دانلود مقالات ISI درباره Gsk-3 + ترجمه فارسی

NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease

Keywords: Huntington disease; Transgenic mouse model; Lithium; Caspase-6; BDNF; GSK-3; Tau;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: Implications of autophagy promotion

Keywords: Tau protein; GSK-3; Lithium; Autophagy; Microtubule-associated protein 1 light chain 3; Phosphorylation; Neurofibrillary tangles

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Serine-Threonine Kinase 38 is regulated by Glycogen Synthase Kinase-3 and modulates oxidative stress-induced cell death

Keywords: STK38, Serine Threonine Kinase 38; NDR, Nuclear Dbf-2 Related; GSK-3, Glycogen Synthase Kinase-3; PKA, Protein Kinase A; CA-AKT1, Constitutive active AKT1; NTR domain, N-terminal regulatory domainSTK38; GSK-3; Phosphorylation; Oxidative stress; JNK; Free

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease

Keywords: AD; Alzheimer's disease; AKT; protein kinase B; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor; aPKC; atypical protein kinase C; APP; amyloid-β precursor protein; ATG; AuTophaGy-related; BDNF; brain-derived neurotrophic factor; C/EBP; C

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

GSK-3 inhibition by an orally active small molecule increases bone mass in rats

Keywords: GSK-3; Osteoporosis; BMD; Wnt; β-Catenin; Bone formation

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders

Keywords: Aβ; amyloid-β; AD; Alzheimer's disease; AIMP2; aminoacyl tRNA synthetase complex-interacting multifunctional protein 2; CAA; cerebral amyloid angiopathy; CSF; cerebrospinal fluid; EAE; experimental autoimmune encephalomyelitis; ER; endoplasmic reticul

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Prostaglandin E2 stimulates S100A8 expression by activating protein kinase A and CCAAT/enhancer-binding-protein-beta in prostate cancer cells

Keywords: BSA; bovine serum albumin; cAMP; cyclic AMP; ChIP; chromatin immunoprecipitation; C/EBPβ; CCAAT/enhancer-binding-protein-beta; CM; conditioned medium; COX-2; cyclooxygenase-2; CREB; cAMP response element binding protein; EP; prostaglandin E receptor; ERK

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Anesthetic propofol overdose causes endothelial cytotoxicity in vitro and endothelial barrier dysfunction in vivo

Keywords: Propofol; Endothelial cells; GSK-3; Apoptosis; Necrosis; Vascular permeability

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Role of the phosphatidylinositol 3-kinase and extracellular signal-regulated kinase pathways in the neuroprotective effects of cilnidipine against hypoxia in a primary culture of cortical neurons

Keywords: CCBs; calcium channel blockers; COX; cyclooxygenase; DAPI; DNA-specific fluorochrome 4′,6-diamidino-2-phenylindole dihydrochloride; DCF; 2′7′-dichlorofluorescein; DCFH-DA; dichlorodihydrofluorescein diacetate; DCFH2; 2′,7′-dichlorodihydrofluores

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice

Keywords: DISC1; Mutant mice; GSK-3; PDE4B; TDZD-8; Rolipram; Schizophrenia; Depression;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases

Keywords: P2X7; Familiar Alzheimer's disease; APP transgenic mice; GSK-3; α-secretase; APP; Amyloid plaques;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Redox-regulating role of insulin: The essence of insulin effect

Keywords: 4-HNE; 4-hydroxynonenal; 8-OHdG; 8-hydroxydeoxyguanosine; 8-OHG; 8-hydroxyguanine; 8-iso-PGF2α; 8-iso-prostaglandin F2α; AD; Alzheimer's disease; AIDS; acquired immunodeficiency syndrome; Akt; protein kinase B; AMI; acute myocardial infarction; APS; a

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2012 سفارش ترجمه

Calpain regulates N-terminal interaction of GSK-3β with 14-3-3ζ, p53 and PKB but not with axin

Keywords: GSK-3; Calpain; p53; Axin; PKB; 14-3-3ζ;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Modeling mania: Further validation for Black Swiss mice as model animals

Keywords: Bipolar disorder; Animal models; Affective disorder; Validation; GSK-3

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Selective loss of glycogen synthase kinase-3α in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation

Keywords: Evolution; Bird; GSK-3; Brain; Tau phosphorylation

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Postprandial triglyceride-rich lipoproteins induce hepatic insulin resistance in HepG2 cells independently of their receptor-mediated cellular uptake

Keywords: BMI; body mass index; DAPI; 4′,6-diamidino-2-phenylindole; DMEM; dulbeccos minimal essential media; FCS; fetal calf serum; GS; glycogen synthase; GSK-3; glycogen synthase kinase 3; HL; hepatic lipase; HOMA-IR; homeostasis model assessment of insulin res

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

AKT Signaling Pathway in the Nucleus Accumbens Mediates Excessive Alcohol Drinking Behaviors

Keywords: Addiction; AKT; alcohol; GSK-3; nucleus accumbens; PI3K;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

