دانلود مقالات ISI درباره Gsk-3 + ترجمه فارسی

Molecular cloning and characterization of glycogen synthase in Eriocheir sinensis

Keywords: GS; glycogen synthase; GN; glycogenin; G6P; glucose-6-phosphate; GSK-3; glycogen synthase kinase-3; PP1; protein phosphatase-1; UDP; uridine diphosphate; EsGS; E. sinensis hepatopancreas GS; EsGS-I; EsGS in inclusion bodies; EsGS-S; EsGS in soluble form;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases

Keywords: α-SYN; alpha synuclein; β-TrCP; β-transducin repeat containing E3 ubiquitin protein ligase; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activated protein kinase; ARE; antioxidant response element; ASK1; apo

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Potential anti-cancer activity of 7-O-pentyl quercetin: Efficient, membrane-targeted kinase inhibition and pro-oxidant effect

Keywords: Akt; protein kinase B (PKB); CK2; casein kinase 2; CsA; Cyclosporin A; DMEM; Dulbecco's Modified Eagle Medium; DTT; 1,4-Dithiothreitol; FBS; fetal bovine serum; GSK-3; glycogen synthase kinase 3; HBSS; Hank's Balanced Salt Solution; IKKα/β; IκB kin

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Dehydropachymic acid decreases bafilomycin A1 induced β-Amyloid accumulation in PC12 cells

Keywords: AD; Alzheimer's disease; ALP; autophagy-lysosome pathway; APP; amyloid precursor protein; ATG; autophagy-related gene; AVs; autophagic vacuoles; Aβ; β-amyloid peptide; DPA; dehydropachymic acid; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GSK-3; Gl

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

Oxidative stress induces mitotic arrest by inhibiting Aurora A-involved mitotic spindle formation

Keywords: CIN; chromosomal instability; CKIs; CDK inhibitors; DDC; sodium diethyldithiocarbamate trihydrate; GSK-3; glycogen synthase kinase 3; NAC; N-acetyl-L-cysteine; PCM; pericentriolar material; PCNT; pericentrin; ROS; reactive oxygen species; SAC; spindle ass

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

Activation of Wnt Signaling Increases Numbers of Enteric Neurons Derived From Neonatal Mouse and Human Progenitor Cells

Keywords: Neural Progenitor; Neurons; Proliferation; Differentiation; bFGF; basic fibroblast growth factor; BrdU; 5-bromo-2′-deoxyuridine; DMSO; dimethyl sulfoxide; EdU; 5-ethynyl-2′-deoxyuridine; ENS; enteric nervous system; FACS; fluorescence-activated cell s

دانلود رایگان متن کامل مقاله ISI 54 صفحه سال انتشار : 2017 سفارش ترجمه

Small-molecule GSK-3 inhibitor rescued apoptosis and neurodegeneration in anesthetics-injured dorsal root ganglion neurons

Keywords: Dorsal root ganglion; GSK-3; SB21673; PKC; Caspase-3;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

GSK-3 inhibition overcomes chemoresistance in human breast cancer

Keywords: Breast cancer; GSK-3; Chemoresistance; 9-ING-41; Drug development; ADMET; absorption, distribution, metabolism, excretion, toxicity; PK; pharmacokinetic; CDK; cyclin-dependent kinase; PKA; protein kinase A; Akt; protein kinase B; PKC; protein kinase C; GL

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Diosmin reduces cerebral Aβ levels, tau hyperphosphorylation, neuroinflammation, and cognitive impairment in the 3xTg-AD mice

Keywords: Alzheimer's disease; Aβ; Tau; Neuroinflammation; γ-Secretase; GSK-3; Diosmin

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Inhibition of GSK-3 reduces prostaglandin E2 production by decreasing the expression levels of COX-2 and mPGES-1 in monocyte/macrophage lineage cells

Keywords: GSK-3; PGE2; COX-2; mPGES-1; Anti-inflammatory drug;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons

Keywords: DIV; days in vitro; E18; embryonic day 18; EGFP; enhanced green fluorescent protein; GSK-3; glycogen synthase kinase-3; PBS; phosphate-buffered saline; PP; protein phosphatase; SDS; sodium dodecyl sulphate; Dementia; Tau; Mitochondria; Axonal transport; P

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Xanthatin anti-tumor cytotoxicity is mediated via glycogen synthase kinase-3β and β-catenin

Keywords: Xanthatin; GSK-3; β-Catenin; Tumor growth; Natural compound;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms

Keywords: ACN; acetonitrile; CDK; cyclin-dependent kinase; CLK; cdc2-like kinase; CK; casein kinase; DIPEA; diisopropylethylamine; DMEM; Dulbecco's modified Eagle's medium; DMF; N,N-dimethylformamide; DMSO; dimethyl sulfoxide; DYRK1A; dual specificity tyrosine

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Etoposide induces pancreatic β-cells cytotoxicity via the JNK/ERK/GSK-3 signaling-mediated mitochondria-dependent apoptosis pathway

Keywords: Etoposide; Pancreatic β-cells; Apoptosis; Mitochondria; JNK/ERK; GSK-3;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis

Keywords: GSK-3; NRF-2; aging; xenobiotic stress; Keap1; dietary restriction; triglycerides

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Analgesic drug delivery via recombinant tissue plasminogen activator and microRNA-183-triggered opening of the blood-nerve barrier

Keywords: (4-6): drug delivery; microRNA; Peripheral nerve; Biocompatibility; In vivo test; In vitro test; BBB; blood-brain barrier; BNB; blood-nerve barrier; CLDN1; claudin-1 gene; DAMGO; [d-Ala2,N-Me-Phe4,Gly5-ol]enkephalin; miR; microRNA; GSK-3; glycogen s

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

TENOgenic MODULating INsider factor: systematic assessment on the functions of tenomodulin gene

Keywords: 3D; three dimensional; Ad-EGFP; adenovirus vector encoding enhanced green fluorescent protein; APOE; apolipoprotein E; Aqp1; aquaporin 1; Arg; arginine; bHLH; basic helix-loop-helix; BMDSC; bone marrow-derived stem cell; BMP; bone morphogenetic protein; B

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2016 سفارش ترجمه

Design, synthesis and biological evaluation of 5-benzylidene-2-iminothiazolidin-4-ones as selective GSK-3β inhibitors

Keywords: GSK-3; CDK-2; Molecular docking; Molecular dynamics; SBDD; ICKPGBPIOPGQTC-UITAMQMPSA-N; KFVQEAUDWUKSMG-BOPFTXTBSA-N; NSRQEPDSABSJEH-YWEYNIOJSA-N; CLAFIVNSSVOTSP-GDNBJRDFSA-N; AKAOIQHIQLGIQQ-BOPFTXTBSA-N; QMZMFQSCRVRMSU-YWEYNIOJSA-N; SQIZTXJHAKRNIQ-WJDWOHS

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2016 سفارش ترجمه

Regulation of the CNC-bZIP transcription factor Nrf2 by Keap1 and the axis between GSK-3 and β-TrCP

Keywords: Nrf2; Keap1; GSK-3; PKB/Akt; PI3K; PTEN; β-TrCP; ARE; antioxidant response element; tBHQ; tert-butyl hydroquinone; bZIP; basic-region leucine zipper; CDDO-Im; 1[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole; CNC; cap'n'collar; Cul1; cullin-1; Cu

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2016 سفارش ترجمه

Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity-Diverse effects on cell growth, metabolism and cancer

Keywords: GSK-3; Wnt/beta-catenin; PI3K; Akt; mTOR; Hedgehog; Notch; Targeted therapy; Therapy resistance;

دانلود رایگان متن کامل مقاله ISI 158 صفحه سال انتشار : 2016 سفارش ترجمه

Role of P2X7 and P2Y2 receptors on α-secretase-dependent APP processing: Control of amyloid plaques formation “in vivo” by P2X7 receptor

Keywords: Alzheimer's disease; APP processing; α-Secretase; GSK-3; P2X7 receptor; P2Y2 receptor

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Regulation of liver cell glucose homeostasis by dehydroabietic acid, abietic acid and squalene isolated from balsam fir (Abies balsamea (L.) Mill.) a plant of the Eastern James Bay Cree traditional pharmacopeia

Keywords: AMPK; AMP-activated protein kinase; CREB; c-AMP-regulator element-binding protein; EtOAc; ethyl acetate fraction; FoxO1; forkhead transcription factor O1; G6Pase; Glucose-6-Phosphatase; GS; Glycogen Synthase; GSK-3; Glycogen Synthase Kinase-3; Hexane; hex

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

The GSK3B gene confers risk for both major depressive disorder and schizophrenia in the Han Chinese population

Keywords: GSK-3; glycogen synthease kinase-3; GWAS; the genome-wide association study; MDD; major depressive disorder; SCZ; schizophrenia; LD; linkage disequilibrium; OR; odds ratio; SNP; Single Nucleotide Polymorphisms; HWE; Hardy-Weinberg equilibrium test; AKT; m

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Phosphorylation of Serine422 increases the stability and transactivation activities of human Osterix

