HSP27 and HSP70 serum and urine levels in patients suffering from chronic kidney disease

► Chronic kidney disease is associated with inflammation of reactive oxygen species. ► As a counterregulation heat shock proteins (HSP) are increased expressed to minimize cell death. ► HSP27 serum levels and fractional excretion were significantly higher in patients with CKD stages 3-5. ► ROC curve analysis showed potential of serum and urine HSP-27 levels to predict various CKD stages.