Keywords: Aβ; amyloid-β peptides; APAF-1; apoptotic protease-activating factor-1; E2; 17β-estradiol; ER; estrogen receptor; ERβ; estrogen receptor β; ERE; estrogen responsive elements; HIF-1; hypoxia-inducible factor-1; mPTP; mitochondria permeability transiti
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Keywords: ANGPTL-4; angiopoietin like protein-4; AMPK; AMP-activated protein kinase; FAS; fatty acid synthase; GLUT; glucose transporter; HIF-1; hypoxic inducible factor-1; HSD; hydroxysteroid dehydrogenase; IL; interleukin; LDH; lactate dehydrogenase; LPS; lipopol
Keywords: collyrium; beta-adrenergic receptors; proangiogenic factors; retinal neovascularization; CD31 immunohistochemistry; β-AR; beta-adrenergic receptor; Ct; cycle threshold; DBS; dried blood spot; ELISA; enzyme-linked immunosorbent assay; HIF-1; hypoxia-induc
Keywords: HRE; hypoxia-responsive element; HIF-1; hypoxia-inducible factor-1; MTT; 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; siRNA; small interfering RNA; AMPK; 5â²-adenosine monophosphate-activated protein kinase; PBS; phosphate buffered sal
Keywords: CAT; catalase; GPx; glutathione peroxidase; HPRT1; hypoxanthine phosphoribosyltransferase 1; HIF-1; hypoxia inducible factor 1; H/R; hypoxia/reoxygenation; NF-κB; nuclear factor-κB; PPIA; peptidylprolyl isomerase A; PARP; poly(ADP-ribose) polymerase; re
Keywords: CARD; caspase activation and recruitment domain; CARDIF; CARD adaptor inducing intereferon-β; CAT; carnitine acyl-CoA transferase; ER; endoplasmic reticulum; FFA; free fatty acid; GSH; reduced glutathione; GSSG; oxidised glutathione; HCC; hepatocellular
Keywords: AML; acute myeloid leukemia; CAM-DR; cell adhesion-mediated drug resistance; CCP; charge-conversion polymer; CLL; chronic lymphocytic leukemia; CNS; central nervous system; CSC; cancer stem cell; EGFR; epidermal growth factor receptor; EPR; enhanced perme
Keywords: Angiogenesis; Antiangiogenic agents; Angiogenic cytokines/peptides; EC; endothelial cells; VEGF; vascular endothelial growth factor; VEGF Receptor; VEGFR; FGF; fibroblast growth factor; EGF; epidermal growth factor; epidermal growth factor receptor; EGFR;
Keywords: ATF-4; activating transcription factor-4; ARNT; aryl hydrocarbon receptor nuclear translocator; bHLH; basic helix-loop-helix; BBB; Basso, Beattie, and Bresnahan; cFLIP; cellular FLICE-inhibitory protein; cyt C; cytochrome C; Cygb; cytoglobin; CYP2B6; cyto
Keywords: Bcl-2; B cell lymphoma 2; Bcl-xL; B cell lymphoma-extra large; ARE; antioxidant-response element; Cul3; cullin 3; Cyt c; cytochrome c; Drp1; dynamin-related protein 1; ERK; extracellular signal-regulated kinase; GSH; glutathione; GST; glutathione S-tran
Keywords: endothelin; HIF-1; hypoxia; kidney;
The interplay between HIF-1 and calcium signalling in cancer
Keywords: HIF-1; Calcium signalling; Cancer;
Vosaroxin induces mitochondrial dysfunction and apoptosis in cervical cancer HeLa cells: Involvement of AMPK/Sirt3/HIF-1 pathway
Keywords: Cervical cancer; Mitochondrial dysfunction; Sirt3; HIF-1;
Metal- and redox homeostasis in prostate cancer with vitamin D3 supplementation
Keywords: Al; aluminium; ALT; alanine transaminase; AP-1; activated protein-1; AR; androgen receptor; AST; aspartate transaminase; B; boron; Ba; barium; BMI; body mass index; Ca; calcium; CDK4; cyclin dependent kinase; CEA; carcynoembrionic antigene; Chol; choles
Hypoxia-inducible factor-1 promotes cancer progression through activating AKT/Cyclin D1 signaling pathway in osteosarcoma
Keywords: HIF-1; AKT; Cyclin D1; Osteosarcoma;
Multiple pharmacological activities of Caesalpinia crista against aluminium-induced neurodegeneration in rats: Relevance for Alzheimer's disease
