Keywords: پاکسازی کبد; Drug metabolism; Aldehyde oxidase; Xenobiotics; Molybdoenzymes; Non-CYP enzymes; Hepatic clearance;
مقالات ISI پاکسازی کبد (ترجمه نشده)
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Keywords: پاکسازی کبد; AAG; α1-acid glycoprotein; IPRL; isolated perfused rat liver; IVIVE; in vitro-in vivo extrapolation; PBPK; physiologically based pharmacokinetic(s); PK; pharmacokinetic(s); Pharmacokinetics; Well-stirred model; Parallel-tube model; Dispersion model; Hepa
Keywords: پاکسازی کبد; AUC; area under the concentration-time curve; BN; benalaxyl; CE; capillary electromigration techniques; CL; clearance; CLH; hepatic clearance; CLint; intrinsic clearance; DC; diclofop; DM; diclofop-methyl; DN; diniconazole; E; hepatic extraction rate; ET;
Keywords: پاکسازی کبد; clinical pharmacokinetics; distribution; hepatic clearance; in vitro-in vivo correlations (IVIVC); metabolic clearance; oral absorption; physiological model; preclinical pharmacokinetics; protein binding; simulations;
Keywords: پاکسازی کبد; drug interaction; hepatic clearance; hepatic transport; organic anion-transporting polypeptide transporters; pharmacokinetics/pharmacodynamics; physiologically based pharmacokinetic model;
Keywords: پاکسازی کبد; in vitro/in vivo correlations (IVIVC); hepatic clearance; hepatic metabolism; hepatic transport; transporters; drug transport; drug metabolizing enzymes; HIV/AIDS; FBS; fetal bovine serum; HEPES; 4-(2-hydroxyethyl)-1- piperazine ethanesulfonic acid; HIV
Keywords: پاکسازی کبد; in vitro/in vivo correlations (IVIVC); hepatic transport; hepatic metabolism; hepatic clearance; hepatocytes; HIV/AIDS; membrane transport; metabolism; organic anion-transporting polypeptide transporters; APV; amprenavir; ATV; atazanavir; CHO; Chinese h
Keywords: پاکسازی کبد; sandwich-cultured hepatocytes (SCH); hepatic clearance; hepatobiliary disposition; bile acid transporters; toxicity; mathematical models;
Keywords: پاکسازی کبد; compartment model; CYP1A2; CYP2C19; drug interactions; fluvoxamine; parallel tube model; hepatic clearance; pharmacokinetics; prediction; simulation;
Keywords: پاکسازی کبد; bioavailability; compartment model; distribution; drug interactions; fluvoxamine; hepatic blood level; hepatic clearance; pharmacokinetics; physiological model; simulation;
Keywords: پاکسازی کبد; Hepatic clearance; Plasma protein binding; Steady-state equations; Fraction unbound; Dissociation/association; Active efflux rate constants;
Keywords: پاکسازی کبد; danazol; nanoemulsion; stearylamine; bioavailability; surfactants; absorption; particle size; hepatic clearance;
Evidence of in vitro metabolic interaction effects of a chlorfenvinphos, ethion and linuron mixture on human hepatic detoxification rates
Keywords: پاکسازی کبد; Health risk assessment; Pesticides mixture; Hepatic clearance; Metabolic interactions; Detoxification;
Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro - in vivo extrapolation of hepatic clea
Keywords: پاکسازی کبد; Fatty acids; CYP450 enzymes; Enzyme inhibition; Michaelis-Menten kinetics; Bovine serum albumin (BSA); Intrinsic clearance; Well-stirred model; Hepatic clearance; In vitro - In vivo extrapolation (IVIVE);
Understanding the Interplay Between Uptake and Efflux Transporters Within In Vitro Systems in Defining Hepatocellular Drug Concentrations
Keywords: پاکسازی کبد; hepatic clearance; hepatic transport; hepatobiliary disposition; hepatocytes; transporters; ABT; 1-aminobenzotriazole; Bcrp; breast cancer resistance protein; BDDCS; Biopharmaceutial Drug Disposition Classification System; BEI; biliary excretion index; Ca
Simulations of Cytochrome P450 3A4-Mediated Drug-Drug Interactions by Simple Two-Compartment Model-Assisted Static Method
Keywords: پاکسازی کبد; bioavailability; cytochrome P450; drug interaction; dynamic simulation; first pass metabolism; hepatic clearance; intestinal metabolism; pharmacokinetics; simulations; parallel tube model; Ae (Ae,oral); dose fractions of urinary excreted unchanged drug af
Comparison of the Predictability of Human Hepatic Clearance for Organic Anion Transporting Polypeptide Substrate Drugs Between Different In Vitro-In Vivo Extrapolation Approaches
Keywords: پاکسازی کبد; active transport; cytochrome P450; glucuronosyltransferase (UGT); hepatic clearance; hepatic transport; hepatocytes; membrane transport/transporters; organic anion transporting polypeptide transporters; transporters; AUC; area under the plasma concentrati
Hepatobiliary Clearance Prediction: Species Scaling From Monkey, Dog, and Rat, and In Vitro-In Vivo Extrapolation of Sandwich-Cultured Human Hepatocytes Using 17 Drugs
