Keywords: ترشح انسولین تحریک شده توسط گلوکز; ACC1; acetylcoenzyme A carboxylase 1; ASIP; agouti signaling protein; BETA2; transcription factor Beta 2; CYP7a1; cytochrome P450, family 7, subfamily a, polypeptide 1; cFOS; transcription factor C-fos; FASN; fatty acid synthase; FOXA2; forkhead box prote
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Keywords: ترشح انسولین تحریک شده توسط گلوکز; Oxidative phosphorylation; Mitochondrial membrane potential; Cell respiration; Metabolic control analysis; Glucose-stimulated insulin secretion; Diabetes;
Keywords: ترشح انسولین تحریک شده توسط گلوکز; T2DM; type 2 diabetes; GSIS; glucose-stimulated insulin secretion; SNP; single nucleotide polymorphism; KoGES; Korean Genome Epidemiology Study; KARE; Korea Association Resource; GWAS; genome-wide-association studies; Cdc42; cell division control protein
Keywords: ترشح انسولین تحریک شده توسط گلوکز; Diabetes; Isoflavones; Insulin resistance; Phytochemicals; Pancreatic β-Cells; DM; diabetes mellitus; T1DM; Type 1 diabetes mellitus; T2DM; Type 2 diabetes mellitus; DHD; dihydrodaidzein; O-Dma; O-desmethylangolensin; DHG; dihydrogenistein; 6-OH-O-Dma; 6
Keywords: ترشح انسولین تحریک شده توسط گلوکز; Angiopoietin-like protein 4 (Angptl4); Pancreas; Insulin secretion; Protein kinase A; Angptls; angiopoietin-like proteins; Angptl4; angiopoietin-like protein 4; cAMP; cyclic adenosine monophosphate; CCD; coiled-coil domain; DMEM; Dulbecco's modified Eagle
Keywords: ترشح انسولین تحریک شده توسط گلوکز; 4-HDDE; 4-Hydroxy-2E,6Z-dodecadienal; 4-HHE; 4-Hydroxyl-2E-hexenal, 4-HNE, 4-Hydroxy-2E-nonenal; AGE; Advanced glycation end products; ALE; Advanced lipoxidation end products; AR; aldose reductase; COX; Cyclooxygenase; EET; Epoxyeicosatrienoic acid; ER; E
Keywords: ترشح انسولین تحریک شده توسط گلوکز; aR'; activity coefficient ratio; CDC; complete depolarization cocktail; ÎÏM; mitochondrial membrane potential; ÎÏP; plasma membrane potential; FCCP; carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone; GSIS; glucose-stimulated insulin secretion; KA
Keywords: ترشح انسولین تحریک شده توسط گلوکز; Baicalin; Baicalein; Flavonoids; Chemoprevention; Inflammatory diseases; 6-OHDA; 6-hydroxydopamine; 12-LOX; 12-lipoxygenase; AIDS; acquired immunodeficiency disorder syndrome; AhR; aryl hydrocarbon receptor; AIH; autoimmune hepatitis; AICAR; 5-aminoimidaz
Keywords: ترشح انسولین تحریک شده توسط گلوکز; Glucose tolerance; Inflammation; Insulin secretion; Insulin resistance; Nitrite; Type 2 diabetes; NO; nitric oxide; GSIS; glucose-stimulated insulin secretion; QUICKI; quantitative insulin sensitivity check index; HOMA-IR; homeostasis model assessment of
Keywords: ترشح انسولین تحریک شده توسط گلوکز; 6PGDH; 6-phosphogluconate dehydrogenase; KATP; ATP-sensitive K+ channel; ER; endoplasmic reticulum; G6PDH; glucose-6-phosphate dehydrogenase; GC; gas chromatography; GHB; γ-hydroxybutyric acid; GSIS; glucose-stimulated insulin secretion; ICDc; cytosolic
Keywords: ترشح انسولین تحریک شده توسط گلوکز; Beta cells; Diabetes; Eicosanoids; Fatty aldehyde dehydrogenase; Glutathione peroxidase; Glutathione-S-transferase4-hydroxyalkenals; 4-Hydroxynonenal; Lipid peroxidation; Phospholipase A; 12-HETE (PubChem CID: 5283155); 15-HETE (PubChem CID: 280724); 4-HN
Keywords: ترشح انسولین تحریک شده توسط گلوکز; AGE-RAGE; advanced glycation end products; AI; atherogenic index; AMPK; AMP-activated protein kinase; Ara; arabinose; Bax; pro-apoptotic Bcl2-associated X; Bcl-2; B-cell leukaemia/lymphoma 2; BG; blood glucose; CAT; catalase; Fuc; fucose; FBG; fasting blo
