Keywords: AGEs; advanced glycation endproducts; BMD; bone mineral density; CAH; congenital adrenal hyperplasia; DM; diabetes mellitus; DPP-4; dipeptydil petptidase-4; DXA; dual-energy X-ray absorptiometry; FRAX; fracture risk assessment tool; FSH; follicle stimulat
مقالات ISI (ترجمه نشده)
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Keywords: SP; short photoperiod; LP; long photoperiod; RQ; respiratory quotient; WAT; white adipose tissue; GC; glucocorticoid; GLP-1; glucagon-like peptide 1; GiP; glucose dependant insulinotropic polypeptide; Mesocricetus auratus; Torpor bout; Periodic arousal; A
Keywords: GIP; GIPR; Polymorphism; BMD; Fat mass; Serum GIP
A validated LC-MS/MS method for simultaneous determination of linagliptin and metformin in spiked human plasma coupled with solid phase extraction: Application to a pharmacokinetic study in healthy volunteers
Keywords: ALG; alogliptin; AUC0-t and AUC0-â; the areas under the plasma concentration-time curve; Cmax; maximum plasma concentration; DPP-IV; dipeptidyl peptidase; ER; extraction recovery; GIP; glucose-dependent insulinotropic polypeptide; GLP 1; glucagon-
Secretion of GLP-1 but not GIP is potently stimulated by luminal d-Allulose (d-Psicose) in rats
Keywords: GLP-1; GIP; Allulose; GLP-1; glucagon-like peptide-1; GIP; Glucose-dependent insulinotropic polypeptide; Allulose; d-Allulose; GLUT5; glucose transporter 5; SGLT; sodium-dependent glucose cotransporter;
GLP-1 receptor agonists show neuroprotective effects in animal models of diabetes
Keywords: GLP-1; GIP; Brain; Neurons; Growth factors; Neurodegeneration; Inflammation;
Investigation of medicinal plants from Madagascar against DPP-IV linked to type 2 diabetes
Keywords: DMSO; dimethyl sulfoxide; DPP-IV; dipeptidyl peptidase-IV; GIP; glucose-dependent insulinotropic polypeptide; GLP-1; glucagon-like peptide 1; GPPN; Gly-pro-p-nitroanilide; HPLC; high-performance liquid chromatography; HR; high resolution; HRMS; high-resol
The incretin hormone GIP is upregulated in patients with atherosclerosis and stabilizes plaques in ApoEâ/â mice by blocking monocyte/macrophage activation
Keywords: Incretin; GIP; Atherosclerosis; Plaque stability; PAD; Macrophages;
Peptide degradation and the role of DPP-4 inhibitors in the treatment of type 2 diabetes
Keywords: DPP-4; dipeptidyl peptidase-4; GIP; glucose-dependent insulinotropic polypeptide; GLP-1; glucagon-like peptide-1; GRP; gastrin-releasing peptide; NEP; neutral endopeptidase; OXM; oxyntomodulin; PACAP; pituitary adenylate cyclase-activating polypeptide; PY
Evaluation of the insulinotropic and glucose-lowering actions of zebrafish GIP in mammalian systems: Evidence for involvement of the GLP-1 receptor
Keywords: Type 2 diabetes; Zebrafish; GIP; GLP-1; Glucagon; Evolution;
Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models
Keywords: Insulin; Neurodegeneration; Inflammation; Growth factors; GIP; GLP-1;
Apelin-13 analogues show potent in vitro and in vivo insulinotropic and glucose lowering actions
Keywords: APJ; apelin receptor; CCK; cholecystokinin; DIO; diet induced obese; DPP; 4 dipeptidylpeptidase-4; GIP; glucose-dependent insulinotropic polypeptide; GLP-1; glucagon-like peptide-1; KRB; krebs ringer bicarbonate; pGlu; pyroglutamyl; SGLT-2; sodium glucose
An incretin-based tri-agonist promotes superior insulin secretion from murine pancreatic islets via PLC activation
Keywords: Tri-agonist; Signaling cascade; Pancreatic islets; Insulin secretion; G proteins; TRP channels; AC; Adenylyl cyclase; cAMP; Cyclic adenosine monophosphate; ECL; Extracellular loop; EPAC; Exchange protein directly activated by cAMP; FCS; Fetal calf serum;
Gut hormone polyagonists for the treatment of type 2 diabetes
Keywords: GLP-1/Glucagon Co-agonism; Polypharmacology; Type 2 diabetes; Gip;
Association of Native American ancestry and common variants in ACE, ADIPOR2, MTNR1B, GCK, TCF7L2 and FTO genes with glycemic traits in Colombian population
