotonin 1A and muscarinic m2 receptors are differentially modulated by the 'short' RGS3 isoform
Keywords: G پروتئین همراه با پروتئین; Inward rectifier potassium channels; G protein coupled receptors; Regulators of G protein signaling; Acetylcholine; Serotonin; Patch clamp; Chinese hamster ovary cells;