Keywords: AD; Alzheimer's disease; AlCl3; aluminium chloride; TNFα; tumour necrosis factor; MDA; malondialdehyde; ACh; Eacetylcholinesterase; ACh; acetylcholine; MECC; methanolic extracts of Caesalpinia crista; IL-1; interleukin-1; IL-6; interleukin-6 BDNF brain
Overexpression of STAT1 suppresses angiogenesis under hypoxia by regulating VEGFâA in human glioma cells
Keywords: STAT; signal transducer and activator of transcription; IHC; immunohistochemistry; GBM; glioblastomas multiforme; HIF-1; hypoxia-inducible factor 1; VEGF; vascular endothelial growth factor; FBS; fetal bovine serum; ECM; endothelial cell medium; ECGS; end
Possible use of Punica granatum (Pomegranate) in cancer therapy
Keywords: 27HC; 27-hydroxycholesterol; 8-OHdG; 8-hydroxy-2â² -deoxyguanosine; 8-oxodG; 8-oxo-7,8-dihydro-2â²-deoxyguanosine; APC; adenomatous polyposis coli; AR; androgen receptors; AOM; azoxymethane; ATP; adenosine triphosphate; B(a)P; benzo(a)pyrene; Bad; Bcl-2
Downregulation of HIF complex in the hypothalamus exacerbates diet-induced obesity
Keywords: ACTH; Adrenocorticotropic Hormone; ARC; Arcuate Nucleus; AgRP; Agouti-Related Peptide; ARNT; Aryl Hydrocarbon Receptor Nuclear Translocator; BAT; Brow Adipose Tissue; DIO; Diet-induced Obesity; FIH; Factor Inhibiting HIF-1α; GFAP; Glial Fibrillary Acidic
The effects of 1st and 2nd generation biodiesel exhaust exposure on hematological and biochemical blood indices of Fisher344 male rats - The FuelHealth project
Keywords: ALP; alkaline phosphatase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; CC; carbonyl compounds; CHO; cholesterol; CRE; creatinine; DEE; diesel exhaust emission; DEP; diesel exhaust particles; DPF; diesel particle filter; EPO; erythropoi
Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer
Keywords: Andrographolide; Andrographis paniculata; Diterpene lactone; Anticancer; Chemotherapy; Bioactive lactone; ACS; American Chemical Society; AKT; activated protein kinase; Andro; Andrographolide derivative or conjugate; AP-1; activator protein-1; Cdk; Cyclin
The dichotomous role of H2S in cancer cell biology? Déjà vu all over again
Keywords: 1400 W; N-[[3-(aminomethyl)phenyl]methyl]-ethanimidamide; 3-MP; 3-Mercaptopyruvate; 3-MST; 3-Mercaptopyruvate sulfurtransferase; ADT-OH; 5-(4-hydroxyphenyl)-3H-1, 2-dithiole-3-thione; AG; Aminoguanidine; AOAA; Aminooxyacetic acid; CAT; Cysteine aminotra
PKM2, a potential target for regulating cancer
Keywords: PK; pyruvate kinase; HCC; hepatocellular carcinoma; FBP; fructose 1,6-bisphosphate; SAICAR; Succinyl-5-aminoimidazole-4-carboxamide-1-ribose-50-phosphate; hnRNPs; heterogeneous nuclear ribonucleoproteins; PTB; polypyrimidine tract-binding protein; NEK2; n
Coordinate regulation by transcription factors and DNA methylation in the core promoter region of SIRT6 in bovine adipocytes
Keywords: SIRT6; Promoter; Transcriptional regulation; DNA methylation; Bovine; Adipocyte; qPCR; real-time quantitative; CEBPβ; CCAAT enhancer binding protein beta; PAX6; paired box 6; KLF2; Kruppel-like factor 2; CMYB; myb proto-oncogene protein; NRF1; nuclear re
Role of heat shock transcription factor 1(HSF1)-upregulated macrophage in ameliorating pressure overload-induced heart failure in mice
Keywords: HSF1; Autophagy; Heart failure; HIF-1; Cardiac function; Transverse aortic constriction;
Effect of hypoxia on caveolae-related protein expression and insulin signaling in adipocytes
Keywords: Caveolin-1; HIF-1; GLUT4; Insulin resistance;
Effects of anoxia on survival and gene expression in Bactrocera dorsalis
Keywords: HIF; hypoxia inducible factor; bHLH; basic helix-loop-helix; PAS; Per-Arnt-Sim; Hsp; heat shock protein; SOD; superoxide dismutase; HIF-1; hypoxia inducible factor 1; VHL; von Hippel-Lindau; HRE; hypoxia response element; CAT; catalase; POX; peroxidase;
Distinct hypoxic regulation of preadipocyte factor-1 (Pref-1) in preadipocytes and mature adipocytes
