کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5844115 | 1560953 | 2015 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sp1 transcription factor: A long-standing target in cancer chemotherapy
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کلمات کلیدی
Bcl-2MRP-1FLIPKLF6HB-EGFDR5P21XIAPMSKMIRHDACAMPKαKRASE2F-1CDC25Bbcl-wp15KCNMA1TGF-βCLDN4CDKcyclin-dependent kinase inhibitor 2BBH3 Interacting Domain Death Agonist - BH3 تعامل دامنه آگونیست مرگc-Met - c-metERK1/2 - ERK1 / 2NFκB - NFKBROS - ROSSp1 - SP1Sp3 - sp3Transforming Growth Factor Beta - تبدیل بتا فاکتور رشدAnticancer drugs - داروهای ضد سرطانTargeted therapy - درمان هدفمندKirsten rat sarcoma viral oncogene homolog - سارکوم موش صحرایی Kirsten همولوگ ویروس انکوزنE2F transcription factor 1 - عامل رونویسی E2F 1Krüppel-like factor 6 - عامل کریپول مانند 6Transcription factors - عوامل رونویسیVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)Heparin-binding EGF-like growth factor - فاکتور رشد مانند EGF مانند هپارینnuclear factor kappa-light-chain-enhancer of activated B cells - فاکتور هسته ای kappa-light-chain-enhancer از سلول های B فعال شده استcyclin-dependent kinase inhibitor 1A - مهار کننده 1A کیناز وابسته به کینازX-linked inhibitor of apoptosis - مهارکننده آپوپتوز X مرتبط با آنMicroRNA - میکرو RNA histone deacetylase - هیستون داستیلازMultidrug Resistance-associated Protein 1 - پروتئین مرتبط با مقاومت چند دارویی 1prognosis - پیش شناخت بیماریBID - پیشنهادKAT - کتClaudin-4 - کلودین-4extracellular signal-regulated kinases 1 and 2 - کینازهای 1 و 2 تنظیم شده سیگنال خارج سلولیcyclin-dependent kinase - کییناز وابسته به سیکلینReactive oxygen species - گونههای فعال اکسیژنdeath receptor 5 - گیرنده مرگ 5
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Sp1 (specificity protein 1) is a well-known member of a family of transcription factors that also includes Sp2, Sp3 and Sp4, which are implicated in an ample variety of essential biological processes and have been proven important in cell growth, differentiation, apoptosis and carcinogenesis. Sp1 activates the transcription of many cellular genes that contain putative CG-rich Sp-binding sites in their promoters. Sp1 and Sp3 proteins bind to similar, if not the same, DNA tracts and compete for binding, thus they can enhance or repress gene expression. Evidences exist that the Sp-family of proteins regulates the expression of genes that play pivotal roles in cell proliferation and metastasis of various tumors. In patients with a variety of cancers, high levels of Sp1 protein are considered a negative prognostic factor. A plethora of compounds can interfere with the trans-activating activities of Sp1 and other Sp proteins on gene expression. Several pathways are involved in the down-regulation of Sp proteins by compounds with different mechanisms of action, which include not only the direct interference with the binding of Sp proteins to their putative DNA binding sites, but also promoting the degradation of Sp protein factors. Down-regulation of Sp transcription factors and Sp1-regulated genes is drug-dependent and it is determined by the cell context. The acknowledgment that several of those compounds are safe enough might accelerate their introduction into clinical usage in patients with tumors that over-express Sp1.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 152, August 2015, Pages 111-124
Journal: Pharmacology & Therapeutics - Volume 152, August 2015, Pages 111-124
نویسندگان
Carolina VizcaÃno, Sylvia Mansilla, José Portugal,