Keywords: ترشح انسولین تحریک شده توسط گلوکز; Îp; proton motive force established on inner mitochondrial membrane; ÎÏ; electrical membrane potential established on inner mitochondrial membrane; COX4.1; cytochrome c oxidase subunit 4 isoform 1; ERK; extracellular signal-regulated kinase; FA; fatty
Keywords: ترشح انسولین تحریک شده توسط گلوکز; CNS; central nervous system; INS-1; insulin secreting β-cell line originated from a rat insulinoma; GK rat; Goto-Kakizaki rat; NOD mouse; non-obese diabetic mouse; TKP; tryptophan/kynurenine pathway; Trp; tryptophan; KYN; kynurenine; 3HK; 3-OH-kynureni
Keywords: ترشح انسولین تحریک شده توسط گلوکز; GSIS; glucose-stimulated insulin secretion; T; testosterone; DHT; 5α-dihydrotestosterone; AR; androgen receptor; Tfam; mitochondrial transcription factor A; PGC-1α; peroxisome proliferator-activated receptor γ coactivator 1α; NRF1; nuclear respiratory
Keywords: ترشح انسولین تحریک شده توسط گلوکز; AA; arachidonic acid; ALP; alkaline phosphatase; ALX; G protein-coupled lipoxin A(4) receptor; AMP; adenosine monophosphate; BAT; brown adipose tissue; BMC; bone mineral content; BMD; bone mineral density; BMI; body mass index; CKD; chronic kidney disease
Keywords: ترشح انسولین تحریک شده توسط گلوکز; Type 2 diabetes; Trans-caryophyllene; Glucose-stimulated insulin secretion; Type 2 cannabinoid receptor; Arf6;
Keywords: ترشح انسولین تحریک شده توسط گلوکز; Catharanthus roseus; Catharanthus roseus (L). Don; GSIS; glucose-stimulated insulin secretion; HFD; high-fat diet; STZ; streptozotocin; OGTT; oral glucose tolerance test; HbA1c; glycated hemoglobin; TG; plasma triglyceride; TEA; tetraethylammonium chlorid
Keywords: ترشح انسولین تحریک شده توسط گلوکز; AA; arachidonic acid; COX; cyclooxygenase; EET; epoxyeicosatrienoic acid; FALDH; fatty aldehyde dehydrogenase; GLUT1; glucose transporter 1, GPx, glutathione peroxidase; GSIS; glucose-stimulated insulin secretion; 4-HDDE; 4-hydroxy-2E, 6Z-dodecadienal; HF
Keywords: ترشح انسولین تحریک شده توسط گلوکز; 20-HETE; 20-hydroxyeicosatetraenoic acid; Ang-II; angiotensin II; AP-1; activator protein 1; ARIC; Atherosclerosis Risk in Communities; ATF-6; activating transcription factor-6; CAC; coronary artery calcification; CARDIA; Coronary Artery Risk Development
Lysophosphatidylcholine and its phosphorothioate analogues potentiate insulin secretion via GPR40 (FFAR1), GPR55 and GPR119 receptors in a different manner
Keywords: ترشح انسولین تحریک شده توسط گلوکز; Lysophosphatidylcholine (LPC); GPR40 (FFAR1); GPR55; GPR119; Insulin secretion; [Ca2+]i; intracellular calcium ions concentration; cAMP; cyclic AMP; GSIS; glucose-stimulated insulin secretion; GPCR; G protein coupled receptor; IBMX; 3-isobutyl-1-methylxan
Durability of protective effect of dulaglutide on pancreatic β-cells in diabetic mice: GLP-1 receptor expression is not reduced despite long-term dulaglutide exposure
Keywords: ترشح انسولین تحریک شده توسط گلوکز; Apoptosis; β-cell; GLP-1 receptor; Cell proliferation; Dulaglutide; Durability; Dula; Dulaglutide; GLP-1R; Glucagon-like peptide-1 receptor; GSIS; Glucose-stimulated insulin secretion; IPITT; Intraperitoneal insulin tolerance test; TG; Triglyceride; NEFA
Cysteinyl leukotriene receptor 1 regulates glucose-stimulated insulin secretion (GSIS)
Keywords: ترشح انسولین تحریک شده توسط گلوکز; Type 2 diabetes mellitus; Glucose-stimulated insulin secretion; Cysteinyl leukotrienes; Montelukast; Arf6;