Keywords: ARNT; aryl hydrocarbon receptor nuclear translocator; C/EBP; CCAAT-enhancer-binding proteins; CM; conditioned media; Epi; epididymal adipose tissue; HFD; high fat diet; HIF-1; hypoxia-inducible factor-1; HRE; hypoxia responsive elements; MDI; 3-isobutyl-1
Expression of AGPAT2, an enzyme involved in the glycerophospholipid/triacylglycerol biosynthesis pathway, is directly regulated by HIF-1 and promotes survival and etoposide resistance of cancer cells under hypoxia
Keywords: AGPAT2; LPAAT-beta; HIF-1; Hypoxia; Triglyceride synthesis; Lipid droplets;
Gender-dependent changes in physical development, BDNF content and GSH redox system in a model of acute neonatal hypoxia in rats
Keywords: ANH; acute neonatal hypoxia; BDNF; brain-derived neurotrophic factor; GPx; glutathione peroxidases; GSH; reduced glutathione; GSSG; oxidised glutathione; HI; hypoxia-ischaemia; HIF-1; hypoxia inducible factor 1; P; postnatal day; ROS; reactive oxygen sp
PI3K pathway in prostate cancer: All resistant roads lead to PI3K
Keywords: CRPC; castration-resistant prostate cancer; ADT; androgen deprivation therapy; PI3K; phosphoinositide 3-kinase; AR; androgen receptor; PTEN; phosphatase and tensin homologue deleted on chromosome 10; INPP4B; inositol polyphosphate 4-phosphatase type II; P
ROS signalling in the biology of cancer
Keywords: AEJ; alternative end joining; ALL; acute lymphoblastic leukaemia; AML; acute myeloid leukaemia; Apaf-1; apoptotic protein activating factor 1; APL; acute promyelocytic leukaemia; ASK1; apoptosis signal regulating kinase 1; Bcr-Abl; breakpoint cluster-Abel
Modulating autophagy in cancer therapy: Advancements and challenges for cancer cell death sensitization
Keywords: 3-MA; 3-Methyl Adenine; Akt; Protein kinase B; AMP; Adenosine monophosphate; AMPK; AMP-activated protein kinase; Atg; Autophagy related genes; ATP; Adenosine triphosphate; Bak; Bcl-2 homologous antagonist/killer; Bax; Bcl-2-associated X protein; BCL-2; B-
Trichosanthis Fructus: botany, traditional uses, phytochemistry and pharmacology
Keywords: T. kirilowii; Trichosanthes kirilowii Maxim.; T. rosthornii; Trichosanthes rosthornii Harms; TF; Trichosanthis Fructus; TP; Trichosanthis Pericarpium; TS; Trichosanthis Semen; TR; Trichosanthis Radix; MI; myocardial infarction; AMI; acute myocardial infar
Nanomedicines and gene therapy for the delivery of growth factors to improve perfusion and oxygenation in wound healing
Keywords: Ang-1; angiopoietin 1; AP-57; antimicrobial peptide 57; CS; chitosan; Cur; curcumin; ECM; extracellular matrix; EGF; epidermal growth factor; eNOS; endothelial nitric oxide synthase; EPCs; endothelial progenitor cells; EPR; electron paramagnetic resonance
Autophagy in hemorrhagic stroke: Mechanisms and clinical implications
Keywords: AIM2; absent in melanoma 2; AMPK; Adenosine 5â² monophosphate-activated protein kinase; ASC; apoptosis-associated speck-like protein containing a CARD; BBB; blood-brain barrier; BH3; Bcl-2 homology 3; BMVECs; brain microvascular endothelial cells; BNIP3;
Impact of HIF-1α and hypoxia on fungal growth characteristics and fungal immunity
Keywords: Hypoxia; SREBP; HIF-1; Fungal immunity;
Redox regulation of proteasome function
Keywords: Abcd1; ATP binding cassette subfamily D member 1; AD; Alzheimer's disease; ALD; adrenoleukodystrophy; ALS; amyotrophic lateral sclerosis; AP-1; activator protein-1; APP; amyloid precursor protein; CNS; central nervous system; DDI; DNA-damage inducible 1;
ReviewExosomes: Key mediators of metastasis and pre-metastatic niche formation
Keywords: BM; bone marrow; BMDCs; bone marrow-derived cells; EVs; extracellular vesicles; FasL; fas ligand; FGF2; fibroblast growth factor 2; GM-CSF; granulocyte macrophage colony-stimulating factor; HGF; hepatocyte growth factor; HIF-1; hypoxia-inducible factor 1;
miR-200b downregulates Kruppel Like Factor 2 (KLF2) during acute hypoxia in human endothelial cells
Keywords: KLF2; Kruppel Like Factor 2; HUVEC; human umbilical vascular endothelial cells; miRNA; microRNA; TP; target protectors; VEGFA; vascular endothelial growth factor A; VEGFR2; vascular endothelial growth factor A receptor 2; KDR; kinase insert domain recepto
Local intra-articular injection of resveratrol delays cartilage degeneration in C57BL/6 mice by inducing autophagy via AMPK/mTOR pathway
Keywords: Resveratrol; Osteoarthritis; Autophagy; AMP activated protein kinase; Mammalian target of rapamycin; ADAMTS5; a disintegrin and metalloproteinase with thrombospondin motifs 5; AMPK; AMP activated protein kinase; DMM; destabilization of the medial meniscu
Synthesis and evaluation of N-(benzofuran-5-yl)aromaticsulfonamide derivatives as novel HIF-1 inhibitors that possess anti-angiogenic potential
Keywords: N-(Benzofuran-5-yl)aromaticsulfonamide derivatives; HIF-1; Transcriptional activity; Migration; Anti-angiogenesis;
Original ArticleAcetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab
Keywords: ACC; AMPK; Cetuximab; EGFR; HIF-1; Warburg effect;
Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1α via the mTOR/p70S6K/4E-BP1 and MAPK pathways
Keywords: HIF-1; hypoxia-inducible factor-1; PI3K; phosphatidylinositol 3-kinase; mTOR; mammalian target of rapamycin; MAPK; mitogen-activated protein kinase; VEGF; vascular endothelial growth factor; EPO; erythropoietin; Topo-I; topoisomerase-I; eIF4E; eukaryotic
Melatonin influences NO/NOS pathway and reduces oxidative and nitrosative stress in a model of hypoxic-ischemic brain damage
Keywords: Melatonin; Nitric oxide; Ischemia; Hypobaric hypoxia; Antioxidant: oxidative and nitrosative stress; C; control; CNS; central nervous system; eNOS; endothelial nitric oxide synthase; GFAP; glial fibrillary acidic protein; HIF-1; hypoxia inducible factor 1
Nicotinamide nucleotide transhydrogenase (NNT) deficiency dysregulates mitochondrial retrograde signaling and impedes proliferation
Keywords: 3-BrPA; 3-bromopyruvate; ÎΨm; mitochondrial membrane potential; DMS; dimethyl succinate; HDAC; histone deacetylase; ETC; electron transport chain; HIF-1; hypoxia-inducible factor 1; IGF-1R; insulin-like growth factor 1 receptor; IDH; isocitrate dehydrog
Characterization of gene expression associated with the adaptation of the nematode C. elegans to hypoxia and reoxygenation stress reveals an unexpected function of the neuroglobin GLB-5 in innate immunity
Keywords: Neuroglobin; GLB-5; Hypoxia; C. elegans; Innate immunity; Hypoxia-reoxygenation stress; HIF-1; EGL-9; npr-1;
Hypoxia promotes the skewed differentiation of umbilical cord mesenchymal stem cells toward type II alveolar epithelial cells by regulating microRNA-145
Keywords: ALI; acute lung injury; ATII; type II alveolar epithelial; AQP5; Aquaporin 5; bFGF; basic fibroblast growth factor basic; CK; cytokeratins; CoCl2; Cobalt Chloride; Col-I; type I collagen; CTGF; connective tissue growth factor; DMEM; Dulbecco's modified Ea
Modulation of signaling mechanisms in the heart by thioredoxin 1
Keywords: Akt; protein kinase B; AMPK; Adenosine Monophosphate-activated Protein Kinase; Ang-II; Angiotensin-II; AP1; Activator protein 1 (AP-1); ASK1; Apoptosis Signal-regulating kinase; Atg4; Autophagy related-4; ATP; Adenosine Triphosphate; CDDP; cis-diammine-di
Anti-fibrotic effects of chronic treatment with the selective FXR agonist obeticholic acid in the bleomycin-induced rat model of pulmonary fibrosis
Keywords: ACE2; angiotensin I converting enzyme 2; AGT; angiotensinogen; ATI; alveolar epithelial cells type I; ATII; alveolar epithelial cells type II; BALF; bronchial alveolar lavage fluid; BMP2; bone morphogenetic protein 2; BMPR1A; bone morphogenetic protein re