The effects of neuropsychiatric drugs on glycogen synthase kinase-3 signaling

Keywords: antipsychotic; mood stabilizer; antidepressant; GSK-3; signal transduction; Aktco-IPs, co-immunoprecipitations; D2DR, dopamine D2 receptor; D3DR, dopamine D3 receptor; Dvl, dishevelled; EPS, extrapyramidal side effects; GSK-3, glycogen synthase kinase-3;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Oxidative stress, insulin signaling, and diabetes

Keywords: AGE; advanced glycated end product; CAP; c-Cbl-associated protein; DAG; diacylglycerol; eNOS; endothelial nitric oxide synthase; ERK; extracellular signal-regulated kinase; ETC; electron transport chain; GH; growth hormone; GLUT4; glucose transporter type

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Effects of acute and chronic treatment elicited by lamotrigine on behavior, energy metabolism, neurotrophins and signaling cascades in rats

Keywords: BDNF; brain-derived neurotrophic factor; NGF; nerve growth factor; Bcl-2; B-cell lymphoma 2; AKT; Protein Kinase B; GSK-3; glycogen synthase kinase 3; Lamotrigine; Neurotrophins; Signaling cascades; Energy metabolism; Forced swimming test; Depression;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications

Keywords: AEN; aminoethyl nitrate; ALDH; aldehyde dehydrogenase; ALDH1A1; cytosolic aldehyde dehydrogenase; ALDH2; mitochondrial low-Km aldehyde dehydrogenase 2; CYP2E1; ethanol-inducible cytochrome P450 2E1 isozyme; DIGE; fluorescence 2-D difference in gel electro

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Inhibition of glycogen synthase kinase-3 enhances the differentiation and reduces the proliferation of adult human olfactory epithelium neural precursors

Keywords: Stem cell; GSK-3; Olfactory mucosa; TAT(47-57); Differentiation;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Inhibition of Tat-mediated HIV-1 replication and neurotoxicity by novel GSK3-beta inhibitors

Keywords: HIV-1; Transcriptional inhibition; GSK-3; Tat; HAND; Neuroprotection; Indirubin; Therapeutic target;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Glycerophospholipids and glycerophospholipid-derived lipid mediators: A complex meshwork in Alzheimer's disease pathology

Keywords: 2-AG; 2-arachidonoylglycerol; 4-HNE; 4-hydroxynonenals; 4-HHE; 4-hydroxyhexenal; AA; arachidonic acid; Aβ; β-amyloid; ADAM; A Disintegrin And Metalloprotease; ADAPT; Alzheimer's Disease Anti-inflammatory Prevention trial; AD; Alzheimer's disease; AE

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2011 سفارش ترجمه

CD151 Amplifies Signaling by Integrin α6β1 to PI3K and Induces the Epithelial-Mesenchymal Transition in HCC Cells

Keywords: Liver Cancer; Tumor Progression; Metastasis; Tumor Invasion; α-SMA; α-smooth muscle actin; Akt; protein kinase B; EMT; epithelial-mesenchymal transition; ERK; extracellular regulated protein kinase; GSK-3; glycogen synthase kinase 3; Ln-5; Laminin 5; MA

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2011 سفارش ترجمه

Myocardial stress remodelling after regional infarction is independent of glycogen synthase kinase-3 inactivation

Keywords: GSK-3; Myocardial infarction; Remodelling;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

RhoB enhances migration and MMP1 expression of prostate cancer DU145

Keywords: RhoB; GSK-3; MMP1; Prostate cancer

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Substrate Competitive GSK-3 Inhibitors strategy and Implications

Keywords: Protein kinase; Phosphorylation; GSK-3; Inhibitors; Substrate recognition;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Identification of eukaryotic elongation factor-2 as a novel cellular target of lithium and glycogen synthase kinase-3

Keywords: Lithium; GSK-3; eEF-2; Phosphorylation; Protein synthesis;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits

Keywords: Alzheimer disease; Dentate gyrus; GSK-3; tau

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Luteolin induces G1 arrest in human nasopharyngeal carcinoma cells via the Akt–GSK-3β–Cyclin D1 pathway

Keywords: 7-AAD, 7-amino-actinomycin D; BrdU, bromodeoxyuridine; CDK, cyclin-dependent kinase; DMSO, dimethyl sulfoxide; EDTA, ethylene diamine tetraacetic acid; EGTA, ethylene glycol tetraacetic acid; FBS, fetal bovine serum; FITC, fluorescein isothiocynate; GSK-3

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Atherosclerosis induced by a high-fat diet is alleviated by lithium chloride via reduction of VCAM expression in ApoE-deficient mice

Keywords: Atherosclerosis; ApoE−/− mice; GSK-3; LiCl; Palmitate

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Lysophosphatidic acid induces upregulation of Mcl-1 and protects apoptosis in a PTX-dependent manner in H19-7 cells

