Keywords: Polychlorinated biphenyls; Signalling disruption; Secondary necrosis; Casein kinase 2; AKT; Serine/Threonine kinase 1; CAR; Constitutive androstane receptor; CASP3; Caspase-3; CD; Control diet; CD+; Control diet + Aroclor 1260 exposure; CDK; Cyclin depend
مقالات ISI (ترجمه نشده)
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Keywords: Liver; Proliferation; Cancer; Tumor-Suppressor Proteins; Progenitor Cells; BrdU; bromodeoxyuridine; cDNA; complementary DNA; C/EBP; CCAAT/enhancer binding protein; Co-IP; co-immunoprecipitation; CUGBP1; CUG triplet repeat binding protein 1; DEN; diethylni
Keywords: GHSR; Ghrelin; Exercise; Treadmill; Endurance; Food intake; ACC; acetyl coA carboxylase; AMP 5â²; adenosine monophosphate; AMPK; AMP-activated protein kinase; CNS; central nervous system; COX IV; cytochrome c oxidase subunit 4; G6P; glucose-6-phosphatase
Effect of luteolin on the expression of intestinal cholesterol transporters
Keywords: DMEM; Dulbecco's Modified Eagle Medium; EDTA; ethylenediaminetetraacetic acid; HC; high cholesterol group; HL; HC with 20 mM luteolin at 5 mL/kg body weight group; HMGCR; HMG CoA reductase; HNF4α; hepatocyte nuclear factor 4α; HQ; HC with 20 mM querceti
Hepatic and renal metabolism of genistein: An individual-based model to predict glucuronidation behavior of genistein in different organs
Keywords: CYP; cytochrome P-450; HKM; human kidney microsomes; HLM; human liver microsome; HNF4α; Hepatocyte nuclear factor 4α; HPLC-ESI-Q-TOF-MS; High-performance liquid chromatography coupled with electrospray ionization/quadrupole-time-of-flight mass spectrome
Keywords: agpat4; the gene encoding 1-Acylglycerol-3-Phosphate O-Acyltransferase 4; arα; the gene encoding androgen receptor α; arβ; the gene encoding androgen receptor β; bdfn; the gene encoding Brain-derived neurotrophic factor; bglap; the gene encoding bone
Keywords: APO; apolipoprotein; ACS; acyl-CoA synthetase; ACSL; acyl-CoA synthetase, long chain; ACAT; acyl-CoA:cholesterol acyltransferase; AGPAT; acylglycerophosphate acyltransferase; ATGL; adipocyte triglyceride lipase; 3BHS1; 3-Beta-hydroxysteroid dehydrogenase;
Keywords: ABC; ATP-binding cassette; AE2 (SLC4A2); anion exchanger 2; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; ALP; alkaline phosphatase; ASBT (SLC10A2); apical sodium-dependent bile acid transporter; ASCOM; activating signal cointegrator-
Keywords: ACAT; acyl-CoA cholesterol acyltransferase; ACC; acetyl CoA carboxylases; ACLY; ATP citrate lyases; ACSL; acyl CoA synthetases long chain family; ADRP; adipose differentiation related protein; AGP; advanced glycation end products; AGPAT; acylglycerophosph
Keywords: Foxa2; forkhead box A2; Hnf4α; hepatocyte nuclear factor 4α; Ncam1; neural cell adhesion molecule 1; PDX-1; pancreatic and duodenal homeobox 1; PPARα; peroxisome proliferator activated receptor alpha; PPARγ; peroxisome proliferator activated receptor
β3-adrenergic receptor activation induces TGFβ1 expression in cardiomyocytes via the PKG/JNK/c-Jun pathway
Keywords: β3-adrenergic receptor; Transforming growth factor β1; Protein kinase G; c-Jun N-Terminal kinase; c-Jun; Cardiomyocyte; AP-1; activator protein 1; β-AR; β-adrenergic receptor; cGMP; cyclic guanosine monophosphate; GRK; G protein-coupled receptor kinas
Cloning and characterization of â6/â5 fatty acyl desaturase (Fad) gene promoter in the marine teleost Siganus canaliculatus
Keywords: ALA; α-linolenic acid (18:3n-3); AP1; activated protein 1; ARA; arachidonic acid (20:4n-6); C/EBP; CCAAT enhancer binding protein; DHA; docosahexaenoic acid (22:6n-3); DR1; direct repeat 1 element; EFA; essential fatty acid; EPA; eicosapentaenoic acid (2
Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice
Keywords: IGF-1R; insulin-like growth factor-1 receptor; Akt2; serine-threonine protein kinase 2; HMGCR; HMG CoA reductase; FASN; fatty acid synthase; PEPCK; phosphoenolpyruvate carboxykinase; PCNA; proliferating cell Nuclear antigen; HNF4α; hepatocyte nuclear fac
MicroRNAs in the pathogenesis and treatment of progressive liver injury in NAFLD and liver fibrosis
Keywords: ApoB; apolipoprotein B; CBDL; common bile duct ligation; CCl4; carbon tetrachloride; CPT1; peroxisome carnitine palmitoyl transferase 1; CREBH; cAMP responsive element binding protein H; DNL; de novo lipogenesis; ECM; extracellular matrix; ER; endoplasmic
FOXO1 cysteine-612 mediates stimulatory effects of the coregulators CBP and PGC1α on FOXO1 basal transcriptional activity
Keywords: Forkhead box transcription factors; CBP/p300; PGC1α; Glucose 6-phosphatase; Selenoprotein P; HNF4α;
Insulin downregulates C3 gene expression in human HepG2 cells through activation of PPARγ
Keywords: C3; PPARγ; PPARα; HNF4α; Insulin; HepG2;
Identification of Slug and SOX7 as transcriptional repressors binding to the hepatitis B virus core promoter
Keywords: HBV; Slug; SOX7; Hepatocytes; Liver; Transcription; HNF4α; pgRNA; cccDNA; Promoter; Repression;
Derivation and molecular characterization of pancreatic differentiated MODY1-iPSCs
Keywords: MODY1; HNF4α; iPS cells; Differentiation; Transcription factor; Binding sites;
Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice
Keywords: Aryl hydrocarbon receptor; TCDD; Bile acids; Biliary excretion; Taurodeoxycholic acid; Cyp8b1; 1°BAs; Primary bile acids; 2°BAs; Secondary bile acids; 6-OH; 6-hydroxylated (6-OH); 12-OH; 12α-hydroxylated; Abc; ATP-binding cassette; AhR; Aryl hydrocarbo
Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR
Keywords: Natural products; Nuclear receptors; Liver X receptor; Farnesoid X receptor; Retinoid X receptor; Metabolic syndrome; Precision medicine; 6-ECDCA; 6α-ethyl-chenodeoxycholic acid (obeticholic acid); AA; arachidonic acid; ABC; ATP-binding cassette transpor
Original ArticleTg737 regulates epithelial-mesenchymal transition and cancer stem cell properties via a negative feedback circuit between Snail and HNF4α during liver stem cell malignant transformation
Keywords: Tg737; Epithelial-mesenchymal transition; Snail; HNF4α; Liver stem cells; ALB; albumin; AFP; alpha-fetoprotein; CSCs; cancer stem cells; DEN; diethyl nitrosamine; EMT; epithelial-mesenchymal transition; FCM; flow cytometry; FLSPCs; fetal liver stem/p
Inhibitory effects of metachromin A on hepatitis B virus production via impairment of the viral promoter activity
Keywords: Hepatitis B virus; Terpenes; Metachromin A; HBV core promoter; HNF4α;
Cloning and expression characterization of peroxisome proliferator-activated receptors (PPARs) with their agonists, dietary lipids, and ambient salinity in rabbitfish Siganus canaliculatus
Keywords: ARA; Arachidonic acid (20:4n-6); AF1; Activation function 1; AF2; Activation function 2; ALA; α-linolenic; cDNA; Complementary deoxyribonucleic acid; DHA; Docosahexaenoic acid (22:6n-3); DBD; DNA-binding domain; DMEM/F12; Dulbecco's Modified Eagle Medium
Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium
Keywords: Barrett's oesophagus; HNF4α; Hepatocyte nuclear factor 4-alpha; Oesophageal cancer; Metaplasia;
Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity
Keywords: MPS; microphysiological system; LDH; lactate dehydrogenase; ALT; alanine aminotransferase; BNF; beta-naphthoflavone; Rif; rifampin; EROD; ethoxyresorufin-O-deethylase; CYPs; cytochrome P450s; HNF4α; hepatocyte nuclear factor 4 alpha; MDZ; midazolam; AFB;
Effects of ABCB1, ABCC2, UGT2B7 and HNF4α genetic polymorphisms on oxcarbazepine concentrations and therapeutic efficacy in patients with epilepsy
Keywords: Oxcarbazepine; Pharmacogenetics; ABCB1; ABCC2; UGT2B7; HNF4α;
Cellular adaptation to xenobiotics: Interplay between xenosensors, reactive oxygen species and FOXO transcription factors
Keywords: AhR; arylhydrocarbon receptor; AIP; AhR interacting protein; ARE; antioxidant response element; ARNT; AhR nuclear translocator; bHLH; basic helix-loop-helix (DNA binding and dimerisation domain); CAR; constitutive androstane receptor; CBP; CREB-binding pr
IRE1α links Nck1 deficiency to attenuated PTP1B expression in HepG2 cells
Keywords: ATF6; activating transcription factor 6; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; HNF4α; hepatocyte nuclear factor 4α; GAP; GTPase-activating protein; HFD; high fat diet; IL-4; interleukin-4; IRE1α; inositol-requiring enzyme 1
Specific OCT1 and ABCG2 polymorphisms are associated with Lamotrigine concentrations in Chinese patients with epilepsy
Keywords: Lamotrigine; Pharmacogenetics; OCT1; ABCG2; ABCC2; HNF4α;
Crosstalk of HNF4α with extracellular and intracellular signaling pathways in the regulation of hepatic metabolism of drugs and lipids
Keywords: HNF4α; Liver; Drug metabolism; Lipid metabolism; Inflammation; Hormone;
Deletion of exons 3 and 4 in the mouse Nr1d1 gene worsens high-fat diet-induced hepatic steatosis
Keywords: Nr1d1; Liver; Lipid metabolism; Cebpα; Hnf4α; Thrsp;
Interleukin 6 inhibits HBV entry through NTCP down regulation
Keywords: HBV; Hepatitis B virus; NTCP; Sodium taurocholate co-transporting polypeptide; IL-6; Interleukin 6; IFN γ; Interferon gamma; ALT; Alanine aminotransferase; TNFα; Tumor Necrosis Factor alpha; IL-1β; Interleukin 1 beta; OSM; Oncostatin M; PHH; Primary Hu
Epigenetic control of EMT/MET dynamics: HNF4α impacts DNMT3s through miRs-29
Keywords: ChIP; chromatin immunoprecipitation; DNMT; DNA methyltransferase; EMT; epithelial to mesenchymal transition; MET; mesenchymal to epithelial transition; TGFβ; transforming growth factor β; HNF4α; hepatocyte nuclear factor 4 alpha; qPCR; real-time polyme
Enhancer cooperativity as a novel mechanism underlying the transcriptional regulation of E-cadherin during mesenchymal to epithelial transition
Keywords: Cadherins; Grhl3; Hnf4α; Transforming growth factor beta; Development; Cancer;
Ablation of Foxl1-Cre-Labeled Hepatic Progenitor Cells and Their Descendants Impairs Recovery of Mice From Liver Injury
Keywords: HPCs; Oval Cells; Mouse Model; Nonalcoholic Fatty Liver Disease; ALP; alkaline phosphatase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; CDE; choline-deficient, ethionine-supplemented; CK19; Cytokeratin 19; CreER; Cre-estrogen receptor
β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis
Keywords: WNT; β-Catenin; E-Cadherin; Liver Fibrosis; NASH; HCC; Liver Tumors; AJ; adherens junction; APC; adenomatous polyposis coli gene product; FNH; focal nodular hyperplasia; FOXO; forkhead box protein O; GS; glutathione synthetase; GSK3β; glycogen synthase
Hepatocystin contributes to interferon-mediated antiviral response to hepatitis B virus by regulating hepatocyte nuclear factor 4α
Keywords: Hepatocystin; Hepatitis B virus; Interferon; HNF4α; MAPK;
Human cytochrome P450 epoxygenases: Variability in expression and role in inflammation-related disorders
Keywords: Inflammation; Cytochrome P450; Epoxygenase; Epoxyeicosatrienoic acids; Variability; AA; arachidonic acid; AhR; aryl hydrocarbon receptor; AP-1; activator protein-1; bZIP; basic leucine zipper; CAR; constitutive androstane receptor; CCRP; cytoplasmic CAR r
Med25 is required for estrogen receptor alpha (ERα)-mediated regulation of human CYP2C9 expression
Keywords: CYP; cytochrome P450; Med; Mediator; CAR; constitutive androstane receptor; PXR; pregnane X receptor; GR; glucocorticoid receptor; HNF4α; hepatic nuclear factor 4α; ERα/β; estrogen receptor α/β; E2; 17β-estradiol; RE; responsive element; ERE; estro
Transcriptional regulation of PCFT by KLF4, HNF4α, CDX2 and C/EBPα: Implication in its site-specific expression in the small intestine
Keywords: PCFT; Gene expression; Transcriptional regulation; Intestine; KLF4; HNF4α; CDX2; C/EBPα;
HNF4α contributes to glucose formation in aged rat hepatocytes
Keywords: Aging; Glucose; Gluconeogenesis; PEPCK; Hypoxia; HNF4α;
Research ArticleTGFβ overrides HNF4α tumor suppressing activity through GSK3β inactivation: implication for hepatocellular carcinoma gene therapy
Keywords: TGFβ; transforming growth factor β; EMT; epithelial-to-mesenchymal transition; HCC; hepatocellular carcinoma; HNF4α; hepatocyte nuclear factor 4 alpha; PTM; post-translational modification; GSK3β; glycogen synthase kinase-3 beta; BIO; GSK3β-inhibitor
Research ArticleEssential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor
Keywords: PUFA; polyunsaturated fatty acids; FA; fatty acid; EFAD; essential fatty acids deficiency; PPAR; peroxisome proliferator-activated receptor; LXR; liver X receptor; HNF4α; hepatic nuclear factor 4α; TR; thyroid receptor; SREBP-1c; sterol responsive eleme
Hepatocyte nuclear factor 4α regulates the expression of the murine pyruvate carboxylase gene through the HNF4-specific binding motif in its proximal promoter
Keywords: ChIP; chromatin immunoprecipitation; DR1; direct repeat 1; EMSA; electrophoretic mobility shift assay; FBPase; fructose-1,6-bisphosphatase; G6Pase; glucose-6-phosphatase; HIP1; housekeeping initiator protein 1; HNF4α; hepatocyte nuclear factor 4 alpha; M
Research ArticleHuman pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus
Keywords: AFP; α-foetoprotein; ALB; albumin; ApoB100; apolipoprotein B100; CLDN1; claudin-1; CLDN6; claudin-6; CYP3A4/5; cytochrome P450 family 3 subfamily A polypeptide 4/5; HCV; hepatitis C virus; hESC; human embryonic stem cells; HNF4α; hepatocyte nuclear fact
Anti-inflammatory and metabolic actions of FXR: Insights into molecular mechanisms
Keywords: AF1; activation function 1; ANIT; α-naphthylisothiocyanate; AR; androgen receptor; BA; bile acids; BDL; bile duct ligation; ChIP-seq; chromatin immunoprecipitation-sequencing; DBD; DNA binding domain; DR; direct repeat; ER; estrogen receptor; FXR; farnes
Allelic and phenotypic spectrum of plasma triglycerides
Keywords: ABL; abetalipoproteinemia; ANGPTL3; angiopoietin-like 3; ANGPTL4; angiopoietin-like 4; APOA4; apolipoprotein A-IV; APOA5; apolipoprotein A-V; APOB; apolipoprotein B; APOC2; apolipoprotein C-II; APOC3; apolipoprotein C-III; APOE; apolipoprotein E; CAD; cor
Hepatocyte-like cells differentiated from human induced pluripotent stem cells: Relevance to cellular therapies
Keywords: AFP; alpha fetoprotein; Alb; albumin; ATP5g1; mitochondrial F0 complex, subunit C1 (subunit 9), ATP synthase 5 subunit e; ATP8; ATP synthase 8; BAL; bioartificial liver; BMP4; bone morphogenetic protein 4; CYP; cytochrome P450; CYP2C19; CYP Family 2, Subf
Liver Progenitor Cells Yield Functional Hepatocytes in Response to Chronic Liver Injury in Mice
Keywords: Liver Disease; Differentiation; Mouse Model; Liver Regeneration; α-SMA; α-smooth muscle actin; CDE; choline-deficient ethionine-supplemented; K19; keratin 19; iCreERT2; codon-improved cyclization recombinase estrogen receptor ligand binding domain varia
Multiple post-translational modifications in hepatocyte nuclear factor 4α
Keywords: PTM; post-translational modification; HNF4α; hepatocyte nuclear factor 4α; MODY-1; maturity onset diabetes of young 1; DR; direct repeat; ApoCIII; apolipoprotein CIII; SDS-PAGE; sodium dodecyl sulfate-polyacrylamide gel electrophoresis; CID; collisi