Lysine demethylase inhibition protects pancreatic β cells from apoptosis and improves β-cell function
Keywords: ترشح انسولین تحریک شده توسط گلوکز; Apoptosis; β cells; Inflammation; Lysine demethylases; Gene expression; Diabetes; ATF; Activating transcription factor; ChIP; Chromatin immunoprecipitation; CHOP; C/EBP homologous protein; DP; Death promoting gene; ER; Endoplasmic reticulum; FDH; Formald
Insights into pathogenesis of five novel GCK mutations identified in Chinese MODY patients
Keywords: ترشح انسولین تحریک شده توسط گلوکز; GCK; Glucokinase; GKRP; Glucokinase regulatory protein; GSIS; Glucose-stimulated insulin secretion; G6P; Glucose-6-phosphate; GKAs; Glucokinase activators; MODY; Maturity-onset diabetes of the young; mGCK; Mutant GCK; OHA; Oral hypoglycaemic agents; WT GC
Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control
Keywords: ترشح انسولین تحریک شده توسط گلوکز; AAV; adeno-associated virus; DIO; diet-induced obesity; GCC; guanylyl cyclase receptor; GN; guanylin peptide; GSIS; glucose-stimulated insulin secretion; GUCA2A; guanylate cyclase activator 2A gene; GUCA2B; guanylate cyclase activator 2B gene; ISH; in sit
Regulation of the β-cell inflammasome and contribution to stress-induced cellular dysfunction and apoptosis
Keywords: ترشح انسولین تحریک شده توسط گلوکز; ASC; Inflammation; Danger associated-molecular patterns; Potassium; Purinergic receptors; KDAC; lysine deacetylase; HDAC; histone deacetylase; HDACi/KDACi; HDAC/KDAC inhibition; NLRP; NLR (NOD-like receptor) family pyrin domain containing; NLRC; NLR Famil
Mitochondrial uncoupling, ROS generation and cardioprotection
Keywords: ترشح انسولین تحریک شده توسط گلوکز; ANT; adenine nucleotide translocator; CCCP; carbonyl cyanide m-chlorophenylhydrazone; CcO; cytochrome c oxidase; DNP; 2,4-dinitrophenol; FCCP; carbonyl cyanide p-trifluoromethoxyphenylhydrazone; GSIS; glucose-stimulated insulin secretion; HNE; 4-hydroxy-2
Effects of bisphenol A on metabolism and evidences of a mode of action mediated through endocrine disruption
Keywords: ترشح انسولین تحریک شده توسط گلوکز; Bisphenol A; BPA; Endocrine disruption; Obesity; Type 2 diabetes; Insulin; BAT; brown adipose tissue; BMI; body mass index; bw; body weight; DES; diethylstilbestrol; DM; Diabete mellitus; ED; endocrine disruptor; eGFR; estimated glomerular filtration; ERR
Prolonged stimulation of insulin release from MIN6 cells causes zinc depletion and loss of β-cell markers
Keywords: ترشح انسولین تحریک شده توسط گلوکز; Zn2+; zinc ions; MT; metallothionein; ZIP; Zrt- and Irt-related protein; ZnT; zinc transporter protein; GSIS; glucose-stimulated insulin secretion; KATP channels; ATP-sensitive potassium channels; L-VGCC; L-type voltage-gated calcium channels; Ca2+; calci
BDE-47 and BDE-85 stimulate insulin secretion in INS-1 832/13 pancreatic β-cells through the thyroid receptor and Akt
Keywords: ترشح انسولین تحریک شده توسط گلوکز; GSIS; glucose-stimulated insulin secretion; POP; Persistent organic pollutant; PBDE; poly-brominated diphenyl ether; BDE-47; 2,2â²,4,4â²- tetrabromodiphenyl ether; BDE-85; 2,2â²,3,4,4â²-pentabromodiphenyl ether; TR; thyroid receptor; BDE-47; BDE-85; G
The impairment of glucose-stimulated insulin secretion in pancreatic β-cells caused by prolonged glucotoxicity and lipotoxicity is associated with elevated adaptive antioxidant response
Keywords: ترشح انسولین تحریک شده توسط گلوکز; Adaptive antioxidant response; Pancreatic β-cells; Glucotoxicity; Lipotoxicity; Glucose-stimulated insulin secretion;
Tiam1/Vav2-Rac1 axis: A tug-of-war between islet function and dysfunction
Keywords: ترشح انسولین تحریک شده توسط گلوکز; HG; high glucose; GEFs; guanine nucleotide exchange factors; GSIS; glucose-stimulated insulin secretion; NOD mice; nonobese diabetic mice; Nox2; phagocyte-like NADPH oxidase; Rac1; Ras-related C3 botulinum toxin substrate 1; ROS; reactive oxygen species;
Transcribing β-cell mitochondria in health and disease
Keywords: ترشح انسولین تحریک شده توسط گلوکز; β-Cell; Mitochondria; Islets; Genome-wide association study (GWAS); Insulin secretion; Expression quantitative trait locus (eQTL); ATGL; adipocyte triglyceride lipase; AMPK; AMP-dependent protein kinase; COX; Cytochrome c oxidase; CYTB; Cytochrome b; ERR
Geniposide improves insulin production and reduces apoptosis in high glucose-induced glucotoxic insulinoma cells
Keywords: ترشح انسولین تحریک شده توسط گلوکز; Glucotoxicity; Glucose-stimulated insulin secretion; Apoptosis; Geniposide;
Mechanisms of the amplifying pathway of insulin secretion in the β cell
Keywords: ترشح انسولین تحریک شده توسط گلوکز; ABCC8; ATP binding cassette subfamily C member 8; ADCY5; adenylyl cyclase type 5; AICAR; 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside; DPP-IV; dipeptidyl peptidase 4; G6PD; glucose-6-phosphate dehydrogenase; GDH; glutamate dehydrogenase; GIP; gast
Drp1 guarding of the mitochondrial network is important for glucose-stimulated insulin secretion in pancreatic beta cells
Keywords: ترشح انسولین تحریک شده توسط گلوکز; Pancreatic beta cells; Dynamin-related protein 1 (Drp1); Mitochondrial fission; Mitochondrial dynamics; Glucose-stimulated insulin secretion; Drp1; dynamin-related protein 1; ER; endoplasmic reticulum; Fis1; fission protein 1; Mff; mitochondrial fission f
Coffee silverskin extract improves glucose-stimulated insulin secretion and protects against streptozotocin-induced damage in pancreatic INS-1E beta cells
Keywords: ترشح انسولین تحریک شده توسط گلوکز; CF; caffeine; CGA; chlorogenic acid; CSE; coffee silverskin extract; DCF; dichlorofluorescein; GPx; glutathione peroxidase; GR; glutathione reductase; GSH; reduced glutathione; GSIS; glucose-stimulated insulin secretion; KRB; Krebs-Ringer bicarbonate bu
The bile acid TUDCA increases glucose-induced insulin secretion via the cAMP/PKA pathway in pancreatic beta cells
Keywords: ترشح انسولین تحریک شده توسط گلوکز; 6E-CDCA; 6-Ethyl-chedeoxycholic acid; ADP; Adenosine diphosphate; AKT or PTB; Protein kinase B; ATP; Adenosine triphosphate; AUC; Area under curve; BSA; Bovine serum albumin; cAMP; Cyclic adenosine monophosphate; CREB; cAMP response element-binding protei
Efficient generation of pancreatic β-like cells from the mouse gallbladder
Keywords: ترشح انسولین تحریک شده توسط گلوکز; GBCs; gallbladder cells; rGBC1; 1st generation reprogrammed islet-like cells; rGBC2; 2nd generation reprogrammed β-like cells; GSIS; glucose-stimulated insulin secretion; FACS; fluorescence-activated cell sorting; Gallbladder; Type 1 diabetes; Pancreatic
GPR40 agonists for the treatment of type 2 diabetes mellitus: The biological characteristics and the chemical space
Keywords: ترشح انسولین تحریک شده توسط گلوکز; GPR40; G protein-coupled receptor 40; FFA1; free fatty acid receptor 1; PK; pharmacokinetic; GSIS; glucose-stimulated insulin secretion; T2DM; type 2 diabetes mellitus; IDF; International Diabetes Federation; GLP-1; glucagon-like peptide1; GIP; gastric in
Disrupted dynamics of F-actin and insulin granule fusion in INS-1 832/13 beta-cells exposed to glucotoxicity: partial restoration by glucagon-like peptide 1
Keywords: ترشح انسولین تحریک شده توسط گلوکز; C; Control; EGFP; Enhanced Green Fluorescent protein; ESI-05; 4-Methylphenyl-2, 4, 6-trimethylphenylsulfone; F-actin; Filamentous Actin; GLP-1; Glucagon-like peptide 1; GSIS; Glucose-stimulated insulin secretion; HG; High-glucose; NPY; Neuropeptide Y; RFP
Hypothalamic AMP-Activated Protein Kinase Regulates Biphasic Insulin Secretion from Pancreatic β Cells during Fasting and in Type 2 Diabetes
Keywords: ترشح انسولین تحریک شده توسط گلوکز; ACC; acetyl CoA carboxylase; AICAR; 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside; AIR; acute insulin response; AMPK; AMP-activated protein kinase; CT; computed tomography; 2-DG; 2-deoxy-d-glucose; 18F-FDG; 2-[fluorine-18]-2-deoxy-d-glucose; GIP; g
Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells
Keywords: ترشح انسولین تحریک شده توسط گلوکز; 4E-BP1; 4E binding protein; AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; ATP; adenosine triphosphate; DEPTOR; DEP domain containing mTOR-interacting protein; CI; complexes I; CII; complex II; CIII; complex III; CIV; complex
Type II PKAs are anchored to mature insulin secretory granules in INS-1 β-cells and required for cAMP-dependent potentiation of exocytosis
Keywords: ترشح انسولین تحریک شده توسط گلوکز; Pancreatic; Endocrine; Insulin; Exocytosis; Potentiation; Protein kinase-A; cAMP; Compartmentalization; AKAP; A-Kinase anchoring protein; Epac; Exchange proteins directly activated by cAMP; GEF; Guanine nucleotide exchange factor; GLP-1; Glucagon-like pep
Oleate protects beta-cells from the toxic effect of palmitate by activating pro-survival pathways of the ER stress response
Keywords: ترشح انسولین تحریک شده توسط گلوکز; FBS; fetal bovine serum; FFA; free fatty acids; FFAR1; free fatty acid receptor 1; GSIS; glucose-stimulated insulin secretion; SFA; saturated FFA; USFA; unsaturated FFA; OCR; oxygen consumption rate; MS; mass spectrometry; Palmitate; Oleate; Insulin secre
Glucagon-like peptide-1 improves beta-cell antioxidant capacity via extracellular regulated kinases pathway and Nrf2 translocation
Keywords: ترشح انسولین تحریک شده توسط گلوکز; DCFH; dichorofluorescin; GLP-1; glucagon-like peptide-1; GPx; glutathione peroxidase; GR; glutathione reductase; GSIS; glucose-stimulated insulin secretion; GSH; reduced glutathione; Nrf2; nuclear transcription factor erythroid 2p45-related factor; ROS; r
Benzimidazole derivatives protect against cytokine-induced apoptosis in pancreatic β-Cells
Keywords: ترشح انسولین تحریک شده توسط گلوکز; Pancreatic β-cells; Benzimidazole; Cytokines; Apoptosis; Glucose-stimulated insulin secretion;
Mechanism of action of hypoglycemic effects of an intestine-specific inhibitor of microsomal triglyceride transfer protein (MTP) in obese rats
Keywords: ترشح انسولین تحریک شده توسط گلوکز; Glucose-stimulated insulin secretion; High fat-induced obesity; Insulin sensitivity; JTT-130; Microsomal triglyceride transfer protein
Specific and redundant roles of PKBα/AKT1 and PKBβ/AKT2 in human pancreatic islets
Keywords: ترشح انسولین تحریک شده توسط گلوکز; (PKB); Protein kinase B; (T2D); type 2 diabetes; (FFA); free fatty acids; (IRS); insulin receptor substrate; (PI3K); phosphoinositide 3-kinase; (mTORC2); mTOR complex 2; (KO); knockout; (INS); rat insulinoma cells; (GOF); gain of function; (GSIS); glucose