Keywords: LPA; lysophosphatidic acid; NPC; neuronal progenitor cell; Mcl; myeloid cell leukemia; GSK-3; glycogen synthase kinase 3; PTX; pertussis toxin; FGF; fibroblast growth factor; S1P; sphingosine 1-phosphate; GPCR; G-protein coupled receptor; E; embryonic day

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders

Keywords: Apoptosis; Brain-derived neurotrophic factor (BDNF); Glycogen synthase kinase 3 (GSK-3); Lithium; Neurodegenerative diseases; Neuroprotection; 3-NP; 3-nitropropionic acid; Aβ; β-amyloid; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AP-1;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2010 سفارش ترجمه

Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors

Keywords: GSK-3; CDK5; Kinase inhibitors; Alzheimer’s disease; Pyrazolo[3,4-b]pyridines; 3,6-Diamino-1H-pyrazolo[3,4-b]pyridine-5-carbonitriles; Molecular modelling

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

Keywords: Alzheimer's disease; Diabetes; Insulin signalling; Tau; APP; Abeta; GSK-3; PP2a; Transthyretin; Irs2;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Coexistences of insulin signaling-related proteins and choline acetyltransferase in neurons

Keywords: Alzheimer disease; Insulin signaling; ChAT; IRS; GSK-3; IDE

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1–5, GSK-3) inhibitors

Keywords: Tripentone; Dipyrrolopyrazinone; Furopyrrolopyrazinone; Curtius rearrangement; Cyclin-dependent kinase; CDK; GSK-3

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo

Keywords: Tau; Amyloid; Neuronal cell death; GSK-3; Transgenic mice; Alzheimer's disease

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Valproic acid enhances protein l-isoaspartyl methyltransferase expression by stimulating extracellular signal-regulated kinase signaling pathway

Keywords: Protein l-isoaspartyl methyltransferase; Valproic acid; Epilepsy; ERK1/2 signaling pathway; RSK-1; GSK-3; β-cateninAdoHcy, S-adenosyl-l-homocysteine; AdoMet, S-adenosyl-l-methionine; CBZ, carbamazepine; DMSO, dimethyl sulfoxide; DSIP-isoD, Delta-sleep-ind

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Identification of potential cellular targets of aloisine A by affinity chromatography

Keywords: Aloisine; Immobilized protein kinase inhibitor; Mass spectrometry; Click chemistry; Pyrrolo[2,3-b]pyrazine; Cyclin-dependent kinase; Pyridoxal kinase; Affinity chromatography; GSK-3; Fuse binding protein 1; Glycogen-debranching enzyme; ERK1

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Wnt signaling in Alzheimer's disease: Up or down, that is the question

Keywords: Wnt signaling; Alzheimer's disease; β-Catenin; GSK-3; Presenilin; Lithium

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2009 سفارش ترجمه

2,5-Diaminopyrimidines and 3,5-disubstituted azapurines as inhibitors of glycogen synthase kinase-3 (GSK-3)

Keywords: Kinase inhibitors; GSK-3; Aurora A; Diabetes; Alzheimer’s; Depression; Bipolar disorder; Molecular modeling

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells

Keywords: Interleukin-18; Inflammation; p35; GSK-3; Cyclin G1; Alzheimer's disease

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3β

Keywords: Alzheimer's disease; FTDP-17; GSK-3; tau; transgenic miceAD, Alzheimer's disease; EtOH, ethanol; FTDP-17, frontotemporal dementia and parkinsonism linked to chromosome 17; GFAP, glial fibrillary acidic protein; GSK-3β, glycogen synthase kinase-3β; NFT, ne

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Ionizing radiation can induce GSK-3β phosphorylation and NF-κB transcriptional transactivation in ATM-deficient fibroblasts

Keywords: Akt; GSK-3; Ataxia telangiectasia; Ionizing radiation

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Dexamethasone and GLP-2 administered to rat dams during pregnancy and lactation have late effects on intestinal sugar transport in their postweanling offspring

Keywords: Akt/PKB; Protein kinase B; BBM; brush border membrane; BLM; basolateral membrane; DEX; dexamethasone; EGF; epidermal growth factor; GC; glucocorticosteroids; GLP-2; glucagon-like peptide-2; GLUT; glucose transporter; GSK-3; glycogen synthase kinase 3; IGF

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

Proteomic analysis of peripheral leukocytes in Alzheimer's disease patients treated with divalproex sodium

Keywords: 2D electrophoresis; Alzheimer's disease; Biomarkers; Glycogen synthase kinase-3; GSK-3; Histone deacetylase inhibitor; HDAC; PBMC; Proteomics; qRT-PCR; Valproic acid; VPA

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

Differential effect of lithium on the circadian oscillator in young and old hamsters

Keywords: Circadian rhythm; GSK-3; Lithium; Suprachiasmatic nucleus; SCN; Aging; Mouse; Hamster; Bipolar disorder

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Gene transfer into Purkinje cells using herpesviral amplicon vectors in cerebellar cultures

Keywords: Purkinje; Gene transfer; Neuronal cell culture; Cerebellum; HSV-1; GSK-3; Neuronal cell death; Ataxia

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه