Keywords: FBS; fetal bovine serum; HB-EGF; heparin-binding epidermal growth factor-like growth factor; GFAP; glial fibrillary acidic protein; MTT; 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide; DMSO; dimethyl sulfoxide; DAPI; 4â²,6-diamidino-2-
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Keywords: cAMP; Cyclic Adenosine Monophosphate; COPD; Chronic Obstructive Pulmonary Disease; CCSP; Club Cell Secretory Protein; CF; Cystic Fibrosis; EGFR; Epidermal Growth Factor Receptor; EMT; Epithelial to Mesenchymal Transition; ERK; Extracellular Signal-Regulat
Keywords: ADMSC; Adipose tissue derived mesenchymal stem cells; bFGF; Basic fibroblast growth factor; Bgn; Biglycan; BM; Bone marrow; BMMSC; Bone marrow derived mesenchymal stem cells; BMP; Bone morphogenetic protein; Col; Collagen; COMP; Cartilage oligomeric matri
Keywords: CBL; casitas B-lineage lymphoma; CtxR; cetuximab-resistant; CtxS; cetuximab-sensitive; CRC; colorectal cancer; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EMT; epithelial to mesenchymal transition; EPR; epiregulin; FDA; food and
Keywords: PM; particulate matter; O3; ozone; COPD; chronic obstructive pulmonary disease; PM2.5-10; PM with an aerodynamic diameter 2.5-10 μm; PM2.5; PM with an aerodynamic diameter less than 2.5 μm; PM0.1; PM with an aerodynamic diameter less than 0.1 μm
Keywords: Amphiregulin; EGFR; HB-EGF; Liver regeneration; MMP-9
Keywords: GUVs; Giant unilamellar vesicles; GPCR; G protein-coupled receptor; eYFP; Enhanced yellow fluorescent protein; ETB; Endothelin B receptor; CXCR4; C-X-C chemokine receptor type 4; Hb-EGF; Pro-Heparin-binding epithelial growth factor like factor; ER; Endopl
Keywords: Anastomotic healing; Growth factors; Gastrointestinal surgery; FGF; EGF; HB-EGF; TGF-β; IGF-I; VEGF; PDGF
Keywords: AP-1; activator protein 1; Dusp; dual-specificity phosphatase; Egr1; early growth response protein 1; ERK; extracellular signal regulated kinase; F2-KO mice; flotillin-2 knockout mice; Flot-1; flotillin-1; Flot-2; flotillin-2; HB-EGF; Heparin Binding-EGF;
Keywords: MMPs, matrix metalloproteinases; MMPI, matrix metalloproteinases inhibitors; ECM, extracellular matrix; TIMPs, tissue inhibitor of metalloproteinase; BM, basal membrane; PBMC, peripheral blood mononuclear cells; FBAT, family-based association test; HB-EGF
Keywords: IGFs; insulin-like growth factors; SHBG; sex hormone binding globulin; BMI; body mass index; IGFBPs; IGF binding proteins; IGF-1R; insulin-like growth factor-1 receptor; CLS; crown-like structure; NFκB; nuclear factor kappa-B; STAT3; signal transducer an
Keywords: SK; seborrheic keratosis; FGFR3; somatic fibroblast growth factor receptor 3; ATRA; all-trans retinoic acid; HB-EGF; heparin-binding epidermal growth factor-like growth factor; EGFR; epidermal growth factor receptor; MN; microneedle; HE; hematoxylin and e
Bevacizumab Injection in Patients with Neovascular Age-Related Macular Degeneration Increases Angiogenic Biomarkers
Keywords: AMD; age-related macular degeneration; BCVA; best-corrected visual acuity; BMP-9; bone morphogenetic protein 9; CNV; choroidal neovascularization; CRT; central retinal thickness; EGF; epidermal growth factor; FGF; fibroblast growth factor; GCSF; granulo
Quantitative proteomics and biochemical analyses reveal the role of endoplasmin in the regulation of the expression and secretion of A Disintegrin And Metalloproteinase 12
Keywords: ADAM12S; Endoplasmin (GRP94); Label-free quantification; Secretion; Spectral counting; Docking; ADAM12S; the short form of a disintegrin and metalloproteinase 12; CANX; calnexin; CPORT; Consensus Prediction Of interface Residues in Transient complexes; Dl