Keywords: پاکسازی کبد; hepatobiliary disposition; hepatic transport; efflux pumps; hepatic clearance; preclinical pharmacokinetics;
Quantitative Analyses of the Influence of Parameters Governing Rate-Determining Process of Hepatic Elimination of Drugs on the Magnitudes of Drug-Drug Interactions via Hepatic OATPs and CYP3A Using Physiologically Based Pharmacokinetic Models
Keywords: پاکسازی کبد; cytochrome P450; drug interaction; hepatic clearance; mathematical model; organic anion-transporting polypeptide transporters; pharmacokinetics; AUC; area under the plasma concentration-time curve; CL; clearance; CLint,all; overall hepatic intrinsic cle
Determinants of Intestinal Availability for P-glycoprotein Substrate Drugs Estimated by Extensive Simulation With Mathematical Absorption Models
Keywords: پاکسازی کبد; drug-drug interaction; P-glycoprotein; physiologically based pharmacokinetic model; modeling and simulation; intestinal absorption; substrate drug; CLh; hepatic clearance; CLr; renal clearance; CYP3A; cytochrome P450 3A; DDI; drug-drug interaction; EQ
Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies With PBPK Modeling
Keywords: پاکسازی کبد; clinical pharmacokinetics; CYP enzymes; drug interaction; drug metabolizing enzymes; elimination; hepatic clearance; interspecies scaling; physiologically based pharmacokinetic modeling; preclinical pharmacokinetics; simulations; AUC; area under the plasm
A Physiologically Based Pharmacokinetic Model to Describe Artemether Pharmacokinetics in Adult and Pediatric Patients
Keywords: پاکسازی کبد; clinical pharmacokinetics; CYP enzymes; drug metabolizing enzymes; elimination; hepatic clearance; interspecies scaling; physiologically based pharmacokinetic modeling; preclinical pharmacokinetics; simulations; AUC; area under the plasma concentration-ti
Ketoconazole Stereoisomers Differentially Induce Cytochrome P450 1A1 Between Human Hepatoma HepG2 and Mouse Hepatoma Hepa1c1c7 Cells
Keywords: پاکسازی کبد; cytochrome P450; dose-response; drug metabolizing enzymes; enzyme kinetics; enzymes; hepatic clearance; hepatic metabolism; kinetics;
Dynamic and Static Simulations of Fluvoxamine-Perpetrated Drug-Drug Interactions Using Multiple Cytochrome P450 Inhibition Modeling, and Determination of Perpetrator-Specific CYP Isoform Inhibition Constants and Fractional CYP Isoform Contributions to Vic
Keywords: پاکسازی کبد; compartment model; cytochrome P450; CYP1A2; drug interactions; fluvoxamine; parallel tube model; hepatic clearance; pharmacokinetics; prediction; simulations;
What is the contribution of human FMO3 in the N-oxygenation of selected therapeutic drugs and drugs of abuse?
Keywords: پاکسازی کبد; FMO3; CYPs; Drugs of abuse; Relative activity factor approach; Hepatic clearance;
Preclinical Pharmacokinetics and In Vitro Metabolism of Asunaprevir (BMS-650032), a Potent Hepatitis C Virus NS3 Protease Inhibitor
Keywords: پاکسازی کبد; ADME; antiinfectives; in vitro/in vivo correlations (IVIVC); disposition; hepatic clearance; clearance; metabolism; P-glycoprotein; pharmacokinetics; bioavailability
Preclinical Pharmacokinetics and In Vitro Metabolism of BMS-605339: A Novel HCV NS3 Protease Inhibitor
Keywords: پاکسازی کبد; preclinical pharmacokinetics; oral absorption; metabolism; hepatic clearance; in vitro/in vivo correlations (IVIVC); ADME; protease;
Evaluation of a Liver Microfluidic Biochip to Predict In Vivo Clearances of Seven Drugs in Rats
Keywords: پاکسازی کبد; hepatic clearance; in vitro model; mathematical model; pharmacokinetics; microfluidic biochips; drug metabolism; rat hepatocytes;
Étude de la variabilité de la clairance hépatique de la mébrofénine-99mTc en scintigraphie hépatobiliaire
Keywords: پاکسازی کبد; Scintigraphie hépatobiliaire; Mébrofénine-99mTc; Chirurgie–foie; Clairance hépatique; QuantificationHepatobiliary scintigraphy; Mebrofenin-99mTc; Hepatic surgery; Hepatic clearance; Quantification
Disposition Kinetics of Diclofenac in the Dual Perfused Rat Liver
Keywords: پاکسازی کبد; albumin; biopharmaceutics classification system (BCS); disposition; hepatic clearance; pharmacokinetics; protein binding; diclofenac; dual liver perfusion; hepatic artery; portal vein
Pharmacokinetic Modeling of Hepatocyte Growth Factor in Experimental Animals and Humans
Keywords: پاکسازی کبد; pharmacokinetics/pharmacodynamics; proteins; receptors; hepatic clearance; elimination; hepatocytes; distribution;
Conceptual underestimation of the total body clearance by the sum of clearances of individual organs in physiologically based pharmacokinetics
Keywords: پاکسازی کبد; total body clearance; hepatic clearance; physiological model; lung metabolism; distribution; elimination; venous blood; arterial blood;