Keywords: Osx; Osterix; PTMs; post-translational modifications; GSK-3; glycogen synthase kinase-3; DMEM; Dulbercco's modified Eagle's medium; α-MEM; α-minimal essential medium; FBS; fetal bovine serum; LiCl; lithium chloride; CHX; cycloheximide; RIPA; radioim

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core

Keywords: GSK-3; Tau-phosphorylation; Alzheimer’s disease; Pyrrolopyridinone; Kinase

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Antidepressant-like effect of zinc is dependent on signaling pathways implicated in BDNF modulation

Keywords: BDNF; brain-derived neurotrophic factor; CAMKII; Ca2 +/calmodulin-dependent protein kinase; CREB; cAMP response element binding protein; ERK; extracellular signal-regulated kinase; GSK-3; Glycogen synthase kinase 3; H-89; N-[2-(p-bromocinnamylamino) ethy

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells

Keywords: EGFR; KRas; GSK-3; Drug resistance; Cancer stem cells; Metformin; miRs

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2015 سفارش ترجمه

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

Keywords: Nrf2; Keap1; β-TrCP; GSK-3; Reactive oxygen species; Inflammation; Nutrient supply; Lipid metabolism; Glutathione; Thioredoxin; Free radicals; aldo-keto reductase (AKR);

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2015 سفارش ترجمه

Stabilization of microtubular cytoskeleton protects neurons from toxicity of N-terminal fragment of cytosolic prion protein

Keywords: CtmPrP; transmembrane form of prion protein with the C-terminus residing in the lumen of endoplasmic reticulum; cytoPrP; cytosolic prion protein; ER; endoplasmic reticulum; GPI; glycosylphosphatidylinositol; GSK-3; glycogen synthase kinase 3; HBSS; Hank's

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2015 سفارش ترجمه

Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/β-TrCP

Keywords: Nrf2; GSK-3; β-TrCP; Cell signaling; Oxidative stress;

دانلود رایگان متن کامل مقاله ISI 52 صفحه سال انتشار : 2015 سفارش ترجمه

Intraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K+ current inhibition mediated by activation of caspases and GSK-3

Keywords: Amyloid-β protein; Intrinsic excitability; A-type K+ current; Caspase; GSK-3; KV4.2; Alzheimer's disease; Hippocampal neurons;

دانلود رایگان متن کامل مقاله ISI 59 صفحه سال انتشار : 2015 سفارش ترجمه

N-heterocyclic carbenes (NHC) with 1,2,4-oxadiazole-substituents related to natural products: Synthesis, structure and potential antitumor activity of some corresponding gold(I) and silver(I) complexes

Keywords: 1,2,4-Oxadiazoles; Gold-NHC; Silver-NHC; Natural product analogs; Anti-tumor activity; Bioisosters; NHC; N-heterocyclic carbene; DCM; dichloromethane; IC50; half maximal inhibitory concentration; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

دانلود رایگان متن کامل مقاله ISI 84 صفحه سال انتشار : 2015 سفارش ترجمه

Sustained behavioral effects of lithium exposure during early development in zebrafish: Involvement of the Wnt-β-catenin signaling pathway

Keywords: DPF; days post-fertilization; Fz or FZd; frizzled; GSK-3; Glycogen synthase kinase-3; HPF; hours post-fertilization; IMPase; Inositol Monophosphatase; LiCl; Lithium Chloride; LRP; Lipoprotein receptor related protein; RT-qPCR; Quantitative Reverse Transcr

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Effects of prenatal chronic mild stress exposure on hippocampal cell proliferation, expression of GSK-3α, β and NR2B in adult offspring during fear extinction in rats

Keywords: ANOVA, analysis of variance; BRDU, 5-bromo-2-deoxyuridine; CMS, chronic mild stress; CON, control; CR, conditioned response; CS, conditioned stimulus; DG, dentate gyrus; GCs, glucocorticoids; GD, gestational day; GSK-3α, glycogen synthase kinase-3α; GSK-3

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Acceleration of bone regeneration by local application of lithium: Wnt signal-mediated osteoblastogenesis and Wnt signal-independent suppression of osteoclastogenesis

Keywords: GSK-3; Lithium; Bone regeneration; Osteoblastogenesis; Osteoclastogenesis;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Activation of β-catenin by inhibitors of glycogen synthase kinase-3 ameliorates cisplatin-induced cytotoxicity and pro-inflammatory cytokine expression in HEI-OC1 cells

