کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2051282 | 1074196 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Monomeric dark rhodopsin holds the molecular determinants for transducin recognition: Insights from computational analysis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Monomeric dark rhodopsin holds the molecular determinants for transducin recognition: Insights from computational analysis Monomeric dark rhodopsin holds the molecular determinants for transducin recognition: Insights from computational analysis](/preview/png/2051282.png)
چکیده انگلیسی
In this computational study, we have investigated the implications of rhodopsin (Rho) oligomerization in transducin (Gt) recognition. The results of docking simulations between heterotrimeric Gt and monomeric, dimeric and tetrameric inactive Rho corroborate the hypothesis that Rho and Gt can be found coupled already in the dark. Moreover, our extensive computational analysis suggests that the most likely Rho:Gt stoichiometry is the 1:1 one. This means that the essential molecular determinants for Gt recognition and activation are contained in one Rho monomer. In this respect, the complex between one Rho molecule and one heterotrimeric Gt should be considered as the functional unit.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 5, 6 March 2007, Pages 944–948
Journal: FEBS Letters - Volume 581, Issue 5, 6 March 2007, Pages 944–948
نویسندگان
Daniele Dell’Orco, Michele Seeber, Francesca Fanelli,