ADAMTS-1 disrupts HGF/c-MET signaling and HGF-stimulated cellular processes in fibrosarcoma
Keywords: ADAMTS; A disintegrin and metalloprotease with thrombospondin motifs; Akt; Protein kinase serine/threonine; BCA; Bicinchoninic Acid; BSA; Bovine Serum Albumine; BrdU; Bromodeoxyuridine; CM; Conditioned medium; DAPI; Dihidrocloreto de 4â², 6â²-diamidino-
Hepatic cell sheets engineered from human mesenchymal stem cells with a single small molecule compound IC-2 ameliorate acute liver injury in mice
Keywords: Hepatic cell sheets; Mesenchymal stem cells; Liver regeneration; Wnt/β-catenin signal inhibitor; Acute liver failure; BM-MSCs; bone marrow-derived mesenchymal stem cells; NF-κB; nuclear factor-kappa B; IL-6; interleukin-6; STAT-3; Signal Tranducer and A
Cross-talk between EGFR and IL-6 drives oncogenic signaling and offers therapeutic opportunities in cancer
Keywords: EGFR; epidermal growth factor receptor; IL-6; interleukin 6; ADC; antibody-drug conjugate; HGF; hepatocyte growth factor; c-met/MET; tyrosine-protein kinase Met; CTLA-4; cytotoxic T-lymphocyte-associated protein 4; VEGF; vascular endothelial growth factor
Molecular mechanisms involved in epidermal growth factor receptor-mediated inhibition of dopamine D3 receptor signaling
Keywords: EGFR; epidermal growth factor receptor; D3R; dopamine D3 receptor; GFP; green fluorescent protein; Veh; vehicle; CRE-luci; cAMP response element-luciferase; GRK2; G protein-coupled receptor kinase 2; KD; knockdown; Forsk; forskolin; Co-IP; co-immunoprecip
Circulating levels of the angiogenesis mediators endoglin, HB-EGF, BMP-9 and FGF-2 in patients with severe sepsis and septic shock
Keywords: Sepsis; HB-EGF; Endoglin; BMP-9; FGF-2; Angiogenesis; Endothelial barrier;
Exposure to diphtheria toxin during the juvenile period impairs both inner and outer hair cells in C57BL/6 mice
Keywords: ABR; auditory brainstem response; DT; diphtheria toxin; DTR; DT receptor; EDTA; ethylenediaminetetraacetic acid; EF-2; elongation factor-2; H&E; hematoxylin and eosin; HB-EGF; heparin-binding epidermal growth factor-like growth factor; HC; hair cell; HEPE
Targeting GPNMB with glembatumumab vedotin: Current developments and future opportunities for the treatment of cancer
Keywords: AE; Adverse Event; α-MSH; alpha-Melanocyte Stimulating Hormone; ADC; Antibody-Drug Conjugate; ASPS; Alveolar Soft Part Sarcoma; ASPSCR1; Alveolar Soft Part Sarcoma Chromosome Region Candidate 1; BMP-2; Bone Morphogenetic Protein-2; BRK; Breast Tumor Kina
Hyper-methylation of the upstream CpG island shore is a likely mechanism of GPER1 silencing in breast cancer cells
Keywords: GPER1; G-protein coupled Estrogen Receptor; COBRA; Combined Bisulfite and Restriction Analysis; RT-PCR; Reverse Transcriptase Polymerase Chain Reaction; TBE-PAGE; Tris Borate EDTA Polyacrylamide Gel Electrophoresis; cAMP; cyclic adenosine monophosphate; P
Nintedanib (BIBF 1120) blocks the tumor promoting signals of lung fibroblast soluble microenvironment
Keywords: ANG-2; angiotensin-2; DMSO; dimethyl sulfoxide; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; FCS; fetal calf serum; FGF; fibroblast growth factor; HB-EGF; heparin-binding EGF-like growth factor; HGF; hepatocyte growth factor; ITGA
Up-regulation of HB-EGF by the COX-2/PGE2 signaling associates with the cisplatin resistance and tumor recurrence of advanced HNSCC
Keywords: HNSCC; HB-EGF; COX-2; PGE2; Cisplatin
HB-EGF embedded in PGA/PLLA scaffolds via subcritical CO2 augments the production of tissue engineered intestine
