Keywords: GPCRs، G گیرنده های پروتئینی G است; GPCRs, G protein-coupled receptors; T2Rs, bitter taste receptors; TRC, taste receptor cells; TAS2R, bitter taste receptor coding genes; PLCβ2, phospholipase C-β2; PIP2, phosphatidylinositol-4,5-bisphosphate; IP3, inositol-1,4,5-triphosphate; DAG, diacyl g
مقالات ISI GPCRs، G گیرنده های پروتئینی G است (ترجمه نشده)
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Keywords: GPCRs، G گیرنده های پروتئینی G است; BRET, bioluminescence resonance energy transfer; CHO, Chinese hamster ovary; Cre-Luc, cyclic AMP response element-luciferase; GPCRs, G protein-coupled receptors; HEK, human embryonic kidney; KS, Kallmann syndrome; PK2, prokineticin 2; PKR2, prokineticin r
The roles and potential therapeutic implications of CXCL4 and its variant CXCL4L1 in the pathogenesis of chronic liver allograft dysfunction
Keywords: GPCRs، G گیرنده های پروتئینی G است; Chemokine; CXCL4 variants; Liver transplantation; Chronic allograft dysfunctionI/R, ischemia/reperfusion; Th1, type-1 helper; Tregs, regular T lymphocytes; NKTs, natural killer T cells; PF4, platelet factor 4; GPCRs, G protein-coupled receptors; NK, natur
Human somatostatin receptor-3 distinctively induces apoptosis in MCF-7 and cell cycle arrest in MDA-MB-231 breast cancer cells
Keywords: GPCRs، G گیرنده های پروتئینی G است; Apoptosis; Breast cancer; G protein-coupled receptor; Somatostatin; Somatostatin receptor-3EGF, Epidermal growth factor; ERK, Extracellular signal-regulated kinase; EST, 17β-estradiol; GPCRs, G protein-coupled receptors; HA, Hemagglutinin; MAPK, Mitogen-a
Stress-induced dendritic internalization and nuclear translocation of the neurokinin-3 (NK3) receptor in vasopressinergic profiles of the rat paraventricular nucleus of the hypothalamus
Keywords: GPCRs، G گیرنده های پروتئینی G است; ACTH, adenocorticotropin hormone; AVP, vasopressin; Avpr 1a, vasopressin receptor 1a; Avpr 1b, vasopressin receptor 1b; CRF, corticotropin-releasing factor; GPCRs, G protein-coupled receptors; HPA, hypothalamic-pituitary-adrenal axis; ME, median eminence;
Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold
Keywords: GPCRs، G گیرنده های پروتئینی G است; Adenosine receptor; 3D-QSAR; Grid-Independent Descriptors (GRIND-2); Suzuki–Miyaura cross-coupling reaction; Pyrimidines; Adenosine antagonists; Library synthesisARs, human adenosine receptors; GPCRs, G protein-coupled receptors; 3D-QSAR, three-dimensiona
Short chain fatty acids and their receptors: new metabolic targets
Keywords: GPCRs، G گیرنده های پروتئینی G است; FFAR2, free fatty acid receptor-2; FFAR3, free fatty acid receptor-3; GLP1, glucagon-like peptide-1; GPCRs, G protein-coupled receptors; IUPAC, International Union of Pure and Applied Chemistry; LCFAs, long chain fatty acids; MCFAs, medium chain fatty aci
RGS19 inhibits Ras signaling through Nm23H1/2-mediated phosphorylation of the kinase suppressor of Ras
Keywords: GPCRs، G گیرنده های پروتئینی G است; ERK, extracellular signal-regulated kinase; GAIP, Gα-interacting protein; GAP, GTPase activating protein; GIPC, GAIP interacting protein C terminus; GPCRs, G protein-coupled receptors; HEK293, human embryonic kidney 293; KSR, kinase suppressor of Ras; MAP
Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease
Keywords: GPCRs، G گیرنده های پروتئینی G است; AD, Alzheimer disease; PD, Parkinson's disease; NMDA receptors, N-methyl-d-aspartate receptors; GPCRs, G protein-coupled receptors; PKA, protein kinase A; PLC, phospholipase C; cAMP, cyclic advenosine monophosphato; CREB, cAMP response element binding pro
Protein kinase Cμ mediates adenosine-stimulated steroidogenesis in primary rat adrenal cells
Keywords: GPCRs، G گیرنده های پروتئینی G است; Ado, adenosine; AR, adenosine receptor; CREB, cyclic AMP responsive-element binding protein; ERK, extracellular signal-related regulated kinase; GPCRs, G protein-coupled receptors; JAK2, Janus kinase 2; MEK, mitogen-activated protein kinase kinase; PKC, p
G protein-coupled receptor kinase 5, overexpressed in the α-synuclein up-regulation model of Parkinson's disease, regulates bcl-2 expression
Keywords: GPCRs، G گیرنده های پروتئینی G است; GRKs, G protein-coupled receptor kinases; LBs, Lewy bodies; pS129-α-synuclein, α-synuclein phosphorylated at Ser-129; shRNA, short hairpin ribonucleic acid; HDAC, histone deacetylase; GPCRs, G protein-coupled receptors; NLS, DNA-binding nuclear localizati
Angiotensin-induced EGF receptor transactivation inhibits insulin signaling in C9 hepatic cells
Keywords: GPCRs، G گیرنده های پروتئینی G است; Ang II, angiotensin II; AT1R, angiotensin type 1 receptor; EGF, epidermal growth factor; GPCRs, G protein-coupled receptors; GSK-3, glycogen synthase kinase-3; IRS, insulin receptor substrate; IR, insulin receptor; mTOR, mammalian target of rapamycin; PI3
An unexpected effect of 5-MCA-NAT in chick retinal development
Keywords: GPCRs، G گیرنده های پروتئینی G است; 5-MCA-NAT, 5-methoxycarbonylamino-N-acetyltryptamine; QR2, dihydronicotinamide riboside: quinone oxidoreductase 2; [125I]-5-MCA-NAT, 2-[125I]-iodo-5-methoxycarbonylamino-N-acetyltryptamine; GPCRs, G protein-coupled receptors; CHO cells, Chinese hamster ov
Brain region-specific N-glycosylation and lipid rafts association of the rat mu opioid receptor
Keywords: GPCRs، G گیرنده های پروتئینی G است; aa, amino acid; CHO, Chinese hamster ovary cells; CPu, caudate putamen; DAMGO, [d-Ala2,N-MePhe4,Glyol5]enkephalin; DOR, delta opioid receptor; Endo H, endoglycosidase H; GM1, ganglioside M1; GPCRs, G protein-coupled receptors; KOR, kappa opioid receptor;
A multi-hit endocrine model of intrinsic adult-onset asthma
Keywords: GPCRs، G گیرنده های پروتئینی G است; cAMP, cyclic adenosine monophospate; CEEs, conjugated equine estrogens; ER, estrogen receptor; FSH, follicle-stimulating hormone; GnRH, gonadotropin-releasing hormone; GPCRs, G protein-coupled receptors; HPA, hypothalamic–pituitary–adrenal; HPG, hypothala
Prostacyclin receptor-induced STAT3 phosphorylation in human erythroleukemia cells is mediated via Gαs and Gα16 hybrid signaling
Keywords: GPCRs، G گیرنده های پروتئینی G است; AC, adenylyl cyclase; cAMP, cyclic AMP; CTX, cholera toxin; C5aR, C5a Receptor; DB-cAMP, dibutyryl-cAMP; ERK, extracellular signal-regulated kinase; FBS, fetal bovine serum; GPCRs, G protein-coupled receptors; HEL, human erythroleukemia; HEK, human embryo
The ibogaine medical subculture
Keywords: GPCRs، G گیرنده های پروتئینی G است; 18-MC, 18-methoxycoronaridine; AC, adenylyl cyclase; EKG, electrocardiogram; FDA, United States Food and Drug Administration; GDNF, glial cell line-derived neurotrophic factor; GPCRs, G protein-coupled receptors; Ibogaine HCl, ibogaine hydrochloride; LSD,
Monomeric dark rhodopsin holds the molecular determinants for transducin recognition: Insights from computational analysis
Keywords: GPCRs، G گیرنده های پروتئینی G است; Molecular recognition; Docking; GPCRs; G proteinsGt, transducin; GPCRs, G protein-coupled receptors; Rho, rhodopsin; PSB, protonated Schiff base; MII, Meta II; MI, Meta I; H, helix; AFM, atomic force microscopy; ZD, ZDOCK; PDB, Protein Data Bank; Cα-RMSD,
New tensio-active molecules stabilize a human G protein-coupled receptor in solution
Keywords: GPCRs، G گیرنده های پروتئینی G است; AIBN, α,α′-azobis isobutyronitrile; CD, circular dichroism; cmc, critical micellar concentration; DDM, dodecyl-β-d-maltoside; DPn, degree of polymerization; GPCRs, G protein-coupled receptors; HDM, hexadecyl-β-d-maltoside; LDAO, dodecyldimethylamino oxide
Comparative analysis of P2Y4 and P2Y6 receptor architecture in native and transfected neuronal systems
Keywords: GPCRs، G گیرنده های پروتئینی G است; BN, Blue Native; DM, N-dodecyl-β-maltoside; DTT, dithiothreitol; FCS, foetal calf serum; GPCRs, G protein-coupled receptors; HDAC, histone deacetylase; PAGE, polyacrylamide gel electrophoresis; SDS, sodium dodecyl sulphate; SNAP, synaptosome-associated pr
Aspects of the general biology of adenosine A2A signaling
Keywords: GPCRs، G گیرنده های پروتئینی G است; GPCRs, G protein-coupled receptors; CREB, cAMP response element binding protein; CRE, cAMP response element; NFκB, nuclear factor-κB; PKC, protein kinase C; DARPP-32, dopamine and cAMP-regulated phophoprotein; CHF, congestive heart failure; HIF, hypoxia i
Opposing effects of β-arrestin1 and β-arrestin2 on activation and degradation of Src induced by protease-activated receptor 1
Keywords: GPCRs، G گیرنده های پروتئینی G است; PAR1, protease-activated receptor 1; ERK1/2, extracellular signal-regulated kinase 1 and 2; HEK 293 cells, human embryonic kidney 293 cells; GPCRs, G protein-coupled receptors; GRKs, G protein-coupled receptor kinases; β2AR, β2-adrenergic receptor; AT1R,
Constitutive dimerization of human serotonin 5-HT4 receptors in living cells
Keywords: GPCRs، G گیرنده های پروتئینی G است; β2AR, β2-adrenergic receptor; BRET, bioluminescence resonance energy transfer; CHO, Chinese hamster ovary cells; DMEM, Dulbecco’s modified Eagle’s medium; FCS, foetal calf serum; GPCRs, G protein-coupled receptors; IB, immunoblot; IP, immunoprecipitation;