Keywords: ACE; angiotensin converting enzyme; MTNR1B; melatonin receptor 1B; GCK; glucokinase; TCF7L2; transcription factor 7 Like 2; FTO; alpha-ketoglutarate dependent dioxygenase; OR; odds ratio; IR; insulin resistance; T2D; type 2 diabetes; MS; metabolic syndrom
Inhibiting RHOA Signaling in Mice Increases Glucose Tolerance and Numbers of Enteroendocrine and Other Secretory Cells in the Intestine
Keywords: Mouse Model; Type 2 Diabetes; Enteroendocrine Cells; Signal Transduction; CCK; cholecystokinin; Ctgf; connective tissue growth factor; Cyr61; cysteine-rich angiogenic inducer 61; Dll1; delta-like protein 1; DBZ; dibenzazepine; EdU; 5-ethynyl-2â²-deoxyuri
Investigation of in vitro genotoxic effects of an anti-diabetic drug sitagliptin
Keywords: Sitagliptin; Antidiabetic drug; Human lymphocytes; Genotoxicity; T2DM; Type 2 diabetes mellitus; DPP-4; dipeptidyl peptidase-4; GLP-1; incretin hormones glucagon-like peptide-1; GIP; glucose-dependent insulinotropic polypeptide; CAs; chromosome aberration
Pancreatic cancer-derived exosomes suppress the production of GIP and GLP-1 from STC-1â¯cells in vitro by down-regulating the PCSK1/3
Keywords: Pancreatic cancer-associated diabetes; Exosomes; GIP and GLP-1; PCSK1/3; Pancreatic juice; EV; Extracellular vesicle; GLP-1; Glucagon-like peptide-1; GIP; Gastric inhibitory polypeptide OR glucose-dependent insulinotropic polypeptide; PCSK1/3; Proprotein
Intestinal CART is a regulator of GIP and GLP-1 secretion and expression
Keywords: CART; Cocaine- and amphetamine-regulated transcript; GIP; GLP-1; Enteroendocrine cells; Incretin hormones;
Constitutive DPP4 activity, inflammation, and microvascular reactivity in subjects with excess body weight and without diabetes
Keywords: ADA; American Diabetes Association; AUC; area uder the curve; BMI; body mass index; CD26; cluster of differentiation 26; DPP4; dipeptidyl peptidase 4; EDTA; ethylenediamine tetraacetic acid; FPG; fasting plasma glucose; GIP; glucose-dependent insulinotrop
Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic
Keywords: Obesity; Chronic low-grade inflammation; Pharmacotherapy; Novel targets; Medicinal plants; Clinical studies; Contents; 5HT2CR; Serotonin receptors subtype 2C; ACC; Acetyl-CoA carboxylase (EC 6.4.1.2); ACTH; Adrenocorticotropic hormone; AgRP; Agouti-relate
Gastric bypass in the pig increases GIP levels and decreases active GLP-1 levels
Keywords: Gastric Bypass; GIP; GLP-1; Insulin; Bariatric surgery; Pig model;
Canagliflozin potentiates GLP-1 secretion and lowers the peak of GIP secretion in rats fed a high-fat high-sucrose diet
Keywords: Diet-induced obesity; Canagliflozin; Glucagon-like peptide-1; Glucose-dependent insulinotropic polypeptide; Sodium-glucose cotransporter 1(SGLT1); SGLT2 inhibitor; DPP-IV; dipeptidyl peptidase-IV; GLP-1; glucagon-like peptide-1; GIP; Glucose-dependent i
Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in ob/ob mice
Keywords: GIP; Hyperphagia; Obesity; Insulin resistance; ob/ob; GIPR; GIP receptor; GFP; green fluorescent protein; OGTT; oral glucose tolerance test; ITT; insulin tolerance test; CT; computerized tomography;
A walnut-containing meal had similar effects on early satiety, CCK, and PYY, but attenuated the postprandial GLP-1 and insulin response compared to a nut-free control meal
Keywords: Walnuts; Insulin; Postprandial gastrointestinal peptides; Satiety; BMI; body mass index; CCK; cholecystokinin; GIP; glucose-dependent insulinotropic peptide; GLP-1; glucagon-like peptide-1; HDL-C; high-density lipoprotein cholesterol; MUFA; monounsaturate
Partial jejunal diversion using an incisionless magnetic anastomosis system: 1-year interim results in patients with obesity and diabetes
Keywords: BMI; body mass index; GIP; gastric inhibitory peptide; GLP-1; glucagon-like peptide-1; HbA1c; glycated hemoglobin; IMAS; incisionless magnetic anastomosis system; NHANES; National Health and Nutrition Examination Survey; PJD; partial jejunal diversion; PY
A novel GLP-1/GIP dual agonist is more effective than liraglutide in reducing inflammation and enhancing GDNF release in the MPTP mouse model of Parkinson's disease
Keywords: Insulin; Growth factor; Incretins; Dopamine; Inflammation; Brain; GLP-1; GIP;
Gq and Gs signaling acting in synergy to control GLP-1 secretion
Keywords: GPCR; GLP-1 secretion; Pharmacological synergy; Incretins; G protein signaling; 2-MAG; 2-monoacylglycerol; BB2; bombesin 2 receptor; CTX; cholera toxin; GLP-1; glucagon-like peptide 1; GIP; gastrointestinal peptide; GPCR; G protein coupled receptor; LCFA;
Research articleDetailed characterisation of STC-1 cells and the pGIP/Neo sub-clone suggests the incretin hormones are translationally regulated
Keywords: CCK; cholecystokinin; HCA; high content analysis; GIP; glucose-dependent insulinotropic peptide; GLP-1; glucagon-like peptide-1; GLP-2; glucagon-like peptide- 2; PYY; peptide YY; PC3; prohormone convertase 3; T2DM; type 2 diabetes mellitus; E2D2; ubiquiti
Competition assays revealed Paenibacillus pasadenensis strain R16 as a novel antifungal agent
Keywords: BC; Botrytis cinerea strain MG53; FV; Fusarium verticillioides strain GV2245; PV; Phomopsis viticola strain PV1; TGYA; Tryptone-Glucose-Yeast Extract-Agar medium; dpi; days post inoculation; GIP; Growth inhibition percentage; GIPv; Growth inhibition perce
Research PaperNovel GLP-1R/GIPR co-agonist “twincretin” is neuroprotective in cell and rodent models of mild traumatic brain injury
Keywords: BCA; bicinchoninic acid; cAMP; cyclic AMP; CDC; Centers for Disease Control and Prevention; CREB; cyclic AMP response element-binding protein; Ex-4; exendin-4; Ex 9-39; exendin fragment 9-39; GIP; glucose-dependent insulinotropic peptide; GIPR; glucos
GIP(3-30)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release
Keywords: BSA; bovine serum albumin; DPP-4; dipeptidyl peptidase-4; GIP; glucose-dependent insulinotropic polypeptide; GIPR; glucose-dependent insulinotropic polypeptide receptor; GLP-1; glucagon-like peptide-1; HBS; HEPES-buffered saline; Glucose-dependent insulin
Direct effects of glucose, insulin, GLP-1, and GIP on bulbospinal neurons in the rostral ventrolateral medulla in neonatal wistar rats
Keywords: aCSF; artificial cerebrospinal fluid; AP; action potential; BP; blood pressure; FAP; frequency of action potential; GIPR; glucose-dependent insulinotropic peptide receptor; GLP-1R; glucagon-like peptide-1 receptor; GLUT; glucose transporter; IML; intermed
ReviewThe dynamic plasticity of insulin production in β-cells
Keywords: T2DM; Insulin production; β-cell rest; ATF6; Activating Transcription Factor 6; CHOP; CCAAT/Enhancer-Binding Homologous Protein; EPAC; Exchange Factor Directly Activated by cAMP; EROβ1; ER-resident oxidoreductase β1; GIP; Gastric Inhibitory Polypeptide
Fructose intervention for 12 weeks does not impair glycemic control or incretin hormone responses during oral glucose or mixed meal tests in obese men
Keywords: Glucagon-like peptide 1; Glucose-dependent insulinotropic polypeptide; Fructose intervention; Incretin response; Liver fat; Metabolic syndrome; Mixed meal test; Oral glucose tolerance test; AUIC; area under incremental curve; AUC; area under curve; GIP; g
Endoscopic Bariatric and Metabolic Therapies: Surgical Analogues and Mechanisms of Action
Keywords: Obesity; Bariatric; Endoscopy; Metabolic; Diabetes; Endoscopic Sleeve Gastroplasty; ESG; POSE; Gastric Balloon; Orbera; Duo; Obalon; Aspire; EndoBarrier; IMAS; Magnetic; Ghrelin; GLP-1; PYY; EBT; EBMT; Incretin; BMI; body mass index; BPD; biliopancreatic
Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV
Keywords: DPP-IV; dipeptidyl peptidase IV; mg V·kgâ 1; mg Vanadium injected/weight of mice in kg; GLP-1; glucagon-like peptide-1; GIP; glucose-dependent insulinotropic peptide; BEOV; bis(ethylmaltolato)oxovanadium(IV); PTP1B; protein tyrosine phosphatase 1B; P
Sitagliptin inhibit human lymphocytes proliferation and Th1/Th17 differentiation in vitro
Keywords: ADA; adenosine deaminase; CBA; cytometric bead array; Cmax; maximum concentration; DC; dendritic cells; DM1; type 1 diabetes mellitus; DPP-4; dipeptidyl peptidase-4; EGR2; early growth response 2; FBS; fetal bovine serum; GIP; glucose-dependent insulinotr
Mechanisms of the amplifying pathway of insulin secretion in the β cell
Keywords: ABCC8; ATP binding cassette subfamily C member 8; ADCY5; adenylyl cyclase type 5; AICAR; 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside; DPP-IV; dipeptidyl peptidase 4; G6PD; glucose-6-phosphate dehydrogenase; GDH; glutamate dehydrogenase; GIP; gast
Novel insight into mutational impacts and binding mechanism of human glutaminase and glutaminase-interacting protein: A bio-molecular modeling and docking analysis
Keywords: MT; mutant type; WT; wild type; SD; standard deviation; GIP; glutaminase interacting protein; P.I.C.; Protein Interaction Calculator; DS; Discovery Studio; MD; Molecular Dynamics; Human glutaminase modeling; Evolutionarily conserved residues; Mutational i
The Na+-D-glucose cotransporters SGLT1 and SGLT2 are targets for the treatment of diabetes and cancer
Keywords: AMG; α-methyl-D-glucopyranoside; BBB; blood brain barrier; BBM; brush-border membrane; BLM; basolateral membrane; CREB; cAMP response element binding protein; DNJ; 1-deoxynojirimycin; EKA; euglycemic ketoacidosis; GGM; glucose-galactose malabsorption; GI
Visceral fat obesity increases serum DPP-4 levels in men with type 2 diabetes mellitus
Keywords: DPP-4; dipeptidyl peptidase-4; T2DM; type 2 diabetes mellitus; MetS; metabolic syndrome; GLP-1; glucagon-like peptide 1; GIP; gastric inhibitory polypeptide; Dipeptidyl peptidase-4; Visceral fat; Metabolic syndrome; Type 2 diabetes mellitus;
Profiling of Brevibacillus borstelensis transcriptome exposed to high temperature shock
Keywords: cDNA; complementary DNA; BLAST; Basic Local Alignment Search Tool; NR; non-redundant; GO; gene ontology; KEGG; Kyoto Encyclopedia of Genes and Genomes; GIP; genetic information processing; EIP; environmental information processing; °C; degree centigrade;
Evidence for neural contribution to islet effects of DPP-4 inhibition in mice
Keywords: Insulin; DPP-4 inhibition; GLP-1; GIP; Vagus nerve
Ala5-galanin (2-11) is a GAL2R specific galanin analogue
Keywords: BBB; blood-brain barrier; CHO cells; Chinese hamster ovary cells; CNS; central nervous system; EDTA; ethylenediaminetetraacetic acid; FBS; fetal bovine serum; Fmoc; 9-fluorenylmethyloxycarbonyl; FSK; forskolin; GAL1R; Galanin receptor 1; GAL2R; Galanin re
Naturally-occurring TGR5 agonists modulating glucagon-like peptide-1 biosynthesis and secretion
Keywords: GLP-1; GIP; Incretin; Secretagogue; TGR5;
Incretin hormone receptors are required for normal beta cell development and function in female mice
Keywords: GLP-1; GIP; Insulin; Glucose; Clamp
Metabolic responses to xenin-25 are altered in humans with Roux-en-Y gastric bypass surgery
Keywords: Xenin; GIP; GLP-1; Gastric bypass; Insulin secretion
GPR40 agonists for the treatment of type 2 diabetes mellitus: The biological characteristics and the chemical space
Keywords: GPR40; G protein-coupled receptor 40; FFA1; free fatty acid receptor 1; PK; pharmacokinetic; GSIS; glucose-stimulated insulin secretion; T2DM; type 2 diabetes mellitus; IDF; International Diabetes Federation; GLP-1; glucagon-like peptide1; GIP; gastric in
Molecular and cellular characterization of GA-Stimulated Transcripts GASA4 and GASA6 in Arabidopsis thaliana
Keywords: GA; gibberellins; ABA; abscisic acid; GAI; GA INSENSITIVE; BR; brassinosteroids; JA; jasmonic acid; SA; salicylic acid; GASA; GA-stimulated transcript in Arabidopsis; GAST; GA-stimulated transcript in tomato; GIP; GA-induced protein; GEG; Gerbera hybrida