Keywords: Polyglycolic acid; Stem cell; HB-EGF; Intestine; Tissue engineering;
Molecular mechanisms of LL-37-induced receptor activation: An overview
Keywords: AMP; antimicrobial peptide; APD; antimicrobial peptide database; IFN; interferon; DC; dendritic cell; NK-cells; natural killer cells; GPCR; G protein-coupled receptor; RTK; receptor tyrosine kinase; LGIC; ligand-gated ion channel; TLR; toll-like receptor;
ADAMs family and relatives in cardiovascular physiology and pathology
Keywords: ADAM; A disintegrin and metalloproteinase; ADAM-TS; ADAM with thrombospondin domains; APP; amyloid precursor protein; APPsα; α-secretase-released N-terminal APP domain; C-domain; cysteine-rich domain; COMP; cartilage oligomeric matrix protein; DCM; dila
Chronic cerebral hypoperfusion-induced impairment of Aβ clearance requires HB-EGF-dependent sequential activation of HIF1α and MMP9
Keywords: BCCAO; HB-EGF; RAGE; LRP-1; BBB; AD
The higher heparin-binding epidermal growth factor (HB-EGF) in missed abortion
Keywords: endometrium; HB-EGF; immunohistochemistry; missed abortion; placenta
A pain in the NEC: Research challenges and opportunities
Keywords: Intestine; HB-EGF; Tissue engineering; Necrotizing enterocolitis
Salusin-β contributes to vascular remodeling associated with hypertension via promoting vascular smooth muscle cell proliferation and vascular fibrosis
Keywords: AC; adenylate cyclase; ALK5; activin receptor-like kinase 5; Ang II; angiotensin II; CCK-8; cell counting kit-8 kits; CREB; cAMP response element binding protein; CTGF; connective tissue growth factor; ECM; extracellular matrix; EGF; epidermal growth fact
Epithelial cell ADAM17 activation by Helicobacter pylori: role of ADAM17 C-terminus and Threonine-735 phosphorylation
Keywords: Helicobacter pylori; ADAM 17; Phosphorylation; EGFR; HB-EGF; TNF-α;
PG545 enhances anti-cancer activity of chemotherapy in ovarian models and increases surrogate biomarkers such as VEGF in preclinical and clinical plasma samples
Keywords: PG545; Ovarian cancer; Tumour microenvironment; Heparanase; VEGF; HB-EGF;
Sp1 transcription factor: A long-standing target in cancer chemotherapy
Keywords: Anticancer drugs; Prognosis; Sp1; Sp3; Transcription factors; Targeted therapy; AMPKα; AMP-activated protein kinase alpha catalytic subunit; Bcl-2; B cell/lymphoma 2; Bcl-w; member of the Bcl-2 family; Bid; BH3 interacting domain death agonist; CDK; cycl
EGFR trans-activation mediates pleiotrophin-induced activation of Akt and Erk in cultured osteoblasts
Keywords: Ptn; pleiotrophin; ALP; alkaline phosphatase; EGF; epidermal growth factor; HB-EGF; heparin-binding-epidermal growth factor; Dex; dexamethasone; Pleiotrophin; EGFR; Akt/Erk signalings; Osteoblasts and bone growth;
Antibody-modified lipid nanoparticles for selective delivery of siRNA to tumors expressing membrane-anchored form of HB-EGF
Keywords: LNP; lipid nanoparticles; LNP-siRNA; LNP encapsulating siRNA; αHB-EGF-LNP; anti-HB-EGF antibody-modified LNP; siRNA delivery; Lipid nanoparticles; Antibody; HB-EGF; Breast cancer;
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) and proteolytic processing by a disintegrin and metalloproteinases (ADAM): A regulator of several pathways
Keywords: HB-EGF; HB-EGF processing; ADAM; Wound healing; Reproductive biology; Transgenic mice; Angiogenesis; Tumor formation; Adipogenesis
Heparin-binding EGF-like growth factor (HB-EGF) promotes cell migration and adhesion via focal adhesion kinase
Keywords: HB-EGF; Cell migration; Cell adhesion; Focal adhesion kinase; Wound healing
Gastrin mediates resistance to hypoxia-induced cell death in xenografts of the human colorectal cancer cell line LoVo