Keywords: GSK-3; glycogen synthase kinase-3; IHCs; inner hair cells; LEF; lymphoid enhancer-binding factor; OCs; organs of Corti; OHCs; outer hair cells; PTpase; protein tyrosine phosphatases; ROS; reactive oxygen species; TCF; T-cell-specific transcription factor;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Inhibition of glycogen synthase kinase (GSK)-3-β improves liver microcirculation and hepatocellular function after hemorrhagic shock

Keywords: GSK-3; Hemorrhagic shock; Intravital microscopy; Cytokine; Plasma disappearance rate

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Cocoa flavonoids attenuate high glucose-induced insulin signalling blockade and modulate glucose uptake and production in human HepG2 cells

Keywords: AKT/PKB; protein kinase B; AMPK; 5′-AMP-activated protein kinase; BrdU; 5-bromo-2′-deoxyuridine; CaMMK; Ca2+/calmodulin-dependent protein kinase kinase; CPE; cocoa phenolic extract; EC; (−)-epicatechin; EGCG; epigallocatechin gallate; ERK; extracell

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Cytosolic functions of MORC2 in lipogenesis and adipogenesis

Keywords: MORC2; Microrchidia family CW-type zinc finger 2; ZF; zinc finger; IP; immunoprecipitation; ATP; adenosine triphosphate; ACLY; ATP citrate lyase; IBMX; 3-isobutyl-1-methylxanthine; GST; glutathione-S-transferase; RIPA; radio-immunoprecipitation assay; MDH

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

β-Amyloid impairs the regulation of N-methyl-D-aspartate receptors by glycogen synthase kinase 3

Keywords: Alzheimer's disease; GSK-3; β-amyloid; NMDA receptor;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis and biological evaluation of tetrahydro[1,4]diazepino[1,2-a]indol-1-ones as cyclin-dependent kinase inhibitors

Keywords: CDK; GSK-3; Kinase; Inhibitor; Indole; Iodolactonisation; Docking

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

MACF1 regulates the migration of pyramidal neurons via microtubule dynamics and GSK-3 signaling

Keywords: MACF1; Neuronal migration; Cytoskeleton; Microtubule; GSK-3

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

Dual inhibitor of PDE7 and GSK-3 - VP1.15 acts as antipsychotic and cognitive enhancer in C57BL/6J mice

Keywords: Schizophrenia; Memory; Mice; PDE7; GSK-3; VP1.15; Amphetamine; MK-801; Antipsychotic; Cognitive enhancer;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Activator or inhibitor? GSK-3 as a new drug target

Keywords: GSK-3; Signaling; Regulation; Disease; Drug development

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Chemical synthesis and biological validation of immobilized protein kinase inhibitory Leucettines

Keywords: Leucettamine B; Leucettine; DYRKs; CLKs; GSK-3; Kinase; Kinase inhibitor; Alzheimer’s disease; Pre-mRNA splicingCDKs, cyclin-dependent kinases; CLKs, cdc2-like kinases; DMSO, dimethylsulfoxide; DTT, dithiothreitol; DYRKs, dual-specificity, tyrosine phosph

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Activation of Mammalian Target of Rapamycin and Synaptogenesis: Role in the Actions of Rapid-Acting Antidepressants

Keywords: BDNF; GABA; glutamate; GSK-3; lithium; scopolamine

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

AR-A014418 as a glycogen synthase kinase-3 inhibitor: Anti-apoptotic and therapeutic potential in experimental spinal cord injury

Keywords: Spinal cord injury; GSK-3beta; AR-A014418; Apoptosis; TGF-beta; Lesión medular; GSQ-3beta; AR-A014418; Apoptosis; TGF-beta; SCI; spinal cord injury; GSK-3; glycogen synthase kinase-3; DMSO; dimethylsulfoxide; PMNL; polymorphonuclear leukocytes; H+E; hema

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Chronic inhibition of glycogen synthase kinase-3 protects against rotenone-induced cell death in human neuron-like cells by increasing BDNF secretion

Keywords: GSK-3; BDNF; Hexokinase II; Neuroprotection

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

PI3K/Akt contributes to increased expression of Toll-like receptor 4 in macrophages exposed to hypoxic stress

Keywords: CoCl2; cobalt chloride; DIC; differential interference contrast; DiI; 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate; GSK-3; glycogen synthase kinase 3; HIF-1; hypoxia-inducible factor-1; LPS; lipopolysaccharide; Mal; MyD88 adapt

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Inhibition of glycogen synthase kinase-3 attenuates psychotomimetic effects of ketamine

Keywords: GSK-3; NMDA antagonist; Locomotor; Cognition; Prepulse inhibition; Schizophrenia

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه