Role of non-MLC20 phosphorylation pathway in the regulation of vascular reactivity during shock
Keywords: Shock; Vascular reactivity; MLC20 phosphorylation; Caldesmon; HSP27
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Lead optimization of dual tubulin and Hsp27 inhibitors
Keywords: Tubulin; Hsp27; Cancer; Lead optimization
Bioassay guided identification of small chaperone proteins α-crystallin and Hsp27 inhibitors from Copaiba oil
Keywords: Copaiba oil; Small chaperone; α-Crystallin; Hsp27; Cancer;
Suppression of Heat Shock Protein 27 Using OGX-427 Induces Endoplasmic Reticulum Stress and Potentiates Heat Shock Protein 90 Inhibitors to Delay Castrate-resistant Prostate Cancer
Keywords: OGX-427; Hsp27; Hsp90 inhibition; Androgen receptor; Castration-resistant prostate cancer;
Pro-inflammatory cytokines downregulate Hsp27 and cause apoptosis of human retinal capillary endothelial cells
Keywords: HREC; human retinal endothelial cells; IDO; indoleamine 2,3-dioxygenase; MT; 1-methyl-dl-tryptophan; NOS; nitric oxide synthase; ROS; reactive oxygen species; TNF-α; tumor necrosis factor-α; IL-1β; interleukin-1β; IFN-γ; interferon-γ; VCAM-1; vascul
MCLR-induced PP2A inhibition and subsequent Rac1 inactivation and hyperphosphorylation of cytoskeleton-associated proteins are involved in cytoskeleton rearrangement in SMMC-7721 human liver cancer cell line
Keywords: Microcystin; PP2A; HSP27; VASP; Rac1; Cofilin;
Hsp27 suppresses the Cu2+-induced amyloidogenicity, redox activity, and cytotoxicity of α-synuclein by metal ion stripping
Keywords: AD; Alzheimer disease; ITC; isothermal titration calorimetric; PD; Parkinson disease; ROS; reactive oxygen species; ThT; thioflavin T; 3-CCA; coumarin-3-carboxylic acid.; Hsp27; Cu2+ binding; Amyloid fibril; α-Synuclein; Reactive oxygen species; Free rad
Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: Therapeutic perspectives
Keywords: Heart; MAPK; Cardiac diseases; Mitochondria; Cell signaling; AngII; angiotensin II; CA; constitutively active; CHIP; C terminus of Hsc70-interacting protein; CT-1; cardiotrophin-1; ÎΨmit; mitochondrial membrane potential; DN; dominant negative; ERK1/2;
Targeted delivery of Dicer-substrate siRNAs using a dual targeting peptide decorated dendrimer delivery system
Keywords: Dendrimer; Nanovector; siRNA; Targeted delivery; Prostate cancer; dsRNA; double-stranded RNA; dsiRNA; Dicer substrate siRNA; G5; generation 5; HES; hematoxylin eosin safran; Hsp27; heat shock protein 27; Nrp-1; neuropilin-1; PAMAM; poly(amidoamine); RGD;
HSP27 expression in primary colorectal cancers is dependent on mutation of KRAS and PI3K/AKT activation status and is independent of TP53
Keywords: HSP27; HSP72; Oncogene induced senescence (OIS); TP53; KRAS; Activated PI3K/AKT;
TRAIL/MEKK4/p38/HSP27/Akt survival network is biphasically modulated by the Src/CIN85/c-Cbl complex
Keywords: TRAIL; tumor necrosis factor-related apoptosis-inducing ligand; CIN85; c-Cbl interacting protein of 85Â kDa; DR4/5; death receptor 4/5; TRAF4; TNF receptor-associated factor 4; GADD45; growth arrest and DNA damage induced gene-45; HSP27; heat shock protei
Small heat shock proteins and toughness in intermediate pHu beef
Keywords: Small heat shock proteins; Intermediate pH; Beef tenderness; αβ-Crystallin; HSP20; HSP27;
Rit subfamily small GTPases: Regulators in neuronal differentiation and survival
Keywords: CA; constitutively active; cAMP; cyclic adenosine monophosphate; CaM; calmodulin; CCI; controlled cortical impact; CREB; cAMP response element binding protein; CRIB; Cdc42/Rac interactive binding; DA; dopamine; DAT; dopamine transporter; DN; dominant nega
Cytokine regulation by MAPK activated kinase 2 in keratinocytes exposed to sulfur mustard
Keywords: SM; sulfur mustard; NHEK; normal human epidermal keratinocytes; MAPK; mitogen activated protein kinase; siRNA; small interfering RNA; MK2/MAPKAPK2; MAPK activated kinase 2; MK3/MAPKAPK3; MAPK activated kinase 3; MK5/MAPKAPK5; MAPK activated kinase 5; TNF-
Basic nutritional investigationTrigonelline isolated from fenugreek seed protects against isoproterenol-induced myocardial injury through down-regulation of Hsp27 and αB-crystallin