Keywords: CCK2R; cholecystokinin 2 receptor; CRC; colorectal cancer; Gamide; amidated gastrin; Ggly; glycine-extended gastrin; PG; progastrin; HB-EGF; heparin-binding epidermal growth factor-like growth factor; HIF-1; hypoxia-inducible factor-1; VEGF; vascular endo
Heparin-binding EGF-like growth factor (HB-EGF) therapy for intestinal injury: Application and future prospects
Keywords: HB-EGF; Hemorrhagic shock; Intestinal injury; Ischemia and reperfusion; Necrotizing enterocolitis
Estrogen activation of the mitogen-activated protein kinase is mediated by ER-α36 in ER-positive breast cancer cells
Keywords: ER-α36; Rapid estrogen signaling; ERK1/2; HB-EGF; Amphiregulin; EGFR; HER2; IGF-IR;
Cross-talk between estradiol receptor and EGFR/IGF-IR signaling pathways in estrogen-responsive breast cancers: Focus on the role and impact of proteoglycans
Keywords: ER; estrogen receptor; PgR; progesterone receptor; HER2/erbB2; human epidermal growth factor receptor-2; E2; estradiol; RTK; receptor tyrosine kinase; IGF-IR; insulin-like growth factor I receptor; EGFR; epidermal growth factor receptor; MAPK; mitogen act
Neurogenesis in neurological and psychiatric diseases and brain injury: From bench to bedside
Keywords: 6-OHDA; 6-hydroxydopamine; 7-OH-DPAT; 7-hydroxy-N,N-di-n-propyl-2-aminotetralin; AD; Alzheimer's disease; ADAM; a disintegrin and metalloproteinase; APH-1; anterior pharynx-defective 1; ApoE4; apolipoprotein E É4 allele; APP; amyloid precursor protein; A
Research ReportVitamin B12 dependent changes in mouse spinal cord expression of vitamin B12 related proteins and the epidermal growth factor system
Keywords: Cbl; Cobalamin (Vitamin B12); Cbi; Cobinamide; EGF; Epidermal growth factor; EGF-R; Epidermal growth factor receptor; HB-EGF; Heparin-binding EGF-like growth factor; LMBRD1; Lysosomal membrane Cbl transporter; MS; Methionine synthase; Mut; methylmalonylCo
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) induction on Snail expression during mouse decidualization
Keywords: Uterus; Decidua; Snail; HB-EGF; Embryo implantation;
Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species
Keywords: ALK; activin-like kinase; α-SMA; α-smooth muscle actin; BMP; bone morphogenic protein; CDK; chronic kidney disease; CTGF; connective tissue growth factor; DAB; 3,3â²-diaminobenzidine; DPI; diphenyleneiodonium chloride; ECM; extracellular matrix; EGF; e
Neurorescue effects and stem properties of chorionic villi and amniotic progenitor cells
Keywords: ANG-2; angiopoietin-2; BDNF; brain-derived neurotrophic factor; ChAT; cholin acetyltransferase; CM; conditioned medium; DAPI; 4â²-6-diamidino-2-phenylindole; DAT; dopamine N acetyltransferase; DCX; double cortin; ELISA; enzyme-linked immunosorbent assay;
Heparin-binding EGF-like growth factor (HB-EGF) protects the intestines from radiation therapy-induced intestinal injury
Keywords: HB-EGF; Radiation injury; Intestines; Proliferation; Permeability
Immunolocalization of heparin-binding EGF-like growth factor (HB-EGF) as a possible immunotarget in diagnosis of some soft tissue sarcomas
Keywords: HB-EGF; Immunohistochemistry; Clear cell sarcomas; Leiomyosarcomas; Phyllodes sarcomas; Chondrosarcomas; Liposarcomas;
NLF2 gene expression in the endometrium of patients with implantation failure after IVF treatment
Keywords: ANGPTL; angiopoietin-like protein 1; APCR; activated protein C resistance; ART; assisted reproductive technology; DKK1; Dickkopf-related protein 1; ECM; extracellular matrix; EG-VEGF; endocrine gland-derived vascular endothelial growth factor; GAPDH; glyc