Influence of the Compound Selection Process on the Performance of Human Clearance Prediction Methods
Keywords: پاکسازی کبد; allometry; interspecies scaling; in vitro/in vivo correlations (IVIVC); pharmacokinetics; human liver microsomes; clearance; hepatic clearance; preclinical pharmacokinetics;
Determination of Hepatic Clearance with the Account of Drug-Protein Binding Kinetics
Keywords: پاکسازی کبد; protein binding kinetics; hepatic clearance; wellâstirred model; parallel tube model; dissociation; drug ionization; extracellular and intracellular water distribution; physiological model; pharmacokinetics;
Assessment of Biliary Clearance in Early Drug Discovery using Sandwich-cultured Hepatocyte Model
Keywords: پاکسازی کبد; biliary excretion; hepatobiliary disposition; drug interactions; in vitro-in vivo correlations (IVIVC); hepatic clearance; permeability; transporters; hepatocytes;
A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes
Keywords: پاکسازی کبد; hepatic clearance; hepatic metabolism; hepatocytes; metabolic clearance; CYP enzymes; cytochrome P450; clearance; flavin monooxygenases (FMO);
In Vitro-In Vivo Extrapolation of Clearance: Modeling Hepatic Metabolic Clearance of Highly Bound Drugs and Comparative Assessment with Existing Calculation Methods
Keywords: پاکسازی کبد; disposition; microsomes; hepatic clearance; metabolic clearance; unbound fraction; computational ADME; in vitro-in vivo extrapolation; IVIVE; pharmacokinetics; PBPK modeling;
Poloxamer 407 Increases the Recovery of Paracetamol in the Isolated Perfused Rat Liver
Keywords: پاکسازی کبد; disposition; elimination; endothelial; protein binding; surfactants; pharmacokinetics/pharmacodynamics; hepatocytes; hepatic metabolism; hepatic clearance; disposition
Validation of 96-well Equilibrium Dialysis with Non-radiolabeled Drug for Definitive Measurement of Protein Binding and Application to Clinical Development of Highly-Bound Drugs
Keywords: پاکسازی کبد; protein binding; drug interactions; renal clearance; hepatic clearance;
In vitro metabolism and disposition of honokiol in rat and human livers
Keywords: پاکسازی کبد; honokiol; hepatic metabolism; hepatic clearance; biliary excretion; glucuronidation; sulfation;
The influence of hepatic transport on the distribution volumes and mean residence time of drug in the body and the accuracy of estimating these parameters by the traditional pharmacokinetic calculations
Keywords: پاکسازی کبد; hepatic transport; steadyâstate volume of distribution; terminal volume of distribution; mean residence time; terminal halfâlife; hepatic clearance; central elimination; physiologically based pharmacokinetic model;
The Corrected Traditional Equations for Calculation of Hepatic Clearance that Account for the Difference in Drug Ionization in Extracellular and Intracellular Tissue Water and the Corresponding Corrected PBPK Equation
Keywords: پاکسازی کبد; hepatic clearance; well-stirred model; parallel tube model; dispersion model; drug ionization; extra- and intracellular water distribution; physiological model; PBPK equation; hepatic uptake and efflux; metabolic elimination; pharmacokinetics;
Species difference of metabolic clearance of bisphenol A using cryopreserved hepatocytes from rats, monkeys and humans
Keywords: پاکسازی کبد; Bisphenol A; Hepatic clearance; Cryopreserved hepatocytes; Rat; Monkey; Human
Theoretical Versus Empirical Allometry: Facts Behind Theories Application to Pharmacokinetics
Keywords: پاکسازی کبد; clearance; pharamcokinetics; population pharmacokinetics; hepatic clearance; renal excretion;
A microfluidic hepatic coculture platform for cell-based drug metabolism studies
Keywords: پاکسازی کبد; Microfluidics; Human hepatocyte; Coculture; Hepatic clearance; Metabolism
The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid
Keywords: پاکسازی کبد; CYP26A1; Retinoic acid metabolism; Vitamin A; Hepatic clearance
On the prediction of hepatic clearance using the diluted plasma in metabolic stability assay
Keywords: پاکسازی کبد; hepatic clearance; intrinsic clearance; metabolic stability; protein binding; microsomal binding; well-stirred model; pharmacokinetics;
Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human
Keywords: پاکسازی کبد; Microfluidic; Human hepatocyte; Hepatic clearance
Prediction of hepatic microsomal intrinsic clearance and human clearance values for drugs
Keywords: پاکسازی کبد; QSAR; Hepatic clearance; Human clearance; Drug metabolism; Cytochrome P450 enzyme
The species differences of intestinal drug absorption and first-pass metabolism between cynomolgus monkeys and humans
Keywords: پاکسازی کبد; bioavailability; first-pass metabolism; intestinal absorption; pharamcokinetics; hepatic clearance; intestinal metabolism;