Keywords: Myocardial injury; Trigonelline; Antioxidative enzymes; Isoproterenol; Hsp27; αB crystalline; Rat;
Effect of Hsp27 on early embryonic development in the mouse
Keywords: apoptosis; early embryo development; Hsp27; oocyte maturation;
Small heat shock protein HSPB1 regulates growth of embryonic zebrafish craniofacial muscles
Keywords: Myogenesis; Hsp27; Muscle development; HspB1; Zebrafish; Embryogenesis;
A NETWORK-BASED APPROACH FOR PREDICTING HSP27 KNOCK-OUT TARGETS IN MOUSE SKELETAL MUSCLES
Keywords: Bioinformatics; Tenderness; Muscle; Interactome; Hsp27; HspB1-null mice
Phosphorylated Hsp27 activates ATM-dependent p53 signaling and mediates the resistance of MCF-7 cells to doxorubicin-induced apoptosis
Keywords: Hsp27; p53; Phosphorylation; Apoptosis;
Inhibition of Lymphangiogenesis and Angiogenesis in Breast Tumor Xenografts and Lymph Nodes by a Peptide Derived from Transmembrane Protein 45A
Keywords: BVD; blood vessel density; FAK; focal adhesion kinase; HSP27; heat shock protein 27; HUVECs; human umbilical vein endothelial cells; LECs; lymphatic endothelial cells; LN; lymph node; LVD; lymphatic vessel density; MECs; microvascular endothelial cells; N
HSP27 and HSP70 serum and urine levels in patients suffering from chronic kidney disease
Keywords: HSP27; HSP70; Chronic kidney disease; Biomarkers; Heat shock proteins;
PKCδ promotes etoposide-induced cell death by phosphorylating Hsp27 in HeLa cells
Keywords: PKCδ; Hsp27; Phosphorylation; Cytochrome c; Caspase activation; ApoptosisDMEM, Dulbecco’s modified Eagle’s medium; DMSO, dimethyl sulfoxide; DTT, dithiothreitol; EGTA, ethyleneglycoltetraacetic acid; FBS, fetal bovine serum; PARP, poly(ADP-ribose) polymer
Healing the diabetic heart: Does myocardial preconditioning work?
Keywords: I/R; Ischemia-reperfusion; TNF-α; Tumor necrosis factor-alpha; IPC; Ischemic preconditioning; FWOP; First window of protection; SWOP; Second window of protection; TWOP; Third window of protection; eNOS; Endothelial nitric oxide synthase; NO; Nitric oxi
Acute temperature and cadmium stress response characterization of small heat shock protein 27 in large yellow croaker, Larimichthys crocea
Keywords: HSP27; Larimichthys crocea; Expression; Temperature; Cadmium; Stress;
Inflammation-related muscle weakness and fatigue in geriatric patients
Keywords: Muscle; Hsp27; Eotaxin; MCP-1; Geriatric patients
Inhibition of heat shock protein (Hsp) 27 potentiates the suppressive effect of Hsp90 inhibitors in targeting breast cancer stem-like cells
Keywords: Heat shock protein; Hsp90; Hsp27; Breast cancer stem cells;
Treadmill training stimulates brain-derived neurotrophic factor mRNA expression in motor neurons of the lumbar spinal cord in spinally transected rats
Keywords: BDNF; brain-derived neurotrophic factor; DIG; Digoxigenin; HSP27; heat shock protein 27; ISH; in situ hybridization; mRNA; messenger ribonucleic acid; ST; spinally transected; ST100; spinally transected + treadmill training for 100 steps/session; ST1000
Histone deacetylase 6 (HDAC6) plays a crucial role in p38MAPK-dependent induction of heme oxygenase-1 (HO-1) in response to proteasome inhibition
Keywords: DAPI; 4â²,6-diamidino-2-phenylindole; DCF; 2â²,7â²-dichlorofluorescein; DMSO; dimethyl sulfoxide; EDTA; ethylenediaminetetraacetic acid; EGTA; ethylene glycol tetraacetic acid; FCS; fetal calf serum; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; HO-
Small heat shock proteins in cancer therapy and prognosis
Keywords: Molecular chaperones; Clusterin; Hsp27; Cancer; Treatment resistance; Apoptosis
Heat shock protein 27 mediates the effect of 1,3,5-trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone on mitochondrial apoptosis in hepatocellular carcinoma
Keywords: TDP; 1,3,5-trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone; Garcinia oblongifolia; G. oblongifolia; Hsp27; heat shock protein 27; HCC; hepatocellular carcinoma; 2-DE; 2-dimensional electrophoresis; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazo
Targeted Therapies in Metastatic Castration-Resistant Prostate Cancer
Keywords: Prostate cancer; Cabazitaxel; Cabozantinib; Dasatinib; Clusterin; Hsp27; OGX-011;
The hsp27 kD heat shock protein and p38-MAPK signaling are required for regular epidermal differentiation
Keywords: hsp27; Inhibition of hsp27 phosphorylation; p38-MAPK pathway; Keratinocyte differentiation; Cornified cell envelope
Role of activating transcription factor 3 in ischemic penumbra region following transient middle cerebral artery occlusion and reperfusion injury
Keywords: Activating transcription factor 3; Cerebral ischemia; Caspase 3; HSP27; Bcl-xl; Fluoro-jade B
Variation in the expression of Hsp27, αB-crystallin mRNA and protein in heart and liver of pigs exposed to different transport times
Keywords: Hsp27; αB-crystallin; Heart; Liver; Transportation; Pig
Immunocompetent cells and cytokine expression in the rat periodontal ligament at the initial stage of orthodontic tooth movement
Keywords: Immunocompetent cells; Initial stage of Orthodontic tooth movement; OX6; ED1; IL-1β; TNF-α; HSP27; Rat;
Regulation of heat shock protein 27 phosphorylation during microcystin-LR-induced cytoskeletal reorganization in a human liver cell line
Keywords: Microcystin-LR; PP2A; HSP27; Cytoskeleton; MAPK;
Phosphorylation status of heat shock protein 27 plays a key role in gemcitabine-induced apoptosis of pancreatic cancer cells
Keywords: HSP27; Phosphorylation; Apoptosis; Gemcitabine; Pancreatic cancer
HMGB1 induces human lung endothelial cell cytoskeletal rearrangement and barrier disruption
Keywords: HMGB1; RAGE; Acute lung injury; Endothelium; MAP kinase; Hsp27;
Heat Shock Protein 27-Targeted Heptapeptide of the PKCÎ Catalytic V5 Region Sensitizes Tumors With Radio- and Chemoresistance
Keywords: Heptapeptide; HSP27; PKCδ-V5; Tumor sensitization;
Altered Cross-Linking of HSP27 by Zerumbone as a Novel Strategy for Overcoming HSP27-Mediated Radioresistance
Keywords: HSP27; Altered cross-linking; Zerumbone; Radiosensitization;
Low ambient temperature reveals distinct mechanisms for MDMA-induced serotonergic toxicity and astroglial Hsp27 heat shock response in rat brain
Keywords: 3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy'); Serotonin (5-HT); Neurotoxicity; Neuroprotection; Hyperthermia; Tryptophan hydroxylase (Tph); Hsp27;
Microcystin-LR induces cytoskeleton system reorganization through hyperphosphorylation of tau and HSP27 via PP2A inhibition and subsequent activation of the p38 MAPK signaling pathway in neuroendocrine (PC12) cells
Keywords: Microcystin-LR; Cytoskeletal rearrangement; Tau; PP2A; P38 mitogen-activated protein kinase; HSP27
Analysis of proteome changes in doxorubicin-treated adult rat cardiomyocyte
Keywords: ACTH; adrenocorticotropic hormone; ADP; adenosine diphosphate; AMP; adenosine monophosphate; ATP; adenosine triphosphate; DOX; doxorubicin; ETC; electron transport chain; ETF; electron transfer flavoprotein; ETF-QO/ETFDH; electron transfer protein dehydro
Probiotics, Enteric and Diarrheal Diseases, and Global Health
Keywords: GI; gastrointestinal; Hsp27; heat shock protein 27; RCTs; randomized, controlled trials; TLRs; Toll-like receptors;
A novel HSPB1 mutation in an Italian patient with CMT2/dHMN phenotype
Keywords: HSPB1; HSP27; CMT; dHMN; Sural nerve biopsy; Electromyography
The activation of p38alpha, and not p38beta, mitogen-activated protein kinase is required for ischemic preconditioning
Keywords: βKO; p38β knock-out; I/R%; myocardial infarction as a percentage of myocardium at risk of infarction; DRα; drug-resistant p38α; DRβ; drug-resistant p38β; HSP27; heat stress protein of 27 kDa; MAPK; mitogen-activated protein kinase; MAPKK; mitogen-a
Co-treating with arecoline and 4-nitroquinoline 1-oxide to establish a mouse model mimicking oral tumorigenesis
Keywords: Arecoline; 4-Nitroquinoline 1-oxide; Oral cancer; αB-crystallin; Hsp27
Heavy metals chromium and neodymium reduced phosphorylation level of heat shock protein 27 in human keratinocytes
Keywords: Heavy metals; Keratinocytes; HSP27; Phosphorylation
Proteome characterization of human articular chondrocytes leads to novel insights in the function of small heat-shock proteins in chondrocyte homeostasis
Keywords: Chondrocyte; HSP27; Proteome; Small heat-shock proteins
Modulating expression of brain heat shock proteins by estrogen in ovariectomized mice model of aging
Keywords: HSP70; HSP27; Brain; Aging; Estrogen; Heat stress