D5 dopamine receptor carboxyl tail involved in D5-D2 heteromer formation

► 3 adjacent c-tail D5 receptor glutamic acids form heteromers with the D2 receptor. ► Adjacent arginines in ic3 of the D2 receptor form heteromers with the D5 receptor. ► Single amino acid changes in the D5 receptor c-tail disrupt the D5-D2 heteromers.